Paige Bergstrom

Oregon Health and Science University | OHSU · Knight Cardiovascular Institute

High levels of circulating Lipoprotein (a) [Lp(a)] are an independent risk factor for CVD. One of the major limitations to investigating Lp(a) biology is the need for large volumes of plasma (4–10 mL) for its isolation. We developed an isolation technique requiring only 0.4 mL of plasma yielding an enriched Lp(a) fraction suitable for compositional...

Lipoprotein (a) [Lp(a)] is an independent risk factor for cardiovascular disease (CVD) and resembles an LDL-like lipoprotein with the addition of apolipoprotein(a) (LPA). The LPA gene results from a duplication of the plasminogen gene ( PLG ) and the proteins share 88% amino acid sequence homology in their protease domains. We recently identified L...

Rationale: Prospective cohort studies question the value of HDL-C for stroke risk prediction. Objective: Investigate the relationship between long-term functional recovery and HDL proteome and function. Methods and Results: Changes in HDL protein composition and function (cholesterol efflux capacity, or CEC) in patients after acute ischemic stroke...

Rationale Elevated serum lipoprotein(a) [Lp(a)] levels are associated with increased cardiovascular disease risk. ABCA1-mediated cholesterol efflux from macrophages is believed to be an anti-atherogenic process. We recently identified plasminogen as a driver of ABCA1-mediated cholesterol efflux and showed that its action is inhibited by purified hu...

In a GM-CSF driven myeloid cell deficient mouse model (Csf2−/−) that has preserved insulin sensitivity despite increased adiposity, we used unbiased three-dimensional integration of proteome profiles, metabolic profiles, and gene regulatory networks to understand adipose tissue proteome-wide changes and their metabolic implications. Multi-dimension...

Background: Plasminogen, is a potent acceptor of cholesterol by the ABCA1 transporter in peripheral cells, and this function is inhibited by lipoprotein (a) [Lp(a)]. Patients with high Lp(a) have increased cardiovascular disease risk, but the mechanism for this effect is not known. The interplay of plasminogen and Lp(a) in contributing to the total...