Pam Mantri

Pam Mantri
Cognitive Tools Limited LLC

Doctor of Philosophy

About

14
Publications
10,056
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108
Citations

Publications

Publications (14)
Article
Lineage plasticity hinders identification of cellular origin of cancers, as malignant cells cease to resemble benign cells from which they presumably evolved. Lung adenocarcinoma (LUAD), the most common primary lung cancer in United States is thought to arise from alveolar type II (AT2) cells. However recent mouse models have shown that LUADs may a...
Article
Full-text available
The 1987 United Nations Brundtland Report established the vision of sustainable development as “development that meets the needs of the present without compromising the ability of future generations to meet their own needs.” How might we anticipate the requirements of future custodians of vast, continuously morphing socio-technical-ecological syste...
Article
The 1987 UN Brundtland Report established the broad definition of sustainable development as ``development that meets the needs of the present without compromising the ability of future generations to meet their own needs.'' How might we anticipate the functional requirements of unknown future generations who will be custodians of vast and continuo...
Chapter
The design of modern cloud computing makes available a plethora of scalable cloud computing offerings. The cloud is increasingly becoming the backbone of the highly complex modern knowledge economy that includes social, mobile, IoT, Big Data, and AI. Knowledge-based products and services follow fat-tail distributions such as the power law that pose...
Article
Full-text available
Artificial Neural Networks (ANN) and Deep Learning (DL) are used to solve complex problems including image recognition, speech recognition,autonomous driving, facial recognition, detecting cancers from imaging samples, etc. Various design considerations are involved in the design, training, and testing of Artificial Neural Networks (ANN). These inc...
Article
Full-text available
Life has existed on earth for at least 3.95 billion years. All along, the flame of life has been successfully passed on from generation to generation, and species to species across an immense temporal span. This includes at least five mass-extinction events that wiped out over 70% of all species in each such biotic crisis. Against such immense odds...
Article
Full-text available
Modern cloud computing makes available a plethora of scalable cloud computing offerings. The cloud is increasingly becoming the backbone of the highly complex modern knowledge-economy that includes Social, Mobile, IoT, Big-Data and AI. Knowledge-based products and services follow fat-tail distributions such as the power-law that poses major opportu...
Conference Paper
Full-text available
The blockchain revolution upholds the decentralizing ideal of “control nothing.” It is natural that such a pursuit would face issues of governance that demand reasonable control; control that is both operational as well as adaptive in nature. Eliminating middlemen and handing over controls to a trusted system of trustless agents does not thereby be...
Article
Full-text available
The blockchain revolution upholds the decentralizing ideal of “control nothing.” It is natural that such a pursuit would face issues of governance that demand reasonable control; control that is both operational as well as adaptive in nature. Eliminating middlemen and handing over controls to a trusted system of trustless agents does not thereby be...
Article
Full-text available
Part 1 established the theoretical framework for undertaking a top-down/bottom-up mash-up between the Axiomatic Design/Complexity Theory (AD/CT) and the Design Patterns (ÐP) framework. It synthesized an integrated N-model from the top-down V-Model and its antipodal/bottom-up Λ-model. Part 2 illustrates the approach in the domain of Cybersecurity. R...
Article
Full-text available
Traditionally, the Axiomatic Design (AD) Framework aids the top-down design in at least three fundamental ways. Firstly, it helps capture the requisite, high-level systemic-property of a given design. Secondly, given an ensemble of candidate designs, it helps evaluate the designs. Finally, when viewed from the Axiomatic Design/Complexity Theory (AD...
Article
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Article
Prostaglandin H synthase (PGH synthase) and 5-Lipoxygenase (5-LO) are important enzymes that catalyze the formation of putative intermediates involved in the inflammatory process. The mechanism by which PGH synthase and 5-LO convert their common substrate arachidonic acid (AA) into prostaglandins, thromboxanes and leukotrienes is discussed. Recent...

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