Panagis Polykretis

Verified

Panagis verified their affiliation via an institutional email.

Learn more

Verified

Panagis verified their affiliation via an institutional email.

Learn more

• Ph.D.
• Post-doctoral researcher at Italian National Research Council

Cadmium is a toxic pollutant that in recent decades has become more widespread in the environment due to anthropogenic activities, significantly increasing the risk of exposure. Concurrently, a continually growing body of research has begun to enumerate the harmful effects that this heavy metal has on human health. Consequently, additional research...

Multiple Sclerosis (MS) is a demyelinating autoimmune disease in which autoreactive T lymphocytes infiltrate the central nervous system (CNS) and react against antigens derived from proteins of the myelin sheath. The reason why T lymphocytes recognize certain myelin antigens as exogenous, activating the autoimmune response, remains unknown and repr...

Introduction: Alzheimer’s disease (AD) is a progressive debilitating neurological disorder representing the most common neurodegenerative disease worldwide. Although the exact pathogenic mechanisms of AD remain unresolved, the presence of extracellular amyloid-β peptide 1-42 (Aβ1-42 ) plaques in the parenchymal and cortical brain is considered one...

As a result of the spread of SARS-CoV-2, a global pandemic was declared. Indiscriminate COVID-19 vaccination has been extended to include age groups and naturally immune people with minimal danger of suffering serious complications due to COVID-19. Solid immuno-histopathological evidence demonstrates that the COVID-19 genetic vaccines can display a...

Alzheimer's disease (AD) is the most common form of dementia and is characterized by the aggregation of two proteins in the parenchymal brain: The amyloid-β peptide, which forms extracellular plaques, and the hyperphosphorylated tubulin-associated unit (Tau), which creates intracellular neurofibrillary tangles [1,2]. However, the precise pathogenic...

Actin is a vital component of the cellular cytoskeleton, essential to numerous cellular processes, particularly in the dynamic remodeling of cytoskeletal structures. Non-Muscle Actinopathies (NMAs) are autosomal-dominant disorders arising from heterozygous mutations in actin isoform genes, primarily affecting neuronal function [1-4]. The mechanisms...

Ideological and financial motivations have undermined science for decades. In this narrative review, we explore how organizations and governments used misinformation, disinformation, censorship, and secrecy to manage the COVID-19 pandemic. Various rationales for employing censorship and secrecy during the COVID-19 pandemic are examined including ho...

Alzheimer's disease (AD) is a gradual, disabling neurological disease and it is the most prevalent type of dementia worldwide [1]. While the precise pathogenic mechanism of AD is still unknown, extracellular amyloid-β (Aβ) plaques in the parenchymal and cortical brain are considered to be one of the hallmarks of disease [2]. AD is usually diagnosed...

A wearable sweat sensor chip based on surface-enhanced Raman spectroscopy (SERS) is here presented. The plasmonic core of the chip, obtained by deposition of silver nanowires on a polytetrafluoroethylene (PTFE) porous membrane, permits the direct and label-free detection of urea and lactate at physiologic concentrations in combination with the pH m...

In this report we describe the case of a healthy, young, athletic woman who developed acute lymphoblastic leukaemia (ALL)/lymphoblastic lymphoma (LBL) after receiving the second dose of the Pfizer/BioNTech modified mRNA (modRNA) COVID-19 genetic vaccine (marketed as Comirnaty®). The first dose of the genetic vaccine did not appear to illicit any no...

Molybdenum selenide nanosheets (MoSe2-NS) were synthesized by liquid-phase exfoliation (LPE) technique and successive liquid cascade centrifugation (LCC) at two different centrifugation rates (1.5 and 5 krpm). By this technique's combination, we were able to prepare MoSe2 nanosheets with different geometric characteristics (i.e., average number of...

Alzheimer's disease (AD) is the most common neurodegenerative condition that affects tens of millions of people worldwide, although its pathogenic mechanism is still poorly understood [1]. The aggregation of the amyloid-β peptide, which forms amyloid plaques, and of the tubulin-associated unit (tau), which forms neurofibrillary tangles, in the pare...

Background The current diagnosis of Alzheimer’s disease (AD) is based on a series of analyses which involve clinical, instrumental and laboratory findings. However, signs, symptoms and biomarker alterations observed in AD might overlap with other dementias, resulting in misdiagnosis. Methods Here we describe a new diagnostic approach for AD which...

As a result of the spread of SARS-CoV-2, a global pandemic was declared. Indiscriminate COVID-19 vaccination has been extended to include age groups and naturally immune people with minimal danger of suffering serious complications due to COVID-19. Solid immuno-histopatholog-ical evidence demonstrates that the COVID-19 genetic vaccines can display...

The biodistribution of genetic vaccines against COVID-19.

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, resulting in memory loss, cognitive decline, bodily function impairment, and finally death. The growing number of people suffering from AD increasingly urges the development of effective early diagnosis and monitoring techniques. Here, we review the most recent developments in...

XIAP is multi-functional protein which regulates apoptosis acting as a direct caspase inhibitor. It is overexpressed in cancer cells, where it antagonizes the pro-apoptotic action of chemotherapeutics, and therefore it has become an important target for the treatment of cancer. In cells undergoing programmed cell death, the pro-apoptotic protein Sm...

The lack of a simple, fast and efficient method for protein delivery is limiting the widespread application of in-cell experiments, which are crucial for understanding the cellular function. We present here an innovative strategy to deliver proteins into both prokaryotic and eukaryotic cells, exploiting thermal vesiculation. This method allows to i...

Methylglyoxal(MG)isahighlyreactivealdehydespontaneouslyformedinhumancellsmainlyasaby-productof glycolysis. Such endogenous metabolite reacts with proteins, nucleotides and lipids forming advanced gly-cationend-products(AGEs).MGbindstoarginine,lysineandcysteineresiduesofproteinscausingtheformationofstableadductsthatcaninterferewithproteinfunction.Am...

The X-chromosome-linked inhibitor of apoptosis protein (XIAP) is a multidomain protein whose main function is to block apoptosis by caspase inhibition. XIAP is also involved in other signalling pathways, including NF-κB activation and copper homeostasis. XIAP is overexpressed in tumours, potentiating cell survival and resistance to chemotherapeutic...

The X-chromosome linked inhibitor of apoptosis (XIAP) is a multidomain metalloprotein involved in caspase inhibition and in copper homeostasis. It contains three zinc-binding baculoviral IAP repeats (BIR) domains, which are responsible for caspase interaction. Recently, it has been suggested that the BIR domains can bind copper, however high resolu...

Structural investigation of XIAP-BIR1 in solution and the interaction with copper ion in vitro and in living cells

Structural investigation of XIAP-BIR1 in solution and the interaction with copper ion in vitro and in living cells.

In previous researches severe damages induced by Cadmium (an ubiquitary environmental pollutant whose intracellular oxidative effects are increasingly lethal) exposure in human have been demonstrated. Morphologic effects were observed in Central Nervous System, liver, kidney, placenta. Recently, the involvement of immune system in Cadmium intoxicat...