Pablo Avanzas

Pablo Avanzas
Hospital Universitario Central de Asturias | HUCA · Cardiology

MD, PhD, FESC

About

470
Publications
30,874
Reads
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4,358
Citations
Introduction
Pablo Avanzas currently works at the Cardiology, Hospital Universitario Central de Asturias. Pablo does research in Cardiology. He is Associate Professor of Medicine at Oviedo University
Additional affiliations
January 2010 - present
Hospital Universitario Central de Asturias
Position
  • TAVI: Conduction abnormalities
January 2009 - December 2010
January 2008 - present
Hospital Universitario de Canarias
Position
  • Biomarkers and left ventricular remodeling
Education
March 2014 - April 2015
ESADE, Universitat Ramon Llull, Barcelona, Spain
Field of study
  • Executive Master en Dirección de Organizaciones Sanitarias
April 2013 - June 2013
IESE Business School
Field of study
  • PROGRAMA DE ALTA DIRECCIÓN EN INSTITUCIONES SANITARIAS
September 2000 - June 2002
Autonomous University of Barcelona
Field of study
  • Statistics

Publications

Publications (470)
Article
To evaluate short‐term changes in tricuspid regurgitation (TR) after transcatheter edge‐to‐edge repair (M‐TEER) in secondary mitral regurgitation (SMR), their predictors and impact on mortality. This is a retrospective analysis of SMR patients undergoing successful M‐TEER (post‐procedural MR ≤2+) at 13 European centres. Among 503 patients evaluated...
Article
Introduction and objectives: Severe tricuspid regurgitation (TR) is associated with poor prognosis when left untreated, and a growing number of studies on transcatheter tricuspid valve repair (TTVr) have been published over the last few months. Methods: We performed a comprehensive systematic review of published literature providing clinical dat...
Article
To the Editor, This is the case of a 72-year-old male examined due to exertional angina, and severe inferior wall ischemia through a single-photon emission computed tomography with Tc-99. After obtaining the patient’s written informed consent he was referred for a coronary angiography that confirmed the chronic total coronary occlusion (CTO) of the...
Article
Background: There are limited data on the outcomes of percutaneous coronary intervention (PCI) following stent thrombosis (ST) and differences exist based on timing. Aims: Our aim was to study the rates of PCI procedures for an ST indication among all patients admitted for PCI at a national level and to compare their characteristics and procedur...
Article
Resumen Introducción y objetivos En insuficiencia cardiaca persistente con insuficiencia mitral (IM) secundaria se debe considerar la reparación transcatéter borde-a-borde (TEER) de la válvula mitral. Los inhibidores de neprilisina (ARNIs) demostraron mejorar el pronóstico en insuficiencia cardiaca. Nuestro objetivo fue evaluar el impacto de los A...
Article
Bioresorbable scaffolds (BRS) emerged as an alternative to conventional stents with a fundamental idea, to avoid a permanent metallic cage with all its harmful effects on the vessel. The absorb BVS was the first widely studied device with the promising concept of performing a percutaneous coronary intervention, giving the necessary initial support...
Article
Sr. Editor: Se presenta el caso de un varón de 72 años con angina de esfuerzo e isquemia grave de la pared inferior confirmada tras exploración mediante tomografía computarizada por emisión de fotón único con Tc-99. Tras obtener el consentimiento informado y por escrito del paciente, se realizó una coronariografía que confirmó la presencia de oclus...
Article
Full-text available
Background: Matrix metalloproteinase-9 (MMP-9) is crucial in tissue remodeling after an adverse cardiac event. In experimental studies, melatonin has been found to attenuate MMP-9 activation. The present study assessed the effects of systemic melatonin administration on the prognosis of patients with acute myocardial infarction (AMI) successfully...
Article
Introduction and objectives Transcatheter edge-to-edge repair (TEER) should be considered in patients with heart failure and secondary mitral regurgitation (MR). Angiotensin receptor-neprilysin inhibitors (ARNIs) have been demonstrated to improve prognosis in heart failure. We aimed to evaluate the impact ARNIs on patient selection and outcomes. M...
Article
Background Risk stratification for transcatheter edge-to-edge mitral valve repair (TEER) is paramount in the decision-making process for treating severe mitral regurgitation (MR). Objectives This study sought to create and validate a user-friendly score (MitraScore) to predict the risk of mortality in patients undergoing TEER. Methods The derivat...
Article
Full-text available
Objectives The aim of this study was to determine if modifying the classical implantation technique for self-expanding (SE) transcatheter aortic valve replacement to a novel cusp-overlapping projection (COP) technique results in a higher implantation depth (ID) and subsequently reduces the rate of permanent pacemaker implantation (PPMI). Backgroun...
Article
Background and objectives: Evidence regarding redo percutaneous interventions for recurrent mitral regurgitation is scarce. We ought to evaluate procedural and clinical outcomes of repeated edge-to-edge transcatheter mitral valve repair (TMVR) interventions. Methods: This multicenter study collected individual data from eight high-volume TMVR Ce...
Article
Transseptal puncture (TSP) was initially described to gain access to the left heart for hemodynamic assessment. Continuous evolution from its origins allows interventionists to perform a myriad of procedures that otherwise would be impossible to accomplish. In the recent years, the number of procedures in cardiology that require TSP has grown expon...
