Ozcan Uzun

Gulhane Medical Faculty

Objective: The aim of this study was to learn the current and former treatment regimens of patients with schizophrenia, and to examine the suitability of treatment period to international treatment guidelines. Methods: This naturalistic and retrospective study included 315 cases who applied to the psychiatry clinic and met the diagnosis criteria fo...

GİRİŞ ve AMAÇ: Obsesif kompulsif bozukluk (OKB) ciddi düzeyde sıkıntıya yol açabilen, tekrarlayıcı takıntı ve zorlantıların görüldüğü, genellikle kronik seyir gösteren, mesleki, sosyal ve toplumsal işlevselliği etkileyen bir hastalıktır. Hastalığın etiyolojisinde nörobiyolojik faktörler ile üstbilişsel süreçleri de kapsayan ruhsal faktörler yer alm...

Introduction Bipolar disorder (BD) is a severe mood disorder, which is characterized by a cycling between the mania and major depression. The relationship between coping strategies and temperament-character traits in BD is unclear at this time. Objectives The aim of our study was to assess the relationship between strategies of coping stress and t...

Introduction Amisulpride is an atypical antipsychotic. Rabbit syndrome(RS) may be seen after antipsychotics use a few days or long‐term application. RS occurs after more frequent typical antipsychotics and also in rare cases atypical antipsychotics.Its characterized by the involuntary rhythmic movements of the lips however involves no tongue moveme...

Introduction Generalized anxiety disorder (GAD) and Obsessive compulsive disorder (OCD) are common psychiatric disorders. Researchers studying the pathophysiology of these two disorders evaluated the effect of metacognition. However, there is no research examining the metacognition differences of these two psychiatric conditions. Objectives This s...

Introduction Venlafaxine is a serotonin-norepinephrine reuptake inhibitor and its extensive use for major depressive disorder and anxiety disorders. Although it has been reported that venlafaxine may have various side effects, as far as we know, spontaneous ejaculation(SE) has not been reported yet. Objectives We aim to describe this clinical case...

BACKGROUND AND AIM: Schizophrenia is a chronic mental disorder that affects approximately one percent of the population and its etiology has not been cleared yet. Neuroinflammation is considered to be involved in the pathophysiology of schizophrenia. Complete blood count and serum biochemistry tests are simple, affordable, and reliable indicators o...

AIM: The "Occult Spinal Dysraphisms" group includes some congenital malformations during embryological development and mesenchymal and ectodermal structures. Tethered Cord Syndrome is not considered a complete closed dysraphism; it generally tends to present as a result of closed dysraphisms. These anomalies are usually seen with neurodevelopmental...

AIM: Dry eye is an ocular surface disorder associated with tear film abnormalities and potentially significant discomfort caused by burning or foreign body sensation, chronic injected eye, increased blinking, or ocular fatigue [1].It is a multifactorial disease, and one of the most prevalent eye diseases, particularly among the elderly [2]. Drug-i...

Objective: The aim of this study was to compare the thickness of the retinal nerve fiber layer (RNFL) with controls in individuals with attention deficit hyperactivity disorder (ADHD) and to examine the relationship between RNFL thickness and the level of performance in disease severity and executive function tests in ADHD cases. Methods: The st...

Nörogelişimsel bozukluklar, çeşitli faktörlerin etkisiyle beyin gelişiminde sorunlara neden olan geniş bir grup hastalığa verilen isimdir. Bu grupta serebral palsi, otizm, şizofreni, dikkat eksikliği ve hiperaktivite bozukluğu, bipolar affektif bozukluk, epilepsi gibi nörolojik ve psikiyatrik açıdan farklı klinik görünümlerle seyreden hastalıklar b...

Schizophrenia is a chronic psychiatric disorder progressing in relapses. Identification of many factors that may potentially increase the risk of relapse will be an important step in preventing relapses. The aim of this study was to determine the rate of early relapse in patients with schizophrenia and possible risk factors related to early relapse...

Transcranial Magnetic Stimulation (TMS) is used reliably as an alternative method in the treatment of a number of treatment-resistant psychiatric disorders. However, information about the daily practice is limited. In this article, we aim to report and discuss the 10-years results of a clinic that applies TMS to treatment-resistant psychiatric diso...

