Orfeu M Buxton

Orfeu M Buxton
Pennsylvania State University | Penn State · Department of Biobehavioral Health

PhD

About

272
Publications
56,492
Reads
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11,139
Citations
Introduction
Orfeu M Buxton currently works at the Department of Biobehavioral Health, Pennsylvania State University. Orfeu does research in Neuroscience, Health Psychology, Sleep Medicine, and Health Disparities.
Additional affiliations
August 2014 - June 2021
Harvard University
Position
  • Professor (Associate)
Description
  • https://www.hsph.harvard.edu/orfeu-buxton/
July 2014 - October 2021
Harvard Medical School
Position
  • Lecturer
July 2011 - June 2014
Harvard Medical School
Position
  • Professor
Description
  • http://sleep.med.harvard.edu/people/faculty/237/Orfeu
Education
August 1993 - June 2000
Northwestern University
Field of study
  • Neuroscience

Publications

Publications (272)
Article
Full-text available
Background: Pharmaceutical drug therapy problems (DTPs) are a major public health problem. We examined patient-level risk factors for DTPs among Cambodian Americans. Methods: Community health workers (CHWs) verbally administered surveys and completed a detailed medication review form with participants. A doctoral-level pharmacist reviewed the fo...
Chapter
Machine learning (ML) offers some of the most cost-effective methods for extracting useful insights from large data sets. Availability of large data sets and tools for modular, scalable, reproducible, open, shareable data analytic workflows, allow researchers to rapidly train, rigorously validate and share predictive models in health research. Thes...
Article
Full-text available
Objectives Pain is common among torture survivors and refugees. Clear communication about one’s pain is vital to timely and precise diagnosis and treatment but is rarely recognized as a social determinant of health. We examined whether self-reported difficulty communicating with their health care provider, along with standard social determinants, i...
Article
This paper reports secondary data analysis of associations between psychological distress and health behaviors among Cambodian Americans. Data are from baseline assessments from a diabetes prevention trial. All participants met criteria for depression and were free of diabetes. Participants (n=191) completed surveys, a food frequency assessment, an...
Article
Full-text available
Stress and sleep are related, but the nature and time course of this relation is not well understood. We explored the within-person associations of three components of emotional responses to everyday stressors, indexed by negative affect, reactivity (initial response to a stressor), recovery (persistence of the post-stressor response), and pile-up...
Article
OBJECTIVES The current study examined longitudinal linkages between child sleep duration and children’s socioemotional, learning engagement, executive functioning, and academic outcomes across the full kindergarten (K) year. METHODS A measurement-burst design was employed to examine 3 different measures of child sleep duration in 7-day bursts at p...
Article
Objective/background Night wakings are common during infancy, with variability in infant self-soothing or requiring parent involvement to fall back asleep. Reasons for variable soothing behaviors are unclear and may be influenced by early-life sleep parenting practices. The study applied a novel method using sleep actigraphy in mother-father-infant...
Article
Full-text available
Objectives Although individual sleep characteristics are related to frailty, these characteristics do not occur separately. A multidimensional measure of sleep might provide a better estimation of frailty compared to isolated sleep characteristics. This study investigated the association of a multidimensional measure of sleep health with frailty bo...
Article
Full-text available
Background Poor self-reported sleep health has been linked to not consuming breakfast in adolescents, but it is unknown whether poor sleep measured objectively predicts next-day breakfast consumption within adolescents. We investigated within- and between-person associations of objectively measured sleep dimensions and subjective sleep quality with...
Article
BACKGROUND AND OBJECTIVES The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) responsive parenting (RP) intervention for first-time mothers improved firstborn infant sleep compared with controls. The goals of this analysis were to test intervention spillover effects on secondborn siblings and examine birth order differen...
Preprint
Background Endocrine therapy (ET) for breast cancer treatment is associated with cognitive complaints, but their etiology is poorly understood. To address this, we developed and implemented an ambulatory assessment protocol consisting of wearable activity monitors, brief surveys of affect, context, and perceived impairments, and ultra-brief perform...
Article
Background: Epidemiological data suggest that populations exposed to starvation show increased incidence of type 2 diabetes but these studies are limited by lack of person-level data. Cambodians resettled in the USA survived severe malnutrition during distinct historical eras. We examined the relationship of individual exposure to starvation with...
