Orlando Petrucci

Orlando Petrucci
University of Campinas | UNICAMP · Departamento de Cirurgia

MD, PhD

About

106
Publications
12,024
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922
Citations
Additional affiliations
September 2008 - September 2009
Cincinnati Children's Hospital Medical Center
Position
  • Professor
January 2007 - December 2012
University of Campinas

Publications

Publications (106)
Article
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Introduction: Risk factors and postoperative complications can worsen the condition of patients undergoing coronary artery bypass grafting; some of these factors and complications are closely related to mortality rate. Objective: To describe clinical factors and outcomes related to mortality of patients undergoing coronary artery bypass grafting...
Article
Background In-hospital delays in permanent cardiac pacemaker (PPM) implantation are common and may result in in-hospital infection among patients waiting for PPM implantation (pre-PPM-HI). This study investigated the predictors and prognostic impact of these events. Methods We retrospectively evaluated 905 consecutive patients (68.2 ± 16.0 years;...
Article
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Objective This study compared clinical, echocardiographic, and prognostic characteristics among patients with aortic dissection (AD) with (HypHist) and without (No-HypHist) hypertension history and evaluated the association of blood pressure (BP) at presentation with 1-year mortality, left ventricular (LV) remodeling and renal dysfunction. Methods...
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Obesity and insulin resistance (IR) are well-studied risk factors for systemic cardiovascular disease, but their impact on pulmonary hypertension (PH) is not well clarified. This study aims to investigate if diet-induced obesity induces PH and if peroxisome-proliferator-activated receptor (PPAR-γ) and/or endoplasmic reticulum (ER) stress are involv...
Article
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Background This study compared left ventricular (LV) characteristics between patients with type‐A and type‐B aortic dissection (AD) and evaluated the ability of LV remodeling phenotypes (hypertrophy, concentricity, or geometric patterns) to predict mortality in both AD types. Methods and Results We evaluated 236 patients with type A and 120 patien...
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Objectives The objectives of this study were to describe a novel statewide registry for cardiac surgery in Brazil (REPLICCAR), to compare a regional risk model (SPScore) with EuroSCORE II and STS, and to understand where quality improvement and safety initiatives can be implemented. Methods A total of 11 sites in the state of São Paulo, Brazil, for...
Conference Paper
Transient thrombocytopenia is common after surgery for aortic valve replacement (AVR), but rarely studied systematically. Severe thrombocytopenia (platelets <50000/mL) often requires replacement of platelets and other blood products and exposure to their risks. The aims of this study are to verify the occurrence of complications in patients present...
Conference Paper
As cirurgias cardíacas são cirurgias de grande porte com relevante impacto psicológico aos pacientes e pós-operatórios com elevado risco de complicações. Existem evidências da relação entre expectativas do paciente quanto ao procedimento a que será submetido e os desfechos clínicos obtidos. Tais estudos, entretanto, utilizam formas de abordagem pou...
Article
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O trabalho em questão consiste em verificar o SYNTAX Score (SS) e sua relação com o índice preditor de risco EuroSCORE e as complicações pós-operatórias da cirurgia de revascularização do miocárdio (RM). O SS foi desenvolvido para analisar a complexidade da carga aterosclerótica da vasculatura coronária e nortear qual o tratamento invasivo mais ade...
Article
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Risk stratification in secondary prevention has emerged as an unmet clinical need in order to mitigate the Number-Needed-to-Treat and make expensive therapies both clinically relevant and cost-effective. P wave indices reflect atrial conduction, which is a sensitive marker for inflammatory, metabolic, and pressure overload myocardial cell remodelin...
Data
Figure A. Linear regression between P-wave duration and dispersion. Table A. Clinical correlates of P-wave indices. (DOCX)
Article
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Objective: The present study aimed the functional recovery evaluation after long term of cardiac arrest induced by Custodiol (crystalloid-based) versus del Nido (blood-based) solutions, both added lidocaine and pinacidil as cardioplegic agents. Experiments were performed in isolated rat heart perfusion models. Methods: Male rat heart perfusions,...
Article
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Purpose Therapeutic strategies that modulate ventricular remodeling can be useful after acute myocardial infarction (MI). In particular, statins may exert effects on molecular pathways involved in collagen metabolism. The aim of this study was to determine whether treatment with atorvastatin for 4 weeks would lead to changes in collagen metabolism...