Mental health effects of the COVID-19 pandemic over healthcare workers who are struggling in the foreground are known. However, studies about evaluating the mental state of healthcare workers after COVID-19 infection are limited. This study aimed to assess the effects of COVID-19 infection on depression, anxiety and stress levels in physicians and...

An increasing number of studies have focussed on the neurobiology of schizophrenia (SCH), contributing to a better understanding of this disorder. Prolidase is a metalloprotease found in various tissues, which has been associated with the concentrations of proline, a neurotransmitter, in the brain. There is evidence to suggest that elevated proline...

Introduction Brain‐derived neurotrophic factor (BDNF) is involved in the regulation of many neuronal processes, including neurogenesis. Therefore, it is thought to be closely associated with many psychopathologies with a neurodevelopmental basis, for example, schizophrenia. Methods The patients admitted to the Psychiatry Department of the Faculty...

Clozapine is an atypical antipsychotic demonstrated to be superior in the treatment of refractory schizophrenia. Despite all this effectiveness, it has side effects that can be serious and bothersome. Sialorrhea is the most common adverse drug reaction that occurs during clozapine treatment. It is usually persistent, may impair the patient's qualit...

Background: Negative myoclonus is rarely seen in the clinical setting. It can be involved in some central nervous system pathologies. It has also been observed after antipsychotic treatment. Case reports: In this article, we will present 3 cases diagnosed with negative myoclonus in a 120-bed university-affiliated hospital within the past 7 years...

Psikojenik kusma tedavisinde daha önce çeşitli antidepresan ve antipsikotik ilaçlar kullanılmıştır. Bildiğimiz kadarıyla vakamız psikojenik kusma tedavisinde EMDR uygulanan ilk vakadır. EMDR'nin psikojenik kusma üzerine etkisinin açıklanabilmesi daha çok ve kontrollü çalışmalara ihtiyaç bulunmaktadır. Olgumuzdan yola çıkarak EMDR'nin psikojenik kus...

Konuşma kişiler arası iletişimin en önemli yoludur. Konuşma bozukluğu; konuşmanın akışında, ritminde, tizliğinde, vurgularında, ses birimlerinin çıkarılmasında ve anlaşılmasında bir bozukluğun olması olarak tanımlanmaktadır. Konuşmanın bozuk olması kişide ruhsal bozukluklara sebep olabildiği gibi bazen de konuşmanın bozulmasının altında yatan neden...

Non-invazif beyin uyarım yöntemi olan rTMS'nin kullanımının artması ile birlikte depresyon dışında çeşitli psikiyatrik bozukluklarda kullanımı artmaya başlamıştır. Literatür incelendiğinde rTMS depresyon dışında obsesif kompulsif bozukluk, işitsel halüsinasyonlar, tinnitus gibi çeşitli hastalıklarda kullanılmıştır. Çalışmaların sonuçları halen çeli...

Objective: Findings about inflammatory processes in schizophrenia are increasing day by day. Inflammatory processes in schizophrenia are associated with both its etiology and clinical symptoms. Serum high-sensitivity C-reactive protein (hsCRP) is also one of these inflammatory processes. Particularly, it is thought to be closely related to clinica...

Mirtazapine Associated Prostatism: A Case Report

Parkinsonism is a clinical disorder that can occur after initiation of antipsychotic treatment, and is characterized by tremor, akinesia, bradykinesia and muscle rigidity. The development of parkinsonism symptoms are dose dependent and occurs in approximately 20‐40% of patients. This article is protected by copyright. All rights reserved.

Objective: Myostatin is a growth factor which is investigated regarding musculoskeletal system. Albeit its effect on muscle mass is known, it is considered likely having other unknown effects as well, particularly on central nervous system. With this study, it is aimed to find out that what type of effect electroconvulsive therapy (ECT) does on my...

Agmatine is an endogenous NMDA (N-methyl-D-aspartate) antagonist which is synthesized from L-arginine and described as a novel neurotransmitter. Agmatine is considered to play an important role for the development of schizophrenia. The aim of the present study is to explore the role of agmatine and L-arginine metabolism in medication-naive first-ep...

Objective: Although it has been known that adult patients with an adjustment disorder diagnosis do not have suicidal behavior similar to adolescents, the validity of this assertion in particular groups is unknown. This study was designed to determine the prevalence and risk factors associated with suicide in patients with adjustment disorder that r...

