Oscar E. Rodriguez A.

• MS, PhD
• Docente investigador at Pontifical Xavierian University

The antibacterial activity of the total ethanolic extract and fractions of Pelargonium graveolens against Candida albicans, Escherichia coli, Pseudomonas spp, Staphylococcus aureus and Bacillus spp. Methods: To measure the relative antimicrobial activity, the percentage of inhibition was calculated by the plate and well method. Results: It was esta...

The flavonoid izalpinin was isolated from the aerial parts of Chromolaena leivensis. Its structural determination was carried out using MS and NMR spectroscopic techniques (¹H, ¹³C). This compound was evaluated for its anti-inflammatory effect in a rat model on λ-carrageenan-induced plantar edema. Paw inflammation was measured at one-hour intervals...

The flavonoid izalpinin was isolated from the aerial parts of Chromolaena leivensis. Its structural determination was carried out using MS and NMR spectroscopic techniques (1 H, 13 C). This compound was evaluated for its anti-inflammatory effect in a rat model on λ-carrageenan-induced plantar edema. Paw inflammation was measured at one-hour interva...

Aim. Heavy metal concentration [mg/dL, MP] in soil and the transfer to vegetable organs may have a sampling e‹ect. We compared the [MP] in soil and organ samples of Beta vulgaris collected in sites with socioeconomic di‹erences potentially inducing phytotoxicity. Materials and Methods. Samples of Beta vulgaris and soils (n 4 per sample of soil and...

Objective Antimicrobial capacity of extracts from the fruit and leaf of F. carica L. was evaluated using the plate and well method, Method three different concentrations of extracts and fractions under evaluation were tested against three bacterial and fungal microorganisms. a suspension of each microorganism to be evaluated was prepared in 0.85% s...

Background: Ilex guayusa Loes. belongs to the family Aquifoliaceae. It is an evergreen tree native to the Amazon region. According to traditional uses, it is used as a diaphoretic, narcotic, purgative, among other uses. Objective: To evaluate the antioxidant capacity, quantify phenols and total flavonoids of extracts obtained from Ilex guayusa leav...

Los musgos son utilizados por muchas culturas para tratar diferentes enfermedades, probablemente por sus compuestos bioactivos, algunos de los cuales pueden presentar actividad antioxidante. Esta investigación evaluó la actividad antioxidante (AA) de Breutelia subdisticha (Hampe) A. Jaeger, Leptodontium viticulosoides (P. Beauv.) Wijk & Margad. y P...

Objective: Antifungal activity of total ethanolic extract and fractions of Usnea varieties were proved against Aspergillus niger, Penicillium digitatum, and Rhizopus nigricans fungi. Methods: To perform the study of relative antifungal activity (AFR), fluconazole and ketoconazole were used as standards. The inhibition coefficient 50 (IC 50) for eac...

ABSTRACT Objective: The objective of the study was to determine the antimicrobial activity of leaf and flower extract in Chromolaena scabra (L. f.) R.M. King and H. Rob., against selected strains of bacteria and fungi. Methods: The agar diffusion method with plate perforation was developed; the microorganisms used were strains of Staphylococcus aur...

Water is undoubtedly an essential resource for humanity and a key factor in the quality of life of populations worldwide. To decrease water turbidity, aluminum sulfate, an inorganic coagulant is used. However, this compound is unable to meet current demand. Therefore, alternative options from natural plant species are sought. Objective: Determine c...

Chromolaena is a genus of phanerogamic plants belonging to the Asteraceae family. They are native to America, from the southern United States to South America (especially Brazil). The species, Chromolaena scabra (L.f.) R.M. King and H. Rob, is registered in Colombia and Ecuador. Objective: The objective of this research was to determine the antioxi...

Heavy metal contamination in water resources, soil, and food sources is an issue that compromises food safety in Sibat e, Colombia. In the present study concentration of heavy metals [HMs], such as Cu, As, Pb, Cr, Zn, Co, Cd and Ni, present in vegetables included in the typical Colombian diet were measured. The study was conducted as follows: sampl...

