Paola Angelini

• Associate Professor
• University of Perugia

In this study, we assessed in vitro minimum inhibitory concentration (MIC) values of some natural geranyloxycoumarins, geranyloxy- and isopentenyloxy acids against growth of Helicobacter pylori. Boropinic acid, active principle isolated from Boronia pinnata (Fam. Rutaceae), was seen to be the most effective compound with a MIC value of 1.62 microg/...

Twenty-eight clinical fungal isolates were characterised by morphological (macro- and micro-features and growth response at 25, 30 and 37°C) and molecular (nuclear rDNA-internal transcriber spacer, calmodulin, cytochrome c oxidase 1 and the largest subunit of RNA polymerase II) analyses. The clinical fungal isolates were ascribed to the following t...

We surveyed the fungal endophytes in the leaves and roots of Phragmites australis plants along a gradient of reed decline at Lake Trasimeno (central Italy) in Oct. 2010. An integrated approach consisting of cultivation and molecular identification was used. Endophytes were recovered from 61.59% of the samples, with a total of 1 541 isolates. On the...

e Osteopatia) nel mondo occidentale vengono usate dal 30-35% dei cittadini europei e da oltre il 50% dei cittadini statunitensi (Vickers, 1998). Le cause di questa grande espansione sono l’efficacia, dimostrata dalle numerose analisi dei risultati ottenuti, la tollerabilità e il particolare rapporto tra terapeuta e paziente. L’attributo “non conven...

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Antimicrobial resistance (AMR) is a growing global health crisis that threatens the efficacy of antibiotics and modern medical interventions. The emergence of multidrug-resistant (MDR) pathogens, exacerbated by the misuse of antibiotics in healthcare and agriculture, underscores the urgent need for innovative solutions. (1) Background: AMR arises f...

Mushrooms have long been an integral part of human culture and health and are valued for their nutritional and therapeutic properties. Often referred to as a superfood, mushrooms are rich in bioactive compounds that provide a range of health benefits including antioxidant, antimicrobial, anticancer, prebiotic, antidiabetic, and anti‐inflammatory ef...

The aim of the present study was to investigate the phenolic composition and the efficacy of an innovative formulation based on Mg, Vitamin B6, and water extracts from Vitex agnus-castus, Crocus sativus, Melissa officinalis, Betula pendula, and Betula pubescens developed as an effective tool to face neuroinflammation and depression symptoms occurri...

Hymenochaetaceae is a large and noteworthy family of macrobasidiomycetes predominantly growing on woody plants. Several Hymenochaetaceae members have a long history of recognition in traditional medicine and modern pharmacological studies have demonstrated their therapeutic properties. This review comprehensively surveys the studies on biological a...

The present study investigates the chemical profile and biological activities of Polygonum istanbulicum M. Keskin, a species endemic to Turkey, aiming to explore its potential applications in pharmacology. We assessed its phenolic and flavonoid content by employing ethyl acetate, methanol, and water as extraction solvents. The methanol extract demo...

Background/Objectives: The increase in fungal infections, both systemic and invasive, is a major source of morbidity and mortality, particularly among immunocompromised people such as cancer patients and organ transplant recipients. Because of their strong therapeutic activity and excellent safety profiles, azole antifungals are currently the most...

Micromonospora profundi TRM 95458 converts glycerol to a new osmotic compound Di Lu, Hong-ling Shen, Lei Wang and Chuan-xing Wan Isolation of anticancer bioactive secondary metabolites from the sponge-derived endophytic fungi Penicillium sp. and in-silico computational docking approach Kumaravel Kaliaperumal, Limbadri Salendra, Yonghong Liu, Zhira...

Stellaria media L., also called chickweed, is widespread in all parts of the world. In the present study, we investigated the biological properties and chemical profiles of different extracts (ethyl acetate, ethanol, ethanol/water, and water) of S. media. The chemical profiles were examined using UHPLC/MS/MS technique. Regarding the biological prop...

