Paola Borrego-Muñoz

Fundación Universitaria Juan N. Corpas · Escuela de Medicina

The search for active phytopharmacological principles could contribute to findingmolecules as an alternative for themanagement of different pathologies. In this context, it is important to carry out a toxicological evaluation in order to know the safety of extracts derived from promising plant species. In Colombia, the use of medicinal plants is im...

Crop losses caused by microbial infections are a significant global issue, especially in tropical regions. The development of novel antimicrobial agents, particularly antifungal agents, has been explored from various perspectives, including chemical synthesis. However, conventional approaches typically involve synthesizing new and potent compounds...

Una serie de amidas N-alquilsustituidas 1-16 fueron sintetizadas a partir de malonato de dietilo y ésteres de alquilo derivados de los aminoácidos ʟ-triptófano, ʟ-alanina, ʟ-fenilalanina y ʟ-tirosina. Los métodos de síntesis empleados involucraron calentamiento por irradiación de microondas empleando tanto un ácido de Lewis (AlCl3) o 4-dimetilamino...

One of the main problems affecting the world is food scarcity which is occasioned by different causes, including difficult climatic conditions, economic and technical limitations, infrastructure and transportation, food safety and insecurity, and diseases caused by microorganisms (phytopathogens) such as Fusarium oxysporum whose damage triggers a s...

Citation: Mancipe, J.C.; Vargas-Pinto, P.; Rodríguez, O.E.; Borrego-Muñoz, P.; Castellanos Londoño, I.; Ramírez, D.; Piñeros, L.G.; Mejía, M.C.; Pombo, L.M. Anti-Inflammatory Effect of Izalpinin Derived from Chromolaena leivensis: λ-Carrageenan-Induced Paw Edema and In Silico Model. Molecules 2023, 28, 3722. https://doi. Abstract: The flavonoid iza...

The flavonoid izalpinin was isolated from the aerial parts of Chromolaena leivensis. Its structural determination was carried out using MS and NMR spectroscopic techniques (1 H, 13 C). This compound was evaluated for its anti-inflammatory effect in a rat model on λ-carrageenan-induced plantar edema. Paw inflammation was measured at one-hour interva...

The flavonoid izalpinin was isolated from the aerial parts of Chromolaena leivensis. Its structural determination was carried out using MS and NMR spectroscopic techniques (1H, 13C). This compound was evaluated for its anti-inflammatory effect in a rat model on λ-carrageenan-induced plantar edema. Paw inflammation was measured at one-hour intervals...

In this manuscript, the synthesis of enamine-type Schiff bases 1–48 derived from the amino acids L-Ala, L-Tyr, and L-Phe was carried out. Their in vitro activity and in vivo protective effect against Fusarium oxysporum were also evaluated through mycelial growth inhibition and disease severity reduction under greenhouse conditions. The in vitro act...

Neurodegenerative diseases (NDD) have been of great interest to scientists for a long time due to their multifactorial character. Among these pathologies, Alzheimer's disease (AD) is of special relevance, and despite the existence of approved drugs for its treatment, there is still no efficient pharmacological therapy to stop, slow, or repair neuro...

Schiff bases are widely used molecules due to their potential biological activity. In this manuscript, we presented the synthesis and NMR study of new enamine Schiff bases derived from l-tryptophan, showing that the Z-form of the enamine is the main tautomeric form for aliphatic precursors. The DFT-B3LYP methodology at the 6-311+G**(d,p) level sugg...

Compounds containing a C=N moiety, namely imines, have been widely used for industrial purposes due to their various biological activities. Cyclic imines are an essential class of nitrogen-based heterocycles and valuable scaffolds for designing and obtaining new biologically active compounds. However, the proposal and implementation of synthetic me...

Background: Ilex guayusa Loes. belongs to the family Aquifoliaceae. It is an evergreen tree native to the Amazon region. According to traditional uses, it is used as a diaphoretic, narcotic, purgative, among other uses. Objective: To evaluate the antioxidant capacity, quantify phenols and total flavonoids of extracts obtained from Ilex guayusa leav...

