Pallavi Singh

Verified

Pallavi verified their affiliation via an institutional email.

Learn more

Verified

Pallavi verified their affiliation via an institutional email.

Learn more

• Doctor of Philosophy
• Professor at Graphic Era University

Breast cancer poses a global health challenge and requires innovative approaches for prevention and treatment. Phytochemicals have gained attention for their potential anti-cancer properties by offering promising therapeutic interventions with their many advantageous effects and activity in promoting apoptotic pathways and other molecular pathways...

Pancreatic cancer remains one of the fatal malignancies with limited treatment options and a high rate of drug resistance. Y-box binding protein 1 (YBX1) plays an essential role in pancreatic cancer by upregulating the low-density lipoprotein receptor-related protein-1 (LRP1), which promotes tumour growth through the Wnt/β-catenin pathway. Diospyro...

Millet is one of the oldest cereal grains, used for several centuries in Asia and Africa. Its ease of growth in adverse environmental conditions and with minimum agricultural inputs made it a popular choice before the advent of the green revolution. However, the green revolution's recent focus on nutritional insecurity has led to a renewed interest...

The WHO estimates that 1.3 million people died from chronic renal disease (CRD) in 2016, making it the ninth leading cause of death worldwide. Around 50,000 deaths in the United States were attributed to CRD in 2016, according to the Centers for Disease Control and Prevention (CDC). CRD is a progressive disorder in which the kidneys gradually lose...

Rapid development of human civilization with increase in human population has contributed to the accumulation of hazardous pollutants in the environment. Fluorine a highly reactive element, is ubiquitously found in the world environment, mostly as inorganic compounds of fluoride. Fluoride is beneficial in trace amounts to the human body, but is ext...

The tribes of the Tons Valley in Uttarakhand, India, prepare Pakhoi, a traditional drink, as the subject of the current study. This drink is known to have therapeutic properties and has potential applications in anti-cancer research. The present study investigates the antiproliferative activity of key compounds found in this drink. Numerous computa...

Prostate cancer (PC) depicts a major health challenge all over the globe due to its complexities in the treatment and diverse clinical trajectories. Even in the advances in the modern treatment strategies, the spectrum of resistance to the therapies continues to be a significant challenge. This review comprehensively examines the underlying mechani...

Ever since the start of the Industrial Revolution, environmental pollution has significantly increased. The prominent cause of most diseases in humans, animals, and plants is the presence of toxic materials, pollutants, contaminants, and hazardous com- pounds released by industries. One of the major factors is the presence of heavy metals in the a...

The incidence of Lung Cancer (LC) is rising in India. LC has been diagnosed and detected numerous times utilizing numerous data processing and identification strategies. Since the underlying origin of LC is still unknown, treatment is hopeless, making early diagnosis of lung tumors the only viable treatment option. So, a Machine Learning (ML) and D...

Introduction: Catharanthus roseus, commonly known as Vinca Rosea or Madagascar periwinkle, is a significant plant species within the Apocynaceae family, known for its diverse medicinal properties and ornamental attri- butes, long embraced by Chinese traditional medicine practices. Methodology: Electronic records of papers published in various dat...

Pennisetum purpureum is an easily cultivated fast-growing perennial grass with great potential as a bioenergy crop due to its high biomass production. Recent advancements in the processing of P. purpureum for the generation of bioethanol are highlighted in this review paper. Various pretreatment methods, namely, enzymatic, acid, and alkaline pretre...

Groundwater is essential to human well-being and sustains a variety of aquatic ecosystems in both urban and rural settings. Yet, it is commonly overlooked in these contexts. As a result, groundwater may be very important to the development and well-being of many nations if it is properly evaluated and utilized. Although the possibility for sustaina...

One of the biggest healthcare threats of this century is COVID-19, undoubtedly. It has caused millions of deaths and raised alerts in the healthcare domain. This study focuses on the importance of 10 native Indian plant species and the phytochemicals obtained from them as a potential inhibitor to the Main protease enzyme of SARS CoV-2. About 26 phy...

The growing urban population, increasing income per capita, and significant rise in the number of people living in cities are all placing a strain on the nation's water supply and calling for innovative methods of urban water management. Water stress, excessive resource consumption, nutrient discharge into aquatic ecosystems, and financially unstab...

Pesticide is the amalgam of substances that are meant for destroying or controlling and preventing any pest, which includes disease vectors of animal or human, undesirable species of animals or plants that causes damage through the interference accompanied by agricultural commodities, either storage or food marketing, production, wood and wooden pr...