This study investigates the biochemical composition and biological properties of different parts (leaves, roots, and twigs) of two Cistus species (Cistus monspeliasis and Cistus parviflorus). The extracts were analysed using UHPLC-MS/MS to determine their chemical profiling. A range of antioxidant assays were performed to evaluate the extract’s ant...

Antibiotic resistance emerged shortly after the discovery of the first antibiotic and has remained a critical public health issue ever since. Managing antibiotic resistance in clinical settings continues to be challenging, particularly with the rise of superbugs, or bacteria resistant to multiple antibiotics, known as multidrug-resistant (MDR) bact...

Mushroom polysaccharides, key components of fungal cell walls, exhibit various biological properties and hold significant medicinal and industrial value. These polysaccharides are known for their medicinal properties like antitumor, antioxidant, anticancer, immunomodulatory, and an-tiviral properties. Mushroom polysaccharides, particularly β-glucan...

Ultrasound-assisted extraction of (poly)phenols from pumpkin pulp was optimized using response surface methodology. Time, solvent-to-sample ratio and percentage of water in ethanol were considered and a full factorial design was applied. The optimized conditions (10 min; 30 mL/g; 50% water in ethanol) were used to isolate (poly)phenols from five pu...

The beech mushroom (Hypsizygus marmoreus) is a highly nutritious, edible medicinal mushroom native to East Asia. The present research investigated the impact of different substrates on the metabolite compositions of H. marmoreus mycelia cultivated in vitro. The substrates tested included malt extract agar, malt extract agar enriched with barley mal...

Lentinus arcularius (Batsch) Zmitr.; Lentinus brumalis (Pers.) Zmitr.; Lentinus ciliatus (Fr.) Zmitr.; Lentinus squarrosulus Mont.; Lentinus tigrinus (Bull.) Fr. - POLYPORACEAE Yusufjon Gafforov, Paola Angelini, Gaia Cusumano, Roberto Venanzoni, Giancarlo Angeles Flores, Michal Tomšovský, Manzura Yarasheva, Milena Rašeta, Rainer W. Bussmann et Sylv...

Laetiporus sulphureus (Bull.) Murrill - FOMITOPSIDACEAE . Yusufjon Gafforov, Michal Tomšovský, Lei Cai, Paola Angelini, Gaia Cusumano, Roberto Venanzoni, Giancarlo Angeles Flores, Milena Rašeta, Sunil K. Deshmukh et Sylvie Rapior. Laetiporus sulphureus (Bull.) Murrill - FOMITOPSIDACEAE. Pages 1219-1236. doi:10.1007/978-3-031-23031-8_115 ; hal-04373...

Auricularia mesenterica (Dicks.) Pers. - AURICULARIACEAE Yusufjon Gafforov, Paola Angelini, Gaia Cusumano, Roberto Venanzoni, Giancarlo Angeles Flores, Milena Rašeta et Sylvie Rapior. Auricularia mesenterica (Dicks.) Pers. - AURICULARIACEAE. Pages 931-937. doi: 10.1007/978-3-031-23031-8_100 ; hal-04373459v1

Inonotus hispidus (Bull.) P. Karst.; Inonotus obliquus (Fr.) Pilát - HYMENOCHAETACEAE

Fomes fomentarius (L.) Fr. - POLYPORACEAE Yusufjon Gafforov, Liudmila Kalitukha, Michal Tomšovský, Paola Angelini, Roberto Venanzoni, Giancarlo Angeles Flores, Manzura Yarasheva, Wan Abd Al Qadr Imad Wan-Mohtar et Sylvie Rapior. Fomes fomentarius (L.) Fr. - POLYPORACEAE. Pages 1045-1063. doi:10.1007/978-3-031-23031-8_106 ; hal-04373699v1 ; hal-043...

