Panduka Karunanayake

Panduka Karunanayake
University of Colombo · Department of Clinical Medicine

MB BS (NCMC) MD (Col) FRCP (Lon) PgCertTHE (Col) PgDipApplSociol (Col)

About

58
Publications
12,181
Reads
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226
Citations
Introduction
Panduka Karunanayake currently works at the Department of Clinical Medicine, University of Colombo. Panduka does research in Infectious Disease (leptospirosis, visceral leishmaniasis, brucellosis, dengue), and has interests in Internal Medicine (General Medicine) and Ethics.
Additional affiliations
January 2002 - present
University of Colombo
Position
  • Professor (Associate)
January 2002 - present
University of Colombo
Position
  • Professor (Associate)

Publications

Publications (58)
Article
Full-text available
Background: The critical phase of dengue carries a high risk of bleeding. Associations of coagulation test parameters and the risk of bleeding in the critical phase is unclear. This study examines the association of rotational thromboelastometry (ROTEM delta and ROTEM platelet) with bleeding risk of patients with dengue in the critical phase. Met...
Article
Melioidosis is an infectious disease with high mortality and a wide spectrum of clinical manifestations. Successful treatment requires lengthy antibiotic regimens, making microbiological diagnosis crucial. In this article, we briefly review the diagnosis and management of melioidosis from the clinician's viewpoint.
Article
Full-text available
Music preference is being influenced by various sociological factors. This study was undertaken to investigate music preferences across five different socio-economic classes in selected urban and suburban areas of Sri Lanka. Ten music tracks representing the correspondent musical genres were selected. The single most preferred and the weighted hedo...
Article
Full-text available
The relationship between music preferences with associated stress was suggested in previous studies and music was proposed as a popular diversion strategy from stressors to resort to on a daily basis. However, the possibility of utilizing music as a potential perceived stress reducer in Sri Lanka is seldom studied. This preliminary study assesses t...
Conference Paper
Full-text available
Background: Music preference has correlated with sociological and psychological aspects of humankind. Thus, age, economic status and type of music are some key attributes linked with the music choice of people. Objectives: This study was undertaken to investigate the orientation of preferred music styles, artists and instruments with regards to two...
Book
Full-text available
This is the 2nd Edition of pioneering textbook in Palliative care in Sri Lanka. This is meant to be a handbook to manage of both cancer and non-cancer palliative patients. Contents include introduction to palliative care, skills required in palliative patient management, guide to symptom control, clinical problem management, management of special p...
Article
Full-text available
Background: Leishmaniasis is a neglected tropical vector-borne disease, which is on the rise in Sri Lanka. Spatiotemporal and risk factor analyses are useful for understanding transmission dynamics, spatial clustering and predicting future disease distribution and trends to facilitate effective infection control. Methods: The nationwide clinical...
Article
Full-text available
Dengue fever has a wide range of clinical manifestations from asymptomatic disease to complicated dengue haemorrhagic fever and dengue shock syndrome. Bleeding manifestations in dengue is well known but thrombotic events complicating dengue is uncommon. ST elevation myocardial infarction during dengue is rare and poses important management dilemma....
Article
Full-text available
Dengue fever has a wide range of clinical manifestations from asymptomatic disease to complicated dengue haemorrhagic fever and dengue shock syndrome. Bleeding manifestations in dengue is well known but thrombotic events complicating dengue is uncommon. ST elevation myocardial infarction during dengue is rare and poses important management dilemma....
Article
Full-text available
ABSTRACT Age and the social class have demonstrated to be the most influential factors for music preference thus least explored in the Sri Lankan contest. This study was explored the patterns in music preference among different socio-demographic groups in selected urban and sub-urban areas in Sri Lanka. A total of 75 individuals representing differ...
Conference Paper
Full-text available
The preferences towards music have socio-psychological influences. Thus, this study was undertaken to investigate musical preferences across five different social classes; upper class, upper middle class, middle class, working class and poor class in selected urban and suburban areas of Sri Lanka (N=75). The social classes were categorized accordin...
Article
Full-text available
Background Leptospirosis has gained much attention in Sri Lanka since its large outbreak in 2008. However, most of the cases were clinically diagnosed and information on Leptospira genotypes and serotypes currently prevailing in the country is lacking. Methodology/Principal findings We retrospectively analyzed 24 Leptospira strains from human pati...
Poster
Full-text available
Cross-sectional Study on Perceived Stress across socio-economic classes and age groups in Sri Lanka
Conference Paper
Full-text available
Introduction and objectives Enduring stress responses are associated with health problems. Objectives were to assess perceived stress levels (PSL) across different social classes and age generations. Methods PSL was calculated among 75(N=75) subjects selected by convenient sampling distributed across five social strata (upper, upper-middle, middle,...
Article
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Article
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Background: A nano-scale surface coating containing silicon nanoparticles (Bacterlon®) creates a hydrophobic surface which prevents the growth of bacteria. Study objective was to evaluate the performance of this silicon nano-coating in Sri Lankan healthcare setting. Methods: This prospective study was conducted from September 2015 to December 20...
Article
Full-text available
Background The emergence of leptospirosis-associated severe pulmonary hemorrhagic syndrome (SPHS) with high case fatality has been reported from many countries. Understanding of clinical disease and sequel of SPHS needs larger studies with adequate numbers. The purpose of this study was to describe the characteristics and sequel by different therap...
Article
Full-text available
