Pablo G A Cirrone

Pablo G A Cirrone
INFN - Istituto Nazionale di Fisica Nucleare | INFN · Laboratori Nazionali del Sud LNS

PhD Nuclear Physics

About

431
Publications
68,691
Reads
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12,864
Citations
Introduction
-- Clinical hadrontherapy -- Absolute and relative dosimetry -- Monte Carlo simulations and modelling for hadrontherapy and medical physics -- Laser-accelerated ions beams for medical applications
Additional affiliations
January 2012 - December 2014
Institute of Physics ASCR
Position
  • Senior Researcher
January 2011 - April 2013
University of Catania
Position
  • Lecturer
Description
  • Physics for nurrsery
December 2005 - April 2019
INFN - Istituto Nazionale di Fisica Nucleare
Position
  • Researcher
Education
November 2001 - February 2004
University of Catania
Field of study
  • Nuclear and Medical Physics
January 1999 - July 2001
University of Florence
Field of study
  • medical Physics
November 1992 - April 1998
University of Catania
Field of study
  • Nuclear Physics

Publications

Publications (431)
Article
Full-text available
Objective In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, dep...
Article
A proof-of-principle experimental setup for the extraction of 6 GeV electrons from the DESY II Booster Synchrotron using the channeling effect in a bent crystal is elaborated. Various aspects of the experimental setup were investigated in detail, such as the particle beam dynamics during the extraction process, the manufacturing and characterizatio...
Article
Hydrogenated Amorphous Silicon (a-Si:H) is a well known material for its intrinsic radiation hardness and is primarily utilized in solar cells as well as for particle detection and dosimetry. Planar p-i-n diode detectors are fabricated entirely by means of intrinsic and doped PECVD of a mixture of Silane (SiH 4 ) and molecular hydrogen. In order to...
Preprint
Full-text available
A system of permanent magnet quadrupoles (PMQs) is going to be realized by INFNLNS to be used as a collection system for the injection of laser driven ion beams up to 60 AMeV in an energy selector based on four resistive dipoles. This system is the first element of the ELIMED (ELI-Beamlines MEDical and Multidisciplinary applications) beam transport...
Article
The acceleration processes based on the coherent interaction of high-power lasers with matter are, by now, one of the most interesting topics in the field of particle acceleration, becoming day by day a real alternative to conventional approaches. Some of the extraordinary peculiarities of laser–matter interaction, such as the production of multi-s...
Article
Full-text available
ELIMED has been developed and installed at ELI beamlines as a part of the ELIMAIA beamline to transport, monitor, and use laser-driven ion beams suitable for multidisciplinary applications, including biomedical ones. This paper aims to investigate the feasibility to perform radiobiological experiments using laser-accelerated proton beams with inter...
Preprint
Full-text available
We propose to apply crystal-based beam extraction technique to extract multi-GeV electron beams in a parasitic mode from electron synchrotrons worldwide. This technique will be able to supply fixed-target experiments by intense high-quality monoenergetic electron beams. We design the experimental setup to extract 6 GeV electron beam from the DESY I...
Poster
Full-text available
No ion recombination for ionization chamber (future investigations-before the end of 2012) • For proton beam : recombination for ionization chamber = 0.4% (Palmans et al. (2006)) • No heat transfer between different components of calorimeter (future investigations) • Value for the specific heat capacity of the core : 730 J/kg K (overestimation) (fu...
Article
Hydrogenated amorphous silicon (a-Si:H) can be produced by plasma-enhanced chemical vapor deposition (PECVD) of SiH4 (silane) mixed with hydrogen. The resulting material shows outstanding radiation hardness properties and can be deposited on a wide variety of substrates. Devices employing a-Si:H technologies have been used to detect many different...
Preprint
Full-text available
Hydrogenated Amorphous Silicon (a-Si:H) is a material well known for its intrinsic radiation hardness and is primarily utilized in solar cells as well as for particle detection and dosimetry. Planar p-i-n diode detectors are fabricated entirely by means of intrinsic and doped PECVD of a mixture of Silane (SiH4) and molecular Hydrogen. In order to d...
Preprint
Full-text available
Hydrogenated Amorphous Silicon (a-Si:H) is a material well known for its intrinsic radiation hardness and is primarily utilized in solar cells as well as for particle detection and dosimetry. Planar p-i-n diode detectors are fabricated entirely by means of intrinsic and doped PECVD of a mixture of Silane (SiH4) and molecular Hydrogen. In order to d...
