Pablo Sevilla

Escola Universitària Salesiana de Sarrià | EUSS · Mechanics

The synthesis of a terbium-based 2D metal–organic framework (MOF), of formula [Tb(MeCOO)(PhCOO)2] (1), a crystalline material formed by neutral nanosheets held together by Van der Waals interactions, is presented. The material can be easily exfoliated by sonication and deposited onto different substrates. Uniform distributions of Tb-2D MOF flakes o...

We report the microwave assisted synthesis of a bidimensional (2D) MOF of formula [Dy(MeCOO)(PhCOO)2]n (1) and its magnetically diluted analogue [La0.9Dy0.1(MeCOO)(PhCOO)2] (1 d). 1 is a 2D material with single‐ion‐magnet (SIM) behaviour and 1 d is a multifunctional, magnetic and luminescent 2D material. 1 can be exfoliated into stable nanosheets b...

Microwave assisted synthesis is applied to prepare a dysprosium 2D-MOF with simple carboxylato ligands, [Dy(MeCOO)(PhCOO)2]n (1). The Dy(3+) ions are arranged into nanosheets in a hexagonal pattern, stacked by van der Waals forces similar to those of graphene. The magnetically diluted MOF 1 d is a bifunctional 2D luminescent material with SIM prope...

The aim of this study was to evaluate the effect of biofunctionalization with two TGF-β1 inhibitor peptides, P17 and P144, on osseointegration of CP-Ti dental implants. A total of 36 implants (VEGA, Klockner®) with 3.5 × 8 mm internal connection were used in this study, divided in three groups: (1) control group (n = 12), (2) implants which surface...

Objectives: The aim of this research was to determine the osseointegration of two presentations of biphasic calcium phosphate (BCP) biomaterial-one untreated and another submitted to biofunctionalization with a TGF-β1 inhibitor peptide, P144, on dental alveolus. Materials and Methods: A synthetic bone graft was used, namely, (i) Maxresorb® (Botiss...

Osseointegration of implants is conversely related to the generation of a fibrous tissue capsule around the implant by the host environment. Although TGF-β1 plays many roles in regeneration processes, it is the cytokine to be mostly associated to the production of fibrotic tissue and thus, its inhibition has demonstrated to be beneficial to prevent...

Understanding protein and oligopeptide adsorption on biomaterial surfaces is important to develop new biomaterials with improved properties. The phenomenon of peptide adsorption is determined by many parameters such environmental pH, surface topographical features, surface polarity, peptide structure, and/or surface and peptide electric charges. We...

The aim of this study was to evaluate the in vivo effect of antibacterial modified dental implants in the first stages of peri-implantitis. Thirty dental implants were inserted in the mandibular premolar sites of 5 beagle dogs. Sites were randomly assigned to Ti (untreated implants, 10 units), Ti_Ag (silver electrodeposition treatment, 10 units), a...

Bacterial infection in dental implants along with osseointegration failure usually leads to loss of the device. Bioactive molecules with antibacterial properties can be attached to titanium surfaces with anchoring molecules such as silanes, preventing biofilm formation and improving osseointegration. Properties of silanes as molecular binders have...

TGF-β1 is the most related cytokine with the production of fibrotic tissue. It plays an important role on the production of collagen by fibroblasts and other types of cells. The inhibition of this cytokine reduces fibrosis in various types of tissue. Biofunctionalization of dental and orthopedic implants with biomolecules enables modification of th...

Objective: This study focuses on the fatigue behavior of titanium dental implants as-received, with a grit-blasted surface and with a new bioactive surface treatment (2Steps). Background: The 2Step process consists of (1) an initial grit-blasting process to produce a micro-rough surface, followed by (2) a combined thermo-chemical treatment that...

Objectives:Recent evidence proves that peri-implantitis is of major concern with increasing prevalence over long-term. There are not current treatments addressingthis new concern. Our aim was developing an antimicrobial coating against key pathogens, strong resistance to degradation, and long-sustained activity. We coated titanium with tethered ant...

Functionalization of implants with multiple bioactivities is desired to obtain surfaces with improved biological and clinical performance. Our objective was developing a simple and reliable method to obtain stable multifunctional coatings incorporating different oligopeptides. We co-immobilized on titanium surface oligopeptides of known cooperative...

Aim: The effective results shown in the porous systems of tantalum employed for the use of osseointegrates has been demonstrated by means of animal experimentation. However, there is a total lack of any research studies on the osseointegration of tantalum implants from retrieval of the same after a period of time whereby the material had been impl...

Objectives. To investigate the in vitro electrochemical corrosive behavior of archwires used in lingual orthodontics and the effects on the phase transition temperatures. Materials and Methods. Six different types of archwires of stainless steel, titanium-molybdenum, nickel-titanium and nickel-titanium-copper were used. Corrosion tests were perform...

En la actualidad, el campo de la implantología se encuentra en pleno crecimiento. En pocos años hansurgido numerosas empresas fabricantes de implantes dentales y la competencia es cada vez másfuerte. Por esta razón las empresas de implantes dentales apuestan por la innovación y tratan delanzar al mercado nuevos productos a fin de aumentar su cota d...

