Pabitra Hriday Patra

Pabitra Hriday Patra
Transpharmation

PhD

About

31
Publications
6,598
Reads
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590
Citations
Introduction
I am a pharmacologist and a trained veterinarian with over a decade of research experience in the area of neuropharmacology, pharmacokinetics and toxicology. Currently, I am leading the epilepsy research at Transpharmation. My PhD research significantly contributed to the preclinical antiepileptic drug development process and FDA approval of Epidiolex® (GW Pharmaceuticals, UK) in the year 2018. In my postdoctoral position at the University of Bristol, I investigated the role of proopiomelanocort
Additional affiliations
October 2018 - present
University of Bristol
Position
  • Research Associate
July 2012 - September 2015
College of Veterinary Sciences and AH
Position
  • Professor (Assistant)
July 2012 - September 2015
College of Veterinary Sciences and Animal Husbandry
Position
  • Professor (Assistant)
Education
October 2015 - May 2019
University of Reading
Field of study
  • Neuropharmacology
September 2009 - September 2011
West Bengal University of Animal and Fishery Sciences
Field of study
  • Pharmacology and Toxicology
July 2004 - June 2009

Publications

Publications (31)
Article
Full-text available
1,8-cineole, a monoterpenoid is a major component of eucalyptus oil and has been proven to possess numerous beneficial effects in humans. Notably, 1,8-cineole is the primary active ingredient of a clinically approved drug, Soledum® which is being mainly used for the maintenance of sinus and respiratory health. Due to its clinically valuable propert...
Article
Full-text available
Chronic arsenic poisoning is one of the serious health hazards in West Bengal, India, and Bangladesh. It occurs due to contaminated subsoil water. The aim of this study is conducted to find out the ameliorative effect of turmeric and P. foetida powder on experimentally induced arsenic toxicity in sheep. Twelve sheep were divided into four groups; g...
Article
Full-text available
Background and purpose: Dravet syndrome is a severe, genetic form of paediatric epilepsy associated with premature mortality and co-morbidities such as anxiety, depression, autism, motor dysfunction and memory deficits. Cannabidiol is an approved anticonvulsive drug in the United States and Europe for seizures associated with Dravet syndrome in pa...
Article
Full-text available
Background and purpose: Epidiolex™, a form of highly purified cannabidiol (CBD) derived from Cannabis plants, has demonstrated seizure control activity in patients with Dravet syndrome, without a fully elucidated mechanism of action. We have employed an unbiased approach to investigate this mechanism at a cellular level. Experimental approach: W...
Article
Isorhapontigenin is a polyphenolic compound found in Chinese herbs and grapes. It is a methoxylated analogue of a stilbenoid, resveratrol, which is well-known for its various beneficial effects including anti-platelet activity. Isorhapontigenin possesses greater oral bioavailability than resveratrol and has also been identified to possess anti-canc...
Article
Full-text available
Objective Epilepsy is a progressive neurological disease characterized by recurrent seizures and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol (CBD) in a battery of acute seizure models. Additionally, we defined the disease‐modifying potential of chronic oral administration of CBD on associated comorbidities in the...
Article
The isolation and identification of the discrete plant cannabinoids in marijuana revived interest in analyzing historical therapeutic claims made for cannabis in clinical case studies and anecdotes. In particular, sources as old as the 11th and 15th centuries claimed efficacy for crude marijuana extracts in the treatment of convulsive disorders, pr...
Article
Full-text available
Arsenic, a dangerous bio-accumulative poison, is a grave threat affecting a large number of people as well as animals throughout the World, particularly in Bangladesh and West Bengal, India. It is also a matter of concern as continuously entering into food chain through biotic and abiotic products. The present study was conducted to evaluate the ex...
Article
The present study was designed to enumerate the antioxidant status and trace mineral profile of yaks with haemorrhagic diarrhoea associated with enterovirulent E. coli. The study was conducted in 15 yaks with haemorrhagic diarrhoea and with PCR based evidence for enteropathogenic E. coli (EPEC) and enterotoxigenic E. coli (ETEC) infection. A signif...
Article
The present study aimed to examine the status of antioxidant systems of the pigs naturally suffering from sarcoptic mange. Fifty nine pigs were divided into three groups, healthy control (group I, n = 15), subclinical sarcoptic mange (group II, n = 22) and clinical sarcoptic mange (group III, n = 22). To assess the status of antioxidant systems; li...
Article
Full-text available
Bidyadhari river originates in Nadia district of West Bengal, India and then flows through North 24 Parganas district and now serves as a sewage and excess rainwater outlet from the city of Kolkata and adjacent area, which ultimately empties at the Bay of Bengal through the Indian Sundarban delta. Four different stations situated around the course...