Article
Full-text available
Clinical routine in proton therapy currently neglects the radiobiological impact of nuclear target fragments generated by proton beams. This is partially due to the difficult characterization of the irradiation field. The detection of low energetic fragments, secondary protons and fragments, is in fact challenging due to their very short range. How...
Article
Full-text available
CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) was the first Italian protontherapy facility dedicated to the treatment of ocular neoplastic pathologies. It is in operation at the LNS Laboratories of the Italian Institute for Nuclear Physics (INFN-LNS) and to date, 500 patients have been successfully treated. Even though proton the...
Article
The aim of the NEPTUNE (Nuclear process-driven Enhancement of Proton Therapy UNravEled) project is to investigate in detail both the physical and radiobiological phenomena that could justify an increase of the proton-induced cytogenetic effects in cells irradiated in presence of an agent containing natural boron. In this work, a double-stage silico...
Article
Full-text available
Experimental microdosimetry measures the energy deposited in a microscopic sensitive volume (SV) by single ionizing particles traversing the SV or passing by. The fundamental advantage of experimental microdosimetry over the computational approach is that the first allows to determine distributions of energy deposition when information on the energ...
Article
Full-text available
This paper describes a new real-time, in vivo, noninvasive, biasless detector system acting as a beam monitoring and relative dose measurement system. The detector is based on the idea that when a beam current is injected into the body of a patient undergoing a charged particle therapy, the current itself can be collected using a conductive electro...
Preprint
Full-text available
Hydrogenated amorphous silicon (a-Si:H) can be produced by plasma-enhanced chemical vapour deposition (PECVD) of SiH4 (Silane) mixed with Hydrogen. The resulting material shows outstanding radiation resistance properties and can be deposited on a wide variety of different substrates. These devices have been used to detect many different kinds of ra...
Article
Purpose The complex relationship between linear energy transfer (LET) and cellular response to radiation is not yet fully elucidated. To better characterize DNA damage after irradiations with therapeutic protons, we monitored formation and disappearance of DNA double strand breaks (DNA DSB) as a function of LET and time. Comparisons with convention...
Preprint
Full-text available
Background There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect observed in FLASH radiotherapy, where particles are delivered at 40-1000 Gy/s. Furthermore, the development of laser-driven accelera...
Preprint
Full-text available
In this paper we discuss the possibility to generate and accelerate proton nanobeams in fully dielectric laser-driven accelerators (p-DLAs). High gradient on-chip optical-power dielectric laser accelerators (DLAs) could represent one of the most promising way towards future miniaturized particle accelerator. A primary challenge for DLAs are small b...
Article
Full-text available
Protontherapy is a rapidly expanding radiotherapy modality where accelerated proton beams are used to precisely deliver the dose to the tumor target but is generally considered ineffective against radioresistant tumors. Proton-Boron Capture Therapy (PBCT) is a novel approach aimed at enhancing proton biological effectiveness. PBCT exploits a nuclea...
Article
Full-text available
In Glioblastoma Multiforme (GBM), hypoxia is associated with radioresistance and poor prognosis. Since standard GBM treatments are not always effective, new strategies are needed to overcome resistance to therapeutic treatments, including radiotherapy (RT). Our study aims to shed light on the biomarker network involved in a hypoxic (0.2% oxygen) GB...
Article
Full-text available
Conjunctival melanoma is a rare neoplasia, whose therapeutic management is generally of ophthalmological relevance, through radical surgical resection. The high incidence of local relapses after surgery, has made it necessary to combine various types of adjuvant treatments, which in some cases take on the role of radical treatments. Among these non...
Poster
Full-text available
The use of beams of charged particles in therapy, such as protons, is motivated by the presence of the Bragg Peak which gives an inverted depth-dose profile. Consequently, to reach the prescribed dose, it is possible to combine different energy beams able to selectively reach the area corresponding to the tumor target producing what is called Sprea...
Article
Aim Conjunctival squamous cell carcinoma (SCC) is a rare tumour of the ocular region and microscopic radical surgical is difficult. There are no single guidelines for therapeutic management and the role of radiation therapy is not clearly defined although conventionally photon or electron beams are used. Proton beam radiotherapy (PBRT) is a new opt...
Article
Full-text available
The main effort of the laser-driven ion acceleration community is aimed at improving particle beam features (in terms of final maximum energy, particle charge, and beam divergence) and to demonstrate reliable approaches for use for multidisciplinary applications. An ion acceleration target area based on unique laser capabilities is available at ELI...
