Paolo Ruggero ErranteUniversidade Federal de São Paulo | UNIFESP · Departamento de Farmacologia
Paolo Ruggero Errante
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76
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Introduction
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January 2006 - December 2010
Publications
Publications (76)
Canine demodicosis is a parasitic dermatopathy caused by Demodex canis, a mite that is part of cutaneous microbiota of dogs. Its overgrowth inside hair follicles and sebaceous glands causes alopecia and erythema in the localized form, and its generalized form usually goes along with a severe case of folliculitis. Its diagnosis is performed through...
O tumor ósseo multilobular, também conhecido como osteocondrossarcoma multilobular ou chondroma rodens, é um tumor maligno de crescimento lento, localmente invasivo, capaz de comprimir e invadir o tecido adjacente. Sua ocorrência é maior nos ossos planos do crânio e palato duro. Os sinais clínicos dependem da localização do tumor e, geralmente, est...
The naturally occurring high-grade invasive transitional cell carcinoma or canine invasive urothelial carcinoma localized in bladder can be successfully treated surgically, however, at time of your diagnosis, it may present itself at an advanced stage, and distant metastases occur in 50% of cases. The urothelial carcinoma has a poor prognosis due t...
Epidermolysis bullosa is an inherited group of rare genetic dermatosis characterized by mucocutaneous fragility and blister formation, inducible by often minimal trauma. Epidermolysis bullosa is described in humans and domestic animals, and this dermatosis in humans is classified in four categories based predominantly on the plane of skin cleavage...
Canine dermatomyositis is an inflammatory vasculopathy from skin and muscles, with cutaneous manifestations involving face, ears, tail and distal ends over bony prominences. The muscles involved include the muscles of the head, leading to difficulty in swallowing, reduction of reflex of vomit. Some animals have muscle changes that lead to the devel...
In the recent years, benign ureteral obstruction by nephrolithiasis has an increased incidence in the feline population, whose causes are not yet fully established. Its diagnosis is based on clinical signs, biochemical analyzes and imaging methods such as radiography and ultrasound. For its treatment, initially one can resort to pharmacological the...
The canine cognitive dysfunction syndrome is a chronic and progressive neurodegenerative disease that affects elderly dogs, leading to the emergence of anatomical and functional changes in the central nervous system and development of characteristic behavioral clinical signs, such as memory loss, alteration of the sleep/wake cycle, decreased respon...
Purpose
To evaluate the preventive cardioprotective effects of resveratrol and grape products, such as grape juice and red wine, in animal model of cardiac ischemia and reperfusion.
Methods
Male Wistar rats orally pretreated for 21-days with resveratrol and grape products were anesthetized and placed on mechanical ventilation to surgically induce...
A dermatomiosite canina é uma vasculopatia inflamatória da pele e músculos, com manifestações cutâneas envolvendo a face, orelhas, extremidades da cauda e distais por sobre proeminências ósseas. O envolvimento muscular manifesta-se sob a forma de mioatrofia cefálica, dificuldade de deglutição, redução do reflexo do vômito e marcha atípica. A dermat...
Abstract:
Purpose: To evaluate whether the attenuation of mitochondrial Ca2+ overload produced by pharmacological blockade of mitochondrial Ca2+ uniporter (MCU) protects the myocardium against injuries caused by cardiac ischemia and reperfusion (CIR).
Methods: CIR was induced in adult male Wistar rats (300-350 g) by
occlusion of the left anterior...
Most severe manifestations of COVID‐19 cases, such as multiple organ failure and death, have been linked to coagulation dysfunction markers, such as platelet reduction and increases in prothrombin time, fibrin degradation products and, mainly, D‐dimer [1]. A recent paper by Tang et al. [2] in this journal reported that heparin treatment reduced mor...
Ischemic heart diseases (IHD) are the leading cause of death worldwide. Although the principal form of treatment of IHD is myocardial reperfusion, the recovery of coronary blood flow after ischemia can cause severe and fatal cardiac dysfunctions, mainly due to the abrupt entry of oxygen and ionic deregulation in cardiac cells. The ability of these...
