Orlando Todarello

Orlando Todarello
Università degli Studi di Bari Aldo Moro | Università di Bari · Dipartimento di Scienze Mediche di Base, Neuroscienze e Organi di Senso (SMBNOS)

About

92
Publications
19,730
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
3,280
Citations
Citations since 2017
3 Research Items
1180 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200

Publications

Publications (92)
Article
Full-text available
Background: Migrants present high rates of psychosis. A better understanding of this phenomenon is needed. Methods: We conducted a multicentre First-Episode Psychosis (FEP) prospective study over two years (January 2012-December 2013) to evaluate first-generation migrants presenting with FEP at the participating Community Mental Health Centers (...
Article
Full-text available
Objective Gender Confirming Surgery (GCS) and Cross-Sex Hormones (CSH) are crucial steps in the self-realization of a transsexual individual. However, no study has analyzed the outcome of GCS in a eudaimonic perspective, nor explored eudaimonic well-being before GCS. Methods The study compares the eudaimonic well-being of trans men (N=56) and women...
Article
Introduction: The aim was to evaluate and stratify early cardiovascular risk of transsexuals undergone pharmacological and/or surgical gender reassignment. Methods: Fifty-six transsexuals were divided into two groups: 1- undergone gonadectomy (orchiectomy for trans women and hystero-annessiectomy for trans men); group 2- hormone replacement ther...
Research
Full-text available
To estimate the GDS-30 accuracy for depression assessment against the gold standard diagnosis (SCID for DSM-IVTR) in subjects 65 years and more in a random sampling of the general population
Article
Introduction Depression is a common disorder in late-life. Structured clinical interviews may be less efficient compared to self-administered questionnaires, but provide more accurate findings in terms of diagnosis. No population-based studies with both these depression assessment instruments have been ever performed. Objectives To estimate the GD...
Article
Full-text available
The present study aims to provide an overview of experiences of discrimination, harassment and violence in a sample of Italian transsexuals who have undergone sex reassignment surgery (SRS). Lack of support for gender transition from family members was also assessed, before and after SRS. Data were collected in the context of a multicentric study (...
Article
Objective: Sex reassignment surgery (SRS) in the treatment of Gender Dysphoria has been shown to be followed by high levels of postsurgery satisfaction, improvement in quality of life and in the general psychosocial functioning of clients, both on a short and long-term perspective (Michel et al., 2002; Landén et al., 1998; Lawrence, 2003). More rec...
Article
Full-text available
Earlier studies have demonstrated that emotional stimulation modulates attentional processing during goal-directed behavior and related activity of a brain network including the inferior frontal gyrus (IFG) and the caudate nucleus. However, it is not clear how emotional interference modulates behavior and brain physiology during variation in attent...
Article
Introduction The prevalence of Anxiety Disorders (ADs) among the elderly (65 plus) varies across studies, because of differences in diagnostic criteria's definition and the heterogeneity of clinical presentation. Furthermore the comorbidity of anxiety with affective disorders is controversial. Objectives Estimate the prevalence of ADs in 65 years...
Article
Full-text available
Background: As lithium treatment might be effective in reducing the risk of deliberate self-harm (DSH) in adult patients with unipolar affective disorders, we designed a pragmatic randomised trial to assess its efficacy in more than 200 patients with treatment-resistant depression. However, we randomised 56 patients only. The aim of this report is...
Article
Full-text available
"Schizotypy" is a latent organization of personality related to the genetic risk for schizophrenia. Some evidence suggests that schizophrenia and schizotypy share some biological features, including a link to dopaminergic D2 receptor signaling. A polymorphism in the D2 gene (DRD2 rs1076560, guanine > thymine (G > T)) has been associated with the D2...
Article
Full-text available
I inform the people of Research Gate that from months I do not receive e-mails from RG and all my efforts to solve the problem have not given results. Please, in case contact me to elio.conte@fastwebnet.it The Abstract :A new method for HRV analysis is described and experimental results are given.
Article
Full-text available
Background It has been frequently reported a higher incidence of psychotic disorders in immigrants than in native populations. There is, however, a lack of knowledge about risk factors which may explain this phenomenon. A better understanding of the causes of psychosis among first-generation migrants is highly needed, particularly in Italy, a count...
