Pablo Molina-Garcia

• PhD
• PostDoc Position at Hospital Universitario Virgen de las Nieves

Background Mobile health (mHealth) systems are a promising alternative for rehabilitation of hip fracture, addressing constrained healthcare resources. Half of older adults fails to recover their pre-fracture routines, which imposes a burden on caregivers. We aimed to test the effectiveness of the 3-month ActiveHip + mHealth intervention on physic...

Introduction Osteoporotic hip fracture is a major health problem. Falls, the primary cause, might lead to a persistent fear of falling (FoF) among older adults, affecting their daily activities and rehabilitation. While in-person interventions exist, limited research is available on the effects of tele-rehabilitation on the FoF after a hip fracture...

Background. Low back pain (LBP) is among the most common types of chronic pain and the leading cause of disability worldwide. The BACKFIT randomized controlled trial is a multidimensional intervention that aims to determine the effectiveness of a multidimensional program, based on supervised exercise and mindfulness, compared to a control group on...

Background Accumulation of amyloid-β (Aβ) plaques is one of the main features of Alzheimer’s disease (AD). Physical performance has been related to dementia risk and Aβ, and it has been hypothesized as one of the mechanisms leading to greater accumulation of Aβ. Yet, no evidence synthesis has been performed in humans. Objective To investigate the...

Background: One of the pathological hallmarks distinguishing Alzheimer's disease from other dementias is the accumulation of amyloid beta (Aβ). Higher physical activity is associated with decreased dementia risk, and one potential path could be through Aβ levels modulation. We aimed to explore the relationship between physical activity and Aβ in m...

Background Osteoporotic hip fracture causes a high level of dependency in older adults, as their functional status suddenly decreases greatly. In addition, the high level of pain and the fear of falling that they frequently experience maintain this decrease in functional status for a longer period. Digital health, the promotion of health through th...

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): - HEARTY-BRAIN - Effects of Exercise on Brain in Patients with Coronary Heart Disease: The Heart-Brain Connection. Andalusian Plan for Research Development and Innovation (PAIDI). University of Granada. Funding: 116.000 €. PI: F. Ortega...

Objectives: To compare the effect of a single bout of morning vs. evening exercise on cardiovascular risk factors in adults. Design: Systematic review and meta-analysis. Methods: A systematic search of studies was conducted using PubMed and Web of Science from inception to June 2022. Selected studies accomplished the following criteria: crosso...

Background: The COVID-19 pandemic might negatively impact the quality of life and functional autonomy of Spanish adults with intellectual disability, and meaningful activities could prevent this negative progression. Methods: This is a prospective cohort study in Spanish adults with intellectual disability during the COVID-19 pandemic. Quality o...

Existe escasa literatura sobre las asimetrías en el pádel, un deporte de naturaleza asimétrica. Para estudiar el desarrollo de asimetrías en este deporte se evaluó, con bioimpedancia, la masa magra de ambos miembros superiores de 96 jugadores de pádel jóvenes y de 76 esquiadores (grupo control) y se calculó el índice de simetría. Los jugadores de p...

Objective Half of older adults undergoing hip surgery do not recover their previous functional status. mHealth is a promising tool for rehabilitating older adults after hip surgery. This study aimed to test the feasibility of the ActiveHip+ mHealth system in older adults after hip surgery. Methods Sixty-nine older adults who had undergone hip surg...

Purpose: Hip fracture results in an older person's loss of independence. Limited healthcare resources make mobile Health (mHealth) an alternative. Engaging key stakeholders in health technology development is essential to overcome existing barriers. The aim of this study was to establish perspectives of older adults with hip fracture, family careg...

Objective: Colchicine, an approved treatment for gout, has been trialed in many diseases including osteoarthritis (OA) due to its anti-inflammatory effects. However, its efficacy and safety remain unclear in OA. This systematic review and meta-analysis evaluated the efficacy and safety of colchicine for the treatment of OA. Methods: PubMed, Web...

