Paola Carrillo-Bustamante

Paola Carrillo-Bustamante
Max Planck Institute for Infection Biology | MPIIB · Department of Vector Biology

Doctor of Philosophy

About

27
Publications
3,212
Reads
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281
Citations
Introduction
Initially trained as a Biomedical Engineer, my strong interest lies in Theoretical Biology. In the last years, I have focused on infection Biology and have studied various complex systems, including the evolution of the polygenicity and specificity of NK cell receptors, the complex spread of HIV-1 infected cells in tissue and the effect of therapies during hemorrhagic fevers. Currently, I am working on the fascinating epidemiology of vector-borne diseases, specifically Malaria. I am particularly interested in host-pathogen interactions, ecology and evolution.
Additional affiliations
November 2019 - present
Max Planck Institute for Infection Biology
Position
  • Researcher
July 2017 - October 2019
Max Planck Institute for Infection Biology
Position
  • PostDoc Position
June 2015 - June 2017
Universität Heidelberg
Position
  • PostDoc Position
Description
  • I was mainly involved in two projects: 1)Development of mathematical models of viral dynamics incorporating treatment 2) Development of a Cellular Potts model framework that replicates the migration of HIV-1 infected cells
Education
September 2003 - June 2009
Karlsruhe Institute of Technology
Field of study
  • Biomedical Engineering

Publications

Publications (27)
Article
Full-text available
Pathogens face varying microenvironments in vivo, but suitable experimental systems and analysis tools to dissect how three-dimensional (3D) tissue environments impact pathogen spread are lacking. Here we develop an Integrative method to Study Pathogen spread by Experiment and Computation within Tissue-like 3D cultures (INSPECT-3D), combining quant...
Article
Full-text available
Malaria, a major cause of child mortality in Africa, is engendered by Plasmodium parasites that are transmitted by anopheline mosquitoes. Fitness of Plasmodium parasites is closely linked to the ecology and evolution of its anopheline vector. However, whether the genetic structure of vector populations impacts malaria transmission remains unknown....
Article
Full-text available
Malaria is a fatal human parasitic disease transmitted by a mosquito vector. Although the evolution of within-host malaria virulence has been the focus of many theoretical and empirical studies, the vector's contribution to this process is not well understood. Here, we explore how within-vector resource exploitation would impact the evolution of wi...
Article
Full-text available
Ribavirin is a broad spectrum antiviral which inhibits Lassa virus (LASV) replication in vitro but exhibits a minor effect on viremia in vivo. However, ribavirin significantly improves the disease outcome when administered in combination with sub-optimal doses of favipiravir, a strong antiviral drug. The mechanisms explaining these conflicting find...
Article
Full-text available
The activity of natural killer (NK) cells is tightly regulated by inhibitory and activating receptors. Inhibitory killer immunoglobulin-like receptors (iKIRs) survey the surface of target cells by monitoring the expression of human leukocyte antigen (HLA) class I. The binding of iKIRs has been shown to be sensitive to the peptides presented by HLA...
Article
Full-text available
Natural killer (NK) cells are immune cells that play a crucial role against viral infections and tumors. To be tolerant against healthy tissue and simultaneously attack infected cells, the activity of NK cells is tightly regulated by a sophisticated array of germline-encoded activating and inhibiting receptors. The best characterized mechanism of N...
Article
Full-text available
Natural killer (NK) cells express inhibiting receptors (iNKRs), which specifically bind MHC-I molecules on the surface of healthy cells. When the expression of MHC-I on the cell surface decreases, which might occur during certain viral infections and cancer, iNKRs lose inhibiting signals and the infected cells become target for NK cell activation (...
Article
Full-text available
Natural killer cell receptors (NKRs) monitor the expression of MHC class I and stress molecules to detect unhealthy tissue, such as infected or tumor cells. The NKR gene family shows a remarkable genetic diversity, containing several genes encoding receptors with activating and inhibiting signaling, and varying in gene content and allelic polymorph...
Article
Full-text available
The responsiveness of natural killer (NK) cells is controlled by balancing signals from activating and inhibitory receptors. The most important ligands of inhibitory NK cell receptors are the highly polymorphic major histocompatibility complex (MHC) class I molecules, which allow NK cells to screen the cellular health of target cells. Although thes...
Article
Inhibition of the atrial ultra-rapid delayed rectifier potassium current (I Kur) represents a promising therapeutic strategy in the therapy of atrial fibrillation. However, experimental and clinical data on the antiarrhythmic efficacy remain controversial. We tested the hypothesis that antiarrhythmic effects of I Kur inhibitors are dependent on kin...
Article
Full-text available
Natural killer (NK) cells are circulating lymphocytes that play an important role in the control of viral infections and tumors. Their functions are regulated by several activating and inhibitory receptors. A subset of these receptors in human NK cells are the killer immunoglobulin-like receptors (KIRs), which interact with the highly polymorphic M...
Conference Paper
Full-text available
Atrial fibrillation (AF) is a common pathology. AF modifies the electrophysiological properties of cells (remodeling) promoting the occurrence and maintenance of AF. Electrical remodeling includes changes in I<sub>Ca,L</sub>, I<sub>to</sub>, I<sub>K1</sub> and I<sub>K,ACh</sub>.These effects were integrated in a human atrial computer model. Gap jun...
Conference Paper
Atrial fibrillation is the most common cardiac arrhythmia in humans. The precise cellular mechanisms underlying atrial fibrillation are still poorly understood. Recent studies have identified several genetic defects as predisposing factors for this pathology. One of the identified genetic defects is the mutation N588K, which affects the cardiac IKr...

Projects

Projects (2)
Archived project
Ribavirin is a broad spectrum antiviral which inhibits multiple viruses in vitro. When given alone in vivo the drug often exhibits only a minor effect on viremia but, in combination, the drug can improve the clinical outcome of many viral infections, such as HCV. In this project, I am investigating various non mutually-exclusive roles of RIbavirin in the context of Lassa virus infection by using viral dynamic models.