Article
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Abstract Introduction: Cardiomyocytes are more sensitive to stimulatory electrical fields when the latter are applied longitudinally to the cell major axis. In the whole heart, cells have different spatial orientations, which may limit the effectiveness of conventional electrical defibrillation (i.e., shock delivery in a single direction). This art...
Article
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The inflammatory response has been implicated in the pathogenesis of left ventricular (LV) remodeling after myocardial infarction (MI). An anthraquinone compound with anti-inflammatory properties, diacerein inhibits the synthesis and activity of pro-inflammatory cytokines, such as tumor necrosis factor and interleukins 1 and 6. The purpose of this...
Article
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Introduction: Cholesterol undergoes oxidation via both enzymatic stress- and free radical-mediated mechanisms, generating a wide range of oxysterols. In contrast to oxidative stress-driven metabolites, enzymatic stress-derived oxysterols are scarcely studied in their association with atherosclerotic disease in humans. Methods: 24S-hydroxycholest...
Article
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Objectives: Cardiac arrest after open surgery has an incidence of approximately 3%, of which more than 50% of the cases are due to ventricular fibrillation. Electrical defibrillation is the most effective therapy for terminating cardiac arrhythmias associated with unstable hemodynamics. The excitation threshold of myocardial microstructures is low...
Article
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Introduction: The classic treatment for penetrating injuries of the heart is surgery. Advances in diagnostic and minimally invasive surgery have changed this behavior in selected cases. This study aims to analyze the cases of minor cardiac injuries submitted to surgery at a university hospital and the possibility of a less invasive approach. Materi...
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Introduction: Cardiac arrest during heart surgery is a common procedure and allows the surgeon to perform surgical procedures in an environment free of blood and movement. Using a model of isolated rat heart, the authors compare a new cardioplegic solution containing histidine-tryptophan-glutamate (group 2) with the histidine-tryptophan-alphacetogl...
Article
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A retrospective cohort study was preformed aiming to verify the presence of transient dysfunction of gas exchange in the postoperative period of cardiac surgery and determine if this disorder is linked to cardiorespiratory events. We included 942 consecutive patients undergoing cardiac surgery and cardiac procedures who were referred to the Intensi...
Article
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Myocardial preservation during open heart surgeries and harvesting for transplant are of great importance. The heart at the end of procedure has to resume its functions as soon as possible. All cardioplegic solutions are based on potassium for induction of cardioplegic arrest. To assess a cardioplegic solution with no potassium addition to the form...
Article
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In vitro hydrodynamic characterization of prosthetic heart valves provides important information regarding their operation, especially if performed by noninvasive techniques of anemometry. Once velocity profiles for each valve are provided, it is possible to compare them in terms of hydrodynamic performance. In this first experimental study using l...
Article
Adhesions may increase the incidence of lethal complications of cardiac reoperations, which account for up to 20% of all open-heart surgeries. Herein, we describe the use of a polyvinyl alcohol membrane (PVAM) as a pericardial alternative and describe its performance during reoperation in a relevant animal model. The PVAM samples were reticulated b...
Article
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AIMS: Although an increase in the ventricular pacing threshold (VPT) has been observed after administration of transthoracic shock for ventricular defibrillation, few studies have evaluated the phenomenon with respect to the defibrillation waveform energy. Therefore, this study examined the VPT behaviour after transthoracic shock with a monophasic...
Conference Paper
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Ventricular fibrillation (VF) is a potentially lethal cardiac arrhythmia, for which the only known effective treatment is electrical defibrillation. In this work, a specific instrumentation was developed for the study of a new approach of cardiac defibrillation (multidirectional stimulation), in which shocks were switched and applied to three pairs...
Article
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Background: Several techniques and cardioplegic solutions have been used for heart preservation during transplant procedures. Unfortunately, there is a lack of ideal method for myocardial preservation in the clinical practice. The use of retrograde cardioplegia provides continuous infusion of cardioplegic solution during the graft implantation. Th...
Article
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Objective: To assess the quality of life in patients undergoing myocardial revascularization using the six-minute walk test. Methods: Prospective observational study with patients who undergoing CABG. The clinical variables, the sixminute walk test, and the SF-36 test were recorded. The patients were assessed at the preoperative time and at 2 mo...
Article
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Modified ultrafiltration (MUF) has been shown to decrease the postcardiac surgery inflammatory response and to improve respiratory function and cardiac performance in pediatric patients; however, this approach has not been well established in adults. The present study hypothesized that MUF could decrease the postsurgical inflammatory response, lead...
