Pablo Villoslada-Blanco

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Verified

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• PhD in Biomedical and Biotechnological Sciences
• PostDoc Position at Spanish National Cancer Research Centre

Human immunodeficiency virus (HIV) infection is associated with premature aging and the development of aging-related comorbidities, such as cardiovascular disease (CVD). Gut microbiota (GM) disturbance is involved in these comorbidities and there is currently interest in strategies focused on modulating GM composition and/or functionality. Scientif...

Introduction: Human immunodeficiency virus (HIV) infection can be considered a chronic disease thanks to the extended use of antiretroviral treatment (ART). In this context, low-grade chronic inflammation related to gut microbiota (GM) dysbiosis and bacterial translocation (BT) among other factors has been observed despite the use of ART. In addit...

Viruses are the most abundant components of the microbiome in human beings with a significant impact on health and disease. However, the impact of human immunodeficiency virus (HIV) infection on gut virome has been scarcely analyzed. On the other hand, several studies suggested that not all antiretrovirals for treating HIV infection exert similar e...

Coronavirus disease 19 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to scale and threaten human health and public safety. It is essential to identify those risk factors that lead to a poor prognosis of the disease. A predisposing host genetic background could be one of these factors that...

Background To better understand the biology of COVID-19, we have explored the behavior of calcitonin gene-related peptide (CGRP), an angiogenic, vasodilating, and immune modulating peptide, in SARS-CoV-2 positive patients. Methods Levels of CGRP in the serum of 57 COVID-19 patients (24 asymptomatic, 23 hospitalized in the general ward, and 10 admi...

There is a complex and still poorly understood relationship between pancreatic ductal adenocarcinoma (PDAC) and type 2 diabetes. On the other hand, it's important to highlight that single-cell and spatial transcriptomics allow us to study cells individually and within their spatial context, but they also introduce a hierarchical data structure tha...

Pancreatic ductal adenocarcinoma (PDAC) presents a significant challenge, with a five-year survival rate of approximately 10%. Tumor heterogeneity contributes to the limited effectiveness of treatments. Several tumor and stroma molecular classifiers have attempted to clarify this heterogeneity with moderate agreement. Recognizing the complexity int...

The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest...

Work motivation: Pancreatic Ductal Adenocarcinoma (PDAC) remains a major oncological challenge, with a dismal five-year survival rate of around 10% (1). The diversity of PDAC molecular subtypes contributes to the limited efficacy of current treatments. Thus, tumor molecular classifiers have evolved significantly, with several key studies identifyin...

Background Genome-wide association studies of COVID-19 severity have been carried out mostly on European or East Asian populations with small representation of other world regions. Here we explore the worldwide distribution and linkage disequilibrium (LD) patterns of genetic variants previously associated with COVID-19 severity. Methods We followe...

Introduction: Pancreatic Ductal Adenocarcinoma (PDAC) is a major oncological challenge with a dismal five-year survival rate of around 10%. The diversity of PDAC molecular subtypes contributes to the limited efficacy of current treatments. Recognizing the complexity introduced by the numerous existing molecular classifiers and the pivotal role of s...

Introduction: Pancreatic Ductal Adenocarcinoma (PDAC) is a major oncological challenge with a dismal five-year survival rate of around 10%. The diversity of PDAC subtypes contributes to the limited efficacy of current treatments. Recognizing the complexity introduced by the numerous existing molecular classifiers and the pivotal role of stroma, thi...

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal...

The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we have conducted the larges...

Abstract Oral microbiome is the second largest microbial community in humans after gut. Human immunodeficiency virus (HIV) infection triggers an impairment of the immune system which could favour the growth and the colonization of pathogens in the oral cavity, and this dysbiosis has been associated with oral manifestations that worsen the quality o...

We analyzed the association between HLA polymorphisms and susceptibility to SARS‐CoV‐2 infection and disease severity. Genotyping data from a total of 9373 COVID‐19‐positive cases from the Spanish Coalition to Unlock Research on Host Genetics on COVID‐19 (SCOURGE) consortium and 5943 population controls were included in the study. We found an assoc...