Heavy metal contamination in water resources, soil, and food sources is an issue that compromises food safety in Sibaté, Colombia. In the present study concentration of heavy metals [HMs], such as Cu, As, Pb, Cr, Zn, Co, Cd and Ni, present in vegetables included in the typical Colombian diet were measured. The study was conducted as follows: sample...

Heavy metal contamination in water resources, soil, and food sources is an issue that compromises food safety in Sibat e, Colombia. In the present study concentration of heavy metals [HMs], such as Cu, As, Pb, Cr, Zn, Co, Cd and Ni, present in vegetables included in the typical Colombian diet were measured. The study was conducted as follows: sampl...

Objective: The assessment of the antimicrobial activity of Hymenaea courbaril L. on different microorganisms was realized with four bacteria, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa, two yeasts Candida albicans and Saccharomyces cerevisiae, and finally two filamentous fungi Aspergillus niger. Methods:...

Objective: The evaluation of the antimicrobial activity of Diplostephium phylicoides and Diplostephium revolutum on different microorganisms was carried out on using bacteria such as Escherichia coli (CMPUJ:034), Staphylococcus aureus (CMPUJ:370), Salmonella typhi (CMPUJ:045), and Pseudomonas aeruginosa (CMPUJ:065); yeasts such as Saccharomyces cer...

Objective: The objective of the study was to determine the antimicrobial activity of leaf and flower extract in Chromolaena scabra (L. f.) R.M. King and H. Rob., against selected strains of bacteria and fungi. Methods: The agar diffusion method with plate perforation was developed; the microorganisms used were strains of Staphylococcus aureus and E...

Teloschistes exilis (Michx.) Vain is an underexplored lichen. In the last decades, there has been a growing interest for the study of lichenic biodiversity, as a source of new natural products, because these produce potential secondary metabolites for pharmacological and industrial uses, highlighting their antioxidant and antifungal properties. For...

Teloschistes exilis (Michx.) Vain is an underexplored lichen. In the last decades, there has been a growing interest for the study of lichenic biodiversity, as a source of new natural products, because these produce potential secondary metabolites for pharmacological and industrial uses, highlighting their antioxidant and antifungal properties. For...

This study aimed to evaluate Antioxidant Capacity of extracts and fractions obtained from Lourteigia stoechadifolia (L. f.) R.M. King & H. Rob. Asteraceae, leaves using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. Extracts were obtained in dichloromethane and ethanol, using Soxhl...

The antibacterial effect of the essential oils of Sinapis alba L is known, since these contain mainly allylisothiocyanate, with an inhibitory effect on a great variety of bacteria. This study was carried out to known the antibacterial effects of Sinapis alba L. extracts to three different bacteria strains. The plates and wells methodology was used....

This study aimed to evaluate Antioxidant Capacity of extracts and fractions obtained from Lourteigia stoechadifolia (L. f.) R.M. King & H. Rob. Asteraceae, leaves using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. Extracts were obtained in dichloromethane and ethanol, using Soxhl...

Objective: The aim of this study was to evaluate the activity against amastigotes of Leishmania panamensis and epimastigotes of Trypanosoma cruzi (Chagas), extracts and fractions obtained from leaves and stems of Muehlenbeckia tamnifolia. Methods: Plant material was collected during the flowering, in the town of La Calera (Cundinamarca), at a heigh...

Resumen: Las enfermedades autoinmunes agrupan alrededor de 80 patologías que, en conjunto, generan un alto impacto en salud pública en el mundo y así mismo en Colombia. Esto se debe directamente a la alta prevalencia de estas, la incapacidad física y los costos que genera para el paciente y el sistema de salud (1, 2). Un ejemplo de estas enfermedad...

At present, there is a great variety of plant species widely distributed in different geographical regions worldwide, with phytopharmacological potential; however, its indiscriminate use has limited access to vegetal resources by the population in general and the scientific community. Additionally, the lack of toxicological studies that provide kno...

