Ors Petnehazy DVM

Ors Petnehazy DVM
Kaposvar University · Institute of Diagnostic Imaging and Radiation Oncology

PhD

About

75
Publications
13,782
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1,167
Citations
Introduction
Ventricular parameters of different pig genotypes Cardiac function analysis in pigs with cardiac CT and MR Vascular modeling with preparative anatomical techniques 3D anatomical modeling and animations

Publications

Publications (75)
Article
Full-text available
Various applications of farm animal imaging are based on estimating the weight of specific body parts and cuts from CT images of animals. In many cases, the complexity of the problem is increased by the enormous variability in body postures in the CT images due to scanning unsedated live animals. In this work, we propose a general and robust approa...
Preprint
Full-text available
Various applications of farm animal imaging are based on the estimation of weights of certain body parts and cuts from the CT images of animals. In many cases, the complexity of the problem is increased by the enormous variability of postures in CT images due to the scanning of non-sedated, living animals. In this paper, we propose a general and ro...
Article
Full-text available
There are several studies dealing with the phenotypic variance of the vertebral number in the spinal column of rabbits. According to the literature the number of thoracic and lumbar vertebrae varies between 11-13 and 6-8, respectively. The length of the m. longissimus dorsi (MLD) - a valuable meat part of rabbits - is determined by the length of th...
Article
Full-text available
The middle turbinate’s basal lamella (3BL) is a variable landmark which needs to be understood in endoscopic transnasal skull base surgery. It comprises an anterior frontal and a posterior horizontal part and appears in its simplest depiction to be “L”-shaped, when viewed laterally. In this study we analyzed its 3D morphology and variations focusin...
Article
Full-text available
Purpose: The purpose of this study was to create a detailed cross-sectional anatomical reference atlas of the Pannon minipig by correlating good resolution CT and MR images with high quality cross-sectional anatomical images. According to the authors knowledge, no detailed anatomical atlas is available for the minipig. Material and method: An ad...
Article
Full-text available
Computed tomography (CT) is one of the most useful techniques for digitizing bone structures and making endocranial models from the neurocranium. The resulting digital endocasts reflect the morphology of the brain and the associated structures. Our first aim was to document the methodology behind creating detailed digital endocasts of canine skulls...
Article
Full-text available
The objective of this study was to present the updated segmentation technique predicting the loin muscle weight of rabbits based on in vivo computed tomography measurements. The segmented muscle volumes are used to estimate the weight of the loin muscle and the predicted weights are compared to the real weights of meat cuts measured after the disse...
Article
Full-text available
Introduction Many coronary anastomotic devices have been designed to replace manual stitching in coronary surgery; however, interestingly, none of them became widespread. Our aim was to work out an easy and fast endoluminal vessel-to-vessel stent bridge distal anastomotic technique. Materials and methods Ten coronary arteries of eight fresh human...
Conference Paper
In order to visualize a canine brain with multimodal imaging and enhanced detailedness we made a comparative neuroanatomical study. A two-year-old female Beagle dog was scanned ante- and post mortem with CT and MRI. Arteries were filled with red polyurethane resin through the common carotid arteries post mortem (all procedures were approved in PEI/...
Conference Paper
Full-text available
Introduction: For research applications or veterinary diagnostic work one should know the exact 2‐ and 3‐dimensional anatomy of the desired animal. 3D surgical planning and virtual anatomy teaching both require detailed knowledge of different body regions. Materials and Methods: Whole body ante‐ and post mortem CT and MRI scannings were performe...
Conference Paper
Full-text available
Introduction: The equine carpal and tarsal joints are complex structures with separate cavities, intra‐ and extraarticular ligaments and tendon sheaths around them. There are only a few studies about the detailed CT‐ and MRI‐anatomy of these joints and none of them contains 3‐dimensional reconstructions of these structures. In our study, we create...
Conference Paper
Full-text available
Introduction. Creating a novel anatomical atlas requires a technique showing an organ in a different perspective, or that the applied method results in an enhanced image quality compared to previous work. We visualized a canine brain with multimodal imaging techniques for comparative studies. Materials and Methods. A two-year-old female Beagle do...
Conference Paper
Analyzing gross morphology and inter-species differences of the brain can be done in different ways. Direct methods allow to examine the organ either ex situ by removing it or in situ, through imaging methods (e.g., CT, MRI). Indirect methods rely on the estimation of the volume of an endocranial cast, obtained by filling the endocranium with a cer...
Article
Full-text available
Background and aims: Dogs have recently become an important model species for comparative social and cognitive neuroscience. Brain template-related label maps are essential for functional magnetic resonance imaging (fMRI) data analysis, to localize neural responses. In this study, we present a detailed, individual-based, T1-weighted MRI-based brai...