Article
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Objectives: The effect of erythropoietin (EPO) on neonatal hearts is not well understood. The current hypothesis is that EPO has protective effects against ischaemia-reperfusion when administered prior to ischaemia induction. Methods: Systolic and diastolic indices, as well as the Akt and extracellular-regulated kinase (Erk) signalling pathways,...
Article
The long-term results after surgical repair of rheumatic mitral valve remain controversial in literature. Our aim was to determine the predictive factors which impact the long-term results after isolated rheumatic mitral valve repair and to evaluate the effect of those factors on reoperation and late mortality. One hundred and four patients with rh...
Article
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INTRODUÇÃO: Os resultados tardios da plastia mitral em pacientes reumáticos são controversos na literatura. OBJETIVO: Estudo observacional e prospectivo que avalia os resultados tardios e identifica os fatores associados à reoperação e à mortalidade em pacientes reumáticos submetidos à plastia da valva mitral. MÉTODOS: Incluídos somente os paciente...
Article
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Atrial fibrillation (AF) remains a frequent complication after coronary artery bypass graft surgery (CABG). We evaluate the association of AF occurrence and serum cardiac troponin I (cTnI) levels in the early postoperative period after CABG. Between April 2009 and January 2010, 95 consecutive patients with sinus rhythm who underwent CABG were evalu...
Article
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Background: Myocardial infarction might result in dilated left ventricle and numerous techniques have been described to restore the original left ventricle shape and identify tools for late survival assessment. The aim of this study is to compare our experience with a modified Dor procedure using a rigid prosthesis to the septal anterior ventricul...
Article
Perioperative advances have led to significant improvements in outcomes after many complex neonatal open heart procedures. Whether similar improvements have been realized for the modified Blalock-Taussig shunt, the most common palliative neonatal closed-heart procedure, is not known. Data were abstracted from The Society of Thoracic Surgeons Congen...
Article
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This study aims at the influence on hemolysis of the differences between the maximum and minimum amplitudes of pressure in the outlet of three roller pump models adjusted by dynamic calibration method. Tests were performed with silicone tubes (½ × (3)/(16) inches) in fluid analogous to blood and fresh bovine blood from slaughterhouse. Tests with an...
Article
Protection and preservation of fetal myocardial function are important for successful fetal intracardiac repair. Our objective was to determine fetal biventricular cardiac performance after two cardiac-arrest techniques. Three groups of midterm ovine fetuses underwent 90-minute bypass. A control group (no arrest shams, n = 3), and two groups that i...
Article
Fetal cardiac surgery might improve the prognosis of certain complex congenital heart defects that have significant associated mortality and morbidity in utero or after birth. An important step in translating fetal cardiac surgery is identifying potential mechanisms leading to myocardial dysfunction after bypass. The hypothesis was that fetal cardi...
Article
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OBJECTIVE: Infectious and inflammatory processes mediated by bacteria in distant sites have been described as a risk factor for acute ischemic heart disease (AIHD). METHODS: One hundred one patients with AIHD with and without chronic periodontitis (CP) were included in this study. Patients were admitted to the HC UNICAMP and stratified into three g...
Article
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OBJECTIVE: The inflammatory response after cardiac surgery increases vascular permeability leading to higher mortality and morbidity in the post operative time. The modified ultrafiltration (MUF) had shown benefits on respiratory, and hemodynamic in pediatric patients. This approach in adults is not well established yet. We hypothesize that modifie...
Article
Full-text available
Infectious and inflammatory processes mediated by bacteria in distant sites have been described as a risk factor for acute ischemic heart disease (AIHD). One hundred one patients with AIHD with and without chronic periodontitis (CP) were included in this study. Patients were admitted to the HC UNICAMP and stratified into three groups: in group 1, w...
Article
The inflammatory response after cardiac surgery increases vascular permeability leading to higher mortality and morbidity in the post operative time. The modified ultrafiltration (MUF) had shown benefits on respiratory, and hemodynamic in pediatric patients. This approach in adults is not well established yet. We hypothesize that modified ultrafilt...
Article
Full-text available
As bombas de roletes ocupam um papel de destaque entre os dispositivos utilizados na circulacao extracorporea, pois sao responsaveis pela movimentacao do sangue. O ajuste adequado desses equipamentos e fundamental para minimizar o trauma nas celulas sanguineas. O presente trabalho analisou dois metodos para ajuste das bombas: o metodo de medida de...