Introduction Sri Lanka has a rapidly aging population with an exponential rise in chronic morbidity. There had been no parallel development of palliative and end-of-life care-specific approach in health care. Aim To implement sustainable palliative and end-of-life care services in Sri Lanka through the existing systems and resources by advocacy, c...
Article
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Background: The use of lengthy, detailed, and complex informed consent forms (ICFs) is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of t...
Article
Full-text available
Background: The use of lengthy, detailed, and complex informed consent forms (ICFs) is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of...
Article
Full-text available
Background: Aspergillosis is a serious infection particularly affecting the immunodeficient host. Its co-infection with tuberculosis and cytomegalovirus has not been reported before. Embolic events are well recognized with aspergillous endocarditis and aortitis. Splenic abscess is a rare serious complication of disseminated aspergillosis and is di...
Article
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Sri Lanka, an island in the Indian Ocean, is 65 610km2 with a population of 21 million (population density 315/km2). It is a low-middle income country with GDP per capita of USD 4 310. However, due to policies of free education and health, it is ranked 73 (among 188 nations) in the human development index. Sri Lankans have a life expectancy of 76 y...
Article
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The visceralizing potential of apparently dermotropic Leishmania donovani in Sri Lanka ( L. donovani -SL) was investigated through long-term follow-up of cutaneous leishmaniasis (CL) patients and in vivo and in vitro experimental infection models. CL patients ( n = 250) treated effectively with intra-lesional antimony therapy were followed-up six m...
Conference Paper
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Study of Therapeutic Plasma Exchange as a possible therapeutic option to reduce mortality in leptospirosis patients with pulmonary haemorrhage.....
Conference Paper
Full-text available
Introduction Brucellosis is an important bacterial zoonosis, caused by Brucella species including B. abortus and B. melitensis. Human brucellosis mainly occurs by direct contact, inoculation or ingestion of contaminated/infected animal products. 1 In Sri Lanka cattle and buffaloes act as the main reservoir for B. abortus. 2 Seropositivity and their...
Article
Background: Sri Lanka is a new focus of human cutaneous leishmaniasis caused by a genetic variant of usually visceralizing parasite Leishmania donovani. Over 3000 cases have been reported to our institution alone, during the past two decades. Recent emergence of visceral leishmaniasis is of concern. Methods: Patients suspected of having visceral...
Article
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The MD (General Medicine) program is Sri Lanka’s first, and currently only, postgraduate program that trains specialists in General (‘Internal’) Medicine. It had its origin in 1959 as the MD (Ceylon), offered by the Department of Medicine, Faculty of Medicine, University of Colombo and a brainchild of Professor Kumaradasa Rajasuriya. It was the fir...
Article
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Background: Malaria is a mosquito-borne infectious disease with diverse clinical manifestations caused by a parasitic protozoan of the genus Plasmodium. Complex interrelationships between Mycoplasma species and Plasmodium parasites have been previously noted in vitro. This is the first report of Plasmodium falciparum and Mycoplasma pneumoniae co-in...
Article
Full-text available
Dengue fever is one of the commonest mosquito-borne diseases in the tropics, and Sri Lanka is no exception. Despite its commonness, dengue fever has rarely been described among patients who have undergone transplantation. We report the case of a patient with dengue fever after liver transplantation, which, to the best of our knowledge, is the first...
Article
Full-text available
The incidence of dengue fever is on the rise in tropical countries. In Sri Lanka, nearly 45,000 patients were reported in 2012. With the increasing numbers, rare manifestations of dengue are occasionally encountered. We report a patient who presented with bilateral cerebellar signs as the presenting feature of dengue. A 45-year-old previously healt...
Article
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This case series details clinical observations in 7 survivors of accidental hydrogen sulphide inhalation toxicity at a petroleum refinery in Sri Lanka. One survivor developed status epilepticus and severe neurotoxicity whilst another survivor developed delayed respiratory failure; both patients required intensive care management. One victim manifes...
Article
Full-text available
Background Leptospirosis is a potentially fatal disease which can cause multi-organ dysfunction. It can rarely present as acute pancreatitis. This is the first ever report of leptospirosis presenting with acute pancreatitis and myocarditis followed by diffuse pulmonary hemorrhages to the best of our knowledge. Case presentation A 15-year-old South...
Article
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Background Managing a severe dengue infection is a challenge specially when complicated by other comorbidities. We report a patient with dengue haemorrhagic fever and spontaneous bleeding who required mandatory anticoagulation for a prosthetic mitral valve replacement. This is the first case report in published literature describing this therapeuti...
Article
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We evaluated the effectiveness of MEWS and biochemical parameters in predicting outcomes for acute medical admissions. Data from consecutive admissions to the Acute Medical Unit (AMU) of National Hospital of Sri Lanka were collected. C-reactive protein (CRP), albumin, white cell count, platelet count and haemoglobin values were collected. Adverse e...
Poster
Full-text available
Staying healthy while travelling can help to ensure the trip overseas is a happy, enjoyable and productive one. The need for a medical advisory agent together with geographical information (nearest hospitals, clinics, and contact details in an emergency situation) and special travel advisories (current weather state, major weather fluctuations, mon...
Article
Full-text available
To study the safety of low dose subcutaneous adrenaline given as prophylaxis against acute adverse reactions to anti-venom serum (AVS) in patients bitten by snakes. Patients admitted with snakebite envenoming who satisfied inclusion criteria were given 0.25 ml of 1:1000 adrenaline subcutaneously immediately before administration of AVS. They were o...

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