Ouedraogo Noufou

Centre National de Recherche Scientifique et Technologique | CNRST · Institut de Recherche en Science de la Santé/Médecine-Pharmacopée Traditionnelle/pharmacie

Aims: to determine the antioxidant, anti-inflammatory and analgesic potential of aqueous decoctation (AD), aqueous maceration (AM) and hydroethanol maceration (HEM) of the plant. Methodology: Thin-layer chromatography (TLC) was performed to identify extracts compounds. In vitro evaluation of the antioxidant potential of the extracts was carried out...

This study aims to assess the importance and availability of Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler, a plant confined to the western region of Burkina Faso and used as an alternative herbal remedy for sickle cell disease. Semi-structured interviews were conducted with 60 volunteers from western Burkina Faso in May 2021. The interviews f...

An Improved Traditional Medicine (ITM) in capsule form presented by traditional health practitioners in Burkina Faso as used for hepatoprotective and hepatocurative treatment for viral hepatitis B. The study's main objective was to investigate the anti-inflammatory properties of this ITM, which is used in treating viral hepatitis B in traditional m...

This study aims to contribute to the sustainable use of plant resources. Thus, 38 species with hepatoprotective potential were sampled in several locations of Burkina Faso between May and October 2021. These species were identified during previous surveys with traditional healers. These plants' leaves, roots, and trunk barks were collected and proc...

The aim of this study was to perform phytochemical investigations of three medicinal plants oriented against antioxidant and anti-inflammatory activities. The spectrophotometer was used for quantification tests. The antioxidant activity was evaluated by ABTS •+ , DPPH • and FRAP method. The acute toxicity (OECD 423) and the anti-edematous activity...

La maladie hémorroïdaire est un état pathologique caractérisé par une dilatation de la veine recto-anale plexus. Une enquête ethnobotanique a révélé l’utilisation des écorces de tronc de Parkia biglobosa (Jacq.) sous forme de pommade ou décoction en lavement anal pour son traitement. L’objectif de cette étude était de caractériser l’extrait afin de...

Introduction Waltheria indica Linn (Malvaceae) is a widely distributed plant in West Africa. It is commonly used in Burkina Faso to treat inflammation-related diseases, including asthma. Previous reviews have focused on the ethnobotanical, traditional uses, phytochemistry, and pharmacological properties of Waltheria indica. This report aims to comp...

Introduction: Ampelocissus africana is a medicinal plant used to treat several diseases, including those affecting the prostate. This study investigated the effects of the aqueous extract of rhizomes from Ampelocissus africana (AAA) on a testosterone propionate (TP)-induced benign prostatic hyperplasia (BPH) model. Methods: The effect of the extrac...

Background: The leaves of Odontonema strictum (Nees) Kuntze (Acanthaceae), a decorative plant native to Latin America, are used to treat hypertension in alternative medicine. However, the other parts of the plant have not yet been investigated for their antihypertensive properties. Aims: Our study aimed to investigate phytochemical groups with anti...

Background Dengue fever (DF) is a significant public health concern in Burkina Faso, particularly in the Central Region, previously endemic for malaria. However, limited research has focused on dengue prevalence and associated factors among adult febrile patients in this region. This study aimed to estimate the prevalence of symptomatic dengue feve...

Aims: Our study aimed to evaluate the chemical profile, the antioxidant and anti-inflammatory activities, the spasmolytic effects, and the safety of use of hydroethanolic extract (HE_FDM) and aqueous macerate extract (AM_FDM) of Diospyros mespiliformis immature fruits. Place and Duration of Study: Immature fruits of Diospyros mespiliformis were col...

The present study investigated the phytochemical content of Hibiscus panduriformis, Alternanthera pungens, and Wissadula rostrata and assessed their radical scavenging and anti-inflammatory properties. n-Hexane, dichloromethane (DCM), ethyl acetate, and methanol extracts were prepared from the powdered plant parts. The phytochemical analysis was pe...

Introduction : Sclerocarya birrea (A.Rich.) Hochst est une plante utilisée comme des précurseurs de composés naturels bioactifs utilisées par l’homme pour ses diverses propriétés telles qu’antihelminthiques, antibactériennes, antioxydantes, antidiabétiques, anti-inflammatoires et éventuellement un effet sur l’utérus gravide. Le but de cette étude é...

Objective In traditional folk medicine, Ceiba pentandra has been used for its anti-diabetic and anti-infective effects. The present study investigates the anti-inflammatory and antioxidant activities of the aqueous extract of the plant's leaves. Methods The anti-oedematous tests with carrageenan and Lipoxygenase inhibition assay were carried out c...