Article
Full-text available
The present investigation was conducted to evaluate the nephroprotective activity of Tephrosia purpurea (TPE) against arsenic-induced toxicity. Twenty four number of wistar rats were equally divided into three groups. Sodium arsenite (10 mg/kg) was orally given to group I for 28 days, additionally group II was orally treated with TPE (500 mg/kg), w...
Article
Full-text available
Aim: The present investigation has been conducted to evaluate the hepatoprotective effect of Curcuma longa against lead induced toxicity. Materials and Methods: For this study, 24 Wistar albino rats were taken. Control group (n=8), group-I rats (n=8) were given lead acetate @ 1000 mg/kg bodyweight (BW) and group-II rats (n=8) were treated with Curc...
Article
Full-text available
Bovine herpesvirus-1 (BHV-1) is known to cause several diseases worldwide. It is a double-stranded DNA virus consisting of 33 structural proteins out of which 13 are associated with the envelope. Based on genomic analysis and viral peptide patterns, BHV-1 virus can be divided into several subtypes like BHV-1.1, BHV-1.2, and BHV-1.3. However, all su...
Article
Full-text available
To evaluate the antimicrobial efficacy of berberine, a plant alkaloid. Five multi-drug resistant (MDR) STEC/EPEC and five MDR ETEC isolates from yaks with haemorrhagic diarrhoea were selected for the study. Antibacterial activity of berberine was evaluated by broth dilution and disc diffusion methods. The binding kinetics of berberine to DNA and pr...
Article
Hepatopathy sometimes may interfere with metabolism and/or elimination of drugs which undergo major hepatic clearance. Twelve healthy goats were equally divided into two groups (I and II) and hepatopathy was induced by carbontetrachloride in the second group (group II). A single dose of ceftriaxone at 50 mg/kg was administered to each group intramu...
Article
The study investigated the immunotoxic and genotoxic effect of arsenic and its different species on goats. It was found that arsenic causes haematological crisis. Histopathological changes in spleen and reduced serum immunoglobulin G level without any changes in formazan production in arsenic-treated animals indicated that arsenic is toxic to the h...
Article
A study was undertaken to evaluate an alternative source of arsenicosis in human food chain through livestock. Thirty milch cattle and 20 poultry birds along with their eggs were selected randomly from two endemic villages of Nadia district and one nonendemic villages of Hooghly district in West Bengal, India. Milk, feces, urine, and hair samples o...
Article
Full-text available
Flumethrin is used extensively in livestock periodically, which may cause adverse effect in goats and subsequently to human being through food chain. Flumethrin at 1.0% solution was applied weekly dermally for 84 days and hematobiochemical as well as immunological parameters, anti-oxidant status, liver enzymes, and tissue residues in goats were est...
Article
The aim of the present study was to determine pharmacokinetic interaction of ceftriaxone and polyherbal drug (Fibrosin(®)) in lactating goats following single dose intramammary administration of ceftriaxone with 1 h pre-single dose oral administration of Fibrosin(®). Pharmacokinetic interaction of ceftriaxone and Fibrosin(®) was evaluated in lactat...
Article
Effect of enrofloxacin on haematobiochemical and immunological parameters alongwith the residual level of enrofloxacin and its metabolite ciprofloxacin in black Bengal goat was carried out following daily oral administration at 5 mg kg-1 body weight for 54 days. A significant decrease in haemoglobin %, total erythrocyte and lymphocyte count were no...
Article
Full-text available
The study was conducted to fix the dosage regimen after intravenous administration of ceftizoxime, a third generation cephalosporin group antibiotic along with its efficacy in mastitis condition in goats. Twelve black Bengal goats were divided into two groups containing six animals each out of which mastitis was induced in the second group using pa...
Article
A study was conducetd to know the efficacy of a paste prepared from Terminalia chebula and T. belerica on wound healing. Thirty rabbits were divided into two groups (Group A and Group B) having fifteen animals each. An equi-demensional full-thickness excision wounds were created on the back of the each animal. Each group was again divided into 3 su...
Article
Full-text available
Fifteen broiler chickens (COBB 400) of 42 days of age weighing 1.8 to 2.0 kg were equally divided into 3 groups, each consisting of 5 birds. Hepatopathy was induced by oral administration of paracetamol while nephropathy was induced by intravenous administration of uranyl nitrate. Kinetic study was investigated in healthy, hepatopathic and nephropa...
Article
Sparfloxacin is a third generation fluroquinolone derivative used as antimicrobial agent in human as well as in livestock. To establish proper dosage regimen in healthy as well as in acute renal failure condition in goat sparfloxacin was administered at a dose rate of 30 mg kg-1 body weight by intravenous route. Kidney was damaged experimentally by...

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