Oya Kerimoğlu

Oya Kerimoğlu
Marmara University · Department of Pharmaceutical Technology

Doctor of Pharmacy

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70
Publications
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388
Citations
Introduction

Publications

Publications (70)
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Oxaceprol is well‐defined therapeutic agent as an atypical inhibitor of inflammation in osteoarthritis. In the present study, we aimed to develop and characterize oxaceprol‐loaded poly‐lactide‐co‐glycolide (PLGA) nanoparticles for intra‐articular administration in osteoarthritis. PLGA nanoparticles were prepared by double‐emulsion solvent evaporati...
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Turkey 1. Editorial Transdermal drug delivery systems (TDDS) are adhesive patches which deliver the therapeutic agent through the skin at a controlled rate to the systemic circulation and to the target organs (1). These systems provide more convenient and effective therapy compared with the oral and parenteral ways. The most important advantages ar...
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Mini tablets are solid dosage forms with a diameter ≤ 3 mm and separated into subunits of conventional tablets. Production methods are similar to standard tablets, but the only difference is the use of multiple punches. They have advantageous for use in patients suffering from swallowing diffi culty and receiving multiple drug treatment. They provi...
Poster
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According to new developed technologies, drug industry is also triying to refresh and improve itself. With the conception of rational pharmacotherapy, new technologies becomes smarter than finding new active substances. Correspondingly as a new dosage system, multi-layer tablets that improved to serve this purpose, provides ease of use to patients,...
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Peripheral nerve gaps exceeding 1 cm require a bridging repair strategy. Clinical feasibility of autogenous nerve grafting is limited by donor site comorbidity. In this study we investigated neuroregenerative efficacy of autogenous vein grafts implanted with tissue fragments from distal nerve in combination with vascular endothelial growth factor (...
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Hydrocolloid pectin formulation was utilized as a novel base for fabricating biodegradable micro-needle (MN) arrays. The pectin MNs were, on average, found to be 897.71±3.48 µm in height and 234.31±2.27 µm in base width, with an inter base spacing of 498.66±1.60 µm, and corresponding to an aspect ratio of 3.83±0.04. Bovine serum albumin (BSA) and p...
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Microfabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays (MNs) were extensively investigated based in a nano sensitive fabrication style known as micromilling that is then combined with conventional micromolding technique. The aim of this study was to describe the polymer selection, and optimize formulation compoun...
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The "poke and release" strategy for the delivery of macromolecules using polymeric microneedle (MN) is of great importance because it eliminates microneedle reuse, the risks of biohazardous sharps and cross contamination, and it requires no special disposal mechanism. The main objective of this study was the determination of the stability and deliv...
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Transdermal therapeutic systems (TTS) containing captopril were developed by using synthetic and pH independent polymers, Eudragit RL 100 and RS 100. The formulations were characterized in terms of their appearance, thickness, captopril content, in vitro release rate and diffusion profiles. In vitro release studies demonstrated controlled release f...
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In this study, nano sensitively fabricated metallic micro device was combined with conventional micromolding technique in order to assemble polymeric micro needle arrays. We describe the polymer selection and optimization of the fabrication parameters for dissolvable, swellable, and biodegradable polymeric microneedle arrays. Sodium alginate (SA),...
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The most commonly used surgical technique for repairing segmental nerve defects is autogenous nerve grafting; however, this method causes donor site morbidity. In this study, we sought to produce prefabricated nerve grafts that can serve as a conduit instead of autologous nerve using a controlled release system created with vascular endothelial gro...
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Objective: The aim of this study was to encapsulate vascular endothelial growth factor (VEGF) in poly(lactic-co-glycolic acid) (PLGA) microspheres using a water-in-oil-in-water emulsification method. Particle size distribution and surface morphology of PLGA microspheres and VEGF loaded PLGA microspheres were investigated. The effect of VEGF in free...
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Batch supercritical antisolvent precipitation (SAS) process was used to coprecipitate Cefuroxime Axetil amorphous (CFA, antibiotic) and Polyvinylpyrrolidone (PVP-K30) for preparing drug–polymer composite particles. Solutions of CFA and PVP-K30 in methanol with overall concentrations of 50–150mg/ml and polymer/drug ratios of 1/1–4/1 were sprayed int...
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The purpose of this work was to investigate the physical properties of drug-loaded poly(methacrylic acid-g-ethylene glycol) {P(MAA-g-EG)} particles, their biocompatibility with the gastrointestinal tract of rats and also the effects of these particles on the tight junctions of the rat intestinal epithelium. Model drugs such as diltiazem HCl, diclof...
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The objective of this study was to prepare and evaluate carrageenan beads as a controlled release system for a freely water soluble drug verapamil hydrochloride and a slightly water soluble drug ibuprofen. Beads were prepared by ionotropic gelation method. The influence of formulation factors (drug content, polymer concentration, counterion type an...

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