Reactive oxygen species (ROS), known as normal by-products of various cellular processes, are involved in several human diseases, including cancer and liver diseases. The present study aimed to (i) determine the polyphenol contents, (ii) assess the antioxidant, and (iii) antiproliferative effects of a mixture composed of Balanites aegyptiaca, Calot...

Aims: Herbal remedies are known for their anti-inflammatory and antioxidant properties. The aim of this study was to evaluate the antioxidant activities of the aqueous extracts of the bark of the trunk of 10 medicinal plants used in traditional medicine for the management of hepatic pathologies. This is Acacia nilotica (L.) Willd. ex Delile (Fabace...

Dermatoses are essentially caused by infection or free radical aggression, immunoallergic disorders, or can be secondary to general diseases. Management of dermatoses by modern medicine is complex and costly, and the development of alternative treatments is urgent. Opilia amentacea Roxb. is a woody climber plant traditionally used in Burkina Faso f...

Prosopis africana is one of the plants commonly used in traditional medicine in Burkina Faso. Several studies have shown that this plant contains many compounds, which gives it different pharmacological properties. The objective of this work was to determine the phytochemical and toxicological profile and also the effect of extracts from this medic...

Anastatica hierochuntica L. (Brassicaceae) has been claimed to treat various conditions including complicated childbirth. The principal objective of this research was to provide scientific evidence on the contractile effect of the aqueous and hydroethanolic extracts of the whole plant from A. hierochuntica during labor. Qualitative and quantitative...

Dermatoses are essentially due to infectious or free radical aggression, immunoallergic disor-ders, or can be secondary to general diseases. To investigate new antimicrobial sources against dermatoses, Opilia amentacea crude ethanol extracts and fractions were subjected to phytochemical screening and tested for antioxidant and antimicrobial activit...

Citation: Dofini Magnini, R.; Pedinielli, F.; Vergalli, J.; Ouedraogo, N.; Remy, S.; Hilou, A.; Brunel, J.-M.; Pagès, J.-M.; Davin-Regli, A. Acacia senegal Budmunchiamines as a Potential Adjuvant for Rejuvenating Phenicol Activities towards Escherichia coli-Resistant Strains. Int. J. Mol. Sci. 2023, 24, 8790. https:// Abstract: The continuous emerg...

Introduction: Oxidative stress, through the increased bioavailability of reactive oxygen species (ROS), is a major cause of hypertension. The resulting endothelial remodeling promotes the production of vasoconstrictor substances leading to an increase in blood pressure. This study aimed to evaluate the antioxidant and vasorelaxant properties of the...

Mareya micrantha Müll. Arg. (Euphorbiaceae) is a plant used in the Ivorian traditional medicinal system for various medical properties such as laxative, oxytocic, intestinal infectious diseases, malaria, etc. Six cucurbitacin derivatives (tetracyclic triterpenoids) are isolated from the leaves, stem barks or root barks of M. micrantha. Among these...

Leaves of Lannea velutina are used to treat several human pathologies, such as high blood pressure (HBP) and oxidative stress. Rich in bioactive components that promote prevention and therapy, herbal medicines are affordable and have no adverse effects. This work aims to evaluate the phytochemical profile, antioxidant activity, and acute toxicity o...

Objective: This study focused on the antibacterial and anti-proliferative activity of extracts from Carica papaya and Cocos nucifera roots. Methodology: The minimum inhibitory concentration and the minimum bactericidal concentration of the extracts on Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans, and Staphylococcus aureus were ded...

Objective: This study was conducted to determine the physicochemical characteristics and organic and inorganic contaminants of Parkia biglobosa trunk bark powders collected in four localities (Gonse, Yako, Bobo and Nobere) of Burkina Faso. Methods: The parameters studied were the physicochemical characters, the contents of heavy metals, pesticides...

Background: Some insects are harmful to humans, plants and animals, but some of them can also be a source of proteins, fats, vitamins and minerals and be of therapeutic value. The therapeutic potential requires that medicinal insects and their derived products need to be scrutinized. This study highlights the indigenous knowledge related to their u...

Background Some insects are harmful to humans, plants and animals, but some of them can also be a source of proteins, fats, vitamins and minerals and be of therapeutic value. The therapeutic potential requires that medicinal insects and their derived products need to be scrutinized. This study highlights the indigenous knowledge related to their us...

Moringa oleifera (LAM) is a multipurpose tropical tree. It is nowadays a new food and economic resource for Southern countries. The leaves of Moringa oleifera are very rich in protein vitamins and minerals. They are increasingly used in projects fighting against malnutrition. However, the taste, presentation and quality of these products remain a m...

Hypertension and diabetes are major public health issues in developed and low-income countries today. The prevalence of these diseases is higher in low-income countries due to high population density, weak health care systems, and a high number of undiagnosed and untreated people. Due to these factors, the majority of patients rely heavily on herba...

