Panagis Polykretis

Panagis Polykretis
Italian National Research Council | CNR · Institute of Applied Physics “Nello Carrara”, Via Madonna Del Piano 10, 50019 Sesto Fiorentino, Italy

Post-doctoral research fellow
MSc in Biology, PhD in Structural Biology

About

17
Publications
1,790
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91
Citations
Introduction
Panagis Polykretis currently works at the Institute of Applied Physics “Nello Carrara” of the Italian National Research Council. Panagis does research in the field of neurodegenerative diseases caused by protein aggregation. His most recent publication is "Role of the antigen presentation process in the immunization mechanism of the genetic vaccines against COVID-19 and the need for biodistribution evaluations".

Publications

Publications (17)
Article
Full-text available
Cadmium is a toxic pollutant that in recent decades has become more widespread in the environment due to anthropogenic activities, significantly increasing the risk of exposure. Concurrently, a continually growing body of research has begun to enumerate the harmful effects that this heavy metal has on human health. Consequently, additional research...
Article
Full-text available
Methylglyoxal(MG)isahighlyreactivealdehydespontaneouslyformedinhumancellsmainlyasaby-productof glycolysis. Such endogenous metabolite reacts with proteins, nucleotides and lipids forming advanced gly-cationend-products(AGEs).MGbindstoarginine,lysineandcysteineresiduesofproteinscausingtheformationofstableadductsthatcaninterferewithproteinfunction.Am...
Article
Multiple Sclerosis (MS) is a demyelinating autoimmune disease in which autoreactive T lymphocytes infiltrate the central nervous system (CNS) and react against antigens derived from proteins of the myelin sheath. The reason why T lymphocytes recognize certain myelin antigens as exogenous, activating the autoimmune response, remains unknown and repr...
Article
Alzheimer's disease (AD) is the most common neurodegenerative disorder, resulting in memory loss, cognitive decline, bodily function impairment, and finally death. The growing number of people suffering from AD increasingly urges the development of effective early diagnosis and monitoring techniques. Here, we review the most recent developments in...
Article
XIAP is multi-functional protein which regulates apoptosis acting as a direct caspase inhibitor. It is overexpressed in cancer cells, where it antagonizes the pro-apoptotic action of chemotherapeutics, and therefore it has become an important target for the treatment of cancer. In cells undergoing programmed cell death, the pro-apoptotic protein Sm...
Article
Full-text available
The lack of a simple, fast and efficient method for protein delivery is limiting the widespread application of in-cell experiments, which are crucial for understanding the cellular function. We present here an innovative strategy to deliver proteins into both prokaryotic and eukaryotic cells, exploiting thermal vesiculation. This method allows to i...
Article
Full-text available
The X-chromosome-linked inhibitor of apoptosis protein (XIAP) is a multidomain protein whose main function is to block apoptosis by caspase inhibition. XIAP is also involved in other signalling pathways, including NF-κB activation and copper homeostasis. XIAP is overexpressed in tumours, potentiating cell survival and resistance to chemotherapeutic...
Article
Full-text available
The X-chromosome linked inhibitor of apoptosis (XIAP) is a multidomain metalloprotein involved in caspase inhibition and in copper homeostasis. It contains three zinc-binding baculoviral IAP repeats (BIR) domains, which are responsible for caspase interaction. Recently, it has been suggested that the BIR domains can bind copper, however high resolu...
Poster
Full-text available
Structural investigation of XIAP-BIR1 in solution and the interaction with copper ion in vitro and in living cells
Poster
Full-text available
Structural investigation of XIAP-BIR1 in solution and the interaction with copper ion in vitro and in living cells.
Conference Paper
Full-text available
In previous researches severe damages induced by Cadmium (an ubiquitary environmental pollutant whose intracellular oxidative effects are increasingly lethal) exposure in human have been demonstrated. Morphologic effects were observed in Central Nervous System, liver, kidney, placenta. Recently, the involvement of immune system in Cadmium intoxicat...

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