Osorio Lyda

Universidad del Valle (Colombia) | UNIVALLE · School of Public Health

Background Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia. Methods Individual patient data from eligible antimala...

This protocol proposes an approach to assessing the place of residence as a spatial determinant of health in cities where traffic congestion might impact health services accessibility. The study provides dynamic travel times presenting data in ways that help shape decisions and spur action by diverse stakeholders and sectors. Equity assessments in...

Background and Objectives Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurologic side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed in 1:4,000 ZIKV cases. Whether the neurologic symptoms of ZIKV infection are immune mediated is unclear. We used rod...

Accesibilidad a los servicios de salud con una perspectiva de equidad: Evaluaciones dinámicas con datos públicamente disponibles.

We share progress made with a new approach to assessing equity in accessibility to health services and using travel times as a metric for accessibility to health services. Oral presentation in Hybrid format. Comprehensive primary care in promoting sustainability - Assuring access to health care for all

Objectives To test a new approach to characterise accessibility to tertiary care emergency health services in urban Cali and assess the links between accessibility and sociodemographic factors relevant to health equity. Design The impact of traffic congestion on accessibility to tertiary care emergency departments was studied with an equity perspe...

This protocol proposes an approach to assessing the place of residence as a spatial determinant of health in cities where traffic congestion might impact health services accessibility. The study will explore the use of dynamic travel times, instead of travelled distance, to inform urban and health services planning and evaluation. It aims to presen...

Loop-mediated amplification has been promoted for SARS-CoV-2 screening, however, antigen tests are preferred in low-income countries and remote zones. Poor training in molecular biology, plus the need for RNA purification or reading instruments to overcome issues of sensitivity in colorimetric detection, are some of the reasons limiting the use of...

This study provides data on equity in accessibility to tertiary care emergency services in Cali, accounting for traffic congestion, in two separate weeks in 2020. This cross-sectional study builds on a proof-of-concept, the AMORE Project ⁽¹⁾ and provides a baseline assessment of accessibility to urgent tertiary care at peak and free flow traffic ti...

Objectives: To obtain dynamic spatial-temporal accessibility measurements of travel times by car to haemodialysis services and assess potential benefits of adding new services. Design: Cross-sectional analyses of dynamic spatial-temporal accessibility, accounting for traffic congestion. A web-based platform integrating public census and health ser...

Introduction Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurological side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed in 1:4000 ZIKV cases. Whether the neurological symptoms of ZIKV infection are a consequence of autoimmunity or direct neurotoxi...

Global health research partnerships with institutions from high-income countries and low- and middle-income countries are one of the European Commission's flagship programmes. Here, we report on the ZikaPLAN research consortium funded by the European Commission with the primary goal of addressing the urgent knowledge gaps related to the Zika epidem...

Background Healthcare Workers (HCW) are repeatedly exposed to SARS-CoV-2 infection. The aim of this study was to identify factors associated with SARS-CoV-2 infection among HCW in one of the largest cities in Colombia. Methods We conducted a case–control study, where cases had a positive reverse transcription-polymerase chain reaction and controls...

Here you have the requested PDF. It is a poster abstract. Please note that this is a personnal copy which is not supposed to be shared nor diffused online. Thank you. Best regards Cynthia

Background Control of cutaneous leishmaniasis by public health systems in the Americas relies on case identification and treatment. Point-of-care diagnostics that can be performed by health workers within or near affected communities could effectively bring the health system to the resource-limited sites providing early diagnosis and treatment, red...

Background: Healthcare Workers (HCW) are repeatedly exposed to SARS-CoV-2 infection. The aim of this study was to identify factors associated with SARS-CoV-2 infection among HCW in one of the largest cities in Colombia. Methods: We conducted a case-control study, where cases had a positive reverse transcription-polymerase chain reaction and control...

To improve dengue triage and treatment decisions, the WHO recommends classifying the disease as dengue with or without warning signs or severe dengue. Vascular leakage is a key component of the pathophysiology of severe dengue and is detectable by ultrasound. The objective of this scoping review is to describe the primary literature on the use of u...

Introduction: The Xpert MTB/RIF™ is a rapid molecular test that diagnoses tuberculosis and rifampin resistance. Since 2010, it is recommended by the World Health Organization (WHO) and although it was introduced in Colombia since 2012, the results of its implementation are unknown. Objective: To describe the coverage and fidelity in the implementat...