Article
Full-text available
Most common methods that directly show macro- or microscopic anatomy of the brain usually require the removal of the organ from the neurocranium. However, the brain can be revealed in situ by using proper sectioning techniques. Our aim was to both improve the cryosectioning method, test its limits and create a high-resolution macro-anatomical image...
Data
The embedding box (A) and the frozen head block inside the holder (B). (TIF)
Data
The cryomacrotomisation process. (TIF)
Article
Full-text available
Although the application of cardioprotective ischaemia/reperfusion (I/R) stimuli after myocardial infarction (MI) is a promising concept for salvaging the myocardium, translation to a clinical scenario has not fulfilled expectations. We have previously shown that in pigs, ischaemic postconditioning (IPostC) reduces myocardial oedema and microvascul...
Article
Full-text available
SUMMARY Background: The petrosal bone is one of the smallest and most complex among the bones of the equine skull. Its irregular surface, several projections and channels, and hidden inner structures make its visualization challenging. Textbooks usually show this bone on different drawings and photographs, where the structures' relationship and the...
Presentation
Full-text available
Evaluation of the paranasal sinus system at different animals and their relation to the neurocranium
Conference Paper
Full-text available
Cardiac CT examinations and evaluation on different species and breeds.
Preprint
Full-text available
Over the last decades there have been several publications of anatomical and neurological textbooks, which include descriptions about the dogs' brain. However, the terminology used is inconsistent, partly due to individual differences in neocortical gyration and partly due to the common practice of adapting terms from human and murine anatomy. In o...
Conference Paper
Full-text available
Introduction: Dogs’ middle cranial fossa includes several important structures, but due to its relative small size and the pachymeningeal coverage, usually it can be challenging to study for veterinary students, although it has a great importance for certain neurosurgical interventions. Thus we used different techniques to comprehensively visualize...
Conference Paper
Full-text available
Introduction: Surface description terminology of the dogs’ brain is sometimes divergent among different literature sources, partly due to individual differences in the gyration and partly because those medical terms derived from the human and rodent anatomy. As more dog studies and atlases are published, there is a need for a more consistent termin...
Article
Full-text available
SSZeFoGLALÁS A szerzők jelen tanulmányukban a ló térdízületének, keresztmetszeti képalkotással (CT, MR) nyert adatokból, képfúzió segítségével létrehozott, digitális 3D modelljeit mutatják be. Röviden ismertetik a mágneses rezonanciás vizsgálat technikai alapjait, irodalmi adatok alapján áttekintik a ló térdízületének CT és MR anatómiáját. A cikkso...
Article
Full-text available
SUMMARY Background: Computed tomography (CT) and magnetic resonance imaging (MR) became important diagnostic tools in the veterinary practice in the past decades. Data gained with those scanning methods can be used for 3D displaying of different organs, organ systems and body regions as well. There are numerous reconstructional softwares to create...
Data
Flow cytometry analysis of mesenchymal stem cells: cells are negative for CD 34 and CD 45 and positive for CD 29, CD 44, CD 90.
Data
Cell proliferation assay post transfection of MSCs with Ad- green fluorescent protein (GFP) and Ad-Luc. Proliferation assay of the transfected and non-transfected porcine mesenchymal stem cells (MSCs). Transient transfection with adenovirus-associated luciferase and GFP resulted in a temporarily significant decrease in proliferation capacity.
Data
Significant logarithmic correlation between marker matrix metalloproteinase-2 (MMP-2) 64 kD intensity and luciferase activity (index of green fluorescent protein-Luc-mesenchymal stem cell number) in the infarcted injected area.
Article
Full-text available
Background Intracoronary (IC) injection of mesenchymal stem cells (MSCs) results in a prompt decrease of absolute myocardial blood flow (AMF) with late and incomplete recovery of myocardial tissue perfusion. Here, we investigated the effect of decreased AMF on oxidative stress marker matrix metalloproteinase-2 (MMP-2) and its influence on the fate...
Article
Full-text available
SSzeFoGLALÁS A szerzők jelen tanulmányukban bemutatják a légzőszervrendszer egyes elemei-nek CT-vizsgálatra alapozott 3D modelljeit. Ismertetik a madarak légzsákjainak, a lovak orrmelléküregeinek anatómiai alapjait, ezen szervrendszerek vizsgálatának nehézségeit. Röviden bemutatják a vizsgálóeljárás technikai részleteit, irodalmi adatok alapján átt...
