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Bezmiâlem Vakif Üniversitesi · pediatrics

To investigate coronavirus disease 2019 (COVID-19) in infants aged 0 to 3 months because there is currently a significant gap in the literature on the subject. A cross-sectional study was conducted with the involvement of 19 medical centers across Turkey and 570 infants. The majority of the patients were male (58.2%), and the three most common symp...

Purpose Due to its link with the 2019 coronavirus, the multisystem inflammatory syndrome in children (MISC) has garnered considerable international interest. The aim of this study, in which MISC patients were evaluated multicenter, and the data of the third period of the Turk-MISC study group, to compare the clinical and laboratory characteristics...

Aim: The purpose of this study was to evaluate correlation between ABO, Rhesus (Rh) blood type and the disease severity status, pneumonia status in children with COVID-19. Material and Methods: This is a multicenter study of all children 0.05). Conclusions: In our study with pediatric population, no difference was detected between blood types and/o...

Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We describe unrelated children with inherited complete IRF1 deficiency and early-onset, multiple, life-threatenin...

Background: The prevalence of community-acquired methicillin-resistant S. aureus (CA-MRSA) has been increasing worldwide. We aimed to investigate the prevalence of MRSA in community-acquired S. aureus infections, the risk factors for CA-MRSA infection and the clinical features of CA-MRSA. Methods: A multi-center study with prospective and retros...

Multisystemic inflammatory syndrome (MIS-C) diagnosis remains difficult because the clinical features overlap with Kawasaki disease (KD). The study aims to highlight the clinical and laboratory features and outcomes of patients with MISC whose clinical manifestations overlap with or without KD. This study is a retrospective analysis of a case serie...

Aim: We aimed to assess the impact of COVID-19 on asthma exacerbations and to compare the severity of symptoms of SARS-CoV-2 infection of asthmatic children with those of healthy children. Method: The clinical course of COVID-19 was compared among 89 children with asthma and 84 healthy children with age and gender matched. Demographic factors, s...

Objective This study aimed to investigate the frequency of latent and active tuberculosis (TB) in pediatric patients receiving anti-tumor necrosis factor (TNF)-α therapy. Methods Patients younger than 18 years with various inflammatory diseases and treated with anti-TNF-α agents in the past five years were included in the study. The patients' ages,...

Aim: Multisystem inflammatory syndrome in children (MIS-C) may cause shock and even death in children. The aim of this study is to describe the clinical features, laboratory characteristics and outcome of children diagnosed with MIS-C in 25 different hospitals in Turkey. Methods: The retrospective study was conducted between 8 April and 28 Octob...

The frequency of bacterial factors causing central nervous system infections has decreased as a result of the development of our national immunization program. In this study, it is aimed to obtain the data of our local surveillance by defining the viral etiology in cases diagnosed with meningoencephalitis for 1 year. Previously healhty 186 children...

Aim Reports describing coronavirus disease 2019 (Covid-19) in children are fewer than adult studies due to milder clinical picture. We aimed to share our experience at a single center with an emphasis on collective decision making. Materials and Methods A suspected case was defined as the presence of symptoms suggestive of COVID-19 and/or positive...

Brucellosis is one of the most common zoonosis worldwide. It is still endemic in many regions of the world. A 6-year-old female was admitted to the emergency department (ED) due to a sudden change in consciousness, urinary incontinence, vomiting, and difficulty in walking. Neurological examination demonstrated abducens nerve paralysis, mild-to-mode...

Infective endocarditis (IE) is an uncommon infection in children. The recommended treatment for native valve endocarditis secondary to methicillin-susceptible Staphylococcus aureus infection is antistaphylococcal penicillins such as nafcillin or oxacillin. If the initial therapy fails in IE, it can lead to catastrophic results. Nowadays, daptomycin...

Streptococcus anginosus can be frequently isolated from brain abscesses but is a rare cause of the liver, lung, and deep tissue abscesses. In this report; we present a case with subdural empyema, brain abscess, and superior sagittal cerebral venous thrombosis as complications of rhinosinusitis whose purulent empyema sample yielded S. anginosus. A 1...

We report a 13-year-old boy who (initially) had symptoms of toxic shock-like syndrome and mumps. Then, the patient was hospitalized in the pediatric intensive care unit (PICU) because of his ongoing hemodynamic instability (low blood pressure of 70/30 mm Hg and capillary refill time of > 4 seconds). During his stay in the PICU, the patient was trea...