Bjerkandera adusta (Willd.) P. Karst.; Bjerkandera fumosa (Pers.) P. Karst. - MERULIACEAE Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Michal Tomšovský, Paola Angelini, Gaia Cusumano, Roberto Venanzoni, Giancarlo Angeles Flores, Manzura Yarasheva et Li-Wei Zhou. Bjerkandera adusta (Willd.) P. Karst.; Bjerkandera fumosa (Pers.) P. Karst. - MERU...

Urinary tract infections (UTI), which are among the most frequent cases of infectious diseases, mainly affect women. The most common treatment approach involves the use of antibiotics, although this solution is not always the most suitable, mainly because of the resistance that bacterial strains develop. Proanthocyanidins are a class of polyphenols...

Fomitopsis officinalis is a holartic polyporous mushroom that forms large fruiting bodies on old standing trees, fallen logs, or stumps. F. officinalis is a medicinal mushroom species that is most commonly used in traditional European medicine. In this study, we explore the spatial metabolic differences in F. officinalis' mushroom parts, i.e., the...

Pleurotus spp. have been gaining popularity as a source for the creation of functionnutraceuticals, aceuticals and novel pharmaceuticals. Despite Pleurotus is a specious genus including 208 legitimate species, only a few of them such as P. ostreatus are commercially accessible. The genetic and metabolic diversity of Pleurotus both at specific and s...

Cannabis sativa products have historically been used for healing purposes; now their biological properties are supported with scientific evidence, but modern research has not yet fully developed its therapeutic potential. This study focuses on the cultivar of C. sativa called strawberry to understand the biological and medical potentials of hydroal...

Lactuca longidentata is an endemic species present in Sardinia (Italy). The present study aimed to investigate the phytochemical composition and biological properties of leaf and root water extracts obtained from L. longidentata. Phenolic composition, scavenging/reducing, and enzyme inhibition properties were investigated. In vitro studies, namely...

P.A.); luigi.menghini@unich.it (L.M.) † These authors contributed equally to this work. Abstract: Pleurotus species isolated in vitro were studied to determine the effect of different media on their production of secondary metabolites, antimicrobial, and antioxidant activity. The different metabolites among Pleurotus samples covered a total of 58 p...

Industrial hemp (Cannabis sativa L.) female inflorescences have long been considered as waste material in the hemp production chain. However, past studies focused on the valorization of female inflorescences as high-quality byproducts with promising health-promoting applications. In line with this evidence, the present research investigated the phy...

This ISPRA book, entitled “Micological biodiversity and its knowledge. Mushrooms between innovation and tradition ", allow readers to start a journey of knowledge in the world of mushrooms. It intends to be a popularizing tool to solicit basic knowledge and to deepen and suggest a correct and responsible relationship with the environment and with a...

The well-established correlation between diet and health arouses great interest in seeking new health-promoting functional foods that may contribute to improving health and well-being. Herein, the metabolomic investigation of Pleurotus ostreatus samples grown on two different substrates (black poplar wood logs, WS, and lignocellulosic byproducts, L...

Cannabis sativa L. belongs to the Cannabaceae family and includes annual, robust, fast-growing and generally dioecious plants. Industrial hemp, and particularly the inflorescences, has been recently recognized as important source of bioactive extracts with antioxidant and antimicrobial effects. The goal of the present study was to explore botanical...

The genus Scutellinia consists of cup fungi belonging to the Pyronemataceae (Ascomycota). It comprises more than 100 species with a worldwide distribution. Species delimitation is based on morphological characteristics of the ascocarps, such as spore size, form and ornamentation as well as size and morphology of hairs that typically cover the exter...

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In this paper, for the first time a lipidomic analysis on Pleurotus ostreatus species was performed by liquid chromatography quadrupole time-of-flight mass spectrometry (LC/MS Q-TOF). Twenty-seven lipid classes, including polar and non-polar lipid classes, were detected. Free fatty acids (FA) were the predominant fraction (>57%), followed by fatty...