Article
Full-text available
Background - Despite depressive disorders being very common there has been little research to guide primary care physicians on the choice of treatment for patients with mild to moderate depression. Aims - To evaluate the efficacy of interpersonal counselling compared with selective serotonin reuptake inhibitors (SSRIs), in primary care attenders wi...
Article
The aim of the present study was to evaluate the presence of psychiatric diseases/symptoms in transsexual patients and to compare psychiatric distress related to the hormonal intervention in a one year follow-up assessment. We investigated 118 patients before starting the hormonal therapy and after about 12 months. We used the SCID-I to determine m...
Article
Full-text available
Pharmacological stimulation of D2 receptors modulates prefrontal neural activity associated with working memory (WM) processing. The T allele of a functional single-nucleotide polymorphism (SNP) within DRD2 (rs1076560 G > T) predicts reduced relative expression of the D2S receptor isoform and less efficient neural cortical responses during WM tasks...
Article
Full-text available
In some tumors, psychosocial interventions may enhance health-related quality of life (HRQOL) of patients. The effects of psychological variables on HRQOL in hepatocellular carcinoma (HCC) patients have been rarely assessed. The aim of this work is to evaluate the psychopathological profile of HCC and cirrhotic patients and its effect on HRQOL. Twe...
Article
Fibromyalgia syndrome (FM) is frequently associated with migraine. In this study we aimed to compare personality profiles and coping styles across 23 migraine without aura patients sharing FM comorbidity (MWA-FM), 28 migraine without aura patients without FM symptoms (MWA) and 51 age- and sex-matched controls, by means of Big Five Questionnaire (BF...
Article
Full-text available
It is well known that the decrease of the Heart Rate Variability (HRV) is related to a number of important pathologies involving cardiovascular system as well as psychological and psychiatric disorders. In such case a prompt recover of HRV and, in particular, of parasympathetic modulation is required in the ANS (Autonomic Nervous System). In order...
Article
Full-text available
The existence of specific features of Metabolic Syndrome (MetS) in psychiatric population in comparison to not psychiatric patients has not been systematically investigated. The purpose of this study is to evaluate the differences of MetS among a group of psychiatric patients and a group of internal medicine patients in terms of anthropometric meas...
Article
Full-text available
Data on therapeutic interventions following deliberate self harm (DSH) in patients with treatment-resistant depression (TRD) are very scant and there is no unanimous consensus on the best pharmacological option for these patients. There is some evidence that lithium treatment might be effective in reducing the risk of completed suicide in adult pat...
Article
Importance: Serotonin (5-hydroxytryptamine) receptor 2a (5-HT2AR) signaling is important for modulation of corticostriatal pathways and prefrontal activity during cognition. Furthermore, newer antipsychotic drugs target 5-HT2AR. A single-nucleotide polymorphism in the 5-HT2AR gene (HTR2A rs6314, C>T; OMIM 182135) has been weakly associated with di...
Article
IntroductionGender identity disorder may be a stressful situation. Hormonal treatment seemed to improve the general health as it reduces psychological and social distress. The attachment style seemed to regulate distress in insecure individuals as they are more exposed to hypothalamic-pituitary-adrenal system dysregulation and subjective stress. Ai...
Article
Full-text available
The physical technique of the brain entrainment (BWE) is used and simultaneously time series data of R-R intervals are recorded during rest and alfa brain stimulation. The performed Fast Fourier Analysis evidences that, respect to the rest case, alfa brain stimulation induces a constant improvement in the total power spectral density and in particu...
Article
Full-text available
Starting with 2003 some authors performed a number of experiments with the finality to ascertain if quantum mechanics has a role during the perception and cognition in Humans. The arising quantum cognitive model was repeatedly confirmed. In the present paper we perform for the first time a similar experiment but executed this time on the single sub...
Article
Full-text available
The thesis of this paper is that Information, Cognition and a Principle of Existence are intrinsically structured in the quantum model of reality. We reach such evidence by using the Clifford algebra. We analyze quantization in some traditional cases of quantum mechanics and, in particular in quantum harmonic oscillator, orbital angular momentum an...
Article
Full-text available
In the present research, we have used the brain en-trainment (BWE) treatment simultaneously recording time series data of R-R intervals of the ECG during rest condition. In detail, we have used alpha brain stimulation and we have found that it induces an enhancement of HRV, particularly in Total Variability and Vagal Modulation activities. The expe...