Despite the high contagion and mortality rates that have accompanied the coronavirus disease-19 (COVID-19) pandemic, the clinical presentation of the syndrome varies greatly from one individual to another. Potential host factors that accompany greater risk from COVID-19 have been sought and schizophrenia (SCZ) patients seem to present more severe C...

INTRODUCCIÓN/OBJETIVOS La microbiota oral (MO) tiene un papel clave en la salud y la enfermedad. La infección por VIH provoca un deterioro del sistema inmune que podría favorecer el crecimiento y colonización de agentes patógenos en la cavidad oral. De hecho, esta disbiosis se ha asociado con manifestaciones orales como la candidiasis orofaríngea....

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory t...

Más allá del bacterioma - EL VIROMA: impacto en la salud y en la enfermedad, estudio y aplicaciones terapéuticas

Introduction: Oral microbiome is the second largest microbial community in humans after gut. Human immunodeficiency virus (HIV) infection triggers an impairment of the immune system which could favour the growth and the colonization of pathogens in the oral cavity, and this dysbiosis has been associated with oral manifestations that worsen the qual...

Human immunodeficiency virus (HIV) infection is now considered a chronic disease thanks to the extended use of antiretroviral treatment (ART). However, chronic immune activation, inflammation, and increased bacterial translocation (BT) could persist in these patients despite ART. These facts have been described as predictors for clinical events and...

Viruses are the most abundant components of the human gut microbiome with a significant impact on health and disease. The effects of human immunodeficiency virus (HIV) infection on gut virome has been scarcely analysed. Several studies suggested that integrase strand transfers inhibitors (INSTIs) are associated with a healthier gut. Thus, the objec...

Purpose: Viruses are the most abundant components of the human gut microbiome with a significant impact on health and disease. The impact of human immunodeficiency virus (HIV) infection on the gut virome has been scarcely analysed and several studies suggested that integrase strand transfers inhibitors (INSTIs) are associated with a healthier gut....

Introduction: Viruses are the most abundant components of the human gut microbiome with a significant impact on health and disease. The impact of human immunodeficiency virus (HIV) infection on the gut virome has been scarcely analysed and several studies suggested that integrase strand transfers inhibitors (INSTIs) are associated with a healthier...

Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p < 5x10−8) was crossed for varia...

INTRODUCCIÓN/OBJETIVOS Varios estudios han analizado los efectos de la infección por el virus de la inmunodeficiencia humana (VIH) y de los diferentes tratamientos antirretrovirales (TARs) sobre el componente bacteriano de la microbiota intestinal (MI) (1–6). Sin embargo, se han publicado muy pocos estudios en los que se haya analizado el impacto d...

INTRODUCCIÓN/OBJETIVOS La infección por el VIH induce cambios a nivel intestinal y en la composición de la microbiota intestinal (MI) que no son completamente restaurados con el tratamiento antirretroviral (TAR) y que son acompañados de un estado inflamatorio crónico asociado a comorbilidades no SIDA. No existen muchos estudios que investiguen el p...

Characterization of gut phages in HIV-infected patients.

[This corrects the article DOI: 10.3389/fendo.2021.688071.].

Coronavirus disease 19 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to scale and threaten human health and public safety. It is essential to identify those risk factors that lead to a poor prognosis of the disease. A predisposing host genetic background could be one of these factors that...

Background To better understand the biology of COVID-19, we have explored the behavior of calcitonin gene-related peptide (CGRP), an angiogenic, vasodilating, and immune modulating peptide, in SARS-CoV-2 positive patients. Methods Levels of CGRP in the serum of 57 COVID-19 patients (24 asymptomatic, 23 hospitalized in the general ward, and 10 admi...

Ante la pandemia actual de la infección por el SARS-CoV-2 es fundamental identificar a las personas que presentan mayor probabilidad de desarrollar formas severas de la enfermedad COVID-19. El sistema Renina-Angiotensina podría ser una de las vías implicadas en la patogénesis de la enfermedad, ya que la entrada del virus a las células depende de la...

Diversity in berry size and shape has been selected during grapevine domestication. While spherical shapes are more frequent in wine grapes to increase the proportion of secondary metabolites accumulated in the berry skin, larger berries with striking forms are attractive for table grape consumers. To gain insight on the molecular mechanisms genera...