Pablo Chico-Sánchez

• MD. MPH. MSc. PhD
• Medical Doctor at Alicante Institute for Health and Biomedical Research (ISABIAL)

Resumen Objetivo Conocer la efectividad de la vacuna de la gripe de la temporada 2018/2019 para la prevención de casos graves de gripe en un hospital terciario. Método Estudio de casos y controles. Se incluyeron todos los pacientes hospitalizados con gripe confirmada por laboratorio durante la temporada 2018/2019. Los que cumplieron criterios de...

Objetivo. Evaluar la efectividad de un programa de prevención y control de infecciones (PCI) por COVID-19 en los tra- bajadores sanitarios (TS) del servicio de urgencias de un hospital terciario. Método. Se recogió el número de casos confirmados de COVID-19 en TS del 2 de marzo al 12 de abril de 2020. Los TS fueron evaluados si presentaban síntomas...

Introduction This study examines the frequency, associated factors, and characteristics of healthcare personnel coronavirus disease 2019 (COVID-19) cases in a healthcare department that comprises a tertiary hospital and its associated 12 primary healthcare centers. Methods This study included healthcare personnel that showed symptoms or were in co...

Objective: Estimate IgG antibody prevalence against SARS-CoV-2 in Healthcare Personnel (HCP) of a Healthcare Department (HD). Method: Prevalence Study. The presence of IgG antibodies against SARS-CoV-2 was determined in HCP of the HD. Enzyme Linked Immunosorbent Assays (ELISA) tests were used. Field work took place from April 24, 2020 to May 8, 20...

Introduction: Despite the importance of addressing different stages of cancer, there is a lack of data on how these stages relate to coping strategies. This study aims to analyze coping strategies among adolescents with cancer by comparing two distinct time points, the treatment phase and the post-treatment phase, with a particular focus on age and...

Objetives: Patients with digitalis intoxication (DI) and hyperkalaemia are frequently encountered in the emergency department (ED). This alteration may require intravenous (iv) calcium, but its administration has been considered to increase cardiotoxicity and mortality in patients with DI. We studied the effect of iv calcium on mortality and 30-da...

Objective: There is early evidence about Valproic acid (VPA) antiviral effect. Our aim was to investigate the incidence and severity of SARS-CoV-2 infection in VPA users as compared with the general population. Material and methods: A case-control study nested within a cohort, carried out between March 1 and December 17, 2020. Retrospectively, w...

Hand hygiene (HH) is the paramount measure used to prevent healthcare-associated infections. A repeated cross-sectional study was undertaken with direct observation of the degree of compliance on HH of healthcare personnel during the SARS-CoV-2 pandemic. Between, 2018–2019, 9,083 HH opportunities were considered, and 5,821 in 2020–2022. Chi squared...

Influenza is a health problem and vaccination is the most effective measure to prevent it. The objective of this study was to evaluate the impact of the COVID-19 pandemic on vaccination coverage (VC) against influenza in healthcare workers (HCWs). A cross-sectional study was conducted at the Dr. Balmis University General Hospital in the province of...

Objectives: To study differences in the emergency department treatment of acute poisoning according to biological sex of patients and to assess adherence to care quality indicators. Material and methods: Retrospective observational study including all cases of acute poisoning diagnosed in patients over the age of 14 years treated in a tertiary c...

Healthcare-associated infections (HAIs) present a global public health challenge, contributing to high morbidity and mortality and substantial economic burdens. Ventilator-associated pneumonia (VAP) ranks as the second most prevalent HAI in intensive care units (ICUs), emphasizing the need for economic analyses in this context. This retrospective c...

Introduction: The objective of this report is to describe the clinical pathway for early treatment of patients with acute SARS-CoV-2 infection and to evaluate the first results of its implementation. Methods: This is a descriptive and retrospective study of the implementation of a clinical pathway of treatment in outpatients (January 1 to June 3...

Introducción: El objetivo del manuscrito es describir la vía clínica de tratamiento precoz de pacientes con infección aguda por SARS-CoV-2 y evaluar los primeros resultados de su implementación Métodos: Estudio descriptivo y retrospectivo de la implementación de una vía clínica de tratamiento en pacientes no-hospitalizados, (1 de enero al 30 de jun...

The duration of protection of vaccines against SARS-CoV-2 infection has been evaluated in previous studies, but uncertainty remains about the persistence of effectiveness over time and the ideal timing for booster doses. Therefore, the aim of this study was to evaluate BNT162b2 vaccine effectiveness against SARS-CoV-2 infection in health care worke...