Diagnosing dengue in endemic areas remains problematic because of the low specificity of the symptoms and lack of accurate diagnostic tests. This study aimed to develop and prospectively validate, under routine care, dengue diagnostic clinical algorithms. The study was carried out in two phases. First, diagnostic algorithms were developed using a d...

The diagnosis of infectious diseases is difficult without appropriate testing. Presumptive treatment may put the patient in danger and, prompt the emergence of drug resistance, and the spread of these diseases. Laboratory tests are usually expensive, requiring highly trained personnel, and specialized settings. This systematic search found that sim...

Background Arboviruses transmitted by day-biting Aedes mosquitoes are a major public health concern. With the challenges inherent in arbovirus vaccine and therapeutics development, vector control and bite prevention strategies are among the limited options available for immediate intervention. Bite prevention through personal protective technologie...

Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to Jun...

There is insufficient evidence on whether dengue rapid diagnostic tests (dRDTs) influence clinical decisions in endemic areas. Therefore, our objective was to evaluate the impact of dRDTs on the prescription of antibiotics and anti-inflammatory drugs by physicians in a dengue-endemic area in Colombia. A retrospective cohort study was conducted with...

Introducción. Dado el aumento de la incidencia y la mortalidad por dengue, su diagnóstico es relevante para los países endémicos. Las clasificaciones clínicas y las pruebas de laboratorio existentes tienen un desempeño variable en la práctica clínica, pues su sensibilidad fluctúa entre 45 y 98 %, y su especificidad, entre 4 y 98 %, lo cual se debe,...

Objetivo: Se considera que el diagnóstico del dengue es fundamentalmente clínico; sin embargo, las pruebas rápidas basadas en la detección de IgM o NS1/IgM están siendo utilizadas en los servicios de salud. Este estudio determinó la contribución de las pruebas rápidas al diagnóstico de dengue en un área endémica antes de la introducción del virus z...

INTRODUCTION Due to the increase in dengue incidence and mortality, its diagnosis is relevant for endemic countries. Clinical classifications and laboratory tests have a variable performance in clinical practice with a sensitivity level between 45% and 98%, and a specificity level between 4% and 98% partly due to the variety of contexts where they...

Background: Health personnel face challenges in diagnosing vector-borne and other diseases of poverty in urban settings. There is a need to know what rapid diagnostic technologies are available, have been properly assessed, and are being implemented to improve control of these diseases in the urban context. This paper characterizes evidence on the...

http://revistamedicina.net/ojsanm/index.php/Medicina/article/viewFile/117-1/_1 Editorial Natalia Godoy-Casasbuenas, Manuel Franco, Juan Manuel Lozano, Nancy Gore-Saravia, Grupo Promotor de integración inter sectorial de investigación para la salud, Ranniery Acuña, Liliana Alarcón, Martha Ayala, Juliana Barbosa, Diana Caicedo, Martha Castaño, Mabel...

Few studies have addressed Leptospira seroprevalence and risk factors in urban populations in Colombia. This study aimed to determine seroprevalence and factors associated with Leptospira infection in inhabitants of an urban district of Cali, Colombia. We collected sociodemographic and environmental data, as well as blood samples, from 353 subjects...

Background Metabolic syndrome (MetS) is a common chronic condition that increases the cardiovascular disease risk and is also linked to periodontitis. The study aim was to determine if a relationship exists between MetS and chronic periodontitis in adult Colombians. Methods Participants were 220 healthy-gingivitis subjects and 431 periodontitis pat...

Introduction: Reports of therapeutic failure to meglumine antimoniate (MA) and miltefosine in cutaneous leishmaniasis (CL) varies between species, populations and geographic regions. This study aimed to determine the clinical, drug-related factors, and Leishmania species associated with treatment failure in children and adults with cutaneous leish...

STROBE Checklist. (PDF)

Sensitivity analysis of treatment response at 13 and 26 weeks. (DOCX)

This paper highlights the critical importance of evidence on vector-borne diseases (VBD) prevention and control interventions in urban settings when assessing current and future needs, with a view to setting policy priorities that promote inclusive and equitable urban health services. Research should produce knowledge about policies and interventio...