Article
Full-text available
Differences in biological response of breast and lung cancer cells to 62 MeV/u therapeutic protons and carbon ions are investigated on MCF-7 and HTB177 cells. Hydroxyl radical scavenger, dimethyl sulfoxide (DMSO) is applied to reduce indirect effects of irradiation, while serum deprivation provided uniformity of cell population. Survival, immunocyt...
Conference Paper
A microdosimetric characterization of the 62 MeV proton beam line of CATANA has been performed all along the Spread Out Bragg Peak with three different detectors. Two silicon detectors and a Tissue Equivalent Proportional Counter measured at approximately the same depths of the SOBP. The TEPC is a new miniaturized gas counter developed at the Legna...
Article
Purpose: proton beams are widely used worldwide to treat localized tumours, the lower entrance dose and no exit dose, thus sparing surrounding normal tissues, being the main advantage of this treatment modality compared to conventional photon techniques. Clinical proton beam therapy treatment planning is based on the use of a general relative biol...
Article
Purpose: To investigate for the first time the performance of a synthetic single crystal diamond detector for the microdosimetric characterization of clinical 62 MeV ocular therapy proton beams. Methods: A novel diamond microdosimeter with a well-defined sensitive volume was fabricated and tested with a monoenergetic and spread-out Bragg peak (S...
Article
Purpose: Analysis of elimination of four human radioresistant malignant cell lines to mono-energetic and non mono-energetic incoming carbon ion beams, characterized by different linear energy transfer (LET) qualities is performed. Comparisons with protons from the middle of the therapeutic spread out Bragg peak (SOBP) and reference γ-rays are also...
Article
Full-text available
Specific breast cancer (BC) subtypes are associated with bad prognoses due to the absence of successful treatment plans. The triple-negative breast cancer (TNBC) subtype, with estrogen (ER), progesterone (PR) and human epidermal growth factor-2 (HER2) negative receptor status, is a clinical challenge for oncologists, because of its aggressiveness a...
Article
Full-text available
We present preliminary results on generation of energetic α-particles driven by lasers. The experiment was performed at the Institute of Laser Engineering in Osaka using the short-pulse, high-intensity, high-energy, PW-class laser. The laser pulse was focused onto a thin plastic foil (pitcher) to generate a proton beam by the well-known TNSA mechan...
Article
We exploited the power of the Geant4 Monte Carlo toolkit to study and validate new approaches for the averaged linear energy transfer (LET) calculation in 62 MeV clinical proton beams. The definitions of the averaged LET dose and LET track were extended, so as to fully account for the contribution of secondary particles generated by target fragment...
Article
Full-text available
Glioblastoma multiforme (GBM) is a malignant primary brain tumor with very poor prognosis, high recurrence rate, and failure of chemo-radiotherapy, mainly due to a small fraction of cells with stem-like properties (GSCs). To study the mechanisms of GSCs resistance to radiation, two GSC lines, named line #1 and line #83, with different metabolic pat...
Article
Significant challenges in the detection of laser-accelerated ions result from the high flux (10¹⁰-10¹² ions/pulse) and the short bunch duration which are intrinsic to laser-driven sources. The development of diagnostic techniques able to operate in real-time and on a high-rep basis is a key step towards multidisciplinary applications of such non-co...
Article
A sealed miniaturized Tissue Equivalent Proportional Counter (mini-TEPC) able to work in gas-steady modality was developed at the Legnaro National Laboratories of the Italian National Institute of Nuclear Physics (LNL – INFN, Legnaro, Italy). The aim of the present work is to compare the response of this mini-TEPC with that of a silicon microdosime...
Article
A sealed mini-TEPC able to work in gas-steady modality, a monolithic silicon device composed by a matrix of micrometric cylindrical diodes and a residual energy measurement stage and the silicon MicroPlus Bridge detector were used to perform microdosimetric measurements at the 62 MeV proton clinical SOBP of CATANA at the Southern National Laborator...
Article
Full-text available
In the last decades Silicon Carbide (SiC) received special attentions, in particular as semiconductor material, because is considered as alternative to Silicon for the future high-power, low consumption, radiation-hard microelectronics devices. This ambitious goal is particularly interesting also for the physics of the detectors. In this work are d...
Article
Full-text available
The purpose of this paper is to characterize the skin deterministic damage due to the effect of proton beam irradiation in mice occurred during a long-term observational experiment. This study was initially defined to evaluate the insurgence of myelopathy irradiating spinal cords with the distal part of a Spread-out Bragg peak (SOBP). To the best o...