Background Carbohydrate antigen 125 (CA125) is an indicator of inflammation, immune response, and impaired cardiac function. The aim was to investigate whether CA125 behaves as a biomarker of severity and poor clinical outcomes in hospitalized patients with coronavirus disease 2019 (COVID-19). Methods Serum CA125 [Elecsys CA125 II assay-(Roche Dia...

The objective was to understand the effectiveness of the BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2 in health professionals(HPs) in the Valencian Autonomous Community(Spain) who had completed a full vaccination regimen, both in terms of preventing infections and avoiding hospitalisations, according to the time elapsed since the vaccine admi...

Background Pseudomonas aeruginosa (PA) is the third leading aetiological agent in healthcare-associated infections (HAIs) and the one most frequently found in patients with pneumonia associated with mechanical ventilation. In intensive care units (ICU), its appearance is associated with higher mortality, an increase in the days spent on ventilation...

Objective To investigate the impact of COVID19 pandemic on the incidence of health-care associated Clostridioides difficile infection (HA-CDI). Methods Retrospective study conducted in the Hospital Universitario de Valme (HUV) and the Hospital General Universitario de Alicante (HGUA) in Spain between January 2019 and February 2021. The study perio...

Background and aims: Even after two years of pandemic, there are still uncertainties on how to proceed when we schedule endoscopic procedures. During the COVID-19 pandemic, some scientific societies recommended universal preprocedural testing for all patients. However, other societies recommended against and considered enough to maintain strict in...

Objectives To describe breakthrough COVID-19 in patients who needed hospitalization and the factors associated with poor outcomes. Methods A retrospective study on complete (diagnosed two weeks after the second dose of the Pfizer/Moderna/AstraZeneca or first dose of the Janssen vaccine was administered) or partial vaccine scheme (CV or PV) patient...

Resumen Objetivo: Existe evidencia preliminar sobre el efecto antiviral del ácido valproico (VPA). Nuestro objetivo fue investigar la incidencia y la gravedad de la infección por SARS-CoV-2 en usuarios de VPA en comparación con la población general. Material y métodos: Estudio de casos – controles anidado en una cohorte, realizado entre el 1 de mar...

Objective: To investigate the impact of COVID19 pandemic on the incidence of health-care associated Clostridioides difficile infection (HA-CDI). Methods: Retrospective study conducted in the Hospital Universitario de Valme (HUV) and the Hospital General Universitario de Alicante (HGUA) in Spain between January 2019 and February 2021. The study peri...

Among healthcare-associated infections, surgical site infections (SSIs) are the most frequent in Spain. The aim of this work was to estimate the costs of SSIs in patients who underwent a cholecystectomy at the Hospital General Universitario de Alicante (Spain) between 2012–2017. This was a prospective observational cohort study. The Active Epidemio...

Background: Hand Hygiene (HH) is the most important measure to prevent healthcare-associated infections. The aim of this study was to determine the impact of the COVID-19 pandemic on the degree of compliance (DC) of HH in an Emergency Department (ED). Methods: Cross-sectional study. DC of HH in the ED was calculated from 2005 to 2021. We studied as...

Objective: Hand Hygiene (HH) is the most important measure to prevent healthcare-associated infections. The aim of this study was to determine the impact of the COVID-19 pandemic on the degree of compliance (DC) of HH in an Emergency Department (ED). Methods: Cross-sectional study. DC of HH in the ED was calculated from 2005 to 2021. We studied...

RESUMEN Objetivo: Conocer la efectividad de la vacuna BNT162b2 en personal sanitario de un departamento de salud. Método: Estudio de casos y controles con prueba negativa. Se incluyó personal sanitario con sospecha de COVID-19 y personal sanitario que fue contacto estrecho de casos de COVID-19 entre el 25 de enero y el 6 de junio de 2021. Se les re...

Objective: To assess the validity of SARS-CoV-2 Antigen (Ag) detection for the diagnosis of SARS-CoV-2 infection in mildly infected or asymptomatic patients. Methods: Observational study to evaluate diagnostic tests. Non-hospitalized patients with indication for diagnostic testing for SARS-CoV-2 infection were included. The diagnostic test to be...

Background The impact of COVID-19 triggered an unparalleled effort towards the development of a vaccine given that vaccination is currently the most important strategy available for controlling the pandemic. Achieving high levels of vaccination coverage is key to this approach, and requires knowledge of user satisfaction levels. Thus, the objective...