Article
Full-text available
Objetivo: Determinar la percepción de los médicos internos residentes (MIR) de cardiología de España sobre el efecto de la pandemia por COVID-19 en su formación y la adaptación realizada por sus servicios. Métodos: Estudio de corte transversal a través de una plataforma de encuesta digital con el objetivo de conocer la opinión individual de los MI...
Article
Aims: To analyse the relationship among air pollutants, markers of inflammation and infarct size in patients with acute coronary syndrome (ACS). Methods: This was a prospective analysis of consecutive patients admitted to hospital because of ACS. Cardiac biomarkers were drawn. The daily mean values of the air pollutants from the day before until 7...
Article
Background Transcatheter aortic valve implantation has revolutionized the management of aortic stenosis and is currently an alternative to surgical aortic valve replacement. Some studies have found costs of percutaneous procedure to be greater than those of surgical replacement. However, these published studies are based on pooled data from clinica...
Conference Paper
Full-text available
Nowadays the undoubted and continuous increase of Information and Communication Technologies has severely influenced the educational methodologies in higher education. Among them, mobile learning deserves more attention as an effective tool to promote the active participation of students in a classroom. Social network and instant messaging represen...
Article
Resumen Introducción y objetivos Una profundidad más alta del implante percutáneo de una válvula aórtica autoexpandible minimiza el daño en el sistema de conducción y puede reducir las tasas de marcapasos permanente a 30 días. El objetivo es determinar la seguridad y la eficacia de modificar la técnica de implante clásica para el reemplazo percutá...
Article
Background: MAC is commonly found in patients affected with MR and it's associated with high morbidity, mortality and worse cardiac surgical outcomes. Transcatheter edge-to-edge repair could be an alternative treatment although with little evidence in this population. Aims: To analyze the safety, efficacy and durability of MitraClip in patients...
Article
ABSTRACT Introduction and objectives: Patients with left main coronary artery (LMCA) stenosis have been excluded from the trials that support the non-inferiority of the instantaneous wave-free ratio (iFR) compared to the fractional flow reserve (FFR) in the decision-making process of coronary revascularization. This study proposes to prospectively...
Article
RESUMEN Introducción y objetivos: Los pacientes con estenosis en el tronco coronario izquierdo (TCI) han sido excluidos de los ensayos que apoyan la no inferioridad del cociente de presiones en el índice diastólico instantáneo sin ondas (iFR) respecto a la reserva fraccional de flujo (RFF) en la toma de decisiones sobre revascularización coronaria....
Article
Full-text available
Atherosclerosis is a chronic inflammatory disease. Several circulating inflammatory markers have been proposed for clinical use due to their ability to predict future cardiovascular events and may be useful for identifying people at high risk who might benefit from specific treatment to reduce this risk. Moreover, the identification of new therapeu...
Article
Introduction and objectives: This study aimed to determine the safety and efficacy of modifying the classic implantation technique for aortic transcatheter heart valve (THV) implantation to a cusp-overlap-projection (COP) technique to achieve a higher implantation depth and to reduce the burden of new permanent pacemaker implantation (PPMI) at 30...
Article
Objectives The aim of this study was to characterize the feasibility of coronary angiography (CA) and percutaneous coronary intervention (PCI) in acute settings among patients who have undergone transcatheter aortic valve replacement (TAVR). Background Impaired coronary access after TAVR may be challenging and particularly in acute settings could...
Article
Full-text available
Background: Precise evaluation of the degree of frailty is a fundamental part of the global geriatric assessment that helps to avoid therapies that could be futile. Our main objective was to determine the prevalence of frailty in a specific consult of patients undergoing aortic valve replacement. Methods: From May 2018 to February 2020, all cons...
Article
Full-text available
Myocardial ischemia/reperfusion (IR) injury represents a critical problem associated with interventional approaches for coronary reperfusion. Pharmacological cardioprotective interventions are advocated to ameliorate IR injury. Melatonin is an anti-inflammatory and antioxidant agent with a wide range of therapeutic properties that may contribute to...
Article
Background We sought to investigate the antithrombotic regimens applied and their prognostic effects in patients over 75 years old with atrial fibrillation (AF) after revascularization with drug-eluting stents (DES). Methods Retrospective registry in 20 centers including patients over 75 years with AF treated with DES. A primary endpoint of MACCE...
Article
Funding Acknowledgements Type of funding sources: None. Introduction One of the most frequent intraprocedural complication of patients undergoing transcatheter aortic valve replacement (TAVR) is high degree atrioventricular block (HDAVB). The incidence varies from 5-20% depending on the type of valve, previous surgical valve replacement (SVR) and...