Article
Full-text available
Starting with 2003 some authors performed a number of experiments with the finality to ascertain if quantum mechanics has a role during the perception and cognition in Humans. The arising quantum cognitive model was repeatedly confirmed. In the present paper we perform for the first time a similar experiment but executed this time on the single sub...
Article
Full-text available
The thesis of this paper is that Information, Cognition and a Principle of Existence are intrinsically structured in the quantum model of reality. We reach such evidence by using the Clifford algebra. We analyze quantization in some traditional cases of quantum mechanics and, in particular in quantum harmonic oscillator, orbital angular momentum an...
Article
Gender identity disorder (GID) is defined as a strong and persisting cross-gender identification, associated to the discomfort with the biological sex with which subjects were born. Over the last years, the question whether GID really represents a true psychiatric disorder and if it should be included within the upcoming editions of the major diagn...
Article
Full-text available
The physical technique of the brain entrainment (BWE) is used and simultaneously time series data of R-R intervals are recorded during rest and alfa brain stimulation. The performed Fast Fourier Analysis evidences that, respect to the rest case, alfa brain stimulation induces a constant improvement in the total power spectral density and in particu...
Data
Full-text available
It is shown that we have quantum interference in mental states during perception-cognition of ambiguous figures and during semantic conflict as in Stroop effect
Article
Full-text available
Gender identity disorder (GID) is a mental disorder in which gender identity is incongruent with the anatomical sex, in the absence of any clear and defined genetic or biological alteration. The diagnosis of GID as well as the assessment of patient eligibility for sex reassignment surgery (SRS) are prerequisite to the legal recognition procedure. T...
Article
Belief and expectation are part of placebo effect. Migraine patients are characterized by a dysfunctional modulation of pain processing, though a clear placebo effect emerges in clinical trials. The aim of the study was to evaluate the effect of visual and verbal suggestion on subjective pain sensation and cortical responses evoked by CO2 painful l...
Article
Full-text available
Von Neumann in 1932 was the first to outline the possible non-existence of dispersion free ensembles in quantum mechanics, and he used this basic evidence to give a preliminary proof on incompatibility between quantum mechanics and local hidden variables theory. In the present paper, we give a detailed theoretical elaboration on the manner in which...
Article
Full-text available
Neuroscience has realized valuable advances. As example, it has identified brain regions performing learning, memory, feeling and still more. The current tendency in neuroscience retains that adding pieces of knowledge day by day, we will finally arrive to an unified understanding of brain including the manner in which mind and consciousness arise...
Article
The physical technique of the brain entrainment (BWE) is used and simultaneously time series data of R-R intervals are recorded during rest and alfa brain stimulation. The performed Fast Fourier Analysis evidences that, respect to the rest case, alfa brain stimulation induces a constant improvement in the total power spectral density and in particu...
Article
The Diagnostic Criteria for Psychosomatic Research (DCPR) are a diagnostic and conceptual framework that aims to translate psychosocial variables that derived from psychosomatic research into operational tools whereby individual patients could be identified. A set of 12 syndromes was developed and grouped in the clusters of abnormal illness behavio...
Article
Full-text available
Genetic and environmental risk factors and gene-environment interactions are linked to higher likelihood of developing schizophrenia in accordance with the neurodevelopmental model of disease; little is known about risk factors and early development in early-onset schizophrenia (EOS) and very early-onset schizophrenia (VEOS). We present a case-cont...
Article
Full-text available
We discuss the celebrated elaboration on Theory of Games and Economic Behaviour that was formulated by von Neumann and Morgenstern in 1944. It assumes the rationality of individual decisions in Humans. We add discussion on Tvesky and Kahneman who, in their Prospect Theory, identified instead for the first time the presence of cognitive anomalies in...
Article
The study aimed to test the modulation induced by 1 Hz repetitive Transcranial Magnetic Stimulation (rTMS) of the occipital cortex on the alpha phase synchronization under repetitive flash stimuli in 15 migraine without aura patients compared to 10 controls. The EEG was recorded by 7 channels, while flash stimuli were delivered at 9, 18, 21 and 24...
Article
Alexithymia is likely to be involved in the pain experience of cancer patients, but the extent to which psychological interventions may modify both pain and alexithymia is unclear. A group of 52 consecutive cancer patients were enrolled in a 6-month multicomponent psychological intervention trial, and compared to 52 control patients who received st...
Article
Full-text available
We comment some recent results obtained by using a Clifford bare bone skeleton of quantum mechanics in order to formulate the conclusion that quantum mechanics has its origin in the logic, and relates conceptual entities. Such results touch directly the basic problem about the structure of our cognitive and conceptual dynamics and thus of our mind....
