Ornella Argento

Ornella Argento
Foundation Santa Lucia | FSL · Department of Clinical and Behavioural Neurology

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34
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323
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Publications

Publications (34)
Article
Full-text available
Background: Recent studies underscore the intricate relationship between cognitive and motor impairments in Multiple Sclerosis (MS), often exacerbated by CNS damage compromising neural connections. These cognitive–motor deficits contribute to reduced efficiency in daily activities and heightened risks of falls and accidents. The combination of chal...
Article
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BACKGROUND: Multiple Sclerosis (MS) is a chronic inflammatory, demyelinating, degenerative disease of the central nervous system and the second most frequent cause of permanent disability in young adults. one of the most common issues concerns the ability to perform postural and gait tasks while simultaneously completing a cognitive task (namely, d...
Article
Full-text available
N-palmitoylethanolamine (PEA) plays a key role in preventing Aβ-mediated neuroinflammation and neurotoxicity in murine models. It has been demonstrated that PEA provides anti-neuroinflammatory, pain-relieving and neuroprotective actions even in humans. In this project, we aim to evaluate these anti-neuroinflammatory effects via the cognitive evalua...
Article
Full-text available
Multiple sclerosis (MS) is a central nervous system (CNS) disease characterized by inflammation, axonal demyelination, and neurodegeneration, which can have a strong impact on all aspects of the life of the patient. Multiple sclerosis causes motor, sensory, cerebellar, and autonomic dysfunctions, as well as cognitive and psychoemotional impairment....
Article
Background At the moment, the possible options for the management of cognitive dysfunctions in patients with MS (pMS) are pharmacological interventions, cognitive rehabilitation (CR), and physical exercise. However, worldwide, multimodal programs are infrequently applied in pMS and CR is not easily accessible through the National Health System as M...
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Background: The aim of the study was to compare psychological characteristics of adolescent patients with Juvenile Fibromyalgia Syndrome (JFM) with individuals suffering from chronic pain (CP) due to headache or joint pain in the lower limbs unrelated to oncological, inflammatory or autoimmune diseases. Methods: The study was conducted on 37 pat...
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Full-text available
(1) Background: Emotional recognition (ER), the ability to read into others’ minds and recognize others’ emotional states, is important in social environment adaptation. Recently it has been found that ER difficulties affect patients with multiple sclerosis (pMS) and relate to different gray matter atrophy patterns from secondary progressive (SP-pM...
Article
Introduction Gait and balance disorders are marked functional deficits in people with multiple sclerosis (MS) [1]. Walking limitations are frequently reported in people with MS despite the Expanded Disability Status Scale (EDSS) indicates normal walking autonomy [2]. To better identify changes due to disease severity, a combined instrumental assess...
Article
Full-text available
Cognitive impairment (CI) represents a common symptom in patients suffering from multiple sclerosis (MS), which can affect every stage of the disease course. Recent studies seem to support cognitive rehabilitation (CR) for minimizing the CI consequences. We reviewed the currently available evidence on the non-pharmacological approaches to CI, with...
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MS clinical features vary between patients. In approximately 60% of cases, cognitive deficits are associated with motor disabilities, with consequences on both walking and maintaining balance and cognitive efficiency. Multimodal programs are very infrequent for MS patients and cognitive rehabilitation is not provided by the Italian health system, w...
Article
Background: Difficulties in emotion processing and social cognition identified in MS patients have a potential impact on their adaptation to the social environment. Objective: We aimed to explore the neural correlates of emotion recognition in MS and possible differences between Relapsing-Remitting (RRMS) and Secondary-Progressive (SPMS) patient...
Article
Objective Gait, cognitive impairments, and their mutual influence in dual tasking (cognitive–motor dual tasking, CM-DT) are important to address therapeutic approaches in patients with multiple sclerosis (PMS). CM-DT correlates have been widely investigated with variable and dissimilar results, due to differences in methods. However, although the c...
Article
Recent studies suggest that patients with Multiple Sclerosis (MS) might be at risk of unemployment due to physical and psychological symptoms. Furthermore, MS patients appear to be more exposed to a higher level of occupational stress, which might be linked to some personality characteristics. Our aim was to ascertain, by means of a longitudinal st...