Introdução: A epilepsia é uma doença que afeta milhões de pessoas em todas as partes do mundo. Crises epilépticas se apresentam nos pacientes de forma parcial ou generalizada, dependendo do grau de atividade da doença. Atualmente, há muitos fármacos disponíveis no mercado, os quais possuem diversos mecanismos de ação e que podem ser utilizados de f...
Purpose:
To evaluate the cardioprotective response of the pharmacological modulation of β-adrenergic receptors (β-AR) in animal model of cardiac ischemia and reperfusion (CIR), in spontaneously hypertensive (SHR) and normotensive (NWR) rats.
Methods:
CIR was induced by the occlusion of left anterior descendent coronary artery (10 min) and reperf...
Ischemic heart diseases (IHD) are the leading cause of death worldwide. Although the principal form of treatment of IHD is myocardial reperfusion, the recovery of coronary blood flow after ischemia can cause severe and fatal cardiac dysfunctions, mainly due to the abrupt entry of oxygen and ionic deregulation in cardiac cells. The ability of these...
Purpose:
To investigate the cardioprotective effects of ischemic preconditioning (preIC) and postconditioning (postIC) in animal model of cardiac ischemia/reperfusion.
Methods:
Adult rats were submitted to protocol of cardiac ischemia/reperfusion (I/R) and randomized into three experimental groups: cardiac I/R (n=33), preCI + cardiac I/R (n=7) a...
Purpose:
To evaluate in vivo animal model of cardiac ischemia/reperfusion the cardioprotective activity of pancreatic lipase inhibitor of the orlistat.
Methods:
Adult male Wistar rats were anesthetized, placed on mechanical ventilation and underwent surgery to induce cardiac I/R by obstructing left descending coronary artery followed by reperfus...
Cardioprotective effect of lipstatin derivative orlistat on normotensive rats submitted to cardiac ischemia and reperfusion 1 Abstract Purpose: To evaluate in vivo animal model of cardiac ischemia/reperfusion the cardioprotective activity of pancreatic lipase inhibitor of the orlistat. Methods: Adult male Wistar rats were anesthetized, placed on me...
Este relato teve como objetivo mostrar como a implantação do Programa 5S pode melhorar a qualidade do serviço e trazer benefícios a instituição e colaboradores. Foi realizado uma análise do Serviço de Refeição aos Educandos, onde foram observados a estrutura física, os procedimentos realizados e relatórios administrativos. A aplicação da ferramenta...
Purpose:
To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model.
Methods:
Adult Wistar male rats were randomly (n=8), anesthetized and divided in: Sham: submitted to operation only; group SS+IR: intravenous saline infusion following superior mese...
Cancer is a major public health problem and the second leading cause of mortality around the world. Antitumor immunotherapy using monoclonal antibodies is considered selective and efficient in the treatment of different types of tumors, but its cost and toxic effects limit its application. Many tumor microenvironments, including lymphoma and carcin...
Background: Acute myocardial infarction (AMI) is characterized by ischemic lesions that severely compromise the cardiac structure/function, besides the survival of mammals. Although conventional therapy uses cardiac reperfusion, this procedure increases the cardiac damage caused by ischemia. Methods: Adult male Wistar rats (NWR) were anesthetized,...
This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the in...
To study cardioprotective drugs, we developed a simple and efficient methodology to evaluate effects of drugs on cardiac electrical activity using electrocardiogram (ECG) in rats submitted to cardiac ischemia-reperfusion (I/R). Using adult male Wistar rats (14-16-week-old) anesthetized (urethane 1.25 g/kg, i.p.) and kept under mechanical ventilatio...
Introdução: A hipertensão arterial é um dos fatores de risco para doenças cardiovasculares, estando diretamente associada ao elevado consumo de sódio. Objetivo: Avaliar os níveis de marcadores de lesão hepática, renal e cardíaca em ratos hipertensos comparados aos seus controles normotensos, tratados com um salgante isento de sódio, água ou NaCl. M...