Mycobacterium tuberculosis (MTB) is becoming more and more resistant to drugs and it is a common problem, making current antimicrobials ineffective and highlighting the need for new TB drugs. One of the promising targets for treating MTB is MurB enzymes. This study aimed to identify potential inhibitors of MurB enzymes in M. tuberculosis, as drug r...

Food scarcity is a global concern that is growing every year. Biotic stress factors like pathogenic fungi, bacteria, viruses, and nematode pests aggravate the situation by imparting detrimental effects on crops by unfavourably affecting their growth and yield. Abiotic stress factors include extreme heat and cold, drought, high salinity, floods, a...

The increasing demand for food has increased dependence on chemical fertilizers that promote rapid growth and yield as well as produce toxicity and negatively affect nutritional value. Therefore, researchers are focusing on alternatives that are safe for consumption, non-toxic, cost-effective production process, and high yielding, and that require...

Role of Extracellular Vesicles in correlation with the monkey pox virus infection is explored.

Mucormycosis is an insidious fungal infection caused by members of Mucorales and zygomycotic species. During the last few years, mucormycosis has become the third most common invasive fungal infection in patients with haematological malignan-cies and organ transplantations. The incidence of mucormycosis is particularly high in patients with immunoc...

Phosphorous is one of the important elements for life but its surplus amount is not good. It can be retrieved for being reused but can not be produced. It's a good thing that phosphorus can be retrieved and used again since it cannot be produced. Reducing, Reusing, and Recycling is the only method to prevent a supply shortage. Phytic acid is a comm...

Book chapter from Taylor and Francis upcoming book on "Bionanotechnology towards Green Energy".

Background: Globally, diabetes mellitus is the most common cause of premature mortality after cardiovascular diseases and tobacco chewing. It is a heterogeneous metabolic disorder characterised by the faulty metabolism of carbohydrates, fats and proteins as a result of defects in insulin secretion or resistance. It was estimated that approximately...

Agricultural production is improving as a result of recent technological and scientific advances. In agriculture, identifying plant leaf diseases and improving plant leaf quality are critical. There are various laboratory procedures for identifying illnesses, but they are costly and time-consuming for farmers. Polymerase chain response, minimised f...

Chronic obstructive pulmonary disease is one of the main causes of death in many developing countries as well as an Increasing problem for medical services. It is usually a rising issue in densely populated countries with high levels of pollutants in the air. It is crucial to have verifiable evidence of modifiable risk factors for COPD preventio...

: Due to its use as a clean energy source and as a feedstock for some industries, hydrogen is a valuable gas. As a result, the need for hydrogen production has grown significantly in recent years. The well-known technologies for producing hydrogen gas like electrolysis of water, steam reforming of hydrocarbons, and autothermal processes are not eco...

Nanoparticles of titanium diboride (TiB 2) coated with a conductive polymer and subjected to an oxidizing agent was carried out in this research. TiB 2 nanoparticles coated with polypyrrole (PPy) were studied using XRD and TEM techniques. Nitrogen adsorption and desorption properties of nanoparticles are covered with modified polypyrrole to underst...

Bioinformatics is inherently an innovative field that is situated at the limit of life and computer sciences that allowed new technological advances in genome sequencing, data processing, predication and simplified the treatment of complex and huge data. This field is related on two common approaches namely; in silico and molecular docking-dynamic...

Production of Biofuel in higher yield by processing lignocellulosic biomass has been limited by the characteristics of conventional saccharomyces cerevisae which can utilize lesser number of carbon sources and has very less thermotolerance. Further, complex structure of cellulose and hemicellulose bounded by fibrils of lignin makes it difficult to...

Malignant growth, the illness starts when cells in the body begin to grow out of control. Metastatic prostate malignant growth is hopeless, and novel techniques to identify the illness prior to and to coordinate conclusive treatment are required. To combat cancer, microscopically unambiguous methods of restricting radionuclide payloads to malignant...

Chagas disease, also known as Trypanosomiasis, is found mostly in Latin America by the infection of a parasite, Trypanosoma cruzi. It is considered to be vector born disease which is transmitted by an insect, Triatominae Bug. Other sources of transmission of disease are Blood transfusion, oral and Congenital transmission. According to WHO, it is t...

As the energy demand is continuously rising with the increase in population, the use of fossil fuels is also increasing at the same rate. These fossil fuels release greenhouse gases (GHG) which are harmful to human health and our environmental health and these fuels are also expected to exhaust in the near future. This eventually has led to an emer...

Ethanolic extract of Cocculus hirsutus when orally administered at the dose levels of 500mg, 1000mg and 2000mg/kg body weight to Charles Foster rats showed significant platelets counts increasing activity. Thus, we suggest that it can be used as a promising product for the treatment of dengue in our country.