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Cognitive dysfunction occurs in almost 50–60% of patients with multiple sclerosis (MS) even in early stages of the disease and affects different aspects of patient’s life. Aims of the present study were (1) to introduce and validate an Italian version of the minimal assessment of cognitive functions in MS (MACFIMS) battery and (2) to propose the us...
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The present study has two-fold aims: to investigate whether gender differences persist even when more time is given to acquire spatial information; to assess the gender effect when the retrieval phase requires recalling the pathway from the same or a different reference perspective (egocentric or allocentric). Specifically, we analyse the performan...
Article
Objectives: Domestic accidents are an important topic as for different viewpoints: for the people that could be victim of them, for the health and economic systems. It could be imagined that people affected by neurological diseases, such as Multiple Sclerosis (MS), could incur into domestic accidents more frequently than people in the general popu...
Article
Multiple sclerosis (MS) and working status have recently arisen great interest. Fatigue, physical disability, cognition, and psychological disturbances have been linked to unemployment, as well to accidents during daily activities. The aim of our study was to determine frequency of different types of accidents at workplace (AWE) and possible clinic...
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Multiple Sclerosis (MS) is frequently associated with neuropsychiatric abnormalities. The aim of our study was to discriminate between psychosomatic disturbances and MS physically-related symptoms using the Harris-Lingoes subscales of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). Forty-six MS out-patients (35 females; mean age = 44.5)...
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Objective: The Brief Visuospatial Memory Test-Revised (BVMT-R) is one of the most widely used tests for the assessment of learning and memory in the visual/spatial domain. The aim of this study was to use multiple regression to derive normative data for the use of BVMT-R in an Italian population. Method: We employed a regression-based norms proc...
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Full-text available
Background Multiple sclerosis (MS) is associated with significant impairment. Objective The objective of this article is to identify and compare clinical measures that can predict self-rated disability in patients with MS using the World Health Organization Disability Assessment Schedule II (WHODAS-II). Methods Patients with MS and healthy contro...
Article
Multiple Sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system, causing a wide range of neurological and psychological symptoms. Impairment of ambulation and cognition in particular are associated with work difficulties and unemployment. Although many aspects of work status have been investigated in MS, there...
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Neuropsychiatric abnormalities are frequently reported in patients with multiple sclerosis (MS). Previous studies have investigated the neurotic aspects of psychopathology, and the importance of the personality structure underlying neurotic symptoms has only recently been reconsidered. The aim of our study was to investigate the frequency and type...
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Full-text available
Background: The World Health Organization Disability Assessment Schedule (WHODAS-II) is a widely used generic assessment instrument for health and disability. However, a specific psychometric evaluation for this scale in multiple sclerosis (MS) is lacking. This study is aimed at the assessment of the psychometric properties of the WHODAS-II in MS...
Article
The aim of this study was to develop two versions of the California Verbal Learning Test-II (CVLT-II) and to administer them to a large sample of healthy controls representative of the normal Italian population for sex, age, and education levels. Two hundred and eighty healthy controls entered the study and were randomly assigned to one of the two...
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Purpose: Domestic accidents are widespread, but no data are available on their occurrence in pathological populations such as patients with multiple sclerosis (MS). Aim was to investigate domestic habits and occurrence of different types of domestic accidents and near falls in a sample of MS patients compared with healthy controls and to determine...
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Full-text available
Selective visuo-spatial memory deficits can seriously affect many aspects of daily life; for example, an individual may not remember where he put an object or which path he took to reach his destination. In general, visuo-spatial memory is assessed through pen-and-paper tests that mainly assess memory components in peripersonal space. Recent studie...

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