Article
Introduction The concept of Sleep Health, based on self-reports in the RU-SATED model, has been recently extended using parameters derived from 4 days of actigraphy in a cohort of older adults, yielding a 5-component model. Using a longer actigraphy time series from a separate study, the current factor analysis evaluates and extends a theoretically...
Article
Introduction Poor mental health in adolescents has been linked to more variable sleep. However, most studies use self-reported measures of sleep. There is also a lack of research on sex differences in these associations, which is important given that poor emotional health is more common in female than male adolescents. The current study examined wh...
Article
Introduction Sleep and physical activity are related to psychological trauma. Less is known about how individuals with distinct sleep and activity profiles differ on specific clusters of trauma symptoms. Cambodian-Americans who survived the Pol Pot genocide experienced severe collective trauma. This analysis explored group differences between sleep...
Article
Introduction Wrist-worn research-grade actigraphy devices are commonly used to identify sleep and wakefulness in freely-living people. However, common existing algorithms were developed primarily to classify sleep-wake within a defined in-bed period with PSG, and exhibit relatively high sensitivity (accuracy on sleep epochs) but relatively low spec...
Article
Introduction While sleep health is comprised of multiple dimensions, extant research tends to investigate single elements of sleep, such as sleep duration or sleep quality. The current study aimed to explore whether psychological and behavioral factors were associated with a multidimensional sleep health score as well as if sleep health was related...
Article
Introduction Worse sleep health has been linked with greater substance use among adolescents. However, most studies have only cross-sectionally examined this relationship or examined these longitudinal effects in children with sleep disorders. This study investigates whether childhood sleep is longitudinally associated with adolescent alcohol or ma...
Article
Full-text available
New sleep technologies have become pervasive in the consumer space, and are becoming highly common in research and clinical sleep settings. The rapid, widespread use of largely unregulated and unstandardized technology has enabled the quantification of many different facets of sleep health, driving scientific discovery. As sleep scientists, it is o...
Article
Chronic sleep restriction (CSR) has been associated with adverse effects including cognitive impairment and increased risk of diabetes and cardiovascular disease. Yet, sleep restriction therapy is an essential component of most behavioral treatments for insomnia. Moreover, little is known about the impact of CSR on sleep continuity and structure in...
Article
Full-text available
Study Objectives Sleep is a modifiable risk factor for cardiovascular conditions. Holistic examination of within-person, multidimensional sleep patterns may offer more detailed information about the sleep-cardiovascular condition link, including who is more vulnerable to both. This study aimed to identify common sleep phenotypes in adulthood, estab...
Article
Background: Nearly 14% of Americans experience chronic circadian disruption due to shift work, increasing their risk of obesity, diabetes, and other cardiometabolic disorders. These disorders are also exacerbated by modern eating habits such as frequent snacking and consumption of high-fat foods. Methods: We investigated the effects of recurrent...
Preprint
Resting-state functional magnetic resonance imaging (rsfMRI) allows the study of functional brain connectivity based on spatially structured variations in neuronal activity. Proper evaluation of connectivity requires removal of non-neural contributions to the fMRI signal, in particular hemodynamic changes associated with autonomic variability. Regr...
Article
Full-text available
We examined whether subjectively and objectively measured sleep health composites have a relationship with heart disease. 6,820 adults (Mage = 53.4 years) from the Midlife in the United States study provided self-reported sleep characteristics and heart disease history. A smaller sample (n = 663) provided actigraphy sleep data. We tested two sleep...
Article
Differential social and contextual environments may contribute to adolescent sleep disparities, yet most prior studies are limited to self-reported sleep data and have not been conducted at a national level, limiting the variation in neighborhood contexts. This study examined the association between neighborhood disadvantage and objective measures...
Chapter
This chapter describes the specific ways in which the family unit influences the development of infant, child, and adolescent sleep patterns. Sleep health is discussed in the context of both parent practices and quality, as well as family, sociodemographic, contextual, and structural factors. In particular, factors relevant for infant sleep develop...
Article
Full-text available
Caffeine consumption has been linked to poor sleep health in adolescents, but it is unknown whether poor sleep predicts caffeine consumption, and/or whether caffeine consumption predicts poor sleep, particularly when sleep is measured objectively. Data were collected from a micro-longitudinal sub-study of the age 15 wave of the Fragile Families and...