This study aims to improve the osseointegration of titanium implants through surface immobilization of peptides that induce a beneficial biological response. This was carried out biofunctionalizating titanium surfaces by silanization and subsequent covalent binding of a peptide with a sequence that promotes cell adhesion. Objective: The development...

Objective: To evaluate the in vitro osteoblastic response to titanium surfaces biofunctionalized with RGD-containing peptides by two different immobilization methods. Materials and Methods: Commercially pure titanium surfaces were silanized with two different silanes: 3-chloropropyltriethoxysilane (CPTES) and 3-aminopropyltriethoxysilane (APTES). S...

The titanium alloys used in orthopaedic and dental implants are corrosion-resistant and compatible with the human body due to the titanium oxid film which forms spontaneously on the implant surface. However, the utilization of more than one type of alloy or metal on the same patient and the fragility and the thin thickness of the oxid layer, can gi...

El presente estudio pretende mejorar el proceso de osteointegración del implante de titanio mediante la biofuncionalización de su superficie. Para ello se ha realizado una previa silanización de la superficie y una posterior unión covalente entre el silano y un péptido el cual posee la secuencia RGD. Se han estudiado diferentes aspectos como es la...

The objective of the article is to study surface topographic changes and nickel release in lingual orthodontic archwires in vitro. Stainless steel (SS), nickel-titanium (NiTi) and copper-nickel-titanium (CuNiTi) lingual orthodontic archwires were studied using atomic absorption spectrometry for nickel release after immersion in a saline solution. S...

Lately new biomedical grade yttria stabilized zirconia (YTZP) dental implants have appeared in the implantology market. This material has better aesthetical properties than conventional titanium used for implants but long term behaviour of these new implants is not yet well known. The aim of this paper is to quantify the mechanical response of YTZP...

The titanium alloys used in orthopaedic and dental implants are corrosion-resistant and compatible with the human body due to the titanium oxid film which forms spontaneously on the implant surface. However, the utilization of more than one type of alloy or metal on the same patient and the fragility and the thin thickness of the oxid layer, can gi...

The titanium alloys used in orthopaedic and dental implants are corrosion-resistant and compatible with the human body due to the titanium oxid film which forms spontaneously on the implant surface. However, the utilization of more than one type of alloy or metal on the same patient and the fragility and the thin thickness of the oxid layer, can gi...

316L Stainless steel is one of the most used metallic material in orthopedical prosthesis, osteosinthesis plates, and cardiovascular stents. One of the main problems this material presents is the nickel and chromium release, specially the Ni ion release that provokes allergy in a high number of patients. Recently, experimental applications in vitro...

The purpose of this study was to evaluate the long term effect of abrasivity of toothpastes normally used over the surface and mechanical properties of dental casting alloys. Three dental casting alloys (Ni-Cr, Co-Cr, c.p. Ti) and one ceramic were chosen. Four specimens of each material were immersed in artificial saliva, brushed without or with on...

The purpose of this study was to evaluate the long term effect of abrasivity of toothpastes normally used over the corrosion behavior and ion release of the different dental casting alloys. Three dental casting alloys (Ni-Cr, Co-Cr and commercially pure Ti) were studied. Four specimens of each material were immersed, brushed without paste or brushe...

Efficacy of osteointegration of tantalum porous systems has been demonstrated through animal experimentation. However, there is a lack of studies that evaluate osteointegration of implants retrieved after a period of implantation in humans. For this study, eight rod implants used for the treatment of avascular necrosis of the femoral head were retr...

Conventional superelastic orthodontic wires are arch-shaped, have the same mechanical properties all along their length and are used to correct the position of teeth. The disadvantage of these archwires is that there are different types of teeth in the mouth and different forces are therefore needed to rectify their position. The aim of this work w...

Porous NiTi materials were obtained in order to allow the ingrowth of living tissue, thus increasing the mechanical anchorage of implants. This promotes long-term fixation without the need for bone grafting. This study focuses mainly on the determination of mechanical properties: compression, bending and compressive fatigue. The foams obtained had...

This work examines NiTi foams that have been treated using a new oxidation treatment for obtaining Ni-free surfaces that could allow the ingrowth of living tissue, thereby increasing the mechanical anchorage of implants. A significant increase in the real surface area of these materials can decrease corrosion resistance and favour the release of Ni...

Yttria-stabilized tetragonal zirconia may undergo extensive transformation to the monoclinic phase under mechanical and/or hydrothermal stress, with degradation of mechanical and tribologic properties. We hypothesized progressive phase transformation of zirconia in service in vivo is directly related to the time of implantation and to patient-relat...

Metallic porous materials are designed to allow the ingrowth of living tissue inside the pores and to improve the mechanical anchorage of the implant. In the present work, tantalum and nickel–titanium porous materials have been characterized. The tantalum foams were produced by vapour chemical deposition (CVD/CVI) and the NiTi foams by self-propa...