Importance: Pediatric overweight and obesity are highly prevalent across the world, with implications for poorer cognitive and brain health. Exercise might potentially attenuate these adverse consequences. Objectives: To investigate the effects of an exercise program on brain health indicators, including intelligence, executive function, academi...

[This corrects the article DOI: 10.3389/fped.2022.917152.].

Background Technological advances have recently made possible the estimation of maximal oxygen consumption (VO2max) by consumer wearables. However, the validity of such estimations has not been systematically summarized using meta-analytic methods and there are no standards guiding the validation protocols. Objective The aim was to (1) quantitativ...

Background The links of sedentary behavior and physical activity with health outcomes in children and adolescents is well known. However, the molecular mechanisms involved are poorly understood. We aimed to synthesize the current knowledge of the association of sedentary behavior and physical activity (acute and chronic effects) with gene expressio...

Aim: Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the relationships of resting leptin and adiponectin with bone parameters and whether high muscular fitness levels affect these relationships in children with overweight or obesity. Methods:...

Approximately 4–11% of children suffer from sleep-disordered breathing (SDB), and children with obesity are at increased risk. Both obesity and SDB have been separately associated with poorer brain health, yet whether SDB severity affects brain health in children with obesity remains unanswered. This study aimed to examine associations of SDB sever...

Objective: To analyze whether 13 weeks of Integrative Neuromuscular Training can benefit spatiotemporal and kinematic parameters of gait in children with overweight/obesity. Methods: This is a non-randomized controlled trial. Fifty children (10.77 ± 1.24 years, 31 girls) with overweight/obesity were allocated to an exercise group (EG) (n=25) tha...

the benefits of physical activity (PA) and sleep for health, accurate and objective population-based surveillance is important. Monitor-based surveillance has potential, but the main challenge is the need for replicable outcomes from different monitors. This study investigated the agreement of movement behavior outcomes assessed with four research-...

Objectives To investigate the effects of exercise on intelligence, executive functions, academic performance and brain outcomes in children with overweight/obesity. In secondary analyses, we explored potential mediators and moderators of the exercise effects. Methods A total of 109 children (8-11.9y) with overweight/obesity were randomized (intent...

Background Consumer wearables and smartphone devices commonly offer an estimate of energy expenditure (EE) to assist in the objective monitoring of physical activity to the general population. Alongside consumers, healthcare professionals and researchers are seeking to utilise these devices for the monitoring of training and improving human health....

Telerehabilitation interventions administered via a smartphone may provide new feasible and effective rehabilitation options at home for patients with hip fracture. However, to date, no such interventions have been shown to be effective in the recovery key health outcomes of these patients. The present multicentre randomized controlled trial (RCT)...

Introduction Telerehabilitation has emerged in the last decade as a promising alternative to conduct the rehabilitation process at home. However, there are no studies testing the effects of telerehabilitation interventions for patients with hip fracture on quality of life nor psychological factors, whereas the evidence on fitness level is scarce. T...

Musculoskeletal pain in childhood has increased alarmingly and preventive actions are needed to stop its progression to adulthood. This chapter reviews the scientific literature on the role of physical activity and fitness components in the prevention of musculoskeletal pain in childhood and adolescence. Furthermore, the chapter highlights potentia...

Background Further research is required to explore the associations between 24-h movement behaviours and health outcomes in the paediatric population. Therefore, this study aimed to examine the associations between novel data-driven 24-h activity metrics and adiposity among children and adolescents. Methods The sample included 382 children (8–13 y...

Background Alzheimer’s disease is the main cause of dementia in the world. Particularly, amyloid beta (Aβ) plaques are the primary hallmarks of this disease. Previous research has shown that higher levels of physical activity might be associated with lower levels of Aβ accumulation. However, a synthesis of evidence is needed to confirm or refute th...