The prevailing idea of “development” has oriented the emergence of nations since the middle of the twentieth century. The purpose: to assure that the benefits of scientific advances and industrial progress of rich countries are available for underdeveloped areas as well (Sachs 2010). However, every socio-ecosystem today, specially those with vulner...

Background Zika virus (ZIKV) infection has been linked to the Guillain–Barré syndrome. From November 2015 through March 2016, clusters of cases of the Guillain–Barré syndrome were observed during the outbreak of ZIKV infection in Colombia. We characterized the clinical features of cases of Guillain–Barré syndrome in the context of this ZIKV infecti...

Background Non-synonymous mutations in dhfr and dhps genes in Plasmodium vivax are associated with sulfadoxine–pyrimethamine (SP) resistance. The present study aimed to assess the prevalence of point mutations in P. vivax dhfr (pvdhfr) and P. vivax dhps (pvdhps) genes in three countries: Lao PDR, India and Colombia. Methods Samples from 203 micros...

Background: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. An individual pa...

Background Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. An individual pati...

Additional file 2: Figure S1. Relationship between gametocytaemia on enrolment and baseline haemoglobin concentration, parasitaemia and patient age. The predicted probability of gametocyte carriage at enrolment is plotted from the multivariate model; the line indicates the best fit, the shaded area the 95 % CI. Only patients from studies with gamet...

Additional file 3: Table S2. Independent risk factors for the prevalence of gametocytaemia at enrolment in children aged 1–5 years. Logistic multivariable analysis by region with prevalence of gametocytaemia at enrolment as dependent variable. Nobs, Number of observations; Npos, Number of positive observations. The relationship between gametocyte p...

Additional file 8: Table S7. Sensitivity analysis: variation in model coefficients after exclusion of individual studies. 1 Estimates as obtained in the final multivariate models and listed in main tables. 2 RSD, Relative standard deviation was calculated as a ratio of standard deviation to mean of the estimates (odds ratio or hazard ratio) calcula...

Additional file 9: Figure S2. Development of gametocytaemia after treatment evaluated in patients with no gametocytaemia on enrolment and full 28-day follow-up. A: Development of gametocytaemia by artemisinin combination therapy. B: Development of gametocytaemia by treatment outcome. (TIF 284 kb)

Additional file 4: Table S3. The effect of treatment dosing on the appearance of gametocytaemia in participants without microscopically detected gametocytaemia before treatment (time to gametocytaemia) and clearance of gametocytaemia in participants with gametocytaemia at enrolment (time to clearance). All analyses of time to clearance are adjusted...

Additional file 7: Table S6. Factors associated with the development of gametocytaemia after enrolment in individuals who were gametocyte-free before treatment with artemisinin combination therapy. Cox regression model for time to gametocytaemia. Only patients with complete 28-day follow-up are included. (DOC 35 kb)

Additional file 1: Table S1. Overview of all included studies. 1 The sensitivity of microscopy methods was classified into one of four categories: 1 = studies in which slides were specifically read for gametocytes, reviewing at least 100 microscopic high power fields or against ≥ 1000 white blood cells (WBC); 2 = microscopists specifically instruct...

Additional file 5: Table S4. Factors associated with the clearance of gametocytaemia after enrolment in individuals who were gametocytaemic before treatment with artemisinin combination therapy. Nobs, Number of observations; N cleared, Number of patients with day of clearance of gametocytaemia recorded. Derived haemoglobin, conversion from haematoc...

Additional file 6: Table S5. Risk of bias in individual studies included in the analysis. ACT, Artemisinin combination therapy. 1 For trials with non-ACTs, data were only analysed for gametocytaemia on enrolment and regimens, arms, randomization, concealment of treatment, sequence generation and treatment blinding are given as not applicable (NA)....

BACKGROUND: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. An individual pat...

Cada vez son más los países que adoptan las guías de buenas prácticas clínicas como parte de la reglamentación de los estudios clínicos para el registro de productos farmacéuticos y de otros relacionados con la salud. Por ello, todos los involucrados en la investigación y el desarrollo de dichos productos tienen la obligación de conocerlas, impleme...

An increasing number of countries are adopting good clinical practices guidelines as part of the regulation of clinical studies to register pharmaceutical products and other health-related products. Consequently, all parties involved in the research and development of these products should know them, implement them and ensure their compliance. Howe...