Vascular wilt caused by F. oxysporum (FOX) is one of the main limitations of producing several agricultural products worldwide, causing economic losses between 40% and 100%. Various methods have been developed to control this phytopathogen, such as the cultural, biological, and chemical controls, the latter being the most widely used in the agricul...

Plants synthesize a large number of natural products, many of which are bioactive and have practical values as well as commercial potential. To explore this vast structural diversity, we present PSC-db, a unique plant metabolite database aimed to categorize the diverse phytochemical space by providing 3D-structural information along with physicoche...

Las fuentes de agua potable, necesarias para garantizar la salud de los seres vivos y el medioambiente, son cada vez más escasas. Esta grave problemática exige el desarrollo de nuevas tecnologías eco-amigables que permitan el monitoreo de metales pesados, la prevención y, especialmente, la remediación de fuentes hídricas contaminadas. Dada la neces...

N-heterocyclic compounds are widely known as an important family of biologically active compounds. Pyrrolidines are among the most bioactive compounds. Moreover, pyrrolidines are present in several natural products, being considered as important pieces for the synthesis of pharmaceuticals and biologically active compounds. Derivatives such as 3-sub...

Resistance generated by plants against the attack of different pathogens is related to the biosynthesis of secondary metabolites known as phytoalexins. These compounds have shown inhibitory activity against fungi of the genus Fusarium, which cause 80% economic losses worldwide. Given the complexity represented by the chemical control of these phyto...

El libro presenta las monografías de cuatro especies vegetales de gran importancia desde el punto de vista etnofarmacológico.

Inflammation is a complex process that can be induced by physical damage, chemical precursors, microbial invasion, primary immune response or by combination of these. The study of medicinal flora allows the search for new therapeutic alternatives for the treatment of inflammation. Among these species are those belonging to the genus Ageratina (Aste...

In recent decades, essential oils (EOs) have become an important alternative source of antimicrobial agents. The objective of this study was to evaluate the antimicrobial activity of EOs obtained from the leaves of Myrcianthes leucoxyla Mc. Vaughn., Vallea stipularis L.f and Phyllanthus salviifolius Kunth for prevalent microbial strains and also to...

Kalanchoe pinnata (Lam.) Pers. es una planta popular que se emplea en medicina tradicional en muchas partes del mundo y, en especial, en Suramérica. Estudios previos de la especie han reportado actividad antialérgica, antileishmaniasis, antiinflamatoria, cicatrizante, colerética, antidiabética y anticonceptiva. Químicamente, se ha reportado la pres...

For the evaluation of the cytotoxic activity of the species Conyza trihecatactis and Ageratina vacciniaefolia (Asteareaceae), from the aerial parts of the species the complete ethanolic extracts and fractions were obtained with solvents in order of increasing polarity. The evaluation of the cytotoxic activity was performed by the MTT method on tumo...

Introduction: Conventional homeopathy advocates giving 10 strokes (agitation/succussions) to a prescription bottle containing liquid dilution, before taking it. To scientifically support such activity, it must be based on studies on the physicochemical aspects of the memory of water and agitated water chains, supplemented with spectrometry. Objecti...

BACKGROUND: Low back pain due to discopathy has become one of the most expensive and highest impact problems of global public health at present. AIM: To evaluate the effectiveness of alternative therapies (AT) and related factors in lumbar disk disease (LDD). METHODS: Information was collected by using a retrospective descriptive design from medi...

La especie Pelargonium odoratissimum (geranio de olor) pertenece a la familia Geraniaceae. Dentro de su composicion quimica, presenta flavonoides tales como quercetina, kaempferol y miricetina; el aceite esencial de sus hojas es rico en metil-eugenol, limoneno y fencona. A partir de hojas y flores de la especie P. odoratissimum se obtuvo el aceite...

This yearbook gathers and visualizes a large amount of data on research activity and research results between 2013 and 2014 at the Fundación Universitaria Juan N. Corpas. My participation was as a proofreader.