In this review, we have attempted to share our 10 years’ clinical experience with aripiprazole use and switching from other antipsychotics to aripiprazole. There are various reasons for switching, including a partial or complete lack of efficacy, adverse side effects, and partial or noncompliance with medication. Aripiprazole has some unique recept...

Objective: Bipolar disorder (BD) is a chronic mood disorder characterized by recurrent episodes that has a lifetime prevalence of 0.4- 5.5%. The neurochemical mechanism of BD is not fully understood. Oxidative stress in neurons causes lipid peroxidation in proteins associated with neuronal membranes and intracellular enzymes and it may lead to dys...

Choroidal fissure cysts (CFC) are often incidentally identified and generally regarded not to present with overt clinical signs. To the best of our knowledge, any case report of a psychosis with coincidental CFC has not been published before in the literature. Electroconvulsive therapy (ECT) has been frequently considered relatively contraindicated...

Tardive syndromes (TS) are a group of delayed-onset abnormal involuntary movement disorders induced by a dopamine receptor blocking agent. Tardive syndromes remains a relevant clinical problem despite the increasing use of new-generation antipsychotics. Antipsychotic- induced tardive syndromes are difficult to treat and have a low tendency of remis...

Introduction: Hyperarousal and alertness play an important role in the clinical presentation of Post-traumatic stress disorder (PTSD). Strenuous effort has been made to shed light on the mechanisms that cause these symptoms of patients. Based on the claim that there is a relationship between some subtypes of hyperarousal symptoms and aggression in...

Objective: Depression is an important syndrome occuring frequently during the course of schizophrenia. In patients using atypical antipsychotics in the treatment of schizophrenia, depressive symptoms are expected at a lower rate. In this retrospective study, evaluation of depressive symptoms in patients who were monitored for one year with first-ep...

The etiology of schizophrenia is not precisely known; however, mitochondrial function and cerebral energy metabolism abnormalities were determined to be possible factors associated with the etiology of schizophrenia. Impaired mitochondrial function negatively affects neuronal plasticity, and can cause cognitive deficits and behavioral abnormalities...

Objective: The frequency of electroconvulsive therapy (ECT) application rates have been reported between 9% and 16.4% in Turkey. These results are higher than in the United States, European countries and some Asia-Pacific countries. These rates do not reflect the actual prevalence of ECT in the general psychiatric population due to nonexitence of a...

Accession Number: 86653728; Bolu, Abdullah 1; Email Address: abdullah_bolu@yahoo.com Erdem, Murat 1 Balıkcı, Adem 1 Emrah Bilgen, Ali 1 Özgür Akgül, Emin 2 Uzun, Özcan 1 Öztosun, Muzaffer 3; Affiliation: 1: MD, GATA Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Ankara-Türkiye 2: GATA Biyokimya Anabilim Dalı, Ankara - Türkiye 3: TSK Sağlık Komutanlığı...

In explaining the association between depression and immune system pro-inflammatory cytokines have come to the fore and there appears to be an increase in particular at the cellular immune response. Neopterin measurements enable monitoring of the cellular immune response although its specific function is still not fully described. Similarly, haptog...

Objective: Especially for patients with chronic diseases, adherence is an important factor that interferes with the success of treatment. There are few reports examining adherence to appointments and medication in diagnostically specific groups such as individuals with schizophrenia. This study aimed to examine the correlates of missed appointments...

Hypogonadotropic hypogonadism is defined as the failure in production of gonadal hormones, thus resulting in lower amounts of testosterone. Depression, anxiety and decreased quality of life are the most common psychopathological conditions in young hypogonadal men. The aim of the present study was to assess the still debated relationship with testo...

Objective: There is some evidence that acute episode of psychosis is characterized by immune alterations, but there are conflicting results about this issue. The aim of this study was to determine whether serum haptoglobin and neopterin concentrations in patients with first episode psychosis are different from those in control subjects. Methods: Fo...

An increasing number of reports in the literature indicate that asymmetric dimethylarginine (ADMA) regulates nitric oxide generation in numerous disease states. ADMA has been less studied in psychiatric disorders. The purpose of this study was to determine plasma ADMA concentrations in patients with schizophrenia compared to healthy controls. The s...