Hand, foot, and mouth disease (HFMD) is caused by various serotypes of Enterovirus genus. Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) were known to be the only responsible agents for these epidemics; however, this opinion was challenged after the detection that coxsackievirus A6 (CV-A6) was the responsible species for the outbreak in F...

Hand, foot, and mouth disease (HFMD) is caused by various serotypes of Enterovirus genus. Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) were known to be the only responsible agents for these epidemics; however, this opinion was challenged after the detection that coxsackievirus A6 (CV-A6) was the responsible species for the outbreak in F...

Background: For perforated appendicitis in children microbiological cultures should always be sought if adequate sample is available. Knowledge of local epidemiology is important for optimal selection of antimicrobial agents. Objective: We aimed to evaluate etiology and susceptibility of pathogens in patients with perforated appendicitis. Metho...

Introduction: The aim of this point prevalence study was to evaluate the consumption, indications and strategies of antifungal therapy within pediatric population in Turkey. Material-methods: A point prevalence study was performed at 25 hospitals. In addition to general data on pediatric units of the institutes, the generic name and indication o...

Gut microbiota is closely related to acute infectious diarrhea, one of the leading causes of mortality and morbidity in children worldwide. Understanding the dynamics of the recovery from this disease is of clinical interest. This work aims to correlate the dynamics of gut microbiota with the evolution of children who were suffering from acute infe...

Relative abundances of the KEGG pathways inferred by PICRUSt at level 2 of the hierarchy.

Rank Stability matrices for every subject enrolled in the study. In each Figure, are represented the 50 most abundant genera of each subject, and the numbers inside each cell represents the ranking of that specific genus at that specific time point. The color inside each cell ranges from light-yellow for the rank 1 to black, representing very low r...

Boxplots showing the Evenness diversity index between both health status with all times together; and separated by time of sampling. Color blue represents healthy children, and red color represents children with acute diarrhea.

Excel file with clinical data. Dehydration, fever and diarrhea duration are the variables included.

Excel file with subject information of this study. It is specified the hospital where the subjects were treated, the amount of DNA extracted, and the ratios of purity.

Canonical Correspondence Analysis of all individuals and times, separated by different child.

Excel file which summarizes the values of Taylor's parameters V and β. In the file you can see information about each individual of this study: number of OTUs, times, mean of absolute frequencies, standard deviation of absolute frequencies, weighted values for V, β and their errors, and weighted values of the standardization of both parameters with...

Purpose: Ventriculoperitoneal shunt (VPS) is the most common treatment modality for hydrocephalus. However, VPS infection is a common and serious complication with high rates of mortality and morbidity. The objective of this study was to investigate causative agents and the management of VPS infections and to identify risk factors for re-infection...

Objective: Tigecycline has a wide spectrum antimicrobial activity including multi-drug resistant and extended drug resistant nosocomial Gram-negative bacteria. Although its pediatric use has not been approved, clinicians are sometimes obligated to choose tigecycline as salvage therapy. In this study, we present our clinical experience regarding tig...

Adenosine deaminase (ADA) deficiency is a rare autosomal recessive disorder of purine metabolism that leads to severe combined immunodeficiency (SCID) by primarily affecting lymphocyte development and function. ADA deficiency is a medical emergency. Early diagnosis and treatment could provide low morbidity and mortality. Patients present in the fir...

Background: The aim of this study was to identify risk factors, including the type of delivery, breastfeeding and its duration, birth weight, the timing of solid food introduction, the mother's education level at birth, and smoking status during pregnancy, that are associated with obesity in children living in Istanbul. Methods: This study invol...

Objectives: The present studyaimedat evaluating factors affectingscar formationandtuberculin skin test (TST) response in Bacillus Calmette-Guerin (BCG) vaccinated infants. Methods: In the current study, 216 infants with gestational age (GA) of 26 to 40 weeks and birth weight of 730 g to 4590 g were included. The mean corrected age was 6.27 ± 3.79 w...

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Fungal infections like Paecilomyces keratitis have emerged in childhood recently. The diagnosis and treatment of Paecilomyces keratitis is difficult and the outcome is usually poor. Corneal culture should be performed on fungal media such as Sabouraud glucose neopeptone agar (SDA) as soon as possible for diagnosis. We report a rare case of Paecilom...

Background: The purpose of this study was to establish species distribution of Candida isolates from pediatric patients in Istanbul, Turkey, and to determine risk factors associated with nosocomial Candida infections. Methods: This studywas conducted between June 2013 and June 2014 by participation of 7 medical centers in Istanbul. Candida spp stra...