Exploring differences in clinical outcomes based on race and origin among patients hospitalized for COVID-19 is a controversial issue. The ALC COVID-19 Registry includes all confirmed COVID-19 patients admitted to hospital from 3 March 2020 to 17 December 2020. The data were obtained from electronic health records in order to evaluate the differenc...

This observational study included patients who underwent preoperative COVID-19 screening in order to preserve the safety of the patient. Of 8740 surgical procedures, in 2292 RT-PCR for SARS-CoV-2 was performed, with 0.0022% incidence of positive PCRs. No health-care-associated infectionS were detected. There was no difference in overall-mortality a...

Objective Estimate IgG antibody prevalence against SARS-CoV-2 in healthcare personnel (HCP) of a healthcare department (HD). Method Prevalence study. The presence of IgG antibodies against SARS-CoV-2 was determined in HCP of the HD. Enzyme linked immunosorbent assays (ELISA) tests were used. Field work took place from April 24, 2020 to May 8, 2020...

Objective: A first protective dose of vaccine may allow delaying the second dose in a context of low supply. The objective is to assess the effectiveness of a single dose of vaccine against SARS-CoV-2 (BNT162b2) after twelve days of its administration in healthcare personnel (HCP) of a Health Department. Methods: A case-control study was made. H...

Background: Although recommendations to prevent COVID-19 healthcare-associated infections (HAIs) have been proposed, data on their effectivity are currently limited. Objective: The aim was to evaluate the effectivity of a program of control and prevention of COVID-19 in an academic general hospital in Spain. Methods: We captured the number of...

Los procedimientos invasivos en pacientes oncológicos son dolorosos y producen elevada ansiedad, principalmente en niños y adolescentes. Actualmente se dispone de tecnología, como la realidad virtual (RV), para paliar estos efectos negativos. Hay evidencia de la utilidad de estos métodos en pacientes adultos, siendo escasas las experiencias en pobl...

Este trabajo es un comentario del artículo: Seo HJ, Sohng KY, Chang SO, Chaung SK, Wone JS, Choi MJ. Interventions to improve hand hygiene compliance in emergency departments: a systematic review. Abstract This text is a commentary on the article: Seo HJ, Sohng KY, Chang SO, Chaung SK, Wone JS, Choi MJ. Interventions to improve hand hygiene complia...

Background: Pseudomonas aeruginosa , is the third etiologic agent of healthcare associated infections, and the most frequent pathogen in ventilator-associated pneumonia (VAP). In critical care units is associated with high mortality, long hospital stay, and high healthcare-associated costs. We evaluated the effectiveness of filter placement in the...

Background: Annual flu vaccination is the most effective way to prevent the disease and its complications. Vaccine effectiveness (EV) varies from season to season, requiring annual re-evaluation. The objective of this study was to estimate the preliminary effectiveness of the influenza vaccine until epidemiological week 4 of the 2019–2020 season, i...

Background: Hand hygiene (HH) is the most important measure for preventing healthcare-associated infections. The objective is to gain insight into the evolution of the degree of compliance with recommendations (DCR) on HH and its associated factors in the surgical areas of a tertiary-care hospital. Methods: This observational, cross-sectional study...

Introduction: Influenza is a major public health challenge worldwide assuming a special risk within health facilities to have a population of susceptible patients who require more care, the flu is more lethal in this area.The main strategy for the prevention and control of influenza during the last 60 years has been vaccination; It is important to...

Effectiveness of annual flu vaccination until week four of season 2018/2019 Background: Annual flu vaccination is the most effective measure to prevent the disease and its complications. Vaccine effectiveness (EV) varies from season to season, requiring annual re-evaluation. The objective of this work was to estimate the preliminary effectiveness...

Objective: Annual flu vaccination is the most effective measure to prevent the disease and its complications. Vaccine effectiveness (EV) varies from season to season, requiring annual re-evaluation. The objective of this work was to estimate the preliminary effectiveness of the influenza vaccine until epidemiological week 4 of the 2018/2019 season...

Background Ocular B-mode ultrasonography (US) is a widely used technique for evaluation of the eye. The aim this study was to describe a new procedure for conducting ocular B- mode ultrasonography and evaluate pain related to both this procedure and the standard method. Methods and findings Forty-seven subjects (94 eyes) were enrolled in the presen...

La obtención de un proyecto interdepartamental subvencionado por el Ministerio de Educación y Ciencia español ha permitido crear materiales didácticos específicos de Protección Radiológica que se han publicado en varios manuales y cuadernos de actividades prácticas. Estas publicaciones han constituido la base del primer curso continuado sobre Prote...