Chagas disease (CD) or American trypanosomiasis is one of the most prevalent parasitic diseases in humans. Its etiologic agent is Trypanosoma cruzi1. The WHO estimates that globally there are approximately 6 million people infected with T.cruzi, and more than 70 million people are living in areas with high risk of CD transmission2. It was estimated...

Resumen Introducción: Aunque las quemaduras cáusticas representan un bajo porcentaje de las quema-duras, dadas las complicaciones que asocian, son un problema de salud pública que exige nuevas opciones terapéuticas como son el uso de productos derivados de plantas, entre ellos, Calendula offinalis, Aloe vera y Cannabis sativa, cuyo uso está condici...

Background: Flavonoids isolated from plants have demonstrated an important role in cancer chemoprevention and chemotherapy. The genus Cromolaena has been shown to have active principles against this disease and found in species such as C. odorata, and C. laevigata in a concentration lower than 100 mg/L, however, flavonoids from C. leivensis has not...

Objetive: To determine the antioxidant and antiproferative activity of the flavonoids isolated from the leaves of Chromolaena tacotana. Methods: Extraction was carried out with dichloromethane (CH2Cl2) from the leaves by soxhlet, the flavonoids were isolated by column chromatography (Si gel G 60-200 microns 4 x 60cm) eluted with CHCl 3 , mixtures o...

Objective: To purify and identify secondary metabolites of Diplostephium phylicoides and determine the antioxidant capacity through the DPPH* and ABTS*+ techniques. Methods: Extracts were obtained by soxhlet of the different organs with solvents of increasing polarity and by means of column chromatography, triterpenes and flavonoids were purify, wh...

De las hojas de Chromolaena tacotana, se aislaron e identificaron 3,5-dihidroxi-7-metoxi-flavonol y 3,5-dihidroxi-7-metoxi- flavononol por métodos espectroscópicos.

Inflammation is the local or systemic process by which a vascularized tissue defends itself against different situations through cellular and molecular mediators (references of molecules and inflammatory cells) that play a primordial role in the maintenance of the organism homeostasis. Classically its treatment has required the intervention of diff...

http://pharmacologyonline.silae.it ISSN: 1820-8620 ANTI-INFLAMMATORY EFFECT OF THE HYDROALCOHOLIC EXTRACT OF Muehlenbeckia tamnifolia (Kunth) Meins LEAVES IN A RAT PAW MODEL Mojica B. Jasbleidy1, Torrenegra G. Rubén D.1, Pombo O. Luis M.2, Cadavid G. Vanessa2, Rodríguez A. Oscar E.3 1Universidad de Ciencias Aplicadas y Ambientales (UDCA). 2Fundació...

The river Bogotá and its banks show a high contamination by heavy metals like chrome, arsenic, etc., being impacted for decades by anthropic activities including those of tanneries near its source. To restore these riverside soils phytoremediation is employed, which has many socio-economic advantages. Aim: to determine the phytoremediation capacity...

Inflammation is the local or systemic process by which a vascularized tissue defends itself against different situations through cellular and molecular mediators (references of molecules and inflammatory cells) that play a primordial role in the maintenance of the organism homeostasis. Classically its treatment has required the intervention of diff...

The current trend in this field is the search for compounds derived from our vegetal species which have an anti-oxidant activity that is beneficial for human health. Colombia has a number of species known as field weeds (arvenses), like those of the Chromolaena genus, which are reported to have a high content of flavonoids. This study evaluated the...

Background Antineoplastic activity has been previously shown for two isomeric flavones, 5,7-dihydroxy-3,6,8-trimethoxy flavone (flavone A) and 3,5-dihydroxy-6,7,8-trimethoxy flavone (flavone B), against colon cancer cell lines (Thomas et al. in PLoS ONE 7:e39806, 5). Here, we present modified methods for the extraction and quantification of flavone...

Over 5000 flavonoids have been identified so far and many of these are known to have antineoplastic properties. The relationships between the targeting activities by these compounds on cancer cells and the specific features that determine their molecular structures are not completely elucidated. Here we report the differential cytotoxic effects of...

