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Publications (134)
Purpose:
To investigate the differences in the frequency of optic disc hemorrhage (DH) and prevalence of beta-zone parapapillary atrophy (βPPA) between individuals of African descent (AD) and European descent (ED).
Design:
Prospective, multicenter, observational cohort.
Participants:
A total of 1950 eyes of 1172 participants of the African Des...
To evaluate racial differences in the development of visual field (VF) damage in glaucoma suspects.
Prospective, observational cohort study.
Six hundred thirty six eyes from 357 glaucoma suspects with normal VF at baseline were included from the multicenter African Descent and Glaucoma Evaluation Study (ADAGES). Racial differences in the developmen...
Purpose
To compare the rates of retinal nerve fiber layer (RNFL) loss in patients suspected of having glaucoma who developed visual field damage (VFD) with those who did not develop VFD and to determine whether the rate of RNFL loss can be used to predict the development of VFD.
Design
Prospective, observational cohort study.
Participants
Glaucom...
To evaluate three new pixelwise rates of retinal height changes (PixR) strategies to reduce false positive errors while detecting glaucomatous progression.
Diagnostic accuracy of nonparametric PixR-NP cluster test (CT), PixR-NP single threshold test (STT) and parametric PixR-P STT were compared to statistic image mapping (SIM) using Heidelberg Reti...
Purpose:
We evaluated Progression of Patterns (POP) for its ability to identify progression of glaucomatous visual field (VF) defects.
Methods:
POP uses variational Bayesian independent component mixture model (VIM), a machine learning classifier (MLC) developed previously. VIM separated Swedish Interactive Thresholding Algorithm (SITA) VFs from...
To detect localized glaucomatous structural changes using proper orthogonal decomposition (POD) framework with false-positive control that minimizes confirmatory follow-ups, and to compare the results to topographic change analysis (TCA).
We included 167 participants (246 eyes) with ≥4 Heidelberg Retina Tomograph (HRT)-II exams from the Diagnostic...
Altered metabolic activity has been identified as a potential contributing factor to the neurodegeneration associated with primary open angle glaucoma (POAG). Consequently, we sought to determine whether there is a relationship between the loss of visual function in human glaucoma and resting blood perfusion within primary visual cortex (V1).
Arter...
Purpose:
The purpose of the study is to determine the degree of intereye asymmetry of optic disc topography and retinal nerve fiber layer (RNFL) thickness in healthy individuals of African descent (AD) and European descent (ED).
Design:
Observational, clinical study.
Methods:
Five hundred nineteen healthy individuals (AD, n=262, mean age=44.9...
To compare categorical severity classification systems for glaucoma.
This cross-sectional study included 1,921 eyes (49.5% right eye) from 1,137 participants from the Diagnostic Innovations in Glaucoma Study and African Descent and Glaucoma Evaluation Study. Standard automated perimetry fields were classified using the: (1) Advanced Glaucoma Interv...
To determine the structure-function relationship in glaucoma using spectral-domain optical coherence tomography (SDOCT)-derived structural measurements and to evaluate this relationship using a linear model.
In a cross-sectional study, structure-function relationships were determined for all the participants in the DIGS (Diagnostic Innovations in G...
To use machine learning classifiers (MLCs) to seek differences in visual fields (VFs) between normal eyes and eyes of HIV+ patients; to find the effect of immunodeficiency on VFs and to compare the effectiveness of MLCs to commonly-used Statpac global indices in analyzing standard automated perimetry (SAP).
The high CD4 group consisted of 70 eyes o...
To evaluate the effect of disease severity and optic disc size on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular parameters with RTVue (Optovue, Fremont, CA) spectral domain optical coherence tomography (SDOCT) in glaucoma.
110 eyes of 62 normal subjects and 193 eyes of 136 glaucoma patients from...
To provide readers with standards, recommendations, guidelines, and requirements for the application of perimetry to clinical ophthalmic practice and scientific study.