Article
Purpose A reliable model to simulate nuclear interactions is fundamental for Ion-therapy. We already showed how BLOB (“Boltzmann-Langevin One Body”), a model developed to simulate heavy ion interactions up to few hundreds of MeV/u, could simulate also ¹²C reactions in the same energy domain. However, its computation time is too long for any medical...
Article
Background: Geant4 is a Monte Carlo code extensively used in medical physics for a wide range of applications, such as dosimetry, micro- and nanodosimetry, imaging, radiation protection, and nuclear medicine. Geant4 is continuously evolving, so it is crucial to have a system that benchmarks this Monte Carlo code for medical physics against referen...
Preprint
Purpose: A reliable model to simulate nuclear interactions is fundamental for Ion-therapy. We already showed how BLOB ("Boltzmann-Langevin One Body"), a model developed to simulate heavy ion interactions up to few hundreds of MeV/u, could simulate also $^{12}$C reactions in the same energy domain. However, its computation time is too long for any m...
Article
Purpose: The main purpose of this work is the inter-comparison between different devices devoted to the transversal dose profile recostruction for daily QA tests in proton therapy. Methods: The results obtained with the EBT3 radiochromic films, used as a reference, and other common quality control devices, have been compared with those obtained...
Article
The nuclear reaction known as proton-boron fusion has been triggered by a subnanosecond laser system focused onto a thick boron nitride target at modest laser intensity (∼10 16 W/cm 2), resulting in a record yield of generated α particles. The estimated value of α particles emitted per laser pulse is around 10 11 , thus orders of magnitude higher t...
Chapter
Full-text available
An integrated methodology, that combines Hierarchical Task Analysis (HTA), Cognitive Task Analysis (CTA) and a modified Human Error Assessment and Reduction Technique (HEART), is proposed to identify safety-relevant human actions in innovative and advanced facilities. It is suggested to use in HEART the concept of linguistic expressions for proport...
Conference Paper
The ELIMAIA beamline, recently installed at ELI-Beamlines, aims at offering short ion bunches accelerated by high repetition-rate, PW-class lasers to users from multidisciplinary fields by using innovative and compact ion beam transport and dosimetry approaches.
Article
Purpose: To perform the first dosimetric intercomparison for proton beams in Italy using ionization chambers, according to the IAEA TRS-398 code of practice. Methods: Measurement sites included: National Center for Oncological Hadron Therapy (CNAO, Pavia), Center for Proton Therapy (CTP, Trento) and Center for Hadron Therapy and for advanced Nuc...
Article
Full-text available
Purpose: Monte Carlo (MC) simulations are widely used for medical applications and nuclear reaction models are fundamental for the simulation of the particle interactions with patients in ion therapy. Therefore, it is of utmost importance to have reliable models in MC simulations for such interactions. Geant4 is one of the most used toolkits for M...
Article
Full-text available
Glioblastoma Multiforme (GBM) is the most common of malignant gliomas in adults with an exiguous life expectancy. Standard treatments are not curative and the resistance to both chemotherapy and conventional radiotherapy (RT) plans is the main cause of GBM care failures. Proton therapy (PT) shows a ballistic precision and a higher dose conformity t...
Chapter
Full-text available
Monte Carlo simulationELI-Beamlines nowadays one of the powerful approach for the simulation of very complex environments like those typical of medical physics where, in general, an accurate simulation of the involved radiation beams and of the patients are required to fully reproduce a clinical case. It since from 1963, when Berger introduced the...
Article
The Time-of-Flight (TOF) technique coupled with semiconductorlike detectors, as silicon carbide and diamond, is one of the most promising diagnostic methods for high-energy, high repetition rate, laser-accelerated ions allowing a full on-line beam spectral characterization. A new analysis method for reconstructing the energy spectrum of high-energy...
Article
In this work we present the response of a new large volume 4H Silicon Carbide (SiC) detector to 14 MeV neutrons. The device has an active thickness of 100μm (obtained by epitaxial growing) and an active area of 25 mm². Tests were conducted at the ENEA-Frascati Neutron Generator facility by using 14.1 MeV neutrons. The SiC detector performance was c...
Article
A new practical method to determine the ion recombination correction factor ( k<sub>s</sub> ) for plane-parallel and Farmer-type cylindrical chambers in particle beams is investigated. Experimental data were acquired in passively scattered and scanned particle beams and compared with theoretical models developed by Boag and/or Jaffé. The new metho...