Palanisamy Sankar

Palanisamy Sankar
Tamil Nadu Veterinary and Animal Sciences University | TANUVAS · Department of Veterinary Pharmacology and Toxicology

M.V.Sc., Ph.D

About

40
Publications
3,044
Reads
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631
Citations
Additional affiliations
June 2013 - present
Tamil Nadu Veterinary and Animal Sciences University
Position
  • Professor (Assistant)
December 2009 - June 2013
Indian Veterinary Research Institute
Position
  • Researcher

Publications

Publications (40)
Article
Mammary pathogenic Staphylococcus aureus is related to a mastitis and its treatment is still based on the use of antibiotics. In the era of antimicrobial resistance, natural plant based product (curcu-min) as an efficient treatment or prophylactic option. Since curcumin is rapidly eliminated from the body, its oral bioavailability is low. However,...
Chapter
The soundness of animal health is gauged by their ability to withstand infection and remain resistant to reinfection. The robustness of animals can be directly attributed to their sturdy immune system. The animals are often inflicted with potential infectious agents hindering their growth and productivity and occasionally succumb to the disease. He...
Article
Full-text available
The synergistic fly control efficiency of neem seed powder and neem seed oil with methoprene against house fly was evaluated in broiler shed. One hundred and ninety two, day old broiler chicks were randomly divided into eight groups of twelve each with two replicates and the study was conducted for a period of five weeks. Methoprene and neem seed p...
Article
Full-text available
The present study was aimed to prepare a conjugate of Fc fragment of mice IgG with rOMP 28 of Brucella melitensis and investigate its ability to influence the kinetics of humoral and cellular immune response in comparison to its unconjugated counterpart and the rOMP 28 alone in the mice model. Among all the groups, the group of mice immunized with...
Article
Full-text available
The fly control efficiency of neem products (Neem seed powder and Neem seed oil) against house fly was evaluated in experimental broiler shed in comparison with methoprene. One hundred and ninety two, day old broiler chicks were randomly divided into eight groups of twelve each with two replicates and the study was conducted for a period of five we...
Article
Full-text available
A three timed calved Dairy cow with Urea poisoning was treated successfully with 5 % Acetic acid, Normal Saline and Activated charcoal
Article
Full-text available
A five timed calved cross bred HF cow with Nitrate poisoning was successfully treated with 1 % Methylene blue, Normal Saline and supportive therapy
Conference Paper
CMI response to foot and mouth disease virus is crucial to contain the spread of infection.Hence, assessment of cell mediated immune response against FMDV will be suggestive of effective immunity.
Article
Full-text available
Equine colic and its management
Article
Mastitis is the inflammation of the mammary glands caused by bacteria. It causes severe economic loss to dairy industry. Curcumin, a polyphenol obtained from turmeric, has considerable anti-inflammatory effect. Since it is rapidly eliminated from the body, its oral bioavailability is low. However, nanoformulation of curcumin significantly enhances...
Article
A ten months age old non descriptive bitch was referred to the Veterinary College and Research Institute, Namakkal Hospital with subcutaneous emphysema all over the body. It was reported to have been fed with fish four days earlier. The animal had cough, dysphagia and vomiting. Thoracic radiographs showed diffuse subcutaneous emphysema, along with...
Article
Full-text available
Clinico-therapeutic management of clinical mastitis in buffaloes
Article
One year old female Spitz was referred to the Veterinary College and Research Institute Hospital, Namakkal with history of having ingested a piece of chicken bone. Radiography revealed presence of an irregular shaped radioopaque foreign body in thoracic part of oesophagus. Video endoscopy was performed and a four centimetre long and irregular shape...
Article
Two years old Labrador was referred with history of ingestion of foreign bodies and repeated vomiting. Dog was apparently healthy with normal vital and haematological parameters. Abdominal radiography revealed presence of two foreign bodies in the stomach region. Under general anaesthesia, under endoscopic guidance foreign bodies were retrieved suc...
Article
Full-text available
A one year old male Doberman pinscher was presented to Teaching Veterinary Clinical Complex, Namakkal with the history of snake bite. Clinical examination revealed swelling in the mandible andbleeding fang marks in the lower lip. Animal was treated with anti-snake venom, tetanus toxoid, antibiotics and uids. The animalrecovered after two days of co...
Article
We assessed whether repeated arsenic exposure can decrease paracetamol-mediated antinociception by modulating serotonergic and endocannabinoid pathways. Rats were preexposed to elemental arsenic (4 ppm) as sodium arsenite through drinking water for 28 days. Next day paracetamol's (400 mg/kg, oral) antinociceptive activity was assessed through forma...
Article
We explored whether nanoformulation of curcumin can cause better protective effect than free curcumin against arsenic-induced genotoxicity. Curcumin-loaded Poly(lactic-co-glycolic acid) nanoparticles (CUR-NP) were prepared by emulsion technique. The CUR-NP were water soluble and showed biphasic release pattern. Rats were divided into 5 groups of 6...