A working group of perimetry and visual field specialists from many parts of the world constructed a document that would allow current and future perimeters to be assessed by the sam...
To assess the spatial distribution of glaucomatous visual field defects (VFDs) obtained with regionally condensed stimulus arrangements.
Sixty-three eyes of 63 glaucoma subjects were examined with threshold-estimating automated static perimetry (full threshold 4-2-1 dB strategy with at least three reversals) on an automatic campimeter or a full-fie...
To evaluate rates of visual field progression in eyes with optic disc hemorrhages and the effect of intraocular pressure (IOP) reduction on these rates.
Observational cohort study.
The study included 510 eyes of 348 patients with glaucoma who were recruited from the Diagnostic Innovations in Glaucoma Study (DIGS) and followed for an average of 8.2...
To estimate the agreement of confocal scanning laser tomograph (CSLT), topographic change analysis (TCA) with assessment of stereophotographs, and standard automated perimetry (SAP) for detecting glaucomatous progression and to identify factors associated with agreement between methods.
Observational cohort study.
We included 246 eyes of 167 glauco...
To assess the agreement of parapapillary retinal nerve fiber layer (RNFL) thickness measurements among 3 spectral-domain optical coherence tomography (SD-OCT) instruments.
Observational, cross-sectional study.
Three hundred thirty eyes (88 with glaucoma, 206 glaucoma suspects, 36 healthy) from 208 individuals enrolled in the Diagnostic Innovations...
To evaluate retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular thickness measurements for glaucoma detection using the RTVue spectral domain optical coherence tomograph.
Diagnostic, case-control study.
One hundred forty eyes of 106 glaucoma patients and 74 eyes of 40 healthy subjects from the Diagnostic Innovations in Glaucoma St...
To analyze and compare corneal biomechanical properties in healthy black and white subjects using the Ocular Response Analyzer (ORA) and to evaluate their relationship with other ocular parameters.
Observational cross-sectional study.
One hundred eighty one eyes (46 in blacks, 135 in whites) of 119 patients (37 blacks, 82 whites) were recruited fro...
Available at http://iovs.arvojournals.org/article.aspx?articleid=2371380
To define differences in optic disc, retinal nerve fiber layer, and macular structure between healthy participants of African (AD) and European descent (ED) using quantitative imaging techniques in the African Descent and Glaucoma Evaluation Study (ADAGES).
Reliable images were obtained using stereoscopic photography, confocal scanning laser ophtha...
To investigate differences in visual function between the healthy eyes of people of African (AD) and European descent (ED).
Visual function was assessed in 393 AD and 367 ED participants selected from the African Descent and Glaucoma Evaluation Study and the Diagnostic Innovations in Glaucoma Study. Participants had normal appearance of the optic d...
To evaluate rates of change measured with scanning laser polarimetry with enhanced corneal compensation (GDx ECC) and compare them to those measured using the variable corneal compensation (GDx VCC) method in a cohort of glaucoma patients and individuals suspected of having the disease followed over time.
Observational cohort study.
The study inclu...
To evaluate the ability of the GDx Variable Corneal Compensation (VCC) Guided Progression Analysis (GPA) software for detecting glaucomatous progression.
Observational cohort study.
The study included 453 eyes from 252 individuals followed for an average of 46+/-14 months as part of the Diagnostic Innovations in Glaucoma Study. At baseline, 29% of...
To compare the diagnostic accuracy of the pattern electroretinogram (pattern ERG) to that of standard automated perimetry (SAP), short-wavelength automated perimetry (SWAP), and frequency-doubling technology (FDT) perimetry for discriminating between healthy and glaucomatous eyes.
Cross-sectional study.
Eighty-three eyes of 42 healthy recruits and...
PURPOSE. To evaluate and compare rates of change in neuroretinal rim area (RA) and retinal nerve fiber layer thickness (RNFLT) measurements in glaucoma patients, those with suspected glaucoma, and normal subjects observed over time. METHODS. In this observational cohort study, patients recruited from two longitudinal studies (Diagnostic Innovations...