BACKGROUND Hip fracture has a severe impact on patients’ quality of life, psychological factors and fitness level. Tele-rehabilitation has emerged in the last years as a promising alternative to conduct the rehabilitation process at home. However, there is no studies testing the effects of tele-rehabilitation interventions for patients with hip fra...

It is currently unknown the most effective potentiation protocol to increase maximum strength. Hence, we investigated the separated and combined effects of post-tetanic potentiation (PTP) induced by whole- body electrostimulation (WB-EMS) and post-activation potentiation (PAP) induced by voluntary maximum isometric contractions on maximum isometric...

This study aimed to examine the effect of a multidisciplinary tele-rehabilitation program on functional recovery of older adults with hip fracture compared with home-based in-person rehabilitation. In this single-blinded, non-randomized clinical trial, we included older with hip fracture. The tele-rehabilitation group received a 12-week tele-rehabi...

The search for determinants of adiposity gain in older women has become vitally important. This study aimed to (1) analyze the adiposity gain based on the participants’ age and (2) determine the prospective associations of baseline intrapersonal, built environment, physical activity, and sedentary behavior variables with the adiposity gain in older...

Objective: It has been suggested that overweight/obesity (OW/OB) impairs the normal development of body posture in children and adolescents; however, to date, no study has systematically reviewed or quantified the effect of OW/OB on the development of postural alterations in children and adolescents. The purpose of this study was to systematically...

Assessing vital signs such as heart rate (HR) by wearable devices in a lifestyle-related environment provides widespread opportunities for public health related research and applications. Commonly, consumer wearable devices assessing HR are based on photoplethysmography (PPG), where HR is determined by absorption and reflection of emitted light by...

Consumer wearable and smartphone devices provide an accessible means to objectively measure physical activity (PA) through step counts. With the increasing proliferation of this technology, consumers, practitioners and researchers are interested in leveraging these devices as a means to track and facilitate PA behavioural change. However, while the...

There is little literature on asymmetries in paddle-tennis, a sport of an asymmetrical nature. To study the development of asymmetries between upper limbs in this sport, the lean mass of both upper limbs of 96 young paddle players and 76 skiers (control group) was evaluated with bioimpedance and the symmetry index of lean mass was computed. Paddle-...

Colchicine, in the form of Colchicum autumnale , has been used to treat joint swelling for centuries. The anti-inflammatory action o colchicine and the higher prevalence of calcium pyrophosphate crystal deposition (CPPD) in osteoarthritis (OA) joints have led to th use of colchicine as a potential treatment for OA, however, the quality of the evide...

Whereas 3D optical motion capture (OMC) systems are considered the gold standard for kinematic assessment in sport science, they present some drawbacks that limit its use in the field. Inertial measurement units (IMUs) incorporating gyroscopes have been considered as a more practical alternative. Thus, the aim of the study was to evaluate the level...

The present study aims (i) to examine the association of physical fitness components (i.e., cardiorespiratory fitness, speed-agility, and muscular fitness) with brain current source density during working memory; and (ii) to examine whether fitness-related current density was associated to working memory performance and academic achievement. Eighty...

Osteoarthritis (OA) is a common chronic joint disease with limited pharmacological management options. Boswellia extracts (BE) or formulations containing BE are generally considered as safe and offers a modest efficacy for the treatment of OA. Although previous systematic reviews have assessed the efficacy of BE in OA, these reviews had excluded tr...

Recent studies investigated the association of cardiorespiratory fitness with white matter microstructure in children, yet little work has explored to what extent other components of physical fitness (i.e., muscular or motor fitness) are associated with white matter microstructure. Indeed, this association has not been previously explored in childr...

Knee osteoarthritis (OA) is the most common form of OA which affects knee joints and there is currently no disease-modifying treatment available for OA. Therefore, an ideal strategy to prevent the development of OA is to identify and intervene at the modifiable risk factors for the development and progression of OA. Early-life factors such as obesi...