Article
Full-text available
SUMMARY Background: Computed tomography (CT) became an important diagnostic imaging method in the veterinary practice in the past decades. Data gained with the scanning can be used for 3D displaying of organs or body regions as well. The viewer softwares provide more and more options for reconstruction of the target area. Objectives: The authors pr...
Article
Full-text available
Despite numerous studies on cerebrospinal fluid (CSF) and its importance during hydrocephalus or myelography, no reliable values exist about its overall volume in dogs. In this study, our aim was to measure the intracranial (IC) volume of CSF in dogs and assess its possible relationship with body size and the symmetry of the lateral ventricles. We...
Conference Paper
Full-text available
Introduction: The equine stifle joint consist of three well recognizable cavities on MR images: the femoropatellar (FPJ), medial femorotibial (MFTJ) and lateral femorotibial joints (LFTJ). In our study we produced 3D reconstruction model of the horse’s stifle joint based on high resolution CT and MR data and image fusion. Materials and Methods: A s...
Conference Paper
Full-text available
Introduction: The blood supply of the male genital tract in dogs is a complex system. The testicular artery arises from the abdominal aorta, the prepuce is supplied by the external pudendal artery and the blood supply to the penis is from three branches of the internal pudendal artery. The prostate is supplied by the prostatic artery. The venous dr...
Conference Paper
Full-text available
Introduction: In our study we aimed to show the blood supply of the canine orbit using different preparation and reconstruction techniques since proper knowledge about this region is essential for veterinary students and also useful for ophthalmologists. Materials and Methods: Conventional anatomical preparation was performed on two dogs, corrosion...
Conference Paper
Full-text available
Introduction: The temporal bone is one of the most complex osseous structures of the body. Due to its irregular shape and complex architecture it is difficult to comprehend the relative position of its inner components based only on two-dimensional images. We used different 3- dimensional imaging techniques to facilitate the approach to this comple...
Book
This booklet you are holding in your hands, shows the anatomy of the cat’s head from an uncommon view. The cross-sectional diagnostic methods (CT, MR) used in human medicine for decades, are becoming more popular in the diagnostic of various health problems of our pets. For analyzing images gained with the above mentioned methods, it requires preci...
Conference Paper
Full-text available
For body composition analysis, veterinary diagnostic work and for many research applications one should know the exact anatomy of the desired animal. 3D surgical planning and virtual anatomy teaching both require detailed 3D models of different body regions. There are detailed cross sectional atlases, books with colour images of the desired area wi...
Article
Dosages for myelography procedures in dogs are based on a hypothetical proportional relationship between bodyweight and cerebrospinal fluid (CSF) volume. Anecdotal radiographic evidence and recent studies have challenged the existence of such a defined relationship in dogs. The objectives of this prospective cross-sectional study were to describe C...
Conference Paper
Full-text available
Introduction: Correct anatomical visualization and interpretation of the vascular system is a big challenge in the research, clinical work and education. The new 3D reconstruction methods of diagnostic imaging (vascular reconstructions) give us a non-destructive method (Lafayette et al., 2009 : Tissue engineering. 15, 729–738, Mondy WL. Et al. 2013...
Conference Paper
Full-text available
Introduction: Correct anatomical visualization and interpretation are essential for clinical, research and educational activity. Neuroanatomy is one of the most researched field during past decades. Diagnostic imaging (CT, MRI, SPECT) and neurosurgery get more importance in small animal veterinary practice, that’s why knowledge of location and path...
Article
Restenosis occurs invariably within 12 months following balloon valvuloplasty (BAV) in calcific aortic valve disease (CAVD), and is a limiting factor of this treatment. Cellular proliferation secondary to balloon injury is thought to play a pivotal role in the mechanism of restenosis. The study aim was to investigate the potential role of a paclita...
Article
Aims: To evaluate the short-, mid- and long-term safety, efficacy and vascular physiology of Axetis silicon dioxide (SiO2, abrading the micropores) inert-coated stent implantation in a randomised preclinical setting. Methods and results: Coronary arteries of domestic pigs were randomised to receive either Axetis or BMS (same design) stents with...
Chapter
Balloon aortic valvuloplasty (BAV) was introduced in 1986 as an alternative non- surgical therapeutic option in elderly and high-risk patients with aortic stenosis [1]. It generates small to moderate increase in the effective aortic valve area (AVA) and decline in the transvalvular pressure gradient (by average 50 %) which results in early symptoma...
Article
The quantity of cells with paracrine effects for use in myocardial regeneration therapy is limited. This study investigated the effects of catheter-based endomyocardial delivery of secretome of 2.5 × 10(9) apoptotic peripheral blood mononuclear cells (APOSEC) on porcine chronic post-myocardial infarction (MI) left ventricular (LV) dysfunction and o...