Article
Full-text available
In the light of the results obtained during the last two decades in analysis of signals by time series, it has become evident that the tools of non linear dynamics have their elective role of application in biological, and, in particular, in neuro-physiological and psycho-physiological studies. The basic concept in non linear analysis of experiment...
Article
Full-text available
Mental disorders are frequent in hemodialysis (HD) patients. Depression and anxiety along with physical co-morbidity affect quality of life (QOL). Uremia is associated with inflammation and release of cytokines by lymphomonocytes. Inflammatory cytokines are relevant in depression. The aim of this study was to assess the psychological alterations an...
Article
Full-text available
Imprecise characterization of complaints of the upper and lower gastrointestinal (GI) tract puts patients at risks of either a delayed diagnosis or misdiagnosis and contributes to an increase in the overall direct and indirect costs of the health system. The current scenario in the case of functional GI diseases originates from at least two conditi...
Article
Full-text available
We introduce the quantum theoretical formulation to determine a posteriori, if existing, the quantum wave functions and to estimate the quantum interference effects of mental states. Such quantum features are actually found in the case of an experiment involving the perception and the cognition in humans. Also some specific psychological variables...
Article
Full-text available
Processes undergoing quantum mechanics, exhibit quantum interference effects. In this case quantum probabilities result to be different from classical probabilities because they contain an additional main point that in fact is called the quantum interference term. We use ambiguous figures to analyse if during perception cognition of human subjects...
Article
Full-text available
For the first time we perform an experiment to test the possibility of Bell's inequality violation in mental states, during perception-cognition in humans. We study under a theoretical and experimental framework, a Bell-type test for human perception-cognition of ambiguous figures. It is performed a detailed analysis which demonstrates that, althou...
Article
Full-text available
In the first part of the paper we reach an experimental final confirmation that mental states follow quantum mechanics. In the second part further experimentation indicates that in mind states Bell inequality violation is possible.
Article
Full-text available
We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI. A total of 2,963 individuals from a sample of 5,632 65- to 84-year-old subjects were cognitively and functionally e...
Article
We applied the methodology presented in references to study the possible fractal structure of ink-blots of Rorschach, a projective test of personality that may give information about the emotional state, intellectual functioning and integration of a subject. It was found that such ink-blots have a fractal structure which can be characterized in det...
Article
The authors examine the role played by alexithymia in the treatment of various medical and psychiatric disorders, and the post-treatment change of alexithymia. Most studies on patients with complicated grief, gastrointestinal somatization, major depression, substance abuse, and surgery have shown that those with higher alexithymia respond less favo...
Article
Functional gastrointestinal disorders are a variable combination of chronic or recurrent medically unexplained gastrointestinal symptoms. They can be conceptualized within the biopsychosocial model of illness as a dysregulation of the brain-gut axis and its relationships with psychosocial variables (psychopathology, health care seeking, life events...
Article
This paper aimed to investigate the role played by key psychological factors in the experience of pain in cancer. One hundred and eight consecutive cancer patients were administered validated scales for pain, alexithymia, coping with cancer, and illness behavior. Two groups of patients with (n=45, 42%) and without (n=63, 58%) current pain were comp...
Article
We have executed for the first time an experiment on mental observables concluding that there exists equivalence (that is to say, quantum-like behavior) between quantum and cognitive entities. Such result has enabled us to formulate an abstract quantum mechanical formalism that is able to describe cognitive entities and their time dynamics.
Article
Full-text available
We describe a case of 46,XY disorder of sex development in a girl with marked virilization at puberty. The 17-β-hydroxysteroid dehydrogenase type 3 gene analysis showed a homozygous mutation, Arg80Trp. The molecular analysis represents a useful tool for the diagnosis of male pseudohermaphroditism in the presence of suggestive biochemical features.
Article
Full-text available
Functional gastrointestinal disorders are a variable combination of chronic or recurrent medically unexplained gastrointestinal symptoms. They can be conceptualized within the biopsychosocial model of illness as a dysregulation of the brain-gut axis and its relationships with psychosocial variables (psychopathology, health care seeking, life events...
Article
In the last decade, it has become more apparent the important role genes play in the development of late-onset Alzheimer's disease (AD). Great efforts, involving human genome scans and candidate gene studies, have been given towards identifying susceptibility genes for AD. A number of regions on different chromosomes have been reported to demonstra...