Molina-Garcia, P, Mora-Gonzalez, J, Migueles, JH, Rodriguez-Ayllon, M, Esteban-Cornejo, I, Cadenas-Sanchez, C, Plaza-Florido, A, Gil-Cosano, JJ, Pelaez-Perez, MA, Garcia-Delgado, G, Vanrenterghem, J, and Ortega, FB. Effects of exercise on body posture, functional movement, and physical fitness in children with overweight/obesity. J Strength Cond Re...

The aim of this study was to examine the associations of sedentary behaviour, physical activity, cardiorespiratory fitness (CRF), and body composition parameters with risk of sleep-related breathing disorders (SRBD) in children with overweight/obesity. One-hundred and nine children (10.0 ± 1.1 years old, 45 girls) with overweight (n = 27) and obesi...

Background: Best-practice early interventions to increase physical activity (PA) in children with overweight and obesity should be both feasible and evidence based. Walking is a basic human movement pattern that is practical, cost-effective, and does not require complex movement skills. However, there is still a need to investigate how much walkin...

We investigated the associations of different sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8-11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain qu...

Whereas numerous studies have investigated the relationship of cardiorespiratory fitness with inhibition and neuroelectric activity, the role of other physical fitness components and physical activity (PA) intensities in this relationship remain unclear, especially in children with obesity. Therefore, the purpose of this study was to investigate th...

Background Childhood obesity is known to negatively impact on body posture with severe consequences to the musculoskeletal system. Physical performance could play a positive role in the body posture conformation of these children, but there is little evidence to date. Research Question Is physical performance (i.e., physical fitness and functional...

The aim of this study was to examine the associations of fitness and physical activity with academic achievement in children with overweight/obesity. A total of 106 (10.0 ± 1.1y, 61 boys) children participated. The fitness components were assessed by field and laboratory-based tests. Physical activity was measured via accelerometry. The academic ac...

Heart rate variability (HRV) is a non-invasive indicator of autonomic nervous system function. HRV recordings show artefacts due to technical and/or biological issues. The Kubios software is one of the most used software to process HRV recordings, offering different levels of threshold-based artefact correction (i.e., Kubios filters). The aim of th...

Background Low-intensity resistance training (LI-RT) combined with blood flow restriction (BFR) is an alternative to traditional moderate–high-intensity resistance training to increase strength and muscle mass. However, the evidence about the efficacy of this novel training method to increase strength and muscle mass in healthy and older adults wit...

Background Evidence suggests that participation in physical activity may support young people’s current and future mental health. Although previous reviews have examined the relationship between physical activity and a range of mental health outcomes in children and adolescents, due to the large increase in published studies there is a need for an...

Purpose: To investigate the effect of a 13-week exercise program, based on "movement quality" and "multigames" work, on plantar pressure during walking in children with overweight/obesity (OW/OB). Method: Seventy children (10.8 ± 1.2 years, 58.5% girls) with OW/OB, as defined by the World Obesity Federation, were assigned to either a 13-week exe...

Background Heart rate variability (HRV) is negatively associated with body mass index and adiposity in several populations. However, less information is available about this association in children with overweight and obesity, especially severe/morbid obesity, taking into consideration the dependence of HRV on heart rate (HR).Objectives(1) to exami...

Purpose: This study aimed to examine the associations of sedentary time, physical activity (PA) and step-related behaviors with neurotrophic growth factors. Methods: A total of 97 children with overweight/obesity age 8 to 11 yr participated in this study. Sedentary time, PA, and steps were measured by GT3X+ accelerometers in hip and nondominant...

BACKGROUND Best practice early interventions to increment physical activity in children with overweight/obesity should be both feasible and evidence-based. Walking is a basic human movement pattern that is practical, cost-effective and does not require complex movement skills. However, there is still a need to investigate how much walking is perfor...