Cell signaling is a crucial event for the survival and
progress of normal cellular functions. However, mutations
of certain genes can lead to the emerging of cancer cells,
which can use these signaling mechanisms for their
survival, growth and dissemination. Among these
mechanisms, we highlight the role of cyclic nucleotides
such as cAMP, and Ca2+...
Cardiovascular diseases (CD) are one of the main causes of death in
the world, among them is ischemic cardiac disease (ICD). ICD is
believed to cause 26 million deaths worldwide by 2030 [1,2]. Among
ICD, acute myocardial infarction (AMI) is the most common cause of
morbidity and mortality in the world [2,3]. AMI is characterized by a
long period, a...
This editorial article gives insights for the inhibition of cancer progression. The pharmacological modulation of Ca2+/cAMP signalling interaction is also cited.
p>Introdução: o câncer de mama é a segunda causa de morte por câncer em mulheres, e, 25% das mulheres com câncer de mama
apresentam superexpressão do receptor 2 para o fator de crescimento epidérmico (HER2), que confere um comportamento agressivo
e prognóstico reservado. Uma das opções de tratamento é a utilização do Trastuzumabe (TZB), um anticorp...
p>Introdução: o câncer de mama é a segunda causa de morte por câncer em mulheres, e, 25% das mulheres com câncer de mama
apresentam superexpressão do receptor 2 para o fator de crescimento epidérmico (HER2), que confere um comportamento agressivo
e prognóstico reservado. Uma das opções de tratamento é a utilização do Trastuzumabe (TZB), um anticorp...
to review the literature in search of the main
studies that used flow cytometry as the main methodology.
Introdução: A displasia ectodérmica anidrótica com imunodeficiência (DEA) é uma doença caracterizada por mutações nos genes que codificam o NF-kB. Objetivo: Avaliar o efeito do NF-B na regulação gênica dos componentes do sistema NADPH oxidase de pacientes com DEA. Métodos: Sangue periférico de pacientes com DEA e indivíduos saudáveis foram coletad...
Este trabalho relata a experiência de um município da grande São Paulo - SP na adoção da pesquisa de satisfação do usuário SUS como ferramenta para a gestão pública. Utilizou-se a metodologia de pesquisa documental e entrevista que se viabilizou por meio de visita técnica ao setor desenvolvedor do projeto de pesquisa de satisfação. Na análise docum...
A obesidade é uma doença de etiologia multifatorial que está diretamente associada à doenças cardiovasculares ou síndrome metabólica, sendo responsável por grande número de mortes em todo o mundo. Diante das consequências que esta pandemia pode trazer, foi realizada uma pesquisa entre 888 alunos de uma Instituição de Ensino Superior para saber a pr...
Primary immunodeficiency disorders (PID) represent a heterogeneous group of diseases resulting from inherited defects in the development, maturation and normal function of immune cells; thus, turning individuals susceptible to recurrent infections, allergy, autoimmunity, and malignancies. In this retrospective study, autoimmune diseases (AIDs), in...
Primary immunodeficiency disorders (PID) represent a heterogeneous group of diseases resulting from inherited defects in the development, maturation and normal function of immune cells; thus, make individuals susceptible to recurrent infections, allergy, autoimmunity, and malignancies. In this retrospective study, autoimmune diseases (AIDs), in spe...
Introduction: Common variable immunodeficiency (CVID) is an immunological disorder characterized by defective antibody production. Objectives: To study lymphocytes number, surface activation molecules, cell markers, lymphoproliferative response, cytokine production, and cell death. Methods: A study was led on thirty four patients with CVID selected...
Introduction: Nucleic acid methylation may have major effects on gene expression patterns and, by consequence, on the development of autoimmunity, like Systemic Lupus Erythematosus (SLE). Objective: To investigate the pattern of global DNA methylation in SLE patients and compare this pattern with laboratory parameters. Methods: Genomic DNA was isol...