Major depression (MD) is accompanied by systemic immune activation or an inflammatory response with the involvement of phagocytic cells, T cell activation, B cell proliferation, and an acute phase response with increased levels of positive and decreased levels of negative acute-phase proteins. In this study, we aimed to determine any differences in...

Neurosyphilis is an infection of central nervous system caused by Treponema pallidum and may present with neuropsychiatric symptoms. Neurosyphilis can mimic virtually any psychiatric disorder, including depression, mania, psychosis, personality changes, delirium and dementia. Neurosyphilis is a mysterious disease because it imitates psychiatric dis...

Hanging is one of the methods that have the highest mortality rate among other suicide attempts. In the unsuccessful hanging attempts morbidity is usually severe. As a result of hanging, the cerebral blood flow is interrupted due to the acute occlusion of the vertebral arteries and, hypoxic encephalopathy develops due to the reduction in oxygen and...

In this study, it was aimed to evaluate the neuropsychological tests and clinical presentation of Tourette's syndrome in adolescence, which classically begins in childhood by reviewing the patients who were diagnosed to have the syndrome during medical examination of military service. Patients admitted to the Department of Psychiatry of Gulhane Mil...

Body dysmorphic disorder (BDD) is a relatively common and severe disorder for which pharmacotherapy has been only minimally studied. BDD often appears to respond to selective serotonin reuptake inhibitors (SSRIs), but many patients do not respond or respond only partially. Investigation of SSRI augmentation strategies is therefore needed. We report...

Aim: To determine the possible relationship between toxoplasmosis and patients with first-episode schizophrenia (FES). Materials and methods: Seventy-three subjects with FES (15-54 years old; mean: 23.4 years) and 40 healthy individuals (20-54 years old; mean: 30.3 years) were enrolled in the study. Most of the FES patients (90.4%) and the control...

Objective: There is close relation and interaction between the skin and the nervous system. Personality traits are important for this relation and interaction. The results of the studies investigated the impact of personality on skin disorders are controversial. This controversy can also be observed between alexithymia, which is an extension of per...

Bruxism, defined as involuntarily or unconsciously clenching or grinding the teeth, typically during sleep, may cause dysfunction of temporomandybular joint, periodontal disease, tooth wear, hypertrophy of masticatory muscles and headache. It is reported that bruxism can occur because of SSRIs and Venlafaksin. Buspirone, that is partial agonist of...

Objective: Peripheral edema generally develops with systemic diseases and drugs such as non-steroids, antihypertensive, steroids, and immune suppressors (1). There are a limited number of reports among psychotropic drugs indicating that atypical antipsychotic (2-4) may cause peripheral edema. Olanzapin attracts attention among atypical antipsychoti...

It is hypothesized that molecular components of dopaminergic system, especially the dopamine D3 receptor gene (DRD3), may play a crucial role in the pathophysiology of schizophrenia, because it is abundant in the limbic system of the brain and it binds antipsychotic drugs. Several groups attempted to find an association between a serine-to-glycine...

Most of the symptoms of schizophrenia bring mind the symptoms of temporal area illnesses. 1H-MRS studies carried out on schizophrenia patients focused especially on temporal and frontal lobes and basal ganglions. In this study, it was aimed to detect the 1H-MRS findings of left temporal lobe in patients with Schizophrenia. Twenty seven patients dia...

Suicide attempt is a universally observed human behavior related to bio-psychological, social and cultural factors. While some studies have suggested that specific demographic/cultural and clinical variables are associated with suicide attempts in schizophrenia, these associations are often inconsistent. The aim of this study was to investigate the...

Obsessive-compulsive disorder (OCD) is a relatively common, often chronic and disabling disorder with high rates of partial and/or absent response to standard, recommended treatments. We report a case of treatment-resistant OCD that was successfully treated with a pharmacological augmentation of lamotrigine plus clomipramine. The patient, a 59-year...

The focus of this study was the systematic evaluation of the clinical effects of the extract of ginkgo biloba (EGb) as an adjunct to the atypical antipsychotic clozapine in the treatment of refractory schizophrenia. In a placebo-controlled study, 42 patients with chronic, treatment-resistant schizophrenia, who were maintained on optimal doses of cl...