Article
The diagnostic characteristics of electromechanical mapping (EMM) were evaluated in porcine myocardial infarction (MI) models with the parallel application of cardiac magnetic resonance imaging (cMRI) from the aspect of different pathophysiology and localization. Balloon occlusion in the left anterior descending coronary artery (LAD balloon group)...
Conference Paper
Introduction: The topographical anatomy of the canine heart is essential for the everyday veterinary clinical work. Experts from different fields (eg. ultrasonography, radiology, internal medicine and surgery) need this basic knowledge for successful diagnosis and treatment. In this study we give a general overview about the anatomy of the dog’s he...
Presentation
Full-text available
Novel Regulators and Inhibitors of Aortic Valve Calcification –ESC-Congress 2012 ,Munich ,Germany
Conference Paper
Introduction: In the clinical practice, uni- or bilateral facial nerve dysfunction may occur by itself or in association with other circumstances (eg. the commonly experienced middle ear infection, surgical approach to the bulla for various kind of the treatment, brainstem disorders affecting the nucleus and central part of the facial nerve). To ai...
Article
This study sought to determine the time dependency of the endothelium-dependent and -independent vascular responses after percutaneous coronary intervention (PCI) with drug-eluting (DEB) or plain balloons, bare-metal (BMS), and drug-eluting (DES) stents, or controls. Long-term endothelial dysfunction after DES implantation is associated with delaye...
Article
In the present work, our goal was to match high-resolution computed tomography (CT) scans with cross-sectional anatomical pictures of the turkey (Meleagris gallopavo). Two male BUT 6 (a commercial line) turkeys were used. CT scans with 1 mm slice thickness were performed. The images covered the trunk from the level of the 9th cervical vertebra to t...
Article
This study evaluated the protective effect of nitric oxide-coating of introducer sheath on the local complications in juvenile porcine femoral arteries with similar size to human radial arteries. Insertion of an introducer sheath induces vasospasm and transient or permanent vessel occlusion of radial arteries. Nitric oxide-coated or control introdu...
Article
The aim of the present study was to investigate the changes in absolute myocardial blood flow (AMF) after intracoronary injections of mesenchymal SC (MSC) and compared to controls in closed-chest reperfused acute myocardial infarction (AMI) in pigs. Male MSCs, transiently transfected with Luciferase (Luc-MSC) were delivered (9.7 ± 1.2 x 10(6)) intr...
Article
Full-text available
The aim of this preclinical study was to optimize the use of drug-eluting balloon (DEB) DIOR(2nd) (generation) by measurements of tissue and plasma paclitaxel concentrations in porcine coronary artery overstretch and prove efficacy in inhibition of neointimal growth without complementary use of stent. Background: The usually recommended DEB 60 sec...
Article
Full-text available
We have investigated the effect of stem cell delivery on the release of hypoxia-inducible factor 1 alpha (HIF-1alpha) in peripheral circulation and myocardium in experimental myocardial ischemia. Closed-chest, reperfused myocardial infarction (MI) was created in domestic pigs. Porcine mesenchymal stem cells (MSCs) were cultured and delivered (9.8 +...
Article
This study sought to determine whether alginate biomaterial can be delivered effectively into the infarcted myocardium by intracoronary injection to prevent left ventricular (LV) remodeling early after myocardial infarction (MI). Although injectable biomaterials can improve infarct healing and repair, the feasibility and effectiveness of intracoron...
Article
Magnetic resonance imaging (MRI) provides superior visualization of the prostate, its substructure, surrounding tissues, and, most important, focal lesions or cancer. The purpose of our canine study was to demonstrate the feasibility of a low-field (0.35 T) transperineal system that enables precise MR image guidance of prostate interventions. The c...
Article
Porcine bone marrow-derived mesenchymal stem cells (MSCs) were stably transfected with a lentiviral vector for transgene expression of the trifusion protein renilla luciferase, red fluorescent protein and herpes simplex truncated thymidine kinase (LV-RL-RFP-tTK; positron emission tomography [PET] reporter gene) for in vivo noninvasive tracking of t...
Article
Our purpose was to confirm the local drug delivery of a paclitaxel-eluting balloon by percutaneous intervention of single arterial segments or bifurcations of porcine coronary arteries. Eight domestic pigs were subjected to 2 x 30 s Dior balloon dilatation of the mid left anterior descending, left circumflex and proximal right coronary arteries. Bi...
Article
The impaired compliance of large and medium-sized muscular arteries has been shown to correlate with the risk of adverse cardiovascular events. We assessed coronary artery distensibility using simultaneous intracoronary ultrasound and pressure wire measurements in porcine coronary arteries after implantation of paclitaxel-eluting (PES) and bare met...