Article
Full-text available
Pathways through which spousal support and strain influence older adults’ well-being are poorly understood. We examined sleep quality and loneliness as mechanisms through which support and strain predict depressive symptoms across ten years utilizing National Social Life, Health, and Aging Project data. Our sample included partnered participants at...
Article
Full-text available
Alzheimer’s disease (AD) is the most common cause of dementia in the old adult population. AD pathogenesis has been linked to the aggregation of toxic proteins, e.g., amyloid-β and tau. The glymphatic system may play an important role in clearing out these proteins via cerebrospinal fluid (CSF) flows through perivascular and interstitial spaces. Re...
Article
Full-text available
Since the early 2000s, it is increasingly common that people have short sleep durations (<=6 per 24-hour), making this a high-prevalence public health issue, especially among Black individuals. We investigate how trends in short sleep duration are influenced by changes in population aging, socioeconomic factors (e.g., education, labor force partici...
Article
Full-text available
Although individual sleep characteristics are related to frailty, these characteristics do not occur separately. A multidimensional measure of sleep might provide a better estimation of frailty compared to isolated sleep characteristics. This study investigated the association of a multidimensional measure of sleep health with frailty and examined...
Article
Objective To better understand the short-term impact of family interactions on adolescent sleep, this study examined daily associations between family interaction quality and sleep duration, sleep maintenance efficiency, and subjective sleep quality. Methods Participants were 517 diverse youth (Mage = 15.4 years, Range = 15-18) in the Fragile Fami...
Article
Full-text available
Insufficient sleep, which has been shown to adversely affect metabolism, is generally associated with prolonged exposure to artificial light at night, a known circadian disruptor. There is growing evidence suggesting that circadian disruption adversely affects metabolism, yet few studies have attempted to evaluate the adverse metabolic effects of i...
Article
Background Cambodian Americans have high rates of cardiometabolic and psychiatric disorders and disadvantaged social determinants of health (SDOH). These factors can make it challenging to resolve drug therapy problems (DTPs) and improve medication-related outcomes. This manuscript reports planned analyses from a randomized controlled trial in whic...
Article
Full-text available
We investigated whether interindividual attentional vulnerability moderates performance on domain-specific cognitive tasks during sleep restriction (SR) and subsequent recovery sleep. Fifteen healthy men (M ± SD, 22.3 ± 2.8 years) were exposed to three nights of baseline, five nights of 5-h time in bed SR, and two nights of recovery sleep. Particip...
Article
Background: Shift work is associated with long-term health risks. Workplace-based health interventions hold promise for improving or maintaining the health of shift workers; yet, the impact of workplace-based interventions on shift worker sleep duration has not been assessed. We conducted a systematic review of workplace interventions on shift wor...
Article
Full-text available
Purpose: The effects of sleep restriction on subjective alertness, motivation, and effort vary among individuals and may explain interindividual differences in attention during sleep restriction. We investigated whether individuals with a greater decrease in subjective alertness or motivation, or a greater increase in subjective effort (versus oth...
Article
Full-text available
Objectives We tested whether participation in the Supplemental Nutrition Assistance Program (SNAP) moderated the relation between household food insecurity and HbA1c among Cambodian Americans with depression enrolled in a diabetes prevention trial. Methods Community health workers assessed household food insecurity and SNAP participation. HbA1c wa...
Article
Objectives We tested whether participation in the Supplemental Nutrition Assistance Program (SNAP) moderated the relation between household food security status and HbA1c, the gold standard measure of glycemic control, among Cambodian Americans with depression enrolled in a diabetes prevention trial. Methods Participants had elevated risk factors...
Article
Full-text available
The glymphatic system plays an important role in clearing the amyloid-β (Aβ) and tau proteins that are closely linked to Alzheimer disease (AD) pathology. Glymphatic clearance, as well as Aβ accumulation, is highly dependent on sleep, but the sleep-dependent driving forces behind cerebrospinal fluid (CSF) movements essential to the glymphatic flux...
Article
Introduction The prevalence of obesity among U.S. Latinx children is nearly 10% higher than in their white counterparts. Long-term success of diet and activity level-focused interventions has been limited. Poor sleep is associated with increased obesity risk in youth. Application of social ecological models of behavior change to identify influences...