Vitis vinifera (grape) is a multiuse crop rich in biomolecules with recogninzed health-promoting effects. In the wine-making industry, pomace is the main by-product, representing up to 20% of the whole biomass. However, the pomace and juice deriving from the pressing may represent innovative raw materials, and in the present study, the aim was to c...

The enormous burden of the COVID-19 pandemic in economic and healthcare terms has cast a shadow on the serious threat of antimicrobial resistance, increasing the inappropriate use of antibiotics and shifting the focus of drug discovery programmes from antibacterial and antifungal fields. Thus, there is a pressing need for new antimicrobials involvi...

Medicinal mushrooms are a rich source of bioactive molecules, nutraceutic products, as well as natural co-formulants and excipients. The fungal cell wall is rich in branched polysaccharides (mainly β-glucans), peptidic residues, and chitin or chitosan. A plethora of secondary metabolites with current or potential application includes e.g. terpenoid...

The continuous exploration of new sources for drugs and bioactive compounds has never ceased to delve into the fungal kingdom. Indeed, it has entered profoundly into the widest range of environments on Earth as well as into the chemical structure of compounds and the molecular mechanisms underlying metabolism regulation. It can be demonstrated once...

The present work evaluates the aromatic waters of rosemary (Salvia rosmarinus Spenn. syn. Rosmarinus officinalis L.), sage (Salvia officinalis L.), and cypress (Cupressus sempervirens L.) obtained as innovative commercial products of a hydrodistillation process. All extracts were exhaustively analysed by GC-MS, 1H-NMR, and LC-MS in order to evaluat...

In the present study, the phytochemical composition and bioactivities of A. maroccanus (AM) and A. radiatus (AR), two ecotypes collected in the Demnate road and Essaouira regions, respectively, were studied to highlight a pharmacological interest and to enable possible pharmaceutical development. To this end, methanolic and ethyl acetate extracts w...

The genus Pleurotus (Fr.) P. Kumm (Pleurotaceae, Basidiomycota) comprises a cosmopolitan group of mushrooms highly appreciated for their nutritional value and health-promoting benefits. Despite there being many studies about the phytochemical composition of Pleurotus spp., there are very few reports dealing with the phytochemistry, antioxidant and...

Prunus mahaleb L. fruit has long been used in the production of traditional liqueurs. The fruit also displayed scavenging and reducing activity, in vitro. The present study focused on unravelling peripheral and central protective effects, antimicrobial but also anti-COVID-19 properties exerted by the water extract of P. mahaleb. Anti-inflammatory e...

Bidens pilosaL. (fam. Asteraceae) is an annual herb used globally in phytotherapy andeach plant material or the whole plant have been declared to be effective. Therefore, the aim ofthe present study was to conduct metabolomic profiling of different plant materials, includingthe quali-quantitative composition of phenolic compounds. The intrinsic sca...

Nella continua ricerca di nuovi ingredienti funzionali ed efficaci per la cosmesi, lo studio delle attività bio- logiche di varie specie di funghi ha attratto l’atten- zione degli scienziati e delle aziende, in particolare per l’azione antinvecchiamento, ma anche per quelle idratanti e di contrasto dell’acne.

Oyster mushroom (Pleurotus ostreatus) has gained in the last years increasing attention due to its richness in bioactive metabolites with health properties, making this variety an attractive candidate for promising developments in nutraceutical and cosmeceutical fields. According to the conditions planned by the experimental design approach, the ul...

A Red List of the 100 Boletales (Agaricomycetidae) species recorded in Apennine Province ecoregion Subsections “Tuscan Basin, 1C1b” and “Umbria and Marche Apennine, 1C2a” (central Italy) is provided. According to the IUCN categories and criteria, 67% of the assessed species are classified as threatened, whereas 19% are Near Threatened (NT), 11% are...

Industrial hemp is characterized by a huge amount of by-products, such as inflorescences, that may represent high-quality sources of biomolecules with pharmaceutical interest. In the present study, we have evaluated the phytochemical profile, including terpene and terpenophenolic compounds, of the essential oils (EOs) of Futura 75, Carmagnola selez...