At the present time,aluminum sulfate(Al2(SO4)3(s))is used as a traditional coagulant. In the developing countries,supplies of it are short,thus,there is a need for an alternative,taking into account the diversity of promising native plants they has more than 23,500 species distributed among 1600 genera,which means that they are the family of Angios...

Resumen Objetivo: Evaluar la actividad antibacteriana y antioxidante de las partes aéreas de Baccharis revoluta. Métodos: La especie fue colectada en el municipio de Chocontá, Cundinamarca (N 05° 08' 26,3 " W 73° 38' 59,2 "). A los extractos de hojas, tallos y flores de diferente polaridad se les determinó la actividad antibacteriana frente a los m...

p>Evaluar la actividad antibacteriana y antioxidante de las partes aéreas de Baccharis revoluta . Métodos: La especie fue colectada en el municipio de Chocontá, Cundinamarca (N 05° 08’ 26,3” W 73° 38’ 59,2”). A los extractos de hojas, tallos y flores de diferente polaridad se les determinó la actividad antibacteriana frente a los microorganismos St...

The flavone 3,5,7-trihydroxy-6-methoxyflavone was isolated from leaf extracts of Chromolaena leivensis (Hieron), commonly named plant of cancer. It was identified based on their physicochemical propierties and spectroscopic data. This compound presented a methoxylation at C6, this is uncommon in flavonoids and which may confer some specificity of i...

At the present time, aluminum sulfate (Al 2 (SO 4) 3(s)) is used as a traditional coagulant. In the developing countries, supplies of it are short, thus, there is a need for an alternative, taking into account the diversity of promising native plants they may be used as a source. One such source are the Asteraceae, a family which has more than 23,5...

p>B occonia frutescens es un árbol pequeño, posee hojas profundamente lobuladas y con borde dentado, las flores están agrupadas en panículas terminales pendulares, las semillas son de color negro brillante con una cubierta carnosa de color anaranjada. Es nativa de América, es conocida con los nombres vulgares de: Sarno, Palo Amarillo o Trompeto. Ob...

To determine the antimicrobial activity of extracts of different polarities species Everniastrum columbiense, flaventor Flavopunctelia, Parmotrema simulans, Ramalina celastri, Teloschistes exilis and Usnea sp, collected on the western margin of the basin alta of Río Bogotá, to 05. ° 07 '23.4 "N and 73 ° 39' 10.5" W; against microorganisms Staphyloc...

p>Determinar la actividad antimicrobiana de extractos de diferentes polaridades de las especies de Everniastrum columbiense, Flavopunctelia flaventor, Parmotrema simulans, Ramalina celastri, Teloschistes exilis y Usnea sp ., recolectadas en el margen occidental de la cuenca alta del Río Bogotá, a los 05° 07’ 23,4”N y 73° 39’ 10,5”W; frente a los mi...

Flavones, found in nature as secondary plant metabolites, have shown efficacy as anti-cancer agents. We have examined the binding of two flavones, 5,7-dihydroxy-3,6,8-trimethoxy-2-phenyl-4H-chromen-4-one (5,7-dihydroxy-3,6,8-trimethoxy flavone; FlavA) and 3,5-dihydroxy-6,7,8-trimethoxy-2-phenyl-4H-chromen-4-one (3,5-dihydroxy-6,7,8-trimethoxy flavo...

Over 4000 flavonoids have been identified so far and among these, many are known to have antitumor activities. The basis of the relationships between chemical structures, type and position of substituent groups and the effects these compounds exert specifically on cancer cells are not completely elucidated. Here we report the differential cytotoxic...

The aim of the study was to evaluate the acute toxicity of ethanol extract of leaves and flowers of Chromolaena perglabra, for it was collected plants of this species and extracted 500 g dried and ground in 96% ethanol in a soxhlet extractor until exhaustion of the material. The extract was concentrated under vacuum to remove all solvent. It took 2...