Article
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The rotation of rollers in cardiopulmonary bypass pumps propels the blood through various devices to reach the patient. Very occlusive settings may squeeze red blood cells, whereas a nonocclusive setting may result in retrograde flow. Occlusion of roller pumps may be regulated either by measuring the drop rate or by dynamic calibration. This study...
Article
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OBJECTIVE: The post operative pain after open heart surgeries had been often reported. Meager reports about respiratory function and pain correlation had been reported. The aim of this article is to assess the pain intensity and location during hospital admittance and its effect on pulmonary function in patients underwent elective cardiac surgery....
Article
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OBJETIVO: Um dos maiores danos causados pela oclusão em bombas de rolete é a hemólise. Estudos comparativos entre bomba de roletes com ajustes não oclusivos e bombas centrífugas têm sido realizados nas últimas décadas na tentativa de desenvolver novos produtos e ajustes que causem menos trauma aos elementos figurados do sangue. Comumente as bombas...
Article
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The post operative pain after open heart surgeries had been often reported. Meager reports about respiratory function and pain correlation had been reported. The aim of this article is to assess the pain intensity and location during hospital admittance and its effect on pulmonary function in patients underwent elective cardiac surgery. Pulmonary f...
Article
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One of the major damage caused by occlusion in roller pumps is hemolysis. Comparative studies between roller pump with adjustments non occlusive and centrifugal pumps have been made in recent decades in an attempt to develop new products and adjustments that cause fewer traumas to the figurative elements of blood. Usually the roller pumps are adjus...
Article
The bidirectional Glenn procedure is a well-established procedure performed as part of the single-ventricle palliation pathway. Numerous studies have highlighted the potential benefits of an "early" BDG procedure. The ideal age to perform the BDG procedure, however, remains uncertain. We report our experience with the BDG procedure in patients youn...
Article
Heart failure is a common and often fatal disease. Numerous animal models are used to study its aetiology, progression and treatment. This article aims to demonstrate two minimally invasive models of congestive heart failure in a rabbit model and a precise method to assess cardiac performance. Fifty New Zealand White rabbits underwent cervicotomy i...
Conference Paper
Purpose: Recent data suggest that calpain, a calcium-dependent cysteine protease, regulates reperfusion injury associated with cardiopulmonary bypass (CPB) in immature hearts. Calpastatin, the endogenous inhibitor of calpain, has separate inhibitory domains and an L domain that may mediate activity of L-type calcium channels. The hypothesis is that...
Article
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OBJETIVO: Identificar um método estatístico que expresse o tempo da presença do doente na sala de operação e construir a "matriz de relação" de otimização deste tempo, o tempo exato e real da operação. MÉTODOS: A análise de sobrevivência e o estimador de Kaplan-Meier permitiram calcular as curvas de sobrevivência para os diferentes tempos e a "matr...
Article
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To identify a statistical method that may express the patient length of stay in the operating room and build a 'matrix of relationship' for optimizing this time, the real and exact time of the operation. The analysis of survival and the Kaplan-Meier estimator allowed to calculate the survival curves for different times and the 'matrix of relationsh...
Article
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Resumo Objetivo: Dentre os equipamentos utilizados em circulação extracorpórea, as bombas de rolete têm grande importância, com diversos modelos disponíveis de vários fabricantes. A calibração é um fator importante nas taxas de hemólise e o seu potencial difere em cada uma delas. Pesquisadores nem sempre abordam detalhes sobre os perfis do leito rí...
Article
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Among the equipments used in cardiopulmonary bypass the roller pumps have great importance with various models available from several manufacturers. The calibration is an important factor in hemolysis rates and its potential is different in each. Researchers do not always approach details on the pump bed profiles assuming that the standardized cali...
Article
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To investigate the effectiveness of ultrafiltration in removing inflammatory mediators released by cardiopulmonary bypass and to correlate ultrafiltration with alterations in organic function according to the Sequential Organ Failure Assessment Score. Forty patients were included and randomized into two groups: "no ultrafiltration" (n=20; Group I)...
Article
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The aim of this study is to verify in an isolated working heart swine model if the acute administration of trimetazidine to cardioplegia, without pre-treatment improves heart performance. Eighteen pairs of swine were used in this working heart model, divided into three groups (n = 6) that underwent regional and global ischemia. Each group was selec...
Article
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Several methods of myocardial protection have been used. The use of all-blood solutions modified with glutamate and aspartate has increased. Its use in situations of acute ischemia provides improved contractile function, "resuscitating" the previously lesioned muscle. The dilution preconized by literature is around 25% of the hematocrit. The presen...