Article
Data concerning the treatment of lipoprotein disturbances in patients with cerebrovascular disease (CVD) are less robust than those for coronary heart disease (CHD), raising clinical questions as to which is the appropriate therapeutic approach to stroke patients. Although observational cohort studies have failed to demonstrate an association betwe...
Article
Plasma and serum biochemical markers proposed for cognitive decline of degenerative (Alzheimer's disease, AD) or vascular origin and predementia syndromes (mild cognitive impairment and other related entities) are based on pathophysiologic processes such as lipoprotein metabolism (total cholesterol, apolipoprotein E, 24S-hydroxy-cholesterol), and v...
Article
Alexithymic features are close to anhedonia, blunted affect, and alogia that are also characteristics of the negative symptoms of schizophrenia. This study aimed to evaluate whether alexithymia is associated with negative symptoms and is related to the change of schizophrenic symptoms over time. A consecutive sample of 29 schizophrenic outpatients...
Article
Introduction. The clear correlation between depression and coronary heart disease has been confirmed in many epidemiologic studies. Patients affected by Major Depression show more frequently a parasympathetic tone's decrease and a sympathetic modulation's increase in comparison of the non depressed subjects and have also a higher risk of ventricula...
Article
Objective. We aimed to evaluate the controversial association between alexithymia and depression with different assessment methods. Methods. Self-report and personality measures were administered to 92 patients with Inflammatory Bowel Disease (IBD). Alexithymia was assessed with the 20-item Toronto Alexithymia Scale (TAS-20) and with 4 variables fr...
Article
The Diagnostic Criteria for Psychosomatic Research (DCPR) have been demonstrated to be useful in identifying specific psychological conditions of medical patients. The aim of this study was to evaluate the clinical utility of the DCPR in predicting the treatment outcome of patients with functional gastrointestinal disorders (FGID). FGID outpatients...
Article
Alexithymia and psychopathology may influence the way individuals experience psychological distress and somatic symptoms. This study evaluated patients referred to psychiatric and gastroenterologic outpatient settings in order to investigate the levels of alexithymia and psychopathology, and the possible role of alexithymia in symptom perception an...
Article
A previous study found a strong association between alexithymia and functional gastrointestinal disorders (FGID). The objective of this study was to investigate whether alexithymia might be a predictor of treatment outcome in patients with FGID. A group of FGID outpatients classified by the 'Rome I' criteria was divided into improved (N= 68) and un...
Article
Full-text available
Experimental results presented in this paper supports the hypothesis on quantum-like statistical behaviour of cognitive systems (at least human beings). Our quantum-like approach gives the possibility to represent mental states by Hilbert space vectors (complex amplitudes). Such a representation induces huge reduction of information about a mental...
Conference Paper
Full-text available
quantum interference is evidenced in mental states by using ambiguous figures
Article
It has been previously hypothesized that the adverse outcome observed in depressed patients after myocardial infarction might be due to an imbalance in autonomic nervous system activity. The aim of this study was to define the role of depressive and anxious symptoms in influencing autonomic control of heart rate after myocardial infarction. The SD...
Article
To evaluate the influence of hormonal status on somatic, psychopathological and mood symptoms in climacteric women. 122 postmenopausal women have been evaluated by the PISA-system and P.O.M.S. (Profile of Mood States) to evaluate somatic, psychopathological and mood symptoms in a 3-intervention trial (perimenopausal women, postmenopausal women on r...
Chapter
Several studies have hypothesized a relationship between sudden death and neurophysiological factors. In particular, it has been suggested that there is a complex interrelationship between emotional disturbances (in particular, depression) and cardiovascular mortality in patients who have survived an acute myocardial infarction.
Article
In a previous study [Psychother Psychosom 1994;61:199-204] we investigated the relationship between alexithymia, carcinogenesis and immunity in a group of women who were unconscious sufferers from precancerous lesions of the cervix (CIN). The results of this study showed a high level of association between alexithymia and CIN and, an even more inte...
Article
Full-text available
The 20-item Toronto Alexithymia Scale (TAS-20) has been shown in previous research to measure a general dimension of alexithymia with three intercorrelated factors. This study evaluated the reliability and factorial validity of an Italian translation of the TAS-20 in a group of normal adults (N = 206) and in a mixed group of medical and psychiatric...