RESUMO Os hormônios glicocorticóides regulam vários processos fisiológicos, incluindo a gliconeogênese, reatividade vascular as catecolaminas, respostas inflamatória e imune e a atividade do SNC. O uso clínico dos glicocorticóides é indicado na deficiência suprarrenal congênita ou adquirida, doenças reumáticas, renais, alérgicas, infecciosas, oftal...
Glucocorticoids hormones regulate several physiological processes, including of neoglicogenesis, vascular reactivity to catecholamines, immune and inflammatory responses and activity of SNC. The clinical use of glucocorticoids is indicated in congenital adrenal deficiency, rheumatic, kidney, allergy, infections, ophthalmology, skin, gastrointestina...
Toll-like receptors (TLRs) sense microbial products and play an important role in innate immunity. Currently, 11 members of TLRs have been identified in humans, with important function in host defense in early steps of the inflammatory response. TLRs are present in the plasma membrane (TLR1, TLR2, TLR4, TLR5, TLR6) and endosome (TLR3, TLR7, TLR8, T...
Congenital defects of phagocytes are primary immunodeficiency diseases (PIDs), a genetically heterogeneous group of disorders that affect distinct components of the innate immune system, such as neutrophils, macrophages, dendritic cells, and eventually others cells such as T and B lymphocytes and Natural Killer. These diseases involving myeloid dif...
This study investigated environmental endotoxin exposure during early life, sensitization to aeroallergens, the production of cytokines by LPS-stimulated leukocytes, and the development of a wheezing phenotype in a prospective cohort of infants with high risk of developing allergic diseases.
Eighty-four infants were followed from birth until 30 mon...
Primary immunodeficiencies (PIDs) are genetic disorders of the immune system comprising many different phenotypes. Although previously considered rare, recent advances in their clinical, epidemiological, and molecular definitions are revealing how much we still need to learn about them. For example, geographical and ethnic variations as well as the...
Human immunodeficiency virus (HIV) infection leads to T CD4 + cell depletion with progressive immune dysfunction, and despite benefits of antiretroviral therapy, if not judiciously used, it leads to the emergence of drug resistance. In this study, we evaluated 40 patients with HIV that enrolled the Unique Health System-SUS and pharmacy of Medical S...
Este artigo apresenta e avalia o uso da linguagem de BPMN (Business Process Modeling and Notation) em uma organização de pesquisas acadêmicas. Esta organização é um ambiente real, parte de uma universidade pública. Isto a torna diferente das demais organizações de negócio. Aplicar BPMN para prover visão estratégica neste negócio peculiar é um novo...
CD40 ligand (CD40L) deficiency or X-linked hyper-IgM syndrome (X-HIGM) is a well-described primary immunodeficiency in which Pneumocystis jiroveci pneumonia is a common clinical feature. We have identified an unusual high incidence of fungal infections and other not yet described infections in a cohort of 11 X-HIGM patients from nine unrelated Braz...
Common Variable Immunodeficiency (CVID) is a primary immunodeficiency disease characterized by defective immunoglobulin production and often associated with autoimmunity. We used flow cytometry to analyze CD4(+)CD25(HIGH)FOXP3(+) T regulatory (Treg) cells and ask whether perturbations in their frequency in peripheral blood could underlie the high i...
Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by early onset of recurrent and severe infections. The molecular defects causing CGD are heterogeneous and lead to absence, low expression, or malfunctioning of one of the phagocyte NADPH oxidase components. It is known that mutations leading to CGD reside within the ge...
Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia. Leptin has been implicated as an antiapoptotic compound as well as a stimulant of the immune response. Leptin administration is capable of reversing the immune deficiency that occurs upon starvation. We investigated a possible role for lept...
Common variable immunodeficiency (CVID) is an immunological disorder characterized by defective antibody production, recurrent infections, most notably of the respiratory tract, autoimmune phenomena and cancer. Some CVID patients may also present disturbances of the cellular immune response such as a decrease in the number and proportion of differe...