Optimal selection of antimicrobial agents for complicated intrabdominal infections such as perforated appendicitis depends on local epidemiology. We aimed to evaluate pathogens identified and susceptibility patterns in children with appendicitis.

. Tuberculosis (TB) still remains a growing public health problem globally. TB in children is often diagnosed clinically. Methods . We conducted a retrospective chart review of children with TB from November 2004 through December 2010 to determine the appropriateness of using contact history and diagnostic testing. Results . A total of 250 children...

Central nervous system (CNS) infection with Candida is rare but significant because of its high morbidity and mortality. When present, it is commonly seen among immunocompromised and hospitalized patients. Herein, we describe a case of a four-year-old boy with acute lymphoblastic leukemia (ALL) who experienced recurrent Candida albicans meningitis....

Two randomized controlled clinical trials have shown that Lactobacillus (L) reuteri DSM 17938 reduces the duration of diarrhea in children hospitalized due to acute infectious diarrhea. This was the first trial evaluating the efficacy of L. reuteri DSM 17938 in outpatient children with acute infectious diarrhea. This was a multicenter, randomized,...

Achromobacter xylosoxidans is an aerobic gram-negative bacillus and important cause of bacteremia in immunocompromised patients. We describe a leukemia pediatric patient with severe neutropenia who developed bacteremia with A xylosoxidans resistant to multiple antibiotics, and treated the patient with tigecycline and piperacillin-tazobactam in addi...

Evidence from the literature has shown that Saccharomyces boulardii provides a clinically significant benefit in the treatment of acute infectious diarrhoea in children. In this multicentre, randomised, prospective, controlled, single blind clinical trial performed in children with acute watery diarrhoea, we aimed to evaluate the impact of S. boula...

Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome, was first described by Tomisaki Kawasaki in 1967.1 KD is markedly more prevalent in Japan and in children of Japanese ancestry, with an annual incidence of ~112 cases per 100 000 children less than 5 years of age. In the United States, 4248 hospitalizations associated with KD o...

Evidence-based guidance is likely to significantly improve patient care. We aimed to characterize the adequacy of standard diagnostic methods and treatment in children with acute bacterial meningitis (ABM) in Turkey. We conducted a retrospective study among children 1 month to 5 years old hospitalized with ABM in İstanbul. The World Health Organiza...

In recent years, multidrug-resistant microorganisms appear as important nosocomial pathogens which treatment is quite difficult. As sufficient drug levels could not be achieved in cerebrospinal fluid during intravenous antibiotic therapy for central nervous system infections and due to multidrug-resistance treatment alternatives are limited. In thi...

Objective: Asthma is the most common chronic disease of childhood, and magnesium is one of the most frequently found minerals in human body and it is used in the treatment of asthma. Although there are studies on magnesium levels in adult patients with asthma, there is yet no data on the levels of magnesium in children. The present study compared t...

Guidelines consider certain probiotics useful in the management of acute gastroenteritis. This study evaluated the use of Lactobacillus (L) reuteri DSM 17938. A multicenter, randomised, single blind, clinical trial was performed in hospitalised children with acute gastroenteritis lasting 12 to 72 hours. Children received conventional therapy with,...

Recurrent meningitis is a rare problem and can be due to alterations in immune system, or craniospinal defect. Any clue either in patient’s history or physical examination would be helpful for avoiding unnecessary and tiring tests. Here we present the case of a child with recurrent bacterial meningitis who had an unnoticed hair tuft on the occipita...

Pneumococcal infection is an important and preventable cause of morbidity and mortality. The Turkish government introduced 7-valent pneumococcal conjugate vaccine (PCV) into the national immunization program in 2009. This suggests that replacing 7-valent PCV with a higher-valent version could at least maintain "standard of care" if not improve it,...

Oxidative stress has been shown to contribute to the pathogenesis of acute and chronic lung inflammatory diseases. This article aimed to evaluate the oxidant/antioxidant status of children with acute bronchiolitis through the measurement of plasma total antioxidant capacity, total oxidant status, and oxidative stress index. Children with acute bron...

Objective: We report an outbreak of Achromobacter xylosoxidans at a neonatal intensive care unit. We aimed to present clinical, laboratory and treatment data of the patients. Materials and methods: All consecutive episodes of bacteremia due to A. xylosoxidans at our neonatal intensive care unit, beginning with the index case detected at November...