To evaluate the effect of disease severity on the diagnostic accuracy of the Cirrus Optical Coherence Tomograph (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA) for glaucoma detection.
One hundred thirty-five glaucomatous eyes of 99 patients and 79 normal eyes of 47 control subjects were recruited from the longitudinal Diagnostic Innovations i...
To determine if the patterns uncovered with variational Bayesian-independent component analysis-mixture model (VIM) applied to a large set of normal and glaucomatous fields obtained with the Swedish Interactive Thresholding Algorithm (SITA) are distinct, recognizable, and useful for modeling the severity of the field loss.
SITA fields were obtained...
To evaluate and compare the ability of optical coherence tomography (OCT) retinal nerve fiber layer (RNFL), optic nerve head, and macular thickness parameters to detect progressive structural damage in glaucoma.
This observational cohort study included 253 eyes of 253 patients. Images were obtained annually with the Stratus OCT (Carl Zeiss Meditec,...
To evaluate the ability of progressive optic disc damage detected by assessment of longitudinal stereophotographs to predict future development of functional loss in those with suspected glaucoma.
The study included 639 eyes of 407 patients with suspected glaucoma followed up for an average of 8.0 years with annual standard automated perimetry visu...
To determine the within-trial and between-trial repeatability of pattern electroretinogram (PERG) measurements in healthy and patient eyes, using a new clinical instrument, the PERGLA.
In all, 70 eyes of 35 healthy individuals (intraocular pressure <22 mm Hg, healthy optic disc by stereophotograph assessment, standard visual fields within normal li...
To identify factors accounting for differences in glaucoma onset and rate of progression between individuals of African descent and European descent.
A prospective, multicenter observational cohort study of 1221 participants of African descent and European descent with no glaucoma (normal), suspected glaucoma, and glaucoma. Six hundred eighty-six p...
The goal of this work was to (i) determine patterns of progression in glaucomatous visual field loss, (ii) compare the detection rate of progression between locally condensed stimulus arrangements and conventional 6 degrees x 6 degrees grid, and (iii) assess the individual frequency distribution of test locations exhibiting a local event (i.e., an...
To evaluate the new proper orthogonal decomposition (POD) framework for detecting glaucomatous progression from HRT topographies of human subjects and compare it with HRT topographic change analysis (TCA).
Of 267 eyes of 187 participants with > or =4 retinal tomographic examinations in the University of California, San Diego Diagnostic Innovations...
To investigate whether combining optic disc topography and short-wavelength automated perimetry (SWAP) data improves the diagnostic accuracy of relevance vector machine (RVM) classifiers for detecting glaucomatous eyes compared with using each test alone.
One eye of 144 glaucoma patients and 68 healthy controls from the Diagnostic Innovations in Gl...
Abstract We compared two methods for assessing changes in the human lens associated with age. The first is a subjective method for quantifying light absorption by the lens. It is useful for determining the functional effect of age-related increases in lens density, especially for short-wavelength light. The second method objectively and rapidly mea...
To evaluate the relationship between intraocular pressure (IOP) and progressive retinal nerve fiber layer (RNFL) loss, as measured by scanning laser polarimetry with enhanced corneal compensation (GDx ECC), in a cohort of glaucoma patients and individuals suspected of having the disease followed over time.
Observational cohort study.
The study incl...
To evaluate spectral-domain (SD) optical coherence tomography (OCT) reproducibility and assess the agreement between SD-OCT and Time-Domain (TD) OCT retinal nerve fibre layer (RNFL) measurements.
Three Cirrus-SD-OCT scans and one Stratus-TD-OCT scan were obtained from Diagnostic Innovations in Glaucoma Study (DIGS) healthy participants and glaucoma...
To evaluate the impact of atypical retardation patterns (ARP) on detection of progressive retinal nerve fiber layer (RNFL) loss using scanning laser polarimetry with variable corneal compensation (VCC).
Observational cohort study.
