Palanisamy Selvamani

Anna University, BIT Campus, Tiruchirappalli · Department of Pharmaceutical Technology

Aim The present study aims to investigate the toxicity profile and neuroprotective effect of ethanol crude extract of Aristolochia bracteolata (EEAB) leaves in mice. Methods EEAB was subjected to preliminary phytochemical screening and gas chromatography–mass spectrometry (GC–MS) analysis. To determine the toxicity profile in Swiss albino mice, ac...

Aim: The current study aims to investigate the toxicity profile, the anti-amyloidogenic, and anti-ameliorative effects of crude ethanol extract from Cadaba indica leaves in contrast with a prominent drug. Methods: Phytochemical screening of the ethanol extract of C. indica was performed by GC–MS analysis. The cell viability of SH-SY5Y cells was ass...

This review presents about the new diverse drug delivery technologies of omeprazole and also to explore it advantages by formulating omeprazole into magnetic tablets. The first marketed proton pump inhibitor was the omeprazole which irreversibly alter the H+/K+ ATPase activity therefore inhibiting the secretion of gastric acid. The gastric parietal...

Lung cancer is a prevalent and life-threatening disease that requires potent and selective antitumor agents for effective treatment. Antimicrobial peptides (AMPs) have gained popularity as potential antitumor agents due to their reported ability to selectively target tumor cells. In this study, we investigated the anti-tumor activity of Retrocyclin...

Canarium strictum Roxb. (Burseraceae) is a tree distributed in India, China and Thailand. In traditional Ayurvedic medicine, it is used to treat asthma, rheumatism, blood impurities, syphilis, fever, epilepsy and cough. Toxicological information is currently unavailable warrants present research. Ethanol leaf extract obtained by soxhlet extraction...

Roots of Illupai (Madhuca longifolia) are mentioned for Madhumegam in Gunapadam-Mooligai (Siddha Materia Medica). The disease Madhumegam found in siddha text is correlated with Diabetes mellitus type-II. Madhuca longifolia known as Illupai in Tamil has been widely used for the treatment of diabetes. Hence, the present study aimed to demonstrate the...

Lung cancer is a major public health concern due to its high prevalence and mortality, and it is also the second leading cause of cancer death worldwide. Non-small cell lung cancer accounts for more than 80% of lung cancers. In recent years, the use of bioactive peptides in cancer therapy has widened the treatment regimen. They have been confirmed...

Antimicrobial peptides comprise core components of innate defense and act as first-line defense molecules in most marine mollusks. Marine natural products have served as templates for the design and development of novel therapeutic molecules against infectious pathogens in the past decades. In this study, we report the isolation, purification and c...

The primary aim of our study is to formulate the meloxicam loaded chitosan-magnetite nanoconjugates (MC-MNCs) for the magnetically targeted rheumatoid arthritis therapy with an anticipation to improve the drug efficacy through enhancing its regional bioavailability, reducing dose frequency and related toxicity. The chitosan-magnetite nanoconjugates...

Background Owing to the recent scenario on this ongoing Coronavirus pandemic outbreak around the world, the present study has been undertaken. Aim In this study, we adopted two strategies, i.e., via computational method, a search for the novel plant secondary metabolites from the Indian Traditional Medicine to target and combat the enduring novel...

Magnetic microspheres incorporated with pantoprazole sodium—a proton pump inhibitor—were formulated by using two different polymers such as ethyl cellulose and Eudragit RS-100. The magnetic microspheres were prepared by emulsion solvent evaporation technique with different drug carrier ratio of pantoprazole: magnetite: ethyl cellulose (EC-1 = 1:1:2...

Background: Drug delivery is a science that requires the development of tailored systems that can deliver defined quantities of a therapeutic payload at a specific target site, at a controlled release rate, with or without a specific trigger. However, several drug molecules cannot be formulated or administered by standard techniques as they exhibit...

Magnetic nanoliposomes are versatile nanocarriers for targeted drug delivery. These liposomes can enhance the efficacy of bioactive compounds by improving pharmacokinetic parameters. Chemical ingredients of magnetic nanoliposomes include ferrofluid, cholesterol and phospholipid molecules. The preparation of magnetic nanoliposomes involves two steps...

The unexplored marine bivalves: Donax cuneatus and Pitar erycina are collected and the crude tissue proteins are extracted from them by diverse extraction methods. The crude protein fraction obtained from the acidic extraction method showed the highest yield and have further considered in our study. Various process parameters for the crude peptide...