The aim of the present study was to examine the associations of physical fitness, sedentary time and physical activity (PA) with working memory and neuroelectric activity in children with overweight/obesity. Seventy‐nine children with overweight/obesity (10.2 ± 1.1 years old) participated in this cross‐sectional study. We assessed physical fitness...

Cardiac autonomic function can be quantified through mean heart rate (HR) or heart rate variability (HRV). Numerous studies have supported the utility of different HRV parameters as indicators of cardiorespiratory fitness (CRF). However, HR has recently shown to be a stronger predictor of CRF than HRV in healthy young adults, yet these findings nee...

It is known that obesity is associated with biomechanical alterations during locomotor tasks, which is considered a potential risk factor for the development of musculoskeletal disorders (MSKD). However, the association of obesity with biomechanical alterations of walking in the early stages of life have not yet been systematically reviewed. Thus,...

Objective: To examine the associations of physical fitness and physical activity with executive function in children with overweight and obesity. Study design: A cross-sectional study involving 100 children with overweight and obesity (10.1 ± 1.1 years old; 58.0% boys). We assessed physical fitness components (ie, muscular strength, speed-agilit...

This study aimed to compare estimations of sedentary time (SED) and time spent in physical activity (PA) intensities in children with overweight/obesity across different age‐appropriate cut‐points based on different body‐worn attachment sites and acceleration metrics. A total of 104 overweight/obese children (10.1±1.1 years old, 43 girls) concurren...

Objective: to assess if there is an association between a protocol of evaluation of core stability and proprioception and the number of injuries suffered by soccers during a season, as well as to verify if each one of the three tests that conform the protocol is associated or has predictive power over a different type of injury, attending to the le...

Cortical thickness and surface area are thought to be genetically unrelated and shaped by independent neurobiological events suggesting that they should be considered separately in morphometric analyses. Although the developmental trajectories of cortical thickness and surface area may differ across brain regions and ages, there is no consensus reg...

This study aimed to investigate the independent and combined associations between several fatness indicators and fitness components with functional movement quality in overweight/obese children. A total of 56 children (33 girls, aged 8–12) classified as overweight/obese according to the World Obesity Federation standard cut points, participated in...

Objectives To examine the associations of physical fitness (i.e. cardiorespiratory fitness, muscular strength, and speed/agility) with psychological distress and psychological well-being in overweight/obese pre-adolescent children. Design 110 overweight/obese children (10.0 ± 1.1 years old, 61 boys) from the ActiveBrains project (http://profith.ug...

Overweight and obesity at childhood have been associated with biomechanical alterations during locomotor tasks and lower movement competency. Furthermore, suboptimal movement quality may hamper daily physical activity and function, and also may predispose to musculoskeletal diseases in overweight/obese children. Yet, little is known about the assoc...

OBJECTIVES: To examine the associations of physical fitness (i.e. cardiorespiratory fitness, muscular strength, and speed/agility) with psychological distress and psychological well-being in overweight/obese pre-adolescent children. DESIGN: 110 overweight/obese children (10.0±1.1years old, 61 boys) from the ActiveBrains project (http://profith.ugr...

Overweight and obesity at childhood has been associated with a higher prevalence of musculoskeletal pain. Likewise, a recent cohort study has showed that adolescents with multisite musculoskeletal pain have an increased risk of mental health disorders later in life. Yet, little is known about the association of musculoskeletal pain with current men...

El exceso de peso en niños provoca alteraciones en la biomecánica de la marcha, modificándose la funcionalidad de la pisada. El objetivo del estudio fue comparar los efectos de un programa de entrenamiento de 12 semanas orientado a mejorar la calidad del movimiento (patrones de movimiento adecuados), con respecto a otro de fuerza general, sobre el...

Comparar el efecto de un entrenamiento de 12 semanas de duración orientado a la mejora de la calidad de movimiento sobre la superficie de apoyo plantar dinámica, respecto a un entrenamiento de fuerza en niños con sobrepeso/obesidad.