Prevention of relapse of Plasmodium vivax infection is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled phase 2b study in Peru, India, Thailand, and Brazil allowed determination of genetically heterologous or homologous P. vivax infection recurrence following receipt of chlor...

Background: Our aim was to determine the influence of breastfeeding and postnatal nutrition on cardiovascular remodeling induced by fetal growth restriction (FGR). Methods: A cohort study including 81 children with birthweight <10 centile (FGR) and 121 with adequate fetal growth (AGA). Cardiovascular end-points were left ventricular sphericity i...

There is insufficient evidence of the usefulness of dengue diagnostic tests under routine conditions. We sought to analyse how physicians are using dengue diagnostics to inform research and development. Subjects attending 14 health institutions in an endemic area of Colombia with either a clinical diagnosis of dengue or for whom a dengue test was o...

Artesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of falciparum malaria. Individual patient data from AS-AQ clinica...

Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is required to avoid the risk of acute hemolysis associated with 8-aminoquinoline treatment. The performance of the BinaxNOW G6PD test compared with the quantitative spectrophotometric analysis of G6PD activity was assessed in 356 Plasmodium vivax-infected subjects in Brazil,...

Introduction: KPC enzymes are carbapenemases with a great capability to disseminate and to cause epidemics. They are frequently associated with higher mortality rates and prolonged hospital stay. In Colombia, they have been progressively reported since 2007; however, its prevalence in hospitals is not known. Objective: To estimate the prevalence...

Dengue incidence continues to increase globally and, in the absence of an efficacious vaccine, prevention strategies are limited to vector control. It has been suggested that targeting the most productive breeding sites instead of all water-holding containers could be a cost-effective vector control strategy. We sought to identify and continuously...

A pesar de la disminución en el número de casos y la mortalidad atribuible a la malaria, esta sigue siendo un problema mundial e importante de salud pública. Este reporte, presenta algunos ejemplos de la contribución de la epidemiología al control de la malaria y también motiva a una reflexión en el sentido contrario, de la contribución de la malar...

Despite the number of cases and attributable mortality having become reduced, malaria continues to be an important public health problem. This report presents some examples of epidemiology's contribution to malaria control; it also motivates reflexion to the contrary, i.e. malaria's contribution to the development of epidemiology. Attempting to ide...

Introduction: There are very few strategies for the early detection of the patients who might develop the severe form of the illness. Objective: To evaluate the utility of serum levels of some immune response mediators as early biomarkers for the severe dengue prognosis during the early phase of the illness. Materials and methods: Using a case...

Introduction: Maintaining communities abreast of their local dengue situation could help to keep them motivated to participate in dengue control and to decrease Aedes entomological indexes. Objectives: To evaluate the coverage and reach of an intervention based on mass-media communication of dengue surveillance reports and its effect on the pres...

Introducción. Las enzimas carbapenemasas de tipo KPC tienen gran capacidad de diseminación, son causantes de epidemias y se asocian a mayor mortalidad y estancia hospitalaria. En Colombia se han venido reportando cada vez más desde 2007, pero se desconoce la prevalencia hospitalaria. Objetivo. Estimar la prevalencia hospitalaria del gen blaKPC. M...

Single nucleotide polymorphisms (SNPs) used for genotyping Colombian P. falciparum samples from the Pacific region. Detailed information of the 384 coding SNPs used for the GoldenGate® genotyping assay including SNP location, synonymous or non-synonymous SNP status, gene information and summary of the performance of each SNP during the genotyping a...

Validation of P. falciparum genotyped SNPs using reference strains (controls) performing comparison between them and against PlasmoDB SNPs data. Bead Studio package output comparisons between technical replicates for reference strains (Dd2, HB3, 7G8 and Santa Lucia) and comparisons between genotyped reference samples (n = 9) and SNP alleles from Pl...

K value determination using the Evanno’s approach. ΔK vs. K probability plot following Evanno’s approach. The analysis suggest the best K value at K = 4, suggesting four subpopulations of P. falciparum parasites from the Colombian Pacific region.

Pairwise fixation indexes in the Colombian Pacific coast P. falciparum samples. A) Fst values between subpopulations identified by STRUCTURE software and B) Fst values between provinces. The Fst values were computed using the GENALEX software [62].