The host defense peptides or antimicrobial peptides (AMPs) often contain short sequence of amino acids, either positive or negatively charged and express broad-spectrum antibacterial, antiviral and antifungal activity. Many researchers had reported that tryptophan, arginine and proline rich AMPs have a promising source of next-generation antibiotic...

Rheumatoid arthritis (RA) is an autoimmune disease that principally attacks synovial joints. RA also cause inflammation in the joints and associated regions. There is an unmet medical need for RA as well as for the targetted drug delivery of anti‐rheumatic drugs to improve its efficacy at a much lower doses while decreasing its side effects. Hence,...

Many antimicrobial peptides (AMPs) have multiple antimicrobial immunity effects. One such class of peptides is temporins. Temporins are the smallest (AMPs) found in nature and are highly active against gram-positive bacteria. Nowadays, there was a rapid increase in the availability of the 3D structure of proteins in PDB (protein data bank). The con...

Metabolic engineering has evolved exponentially due to rapid progress in the development of omics (proteomics, lipidomics and glycomics) technology and synthetic biology toolsets. Particularly, omics technologies, synthetic biology and metabolic engineering are interdependent in terms of principles of technology and their biological applications. I...

The present study has been undertaken to search the novel co drugs for fighting against the COVID-19 disease through an in- silico approach. We have designed eight co drugs by merging two drugs namely hydroxychloroquine, used in the treatment of COVID-19 and curcumin an immuno modulator. The two drugs were linked through a bio-cleavable hydrolyzabl...

The marine bacterium was widely recognized as a natural manufacturer of novel bioactive secondary metabolites during the last decades, making the marine ecosystems a huge treasure of novel isolates. Marine coastal areas of the southern part of India have huge varieties of ecosystems that produce many marine microbes and organisms which are consider...

Natural products have a unique place in the healthcare industry. The genus Commiphora emerged as a potential medicinal source with huge benefits as evidenced through its use in various traditional and modern systems of medicine. Therefore, we aimed to prepare a concise review on the pharmacological activities and the indigenous uses of various plan...

The objective of this study is to develop a passive targeting of multilayered nanoparticles encountering multiple obstacles on the way to their target due to the mucosal barrier, nonspecific uptake of the drug. To prevent the nonspecific drug toxicity and combination chemotherapy for synergistic effect, multifunctional ferromagnetic properties were...

Peroxisome proliferator-activated receptor gamma (PPARγ) is a multifaceted ligand-activated transcription factor that regulates inflammatory responses in asthma pathophysiology. The present study corroborates PPARγ-mediated anti-asthmatic action of the flavonoid, galangin (norizalpinin). In silico molecular interactions reveal that galangin formed...

A novel series of chalcone bearing pyrazoline moieties were (P1 to P7) synthesized and characterized by various analytical techniques. The anti-inflammatory studies showed the compounds P1, P2, P5, and P6 have produced the noteworthy inhibition on protein denaturation (81.39 - 96.57 %) when compared to standard 98.17% whereas, the antiproteinase ac...

Recently, we reported our methodology for isolating plasma membrane and lysosome from eukaryotic cell using superparamagnetic nanoparticles (SPMNPs). Here in this article, we report a step-by-step protocol for synthesis of hybrid gold nanoparticle (AuNP), surface functionalization of AuNPs on superparamagnetic nanoparticles (SPMNPs), and potential...

National conference

National conference

Antibiotics have saved several millions of lives, but its persistent use of antibiotics in the treatment of various infections, whether bacterial, fungal, viral or parasitic has lead to the development of antibiotic resistance. The rapid emergence of antibiotic resistant strains poses a serious challenge to existing antimicrobial therapies. Due to...

p class="Abstract"> Cadaba indica , a component of traditional siddha medicine, is used for the therapy of gonorrhea, inflammation, eczema etc. The present study shows that it exhibited acetylcholinesterase inhibitory activity (up to 81.5 ± 1.5%) at the concentration of 3 mg/mL, with the IC₅₀value of 1.8 mg/mL. Furthermore, the ethanol...

We report here in about the formulation and evaluation of Magnetic Prednisolone Microcapsules (MPC) developed in order to improve the therapeutic efficacy relatively at a low dose than the conventional dosage formulations by means of magnetic drug targeting and thus enhancing bioavailability at the arthritic joints. Prednisolone was loaded to poly...