Article
Funding Acknowledgements Type of funding sources: None. Introduction and objectives There has been a continuous process of improvement after (ST-segment elevation myocardial infarction) STEMI. Our aim was to know whether patients < and ≥ 65 years suffering a STEMI can recover a life expectancy similar to that of the general population of the same...
Article
Full-text available
Background: Coronary artery disease (CAD) is the most frequent cause of ST-segment elevation myocardial infarction (STEMI). Etiopathogenic and prognostic characteristics in young patients may differ from older patients and young women may present worse outcomes than men. We aimed to evaluate the clinical characteristics and prognosis of men and wom...
Article
Full-text available
The renin–aldosterone–angiotensin system (RAAS) plays an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for SARS-CoV-2 and the host’s expression of this membrane-bound prote...
Article
Full-text available
Background: Transcatheter mitral valve repair (TMVR) is an effective therapy for high-risk patients with severe mitral regurgitation (MR) but heart failure (HF) readmissions and death remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in HF....
Article
Full-text available
Background and aim: Recent randomized data comparing percutaneous mitral valve repair (PMVR) versus optimal medical treatment in patients with functional MR (FMR) seemed to highlight the importance of the learning curve not only for procedural outcomes but also for patient selection. The aim of the study was to compare a contemporary series of pat...
Article
Full-text available
Background: Whether or not inhalation of airborne desert dust has adverse health effects is unknown. The present study, based on a systematic review and meta-analysis, was carried out to assess the influence desert dust on cardiovascular mortality, acute coronary syndrome, and heart failure. Methods: A systematic search was made in PubMed and Em...
Article
Background and aims Apoliprotein B (ApoB) has been associated with hypercholesterolemia and ischemic coronary disease. This study was aimed to determine the effect of two APOB gene variants in the risk of developing early-onset coronary artery disease (EO-CAD) in a Spanish population. The association of these polymorphisms with hypercholesterolemia...
Article
Spontaneous coronary artery dissection (SCAD) is a relatively rare but well-known cause of acute coronary syndrome (ACS) in women. The role of sexual hormones has been related to the pathophysiology of SCAD. However, clinical features, angiographic findings, management and outcomes of SCAD women in relation to menopause status remain unknown. The S...
Article
Full-text available
Background: Long QT syndrome (LQTS) is an inheritable arrhythmogenic disorder associated with life-threatening arrhythmic events (LAEs). In general, patients with LQTS2 (KCNH2) and LQTS3 (SCN5A) are considered to be a greater risk of LAEs than LQTS1 (KCNQ1) patients. Gender differences are also important. Series analyzing families with the same pa...
Article
Background The clinical significance of conduction disturbances after transcatheter aortic valve implantation has been described; however, little is known about the influence of baseline ECGs in the prognosis of these patients. Our aim was to study the influence of baseline ECG parameters, including interatrial block (IAB), in the prognosis of pati...
Article
Introduction The leading cause of valvular heart replacement therapy is symptomatic aortic stenosis (AS). The Mitroflow (MF) bovine pericardial prosthesis is prone to early structural valve deterioration (SVD) and has been used in over 100,000 patients for the treatment of symptomatic AS. The standard of care for degenerated bioprosthesis is surgic...
Article
Resumen Introducción y objetivos El tratamiento médico y las medidas de prevención secundaria en el infarto agudo de miocardio con elevación del segmento ST (IAMCEST) han experimentado una mejora progresiva en las últimas décadas. A pesar de ello, los pacientes > 65 años presentan un mayor riesgo de muerte tras un evento coronario. Nuestro objetiv...
Article
Background In catheter-based procedures, acute kidney injury (AKI) is a frequent, serious complication ranging from 10% to 30%. In MitraClip (Abbott Vascular, Santa Clara, California), a usually contrast-free procedure, there is scarce data about its real incidence and impact. Objectives This study aimed to evaluate incidence, predictive factors,...
Article
Full-text available
Familial hypercholesterolemia (FH) is an underdiagnosed genetic inherited condition that may lead to premature coronary artery disease (CAD). FH has an estimated prevalence in the general population of about 1:313. However, its prevalence in patients with premature STEMI (ST-elevation myocardial infarction) has not been widely studied. This study a...
Article
Resumen Introducción y objetivos El impacto del brote de COVID-19 en el tratamiento del infarto agudo de miocardio con elevación del segmento ST (IAMCEST) no está claro. El objetivo de este estudio es evaluar los cambios en el tratamiento del IAMCEST durante el brote de COVID-19. Métodos Se utilizó un registro multicéntrico, nacional, retrospecti...
Article
Introduction and objectives: In the last few decades, there has been a continuous process of improvement in medical treatment and secondary prevention measures after ST-segment elevation myocardial infarction (STEMI). Patients older than 65 years are at increased risk of death due to this event. Our aim was to determine whether patients aged less...