Pablo Zentilli- Université de Montréal
Pablo Zentilli
- Université de Montréal
About
7
Publications
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Introduction
Skills and Expertise
Current institution
Publications
Publications (7)
Motivation:
High-throughput screening (HTS) is an early-stage process in drug discovery which allows thousands of chemical compounds to be tested in a single study. We report a method for correcting HTS data prior to the hit selection process (i.e. selection of active compounds). The proposed correction minimizes the impact of systematic errors wh...
It is widely accepted that there is more to software construction than basic programming skills. Professional software construction involves not only understanding some theoretical concepts, but also mastering appropriate tools and practices. In this paper, we present an undergraduate course in Software Construction and Maintenance , developed with...
It is widely accepted that there is more to software construc- tion than basic programming skills (13, 11, 15, 16). Profes- sional software construction involves not only understanding some theoretical concepts, but also mastering appropriate tools and practices. In this paper, we present an under- graduate course in Software Construction and Maint...
A typical modern high-throughput screening (HTS) operation consists of testing thousands of chemical compounds to select active ones for future detailed examination. The authors describe 3 clustering techniques that can be used to improve the selection of active compounds (i.e., hits). They are designed to identify quality hits in the observed HTS...
Motivation:
High-throughput screening (HTS) plays a central role in modern drug discovery, allowing for testing of >100,000 compounds per screen. The aim of our work was to develop and implement methods for minimizing the impact of systematic error in the analysis of HTS data. To the best of our knowledge, two new data correction methods included...
High-throughput screening (HTS) is an efficient technological tool for drug discovery in the modern pharmaceutical industry.
It consists of testing thousands of chemical compounds per day to select active ones. This process has many drawbacks that
may result in missing a potential drug candidate or in selecting inactive compounds. We describe and c...
Dans ce mémoire, nous abordons le problème de la correction d'erreurs systématiques et de la recherche des composés prometteurs (i.e. «hits») dans les procédures de criblage à haut débit (HTS). Nous introduisons une nouvelle approche pour la correction des erreurs systématiques dans les procédures HTS et la comparons à quelques méthodes couramment...