Article
We evaluated whether the commonly used analgesic-antipyretic drug acetaminophen can modify the arsenic-induced hepatic oxidative stress and also whether withdrawal of acetaminophen administration during the course of long-term arsenic exposure can increase susceptibility of liver to arsenic toxicity. Acetaminophen was co-administered orally to rats...
Article
We examined whether subacute arsenic exposure can reduce paracetamol-mediated antipyretic activity by affecting COX pathway and cannabinoid CB1 receptor regulation. Rats were preexposed to elemental arsenic (4ppm) as sodium arsenite through drinking water for 28 days. Next day pyrexia was induced with lipopolysaccharide and paracetamol's (200mg/kg,...
Article
Full-text available
T he protective ef fic ienc y of rec ombinant outer memb erane protein 28 (rOMP28) of Brucrella melitensis administered subcutaneously with bacterial plasmid DNA as a source of CpG motifs was investigated in laboratory animal model mice. The mice were immunized on day 0, 14 and 21 except for the group 4 which was given as a single dose. Among the f...
Article
We investigated the therapeutic effectiveness of the nanoparticle-encapsulated curcumin (CUR-NP) against sodium arsenite-induced hepatic oxidative damage in rats. The CUR-NP prepared by emulsion technique was spherical in shape with an encapsulation efficiency of 86.5%. The particle size ranged between 120 and 140 nm with the mean particle size bei...
Article
Arsenic exposure through drinking water causes oxidative stress and tissue damage in the kidney and brain. Curcumin (CUR) is a good antioxidant with limited clinical application because of its hydrophobic nature and limited bioavailability, which can be overcome by the encapsulation of CUR with nanoparticles (NPs). The present study investigates th...
Article
An overview of the progress being made in implementing alternatives to animal experiments in India
Article
We evaluated whether the nanoformulation of curcumin could be more effective than free curcumin against arsenic-induced immune dysfunction in rats. Curcumin was encapsulated in polylactic-co-glycolic acid (PLGA). Nanocurcumin (CUR-NP) exhibited a spherical shape with the mean particle size of 130.8nm. Rats were randomly divided into five groups of...
Article
We evaluated the modulatory role of the groundwater contaminant arsenic on the pharmacodynamic responses of the nonsteroidal analgesic-antipyretic drug ketoprofen and the major pro-inflammatory mediators linked to the mechanism of ketoprofen's therapeutic effects. Rats were pre-exposed to sodium arsenite (0.4, 4 and 40 ppm) through drinking water f...
Article
Acetaminophen (AP) is a widely used, cheap, and over-the-counter nonsteroidal anti-inflammatory drug. Its toxicity depends on the cytochrome P-450 (CYP)-mediated oxidation to the toxic metabolite N-acetyl-p-benzoquinoneimine. On the other hand, arsenic, a global groundwater and environmental contaminant of major public health concern, decreases hep...
Article
We examined whether acetaminophen could alter renal oxidative stress induced by arsenic; also whether withdrawal of acetaminophen treatment can increase susceptibility of kidney to arsenic toxicity. Acetaminophen (400 and 1600 mg/kg) was co-administered orally to rats for 3 days after preexposure to arsenic (25 ppm) for 28 days (Phase-I) and therea...
Article
The aim of present study was to investigate the protective effect of curcumin on cypermethrin-induced changes in blood biochemical markers and tissue antioxidant enzyme in rats. Rats were divided into six groups of six each: group I used as control and II and III groups were used as vehicle control. While, groups IV, V and VI were orally treated wi...
Article
Full-text available
Immunotoxicological effects of cypermethrin and their reversal by curcumin following oral administration were evaluated in rats. Mature male Wistar rats were orally administered cypermethrin (25 mg kg body wt), curcumin (100 mg kg body wt) or both daily for 4 weeks. At the end of fourth week, hematological, serum biochemical, and immunological para...
Article
Cypermethrin is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control, protection of foodstuff and disease vector control. The aim of the present study was to investigate the protective effect of curcumin on cypermethrin-induced genotoxicity in rats. Administration of cypermethrin (25mg/kg, p.o.) for 28 days resulted i...
Article
We evaluated whether repeated arsenic preexposure can increase acetaminophen-induced hepatic oxidative stress. Rats were exposed to arsenic (25 ppm; rat equivalent concentration of maximum groundwater contamination level) via drinking water for 28 days. Next day, they were given single oral administration of acetaminophen (420 or 1000 mg/kg b.w.)....
Article
Arsenic is an environmental contaminant, while acetaminophen is an extensively used nonsteroidal analgesic-antipyretic drug. We evaluated whether subacute co-exposure to arsenic and acetaminophen would produce more toxicity than that caused by exposure to either of the xenobiotics in rats. Toxicity was evaluated through changes in body weight, feed...
Article
Ischemia/reperfusion injury ends up in the cascade of excitotoxic stimulation of superoxide and nitric oxide formation leading to the generation of highly reactive products, including peroxinitrite and hydroxyl radical, which are capable of damaging lipids, proteins and DNA. Several polyphenolic compounds scavenge the radicals and protect from inju...

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