(1) Background: Capsaicin is the main capsaicinoid of the Capsicum genus and it is responsible for the pungent taste. Medical uses of the fruits of chili peppers date from the ancient time until nowadays. Most of all, they are used topically as analgesic in anti-inflammatory diseases as rheumatism, arthritis and in diabetic neuropathy. Reports stat...

Dear Colleague, In light of your outstanding expertise, we would like to cordially invite you to contribute a paper to be included in the Special Issue “Natural Antimicrobial Products from Plants and Fungi: Current Knowledge and Future Prospects, 2nd Edition” published by the journal Antibiotics (IF 3.893) (ISSN 2079-6382, https://www.mdpi.com/jou...

To avail the possible pharmacological actions of Brideliaferruginea Benth., the present investigation was designed to quantitatively analyze the total flavonoid and phenolic contents and assess the various antioxidant and enzyme inhibition properties of leaf and stem bark extracts (ethyl acetate, water and methanolic) of B. ferruginea. Anti-prolife...

Prostatitis is an inflammatory condition that is related to multiple infectious agents, including bacteria and fungi. Traditional herbal extracts proved efficacious in controlling clinical symptoms associated with prostatitis. In this context, the aim of the present study was to explore the efficacy of extracts from Solidago virga-aurea, Ononis spi...

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Coronilla species, belonging to the Coronilla genus (Fabaceae), have long been used in traditional medicine for treating cold, diabetes, pain, and as cardiotonics. The goal of the present study was to explore the phytochemical composition and pharmaco-toxicological properties of C. minima. In this regard, phenolic content, scavenging/reducing prope...

The conservation status of Alessioporus ichnusanus is discussed considering new insights emerged from the IUCN global assessment. New locations were identified and Italy is confirmed as the center of distribution of this species. According to the IUCN categories and criteria, A. ichnusanus is assigned to the category Vulnerable C2a(i).

In the present study, Passiflora foetida extracts characterized by different polarities were studied for their phytochemical profile, enzyme inhibitory, and antioxidant potentials. In silico, in vitro and ex vivo studies were also carried out on methanol and water extracts for predicting pharmacokinetics and pharmacodynamics. In this regard, neuron...

Coprophilous fungi are specialized microorganisms, playing key roles in ecosystems and in several other contexts, whose protection requires more substantial efforts. This paper aims to highlight and discuss valuable and critical aspects faced during the process of the threat status assessment of Poronia punctata, providing inspirations for future c...

Tricholosporum goniospermum (Bres.) Guzmán ex T.J. Baroni is an excellent edible mushroom whose compounds and biological properties are still unknown. In this study, n-hexane, ethyl acetate and methanol extracts from fruiting bodies and liquid-cultured mycelia were compared for the analysis of phenolic compounds, the evaluation of scavenger (DPPH,...

Mangrove forests exemplify a multifaceted ecosystem since they do not only play a crucial ecological role but also possess medicinal properties. Methanolic, ethyl acetate and aqueous leaf and bark extracts were prepared using homogenizer-assisted extraction (HAE), infusion and maceration (with and without stirring). The different extracts were scre...

Industrial hemp (Cannabis sativa) is traditionally cultivated as a valuable source of fibers and nutrients. Multiple studies also demonstrated antimicrobial, anti-proliferative, phytotoxic and insecticide effects of the essential oil from hemp female inflorescences. On the other side, only a few studies explored the potential pharmacological applic...

In the present study, we investigated the water extract of Harpagophytum procumbens DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis...

Bridelia species have been used in traditional African medicine for the management of diverse human ailments. In the current work, the detailed phytochemical profiles of the extracts of the stem bark of B. speciosa were evaluated and the antioxidant and enzyme inhibitory properties of the extracts were assessed. The anti-bacterial and anti-mycotic...