Introduction: Chronic infection with hepatitis B virus (HBV) constitutes a major global threat to public health, causing substantial disease burdens such as liver cirrhosis and hepatocellular carcinoma. Methods: HBV is a member of the Hepadnaviridae family of viruses, the remarkable events of the HBV lifecycle include cellular entry, disassembly, r...

Introduction: Alzheimer's disease (AD) is an incapacitating neurodegenerative disease that progressively declines the memory and cognition. Currently approved acetylcholinesterase inhibitors (AChEIs), fail to provide a permanent cure to the disease which also presents several side effects. Hence at present the search is mainly focused on new AChEIs...

Introduction: An important goal in computer-aided design is to find a correlation between the structural features of ligands and their biological activity i.e. ability to bind to a specific target proteins. Neuraminidase (NA) is a glycoprotein found on the surface of Influenza A virus that is involved in the process of releasing new progeny of viri...

Andrographis paniculata commonly known as “King of Bitters” is a very good medicinal plant used for the therapy of number of diseases such as common cold, colic pain, cancer, immune deficiency etc. Various bioactive alkaloids of A. paniculata such as andrographolide, neoandrographolide, andrographiside, 14, Deoxyandrographolide was mostly found in...

The objective of the present study is to characterize the physicochemical properties and to determine the in vitro antioxidant activity of Albizia stipulata Boiv. gum exudates collected from Northeast India. The total carbohydrate, uronic acid and protein contents, monosaccharide composition and the molecular weight distribution of the purified gum...

Marine organisms represent a valuable source of new compounds. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active substances in the field of the development of bioactive products. Protein rich consumable marine fish named Stingray fish (Thirukkai meen) was colle...

Antimicrobial peptides appear to be ever-present and multipotent components of the innate immune defense mechanism used by both prokaryotic and eukaryotic organisms. These antimicrobial peptides differ in amino acid composition, range of antimicrobial specificities, hemolysis, cytotoxicity and mechanisms of action. AMPs have been isolated from a wi...

Cellular carriers possess great potential and merits in various modules of drug delivery. Among such cellular carriers, erythrocytes have been found to possess huge merits for the targeted and controlled drug delivery since they are non-immunogenic, non-toxic and their circulation can be readily controlled and could be manipulated with reference to...

Andrographis paniculata is a well known traditional plant which yields active botanical ingredient and rographolide responsible to treat a variety of ailments. The quality of the drugs is inconsistent due to several factors. To overcome these issues, the aeration rate played an important role in cell growth and constituent substance production. In...

Andrographis paniculata is a potent medicinal plant in the Indian systems of medicine. Traditionally the leaves are used as/in influenza, bronchitis, gonorrohea, cholera, fertility and antibacterial, anticancer, antidiabetic, anti-inflammatory and anti snake venom etc. In the present study deals with the plant growth promoting rhizobacteria (PGPR)...

In today's endemic world, demand for pharmaceutical products with desire properties is increasing day by day. In seaweeds, concentration of any bioactive compounds depends upon the season, climatic condition and types of solvents used for extraction. All the selected extracts after conformation test subject to Column chromatography followed by Thin...

Andrographis paniculata is a medicinal plant that has been effective against cancers cell lines and HIV induced cell cycle. The kinetics of biomass accumulation and nutrient uptake of Andrographis paniculata in cell suspension was examined for M.S medium and for optimized medium by using statistical methods (Plackett-Burman design).The modified med...

ABSTRACT BOOK

Alzheimer’s disease rises with predictions of 115 million being affected by 2050 due to aging of the population, continuing lack of progress in identifying, effective treatment modalities and lack of predictive diagnostic techniques. Clinical treatment for this disease relies mostly on prolonging the availability of acetylcholine release into the n...

NCADDD CONFERENCE PROCEEDINGS SPECIAL ISSUE IN Asian Journal of Medical and Pharmaceutical Sciences

The marine source was collected from the coast of Cuddalore, Tamil Nadu and it was extracted with 30% acetic acid solution and Tris Hcl buffer. The crude was centrifuged to precipitate and precipitated with Ammonium Sulphate. The attained precipitate was dialyzed with 3.0 kDa membrane using magnetic stirrer and retentates were collected. The antimi...