The study included 377 eyes of 221 patients with a median follow-up of 4.0 years. Images were obtained annually with th...
To assess the ability of the new pattern electroretinogram optimized for glaucoma detection (PERGLA) paradigm to discriminate between healthy individuals and individuals with glaucomatous optic neuropathy (GON).
Cross-sectional study.
One hundred forty-two eyes of 71 participants (42 healthy and 29 with GON in at least 1 eye) enrolled in the Univer...
A new, fast-threshold strategy, German Adaptive Thresholding Estimation (GATE/GATE-i), is compared to the full-threshold (FT) staircase and the Swedish Interactive Thresholding Algorithm (SITA) Standard strategies. GATE-i is performed in the initial examination and GATE refers to the results in subsequent examinations.
Sixty subjects were recruited...
To evaluate the ability of scanning laser polarimetry with variable corneal compensation to detect progressive retinal nerve fiber layer (RNFL) loss in glaucoma patients and patients suspected of having the disease.
This was an observational cohort study that included 335 eyes of 195 patients. Images were obtained annually with the GDx VCC scanning...
To compare the Swedish interactive thresholding algorithm (SITA) with the full-threshold (FT) strategy for short-wavelength automated perimetry (SWAP).
One eye of 286 patients with glaucomatous optic neuropathy (GON) and 289 age-matched participants without GON from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Gla...
To determine the sensitivity and specificity of confocal scanning laser ophthalmoscope's Topographic Change Analysis (TCA; Heidelberg Retina Tomograph [HRT]; Heidelberg Engineering, Heidelberg, Germany) parameters for discriminating between progressing glaucomatous and stable healthy eyes.
The 0.90, 0.95, and 0.99 specificity cutoffs for various (n...
To assess the degree of concordance among clinicians reviewing 3 Heidelberg retina tomograph (HRT) printouts used to detect progression, the Moorfields regression analysis (MRA), the topographic change analysis (TCA), and trend analysis (TA), and to compare with progression identified by stereophotographs.
Observational cohort study.
We longitudina...
Early diagnosis of glaucoma is critical to prevent permanent structural damage and irreversible vision loss. Detection of glaucoma typically relies on examination of structural damage to the optic nerve combined with measurements of visual function. To aid the clinician in evaluation of visual function and structure, computer-based devices such as...
To compare the most recent versions of standard automated perimetry (SAP), short-wavelength automated perimetry (SWAP), and frequency-doubling technology (FDT) using three definitions of visual field (VF) abnormality: single-test abnormality, abnormality confirmed by the same test, and abnormality confirmed by a different test.
Data obtained from o...
To investigate whether long-term intraocular pressure (IOP) fluctuations are a risk factor for conversion from ocular hypertension to glaucoma.
Observational cohort study.
The study included 252 eyes of 126 patients with ocular hypertension observed untreated as part of the Diagnostic Innovations in Glaucoma Study. At baseline, ocular hypertensive...
To assess whether baseline Glaucoma Probability Score (GPS; HRT-3; Heidelberg Engineering, Dossenheim, Germany) results are predictive of progression in patients with suspected glaucoma. The GPS is a new feature of the confocal scanning laser ophthalmoscope that generates an operator-independent, three-dimensional model of the optic nerve head and...
To determine whether combining structural (optical coherence tomography, OCT) and functional (standard automated perimetry, SAP) measurements as input for machine learning classifiers (MLCs; relevance vector machine, RVM; and subspace mixture of Gaussians, SSMoG) improves diagnostic accuracy for detecting glaucomatous eyes compared with using each...
To compare the diagnostic accuracy of the Matrix frequency-doubling technology (FDT) 24-2, first-generation FDT N-30 (FDT N-30), and standard automated perimetry (SAP) tests of visual function.
One eye of each of 85 glaucoma patients and 81 healthy controls from the Diagnostic Innovations in Glaucoma Study was included. Evidence of glaucomatous opt...