The phytochemical, antiradical, and enzyme inhibition profile of three solvent extracts (ethyl acetate, methanol, water) of Origanum sipyleum were assessed. We also performed a pharmacological study in order to explore protective effects induced by extracts in inflamed colon. LC‐MS analysis revealed that the extracts contained different classes of...

Phlomis fruticosa L. and P. herba‐venti are species belonging to the Lamiaceae family, which have been traditionally used to prepare tonic and digestive drinks. Multiple studies also demonstrated the inhibitory effects of P. fruticosa extracts and essential oil against oxidative/proinflammatory pathways and bacterial strains deeply involved in ulce...

Photo by Jee Nissen on Unsplash What is it about? This work takes into account molecular variations in a truue sauce with linoleic and stearic acids added at various temperatures and durations of sterilization. Why is it important? Food products based on truues such as truue sauces are commonly sterilized by autoclaving. With the aim of reducing st...

A list of the macrofungi collected from the Marmore Waterfalls (Umbria, Italy) is reported. In particular, a list of basidiomycetes and ascomycetes collected over a period of about ten years was compiled. A total of 125 species belonging to 78 genera, 46 families, and 15 orders were identified. Forty-four species are recorded in Umbria for the firs...

A list of the macrofungi collected from the Marmore Waterfalls (Umbria, Italy) is reported. In particular, a list of basidiomycetes and ascomycetes collected over a period of about ten years was compiled. A total of 125 species belonging to 78 genera, 46 families, and 15 orders were identified. Forty-four species are recorded in Umbria for the firs...

One of the most promising economic perspectives of hemp production chain is female inflorescence valorization, despite there being actually no chemical composition or biological data from water fraction. In this context, the focus of this study is the evaluation of protective effects related to hemp water flower extracts from four commercial cultiv...

Angelini, P., Bricchi, E., Zeppilli, N., Dimitriu, L., Rondolini, M., Angeles, G., Covino, S. & Venanzoni, R.: Screening of the antifungal activity of essential oils against human and plant pathogenic filamentous fungi.-Fl. Medit. 29: 5-12. 2019.-ISSN: 1120-4052 printed, 2240-4538 online. In this study the antifungal activity of five essential oils...

Food products based on truffles such as truffle sauces are commonly sterilized by autoclaving. With the aim of reducing sterilization durations and temperatures and therefore minimizing the formation of new molecules while maintaining sterile conditions, natural molecules with bacteriostatic action can be added. This work takes into account molecul...

Inonotus hispidus (Bull.) P. Karst. has been used as traditional medicine for the treatment of dyspepsia, cancer, and diabetes. Numerous studies have confirmed the antimicrobial, antiviral, antioxidant, anti-inflammatory, immunomodulatory, antiproliferative and cytotoxic biological activities of extracts from this species. The purpose of this study...

This work investigated the antiradical, antibacterial, and antifungal properties of a methanol extract from Fuscoporia torulosa (PeruMyc1834) fruit body from Central Italy. The ITS partial sequence of the F. torulosa strain matched at a 100% rate those of various strains belonging to the species. Two complementary test systems, namely α,α-diphenyl-...

Utilizzati in diversi sistemi di medicina tradizionale, come anche in rituali sciamanici o religio-si di numerose popolazioni dei cinque continenti, i funghi rappresentano da sempre una risorsa alimentare e attualmente anche una fonte interessante di molecole biologicamente attive a uso farmaceutico, oltre ad avere un ruolo preminente nel conservar...

An increased interest by consumers toward pharmacologically active plant-derived natural products as alternatives to synthetic drugs has increased the attention of global scientists. Among the various plant-derived natural products, essential oils have gained popularity because of its use in food, cosmetics, and pharmaceutical industries. Constitut...

A Red List of all 108 Pezizomycotina (Ascomycota) species recorded in Umbria Region (central Italy) is provided. According to the IUCN categories and criteria, 60.18% of the assessed species are classified as threatened, whereas 12.96% are Near Threatened (NT), 1.86% are Least Concerned (LC) and a noteworthy amount of 25% are Data Deficient (DD). A...