In Burkina Faso, sickle cell syndromes affect 8.42% of hospital patients. For the management of sickle cell anemia, a phytomedicine called FACA® capsules based on a mixture of roots barks powdered from Calotropis procera and Zanthozylum zanthozyloïdes has been developed. The objective of this study was to evaluate the acute and sub-chronic toxicity...

Background: Hypertension and diabetes are major public health issues in developed and low-income countries today. The prevalence of these diseases is higher in low-income countries due to high population density, weak health care systems, and a high number of undiagnosed and untreated people. Due to these factors, the majority of patients rely heav...

Lannea velutina is a traditional herbal remedy used to treat various diseases, including hypertension (HBP). Herbal medicines are affordable, and some have minimal side effects; they are rich in bioactive components that encourage prevention and treatment. This work uses appropriate experimental paradigms to investigate the phytochemical compositio...

Herbal therapies are used by about 88% of the world's population and 90% of the African population still depend on medicinal plants for their health and well-being. In Burkina Faso, traditional medicine remain the main source of primary health care for 70% of the population. However, some plant-based preparations have toxic effects that can lead to...

Many plants are largely used in alternative medicine of Burkina Faso for neuropsychiatric disorders treatment. However, their neuro-pharmacological properties are less evaluated through scientific studies. The present study aims to evaluate the neuroprotective effect of Calotropis procera leaves and root-bark aqueous extract, focusing on a scopolam...

Prosopis africana (Guill. & Perr.) Taub. (Fabaceae) is used in the herbal medicine of Burkina Faso to treat dental caries. This study aims to contribute to the valorization of the said plant by investigating the antioxidant, anti-inflammatory and antibacterial properties of aqueous leaves and stems extracts. The inhibitory activity on lipoxygenase...

Background: Diethylnitrosamine (DEN) is a hepatotoxin whose metabolic activation by liver cytochromes P450 is responsible for the necrosis, mutagenicity and carcinogenicity of liver cells. The purpose of this study was to evaluate the protective effects of Calotropis procera roots bark against DEN induced hepatocellular damage in rats. Material and...

Aims: The aim of this study is to evaluate the content of phenolic compounds, antioxidant and 15-lipoxygenase inhibition effects of methanolic extract and its fractions of Daniellia. oliveri stem bark. Place and Duration of Study: The work was carried out in the Department of Traditional Pharmacopoeia and Pharmacy (MEPHATRA / PH) of the Institute f...

Aims: The aim of this study was to evaluate the anti-inflammatory and analgesic activities of Daniellia oliveri methanolic extract and its fractions in NMRI mice. Study Design: In vivo acute toxicity, anti-inflammatory and analgesic assays. Place and Duration of Study: The work was carried out in the Department of Traditional Pharmacopoeia and Phar...

Background The present study investigates the effect of an aqueous extract of Anogeissus leiocarpa (AEAL) on normotensive Wistar rats and its chronic antihypertensive effects in L-NAME-induced hypertensive rats by using a non-invasive tail-cuff model. Methods The effects of AEAL (50mg/kg) and NaCl 0.9% on blood pressure were investigated by daily...

Cocos nucifera L. (Arecaceae) and Carica papaya L. (Caricaceae) are two plants used to treat several human pathologies such as oxidative stress and inflammatory diseases. The aim of this study is to assess anti-inflammatory activity, antioxidant activity and acute oral toxicity, of aqueous and methanolic extracts from C. nucifera L. and C. papaya L...

Background and Objectives: Carapa procera is a popular herb used by traditional healers in the western part of Burkina Faso. In a previous study, Carapa procera showed interesting antiplasmodial activity in vitro against P. falciparum . The present study aimed to evaluate its in vivo potential against malaria parasites and its safety in mice. Mater...

Objective: The objective of this study was to evaluate the in vitro and in vivo anti-inflammatory properties of the aqueous extract and fractions of the trunk bark of Acacia nilotica. Methods: A maceration of the powder of the trunks barks of the plant was realized. Then the aqueous macerate obtained was fractionated with dichloromethane, butanol a...

Diabetes mellitus is a socially significant disease characterized by chronic hyperglycemia and metabolic disorders of proteins, carbohydrates, and lipids due to reduced function of insulin. Medicinal plants, rich in bioactive components that promote prevention and treatment, are inexpensive and no side effects. Apium graveolens , Cleome gynandra ,...

Like other countries in sub-Saharan Africa, hypertension is currently a public health problem in Togo. To decrease the insufficient of the methods previously used, a new survey technique, namely ATRM (Achat en Triplet des Recettes Médicinales), has been proposed. This study aims to contribute to a better knowledge of traditional remedies for their...