Objective: To evaluate clinical features and sequela in children with acute bacterial meningitis (ABM). Study Design: Multicenter retrospective study. Material and Methods: Study includes retrospective chart review of children hospitalised with ABM at 11 hospitals in İstanbul during 2005. Follow up visits were conducted for neurologic examination...

We aimed to determine the incidence, etiology, risk factors and outcome of bacterial meningitis in neonates. Neonates who developed bacterial meningitis between 2003 and 2010 in a tertiary hospital in Turkey were included in the study. Patients born in our hospital were defined as Group 1 and patients referred from other centres were defined as Gro...

Background Streptococcus pneumoniae infections, which place a considerable burden on healthcare resources, can be reduced in a cost-effective manner using a 7-valent pneumococcal conjugate vaccine (PCV-7). We compare the cost effectiveness of a 13-valent PCV (PCV-13) and a 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjuga...

Psoas abscess is rare, especially in the neonatal period. It may be primary or rarely secondary to extend on from adjacent structures or to bacteremia caused by distant cutaneous infections. Vague clinical presentation may lead to delayed diagnosis. Appropriate drainage is necessary in addition to antibiotic therapy. Here we present a neonate was a...

Varicella can cause complications that are potentially serious and require hospitalization. Our current understanding of the causes and incidence of varicella-related hospitalization in Turkey is limited and sufficiently accurate epidemiological and economical information is lacking. The aim of this study was to estimate the annual incidence of var...

To the Editor: Kawasaki disease (KD) is an acute systemic vasculitis syndrome predominantly affecting infants and young children. It is the commonest cause of childhood acquired heart disease in developed countries. Coronary artery injury develops in 25% of untreated and 5% of treated children1. We describe KD in dizygotic twins presenting with i...

The frequency and spectrum of fungal infections have been increasing steadily over the last several decades. The reason for this increase may be explained by the increase in the number of immunocompromised patients due to malignancies, AIDS, invasive surgical procedures and transplantation. In parallel with this increase, several therapeutic option...

The involvement of the central nervous system (CNS) in brucellosis is rare and has a broad range of presentations. Subacute and chronic meningoencephalitis are described as the most common neurologic manifestations. We report a six-year-old boy with culture-proven neurobrucellosis who presented with an acute picture of meningoencephalitis. Cerebros...

This report describes a 2-year-old child with neuroectodermal tumor presenting with febrile neutropenia. Blood cultures drawn from the peripheral vein and Hickman catheter revealed Kluyvera cryocrescens growth. The Hickman catheter was removed and the patient was successfully treated with cefepime and amikacin. Isolation of Kluyvera spp. from clini...

A false-positive tuberculin skin test (TST) may be a result of T-cell sensitivity due to Bacille Calmette-Guerin (BCG) vaccination or exposure to non-tuberculous mycobacteria, thus leading to unnecessary isoniazid preventive therapy, especially in low-risk populations. Unlike TST, T-SPOT.TB is not confounded by BCG vaccination or exposure to most o...

Chickenpox is a common infectious disease of the pediatric age group with rare complications such as hemorrhagic varicella and arterial thrombotic purpura. Medical support is the mainstay of treatment in such cases but for the rescue of necrotic tissues, hyperbaric oxygen (HBO) therapy should be applied in addition to anticoagulant intervention. We...

SUMMARY RUPTURED PULMONARY HYDATID CYST PRESENTED AS ANAPHYLACTIC REACTION: A CASE REPORT Echinococcosis or hydatid disease is caused by larvae of Echinococcus. Pulmonary hydatid cysts are usually asympto- matic but patients may occasionally develop symptoms due to expectoration of cyst contents or compression of the surrounding structures. Rupture...

Araştırma ÖZET Amaç: Bu çalışmada yineleyen pnömonili çocuklarda eti-yolojik nedenlerin belirlenmesi ve prognoz üzerine etkileri-nin araştırılması amaçlanmıştır. Yöntemler: Ocak 2005 ve Ocak 2009 tarihleri arasında Sağlık Bakanlığı Bakırköy Kadın Doğum ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi Çocuk Kliniklerinde pnömoni tanısı ile yatırı...

ZET Amaç: Bu çalışmada çocuklarda idrar yolu infeksiyonuna (İYE) neden olan Gram negatif bakteri türlerinin ve anti-mikrobiyal dirençlerinin belirlenmesi hedeflenmiştir. Yöntemler: Ekim 2008-Haziran 2009 tarihleri arasında elde edilen idrar kültürü sonuçları retrospektif olarak ince-lenmiştir. Çocuk kliniklerinden İYE ön tanısıyla mikrobiyo-loji la...