Biofuels are a promising alternative to meet the ever increasing demand of energy and fuel worldwide. As there has been limitations in production of Bioethanol and Biobutanol by application of conventional fungal species like Saccahromyces cerevisae, the focus has shifted to production and application of Biohydrogen by utilizing waste water from va...

The purpose of this research is to evaluate the chromatographic antioxidative activity and thin-layer analysis of medicinal plant leaves. Its antioxidant activities were calculated by calculating its radical scavenging DPPH and radical scavenging ABTS and were obtained in 35.08 per cent, 32.12 per cent, 17.22 per cent, for this research Bacopa monn...

Anaplasma phagocytophilum, has been observed as an emerging human pathogen of public health importance and is commonly transmitted to humans by tick bites. The bacterium Anaplasma phagocytophilum has been known from decades to cause the disease, tick-borne fever (TBF) in domestic ruminants and cattles in various areas in northern Europe, China, Rus...

In the past few years, Scientific studies across the globe have led to the crucial insights about Hydrazone and Hydrazide derivatives. Hydrazone compounds and their derivatives have been known to possess antimicrobial, anti fungal, anti tumorous, anti inflammatory and anti convulsant activity. We had synthesized following chemical entities in our w...

Emergence of multiple drug resistant microbial species is an arena of serious concern all over the globe. Hydrazone derivatives have been assessed to possess significant antimicrobial, antimycotic, anti-inflammatory and anticancerous properties and they have been demonstrated to be a key solution to treat these microbial species which display multi...

PHZ exposure has been shown to affect haematopoietic cells in adults. In developmental experimental animal studies, prenatal exposure of PHZ resulted in fatal effects like reduction in weight, skeletal malformation and increased incidence of the miscarriage and persistent decrease in the no. of blood forming cells. PHZ exposure is also associated w...

Pyrazinamide is a medication used to treat tuberculosis. For active tuberculosis, it is often used together with rifampicin, isoniazid and either streptomycin or ethambutol. Rifampicin also known as rifampin, is an antibiotic used to treat several types of bacterial infections. This includes tuberculosis, leprosy, and Legionnaire's disease. Tubercu...

Hemoglobin-catalyzed Phenylhydrazine oxidation, a model for Heinz-body hemolytic anemias, is known to result in hemoglobin degradation and erythrocyte lysis. Phenylhydrazine can penetrate to the O -binding site of the haemoglobin molecule and react with it. Phenylhydrazine oxidation results in the 2 formation of superoxide and hydrogen peroxide. A...

Itraconazole and fluconazole are oral antifungal drugs, which have a wide spectrum antifungal activity and better efficacy than the older drugs. However, both drugs have been associated with hepatotoxicity in susceptible patients. The mechanism of antifungal drug-induced hepatotoxicity is largely known. Therefore, the aim of this present study was...

Importance of enzyme is ever growing, specifically microbial lipases as they hydrolyze fats into fatty acids and glycerol, and reverse the action in non-aqueous media. Lipases are of great significance in fat and oil processing, detergents, pulp and paper industry, oleochemical industry, cosmetics and perfumery. They are also used in biosensors. Li...

The protective effect of Asparagus adscendens was evaluated on genotoxicity induced by an alkylating agent Cyclophosphamide. The present study deals with the anti-genotoxic effect on DNA and chromosome damage. This study was carried out by using chromosome aberration assay and micronucleus test. Different group of mice were treated with Asparagu...

Phenyl hydrazine (PHZ) is a potent chemical causing haemolytic anaemia in various tissues at various levels. Phenyl hydrazine is used as a model for the induction of haemolytic anaemia in Charles foster rats. It causes the destruction of red blood cells by oxidative stress within erythrocytes and changes at cellular level resulting haemolytic an...

Benzene toxicity involves both bone marrow depression and leukemogenesis caused by benzene damage to multiple classes of hematopoietic cells and a variety of hematopoietic cell functions. Study of the relationship between the metabolism and toxicity of benzene indicates that several metabolites of benzene play significant roles in generating ben...

Extensive developments in the area of industrial biotechnology over past few years have signified the importance of citric acid as one of the most known organic acid, applied mainly as flavoring, emulsifying, cleaning, and chelating agent. It also plays a major role in pharmaceutical and cosmetic industries. Citric acid is produced by various micro...

Argonaute proteins have been well characterized for their key role in RNA mediated gene silencing pathways. Association of Argonaute proteins with siRNA to form RISC (RNA induced silencing complex) to catalyze post transcriptional gene silencing by degrading and slicing messenger RNA is established as a significant role of Argonaute protein family....