To evaluate the prevalence and risk factors for vision loss in patients with clinical or immunologic AIDS without infectious retinitis.
A prospective, multicenter cohort study of patients with AIDS.
One thousand three hundred and fifty-one patients (2,671 eyes) at 19 clinical trials centers diagnosed with AIDS but without major ocular complications...
To compare retinal nerve fiber layer (RNFL) and optic disc topographic imaging for detection of optic nerve damage in patients suspected of having glaucoma.
Observational cohort study.
A cohort of 82 patients suspected of having glaucoma based on the appearance of the optic nerve.
All patients were imaged using the GDx VCC scanning laser polarimete...
To investigate the impact of perimetric measurement scales, sample composition, and 2 statistical methods on the structure-function relationship in glaucoma.
Three hundred eighty-five eyes of 385 participants, covering the full spectrum of the disease from healthy to advanced glaucoma, were tested with the Heidelberg Retina Tomograph and standard a...
To compare machine learning classifiers trained on three clustering schemes to determine whether distinguishing healthy eyes from those with glaucomatous optic neuropathy (GON) can be optimized by training with clustered data.
Two machine learning classifiers-quadratic discriminant analysis (QDA) and support vector machines with Gaussian kernel (SV...
To test the following hypotheses: (1) eyes from patients with human immunodeficiency virus (HIV) have retinal damage that causes subtle field defects, (2) sensitive machine learning classifiers (MLCs) can use these field defects to distinguish fields in HIV patients and normal subjects, and (3) the subtle field defects form meaningful patterns. We...
To compare the interthreshold and intrathreshold strategy agreement of visual field end point criteria for standard automated perimetry (SAP) with the full-threshold (FT) algorithm and the Swedish interactive threshold algorithm (SITA).
Prospective, longitudinal cohort study.
The interstrategy group included a randomly selected eye of 173 participa...
To compare the strength of the structure-function association between scanning laser polarimetry-measured retinal nerve fiber layer (RNFL) thickness and visual sensitivity. Two methods of corneal compensation were evaluated, variable corneal compensation (VCC) and enhanced corneal compensation (ECC).
Observational case series.
One hundred twenty-se...
To compare the relationships between optic nerve structural measures and visual function, as well as the diagnostic sensitivity for glaucoma detection between the retinal nerve fiber layer (RNFL) and neuroretinal rim measurements.
A total of 101 normal and 156 glaucomatous eyes of 257 enrolled subjects were examined. RNFL thickness was measured by...
To compare the effect of disc size and disease severity on the Heidelberg Retina Tomograph (HRT) Glaucoma Probability Score (GPS) and the Moorfields Regression Analysis (MRA) for discriminating between glaucomatous and healthy eyes.
Ninety-nine eyes with repeatable standard automated perimetry results showing glaucomatous damage and 62 normal eyes...
To determine whether the visual field (VF) loss detected by frequency doubling technology perimetry (FDT) but not by standard automated perimetry (SAP) is associated with retinal nerve fiber layer (RNFL) damage measured using optical coherence tomography (OCT).
Observational case-control study.
Ninety-three subjects were recruited from the longitud...
To determine the spatial relationship in neuroretinal rim parameter values between eyes in ocular hypertensives, glaucoma suspects, and glaucoma patients.
Observational-cross-sectional study.
A total of 334 eyes of 167 patients were included. All patients underwent confocal scanning laser ophthalmoscopy imaging in both eyes. Intereye concordance ra...
To determine the spatial characteristics of glaucomatous visual field progression in persons with glaucomatous-appearing optic neuropathy (GON) from the Diagnostic Innovations in Glaucoma Study (DIGS).
Changes in pattern deviation (PD) plot values from the average of two baseline examinations to two follow-up examinations were evaluated in test loc...
To evaluate the relationship between intraocular pressure (IOP) measurements obtained by dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) in African Americans and to assess whether these measures were influenced by ocular parameters including corneal thickness, corneal curvature, and axial length.
Observational clinical stud...