To evaluate the effect of mirtazapine augmentation in patients with sexual dysfunction induced by current selective serotonin reuptake inhibitor (SSRI) treatment. Forty-nine outpatients in remission from major depressive disorder with SSRI treatment and experiencing treatment-emergent sexual dysfunction were invited to participate and 33 (25 women...

Introduction: The prevalence of substance use disorder (SUD) in subjects with first-episode psychosis (FEP) was reported between 6-62 %. The aim of this study was to strengthen our knowledge about characteristics of substance use and its effects on clinical features in these subjects. Methods: The subjects (n=111) were divided into two separate gro...

Several lines of evidence suggest that clozapine is more effective than both first- and second-generation antipsychotic drugs in treatment-resistant schizophrenia (TRS). However, clinicians appear to be hesitant to prescribe this drug. It would therefore be extremely valuable if predictors of response to clozapine could be identified. The aim of th...

Objective: The prevalence of body dysmorphic disorder (BDD) in patients with borderline personality disorder (BPD) is unidentified. We hypothesised that BDD would be more common than realised in patients with BPD and comorbidity with BDD would result in a more severe clinical profile. Also, childhood trauma may play a predictive role in this associ...

The specific associations between antidepressant treatment and alterations in the levels of cytokines remain to be elucidated. In this study, we aimed to explore the role of IL-2, IL-4, IL-12, TNF-alpha, TGF-beta1, and MCP-1 in major depression and to investigate the effects of sertraline therapy. Cytokine and chemokine levels were measured at the...

Tardive oculogyric crisis (OGC) is a dystonic syndrome that starts after long-term use of dopamine receptor antagonists. Atypical antipsychotics have reduced liability for inducing tardive dystonia and show antidystonic properties in patients with pre-existing tardive dystonia. Clozapine is an atypical antipsychotic drug, and there have been case r...

Dissociative experiences are widespread among patients with panic disorder and have a negative impact on cognitive-behavioural therapy. In this study we aimed to investigate whether or not dissociative experiences affect response to drug treatment for panic disorder. Thirty-five patients, 20 women and 15 men, with a mean age of 35.4 years and a dia...

Objective: The purpose of this study was to determine of anxiety disorders at cases of joint hyper-mobility syndrome (JHS) without Mitral Valve Prolapse (MVP) or any other cardiologic problems. Method: Forty-four patients (22.05±1.3 years) with JHS and any cardiologic problems were evalu­ated and 30 normal individuals (21.93±1.6 years) without JHS...

It has been hypothesized that college women are particularly susceptible to the development and maintenance of disturbed eating behaviors. The purpose of this study was to determine the frequency of disordered eating attitudes and eating disorders in a sample of Turkish female college students. The Eating Attitudes Test was administered to a sample...

This study investigated the prevalence of substance use disorders (SUDs) and "substance of choice" in 500 male Turkish psychiatric outpatients manifesting a DSM-IV diagnosed antisocial personality disorder (APD) and a SUD diagnoses (the Structured Clinical Interview for DSM-IV). Lifetime SUDs were diagnosed in 86% of APD subjects. Alcohol, cannabis...

Objective: The purpose of this study was to determine of anxiety disorders at cases of joint hyper- mobility syndrome (JHS) without Mitral Valve Prolapse (MVP) or any other cardiologic problems. Method: Forty-four patients (22.05±1.3 years) with JHS and any cardiologic problems were evalu- ated and 30 normal individuals (21.93±1.6 years) without JH...

Objective: Combination of mitral valve prolapse and joint hypermobility with panic disorder has been studied well, and the data associated with the combination of thorax deformities and mitral valve prolapse has been also reported by a group of studies. However, we couldn't find any study concerning the association of thorax deformities and panic d...

Shared psychotic disorder is a rare psychiatric syndrome in which a symptom of psychosis is transmitted from one individual to another. This syndrome is most commonly diagnosed when the two or more individuals live in close proximity and may be socially or physically isolated and have little interaction with other people. Folie a trois is a conditi...

Folie a trois: A case report Shared psychotic disorder is a rare psychiatric syndrome in which a symptom of psychosis is transmitted from one individual to another. This syndrome is most commonly diagnosed when the two or more individuals live in close proximity and may be socially or physically isolated and have little interaction with other peopl...