Article
Introduction Experiences of discrimination attributed to a range of individual characteristics (race, skin color, age, sex, etc.) may influence the extent to which sleep impacts cognitive functioning in order adults, particularly within older minorities. Thus, we investigated the effect of discrimination on the relationship between actigraphic slee...
Article
Introduction Sleep health is linked to dietary choices, and skipping breakfast is associated with risk of negative health outcomes in adolescents. However, there is a lack of research on whether dimensions of sleep at night predict adolescents eating breakfast the next day. We investigated within- and between-person associations of multiple aspects...
Article
Introduction Daytime and evening screen use have been associated with poor sleep health among adolescents, especially delayed sleep timing. However, most studies only investigate associations between adolescents rather than within the same person across multiple nights. Our multilevel modeling approach allows for assessment of connection between sc...
Article
Introduction Previous studies have linked sleep to risk of diabetes and obesity, at least partially via alterations in food intake. Diabetes and obesity are common among Hispanics/Latinos, and studies are needed to better clarify the role of sleep for health among this group. Methods Data were collected from N=100 adults (age 18-60, 47% female) of...
Article
Full-text available
Background Depression and antidepressant medications are associated with increased risk for type 2 diabetes. It is not known if diabetes can be prevented in the setting of depression. Cambodian Americans have high rates of both depression and diabetes. This paper reports intervention development, experimental design, baseline characteristics, and p...
Article
Full-text available
Background Sleep is a robust determinant of next-day emotions, but people vary in the extent that their emotions fluctuate on days following short sleep duration. These individual differences in day-to-day sleep and emotion dynamics may have long-term health implications. Purpose To evaluate emotional vulnerability to short sleep (within-person as...
Article
Aims Migrants experience social disconnection and also have high risk for metabolic syndrome (MetS). This study explored associations of social alienation, social isolation, and social support with MetS among Cambodian Americans. Methods We conducted secondary data analysis on baseline assessments from a diabetes prevention trial for Cambodian Ame...
Article
Introduction: Previous studies have linked sleep to risk of diabetes and obesity, at least partially via alterations in food intake. Diabetes and obesity are common among Hispanics/Latinos, and studies are needed to better clarify the role of sleep in health among this group. Utilizing the revised TFEQ-R-18, this study will examine whether eating b...
Article
Objective We and others have found that couples’ sleep is a shared and dyadic process. Couples’ sleep-wake concordance (whether couples are awake or asleep at the same time) is associated with couples’ relationship factors; however, we know little of the temporal associations between concordance and daily relationship characteristics. The purpose o...
Conference Paper
Full-text available
We examined daily affective vulnerability to short sleep (i.e., individual differences in the extent that sleeping ≤6h predicts next-day affect) as a risk factor for developing chronic conditions 10 years later. Participants (N=1945, ages 35-85, 57% women) from the National Study of Daily Experiences reported sleep duration and affect in daily diar...
Article
Full-text available
Few longitudinal studies link objectively assessed sleep and cognitive performance in ecologically-valid environments. Participants enrolled in the community-based Einstein Aging Study cohort (n=224, M[age]=77.17). Wake after sleep onset (WASO) was associated with worse cognitive performance with and without MCI (2-week smartphone-based EMA, six as...
Article
Evidence suggests that sleep disturbance may precede cognitive decline and may thus be a target for early intervention. Few studies have examined the short term (day to day) associations between sleep quality and cognitive performance in older adults. The Einstein Aging Study (EAS) provided the opportunity to examine ambulatory measures of sleep (a...
Article
Sleep deficiency and sleep disorders are common in older adults and have been linked to cognitive decline and dementia risk. Better understanding the association of sleep patterns over time with onset of early cognitive changes may facilitate interventions to prevent AD and dementia. Few studies have reported on the association of cumulative longit...
Article
Full-text available
Objectives To investigate the heterogeneous effects of education on sleep duration for Black and White adults and how the education effects changed between 2004 and 2018. Methods A total of 251,994 adult participants in the 2004 to 2018 National Health Interview Survey were included in pooled cross-sectional data analyses. Separately for Black and...