The flavonoids 3,5-dihydroxy-7-methoxy-flavanone, 3,5-dihydroxy-7-methoxyflavone and 3,5,7-trihydroxy-6-methoxyflavone were isolated from the leaves of C. leivensis. Preliminary observations in K562 cells (human erythroleukemia) using the trypan blue test, showed a 90% viability at a concentration of 100 microg/mL; however, further testing of the f...

The flavonoids 3,5-dihydroxy-7-methoxy-flavanone, 3,5-dihydroxy-7-methoxyflavone and 3,5,7-trihydroxy-6-methoxyflavone were isolated from the leaves of C. leivensis. Preliminary observations in K562 cells (human erythroleukemia) using the trypan blue test, showed a 90% viability at a concentration of 100 μg/mL; however, further testing of the flavo...

El estudio pretende conocer si el extracto hidroalcohólico de las hojas y flores de la especie en cuestión puede inducir toxicidad aguda a una muestra de 25 ratones albinos suizos ICR-CD1 hembras y determinar posibles daños producidos después de 72 horas a través de cambios histológicos en estómago, hígado, riñón y bazo después de la administración...

The title compound, C26H42O9·1.5H2O, was extracted from the leaves and flowers of Ageratina vacciniaefolia, a Colombian native plant, which is called ‘chilca’ by locals. The mol­ecule consists a kauranol group connected to a glucopyranosyl group by an O-atom bridge adjacent to a β-type anomeric center. In the crystal structure, inter­molecular O—H⋯...

Se determinó la actividad antimicrobiana de extractos y fracciones de diferentes polaridades de la especie vegetal Cuphea ciliata Ruiz & Pav. frente a microorganismos Gram (+) y Gram (-) por el método de difusión en gel por perforación en placa. Las pruebas de eficacia antimicrobiana exhibieron inhibición significativa en los extractos etanólicos.

The title compound, C26H42O9·1.5H2O, was extracted from the leaves and flowers of Ageratina vacciniaefolia, a Colombian native plant, which is called `chilca' by locals. The molecule consists a kauranol group connected to a glucopyranosyl group by an O-atom bridge adjacent to a β-type anomeric center. In the crystal structure, intermolecular O—H......

Esta investigación se encaminó a determinar los metabolitos secundarios presentes en hojas y tallos de la especie: Chromolaena perglabra (B. L. Robinson) King & H. Rob., colectada en Tinjacá (Boyacá ¿ Colombia). Se estableció la actividad antiprotozoaria (leishmaniosis y chagas.) y toxicidad. Los resultados de este trabajo suministraron herramienta...

Se evaluó la actividad contra las bacterias Escherichia coli y Staphylococcus aureus, y el hongo Fusarium oxysporum de los extractos y fracciones de diferente polaridad de hojas y flores de la especie vegetal Chromolaena subscandens (Hieron.) R.M. King & H. Rob., empleando los métodos de difusión en gel por perforación en placa y macrodilución en p...

CB2, al igual que los otros flavonoides obtenidos de Chromolaena bullata, fue evaluado sobre células dendríticas y células tumorales humanas, para determinar su actividad antitumoral o inmunorreguladora. Sobre las células tumorales (A375 melanoma humano) induce una depolarización temprana de la membrana mitocondrial, la cual es reversible y no cond...

El CT3 un flavonoide de Chromolaena tacotana disminuye la viabilidad celular después de 48 horas de tratamiento de la línea celular K562. Después de 48 horas de tratamiento, el flavonoide induce un cambio significativo en el potencial de la membrana mitocondrial que se mantiene por 12 horas con la aparición tardía de células apoptóticas. Es posible...

La planta fue recolectada en el páramo Cruz Verde, ubicado sobre la vía que de Bogotá conduce a Choachí. Fue sometida a un proceso de extracción utilizando solventes de polaridad creciente y aislándolas por medio de cromatografía RP- 18 y Silica Gel, tanto de columna como de capa fina. La identificación de las sustancias fue realizada por medio del...