Article
Sleep disparities exist among Hispanics/Latinos, although little work has characterized individuals at the United States (US)-Mexico border, particularly as it relates to acculturation. This study examined the association of Anglo and Mexican acculturation to various facets of sleep health among those of Mexican descent at the US-Mexico border. Dat...
Article
Full-text available
Objective: Experimental evidence suggests that inadequate sleep disrupts next-day affective processing and evokes greater stress reactivity. However, less research has focused on whether sleep predicts next-day affective reactivity to naturally occurring stressors and positive events in daily life, as well as the reversed direction of association...
Article
Full-text available
Purpose: In non-rapid eye movement (NREM) stage 3 sleep (N3), phase-locked pink noise auditory stimulation can amplify slow oscillatory activity (0.5-1 Hz). Open-loop pink noise auditory stimulation can amplify slow oscillatory and delta frequency activity (0.5-4 Hz). We assessed the ability of pink noise and other sounds to elicit delta power, sl...
Article
Objective /Background: Clinical recommendations include putting infants to bed using a consistent bedtime routine at an appropriate hour to promote longer nighttime sleep. Actigraphy was used in this exploratory study to examine how bedtime routines and nighttime sleep onset were associated with nighttime total sleep time (TST) and efficiency from...
Preprint
Full-text available
The glymphatic system plays an important role in clearing the amyloid-β and tau proteins that are closely linked to Alzheimer's disease (AD) pathology. Glymphatic clearance, as well as amyloid-β accumulation, is highly dependent on sleep, but the sleep-dependent driving forces behind cerebrospinal fluid (CSF) movements essential to the glymphatic f...
Article
Full-text available
Daily rhythms in several physiological processes are important for cardiometabolic health. The lipid panel is used clinically to assess cardiovascular disease risk, but previous attempts to demonstrate circadian variation in lipids have failed to uncouple the endogenous circadian rhythm from the effects of meals and wake duration. Changes in basal...
Article
Full-text available
Introduction We investigated whether individuals with more lapses on the psychomotor vigilance task (PVT) after sleep restriction (SR) demonstrated poorer working memory compared to those with fewer PVT lapses. Methods Fifteen healthy men (22.3±2.8 years) participated in a 10-night inpatient protocol with three nights of 10-hour baseline time in b...
Article
Introduction Sleep loss negatively impacts many aspects of neurobehavioral performance, including sustained attention and reaction times. However, the time course of recovery from chronic sleep restriction (CSR) is not well understood. To explore this, we assessed the effects of 3 weeks of CSR followed by 1 week of recovery on psychomotor vigilance...
Article
Introduction Differential social and contextual environments may contribute to adolescent sleep disparities. Yet, most prior studies are limited to self-reported sleep data, and the actigraphic studies of sleep are not conducted at a national level, thus limiting the variation in neighborhood contexts. This study examined the association between ne...
Article
Introduction Chronotype refers to a preference for morning hours (morningness) vs. evening hours (eveningness) when individuals tend to feel their best (e.g., higher energy levels). People may be classified at either end of this spectrum or along a continuum between these preferences. Among adolescents, eveningness is positively related to depressi...
Article
Introduction Experimental sleep restriction is associated with elevated daytime cardiac activity, including heart rate (HR) and blood pressure (BP). However, some studies have found changes in systolic (SBP) but not diastolic blood pressure (DBP) or found changes in neither. Although findings are mixed, there may be a dose-response effect of cumula...
Article
Introduction Sleep is vital for healthy development in children. Suboptimal sleep health may play an under-appreciated role in educational achievement gaps among vulnerable student populations. Students of color, students from economically disadvantaged homes, and students with disabilities are especially likely to experience poor sleep. Sleep defi...
Article
Full-text available
Introduction Nearly 14% of Americans experience chronic circadian disruption due to shift work, increasing their risk of obesity and cardiometabolic disorders. These disorders are also exacerbated by modern eating habits such as frequent snacking and consumption of high-fat foods. Here we used a forced desynchrony protocol to investigate the effect...
Article
Full-text available
Introduction Few longitudinal studies link objectively assessed sleep and cognition, especially day to day differences in sleep as they relate to daily cognitive performance in ecologically-valid, natural environments. We examine the associations of sleep (actigraphy) with ambulatory ecological momentary assessments (EMA) of cognitive performance....