Onuralp Ergun

University of Minnesota | UMN · Department of Urology

Background: Nephrectomy is the surgical removal of all or part of a kidney. When the aim of nephrectomy is to reduce tumor burden in people with established metastatic disease, the procedure is called cytoreductive nephrectomy (CN). CN is typically combined with systemic anticancer therapy (SACT). SACT can be initiated before or immediately after...

Simple Summary Prostate cancer is a leading cause of death among men worldwide. Some researchers have speculated that the prostatic microbiome is involved in prostatic inflammation and the pathogenesis of prostate cancer; however, there has not been consensus regarding specific organisms or their overall impact on this process. In order to synthesi...

292 Background: IsoPSA is a structure-based serum assay. Initial studies demonstrated that it outperformed total and percent-free PSA in detecting clinically significant prostate cancer (csPCa) (i.e., grade group (GG) ≥2) on biopsy. This led to an overall reduction in invasive testing and magnetic resonance imaging (MRI). We sought to compare the r...

Background: Kidney stones (also called renal stones) can be a source of pain, obstruction, and infection. Depending on size, location, composition, and other patient factors, the treatment of kidney stones can involve observation, shock wave lithotripsy, retrograde intrarenal surgery (RIRS; i.e. ureteroscopic approaches), percutaneous nephrolithot...

Objectives To assess the effects of PCNL versus retrograde intrarenal surgery (RIRS) for the treatment of renal stones in adults. Methods We performed a comprehensive search of the Cochrane Library, MEDLINE, Embase, three other databases, trials registries, other sources of the grey literature, and conference proceeding up to March 23, 2023. We ap...

Microsurgery has long been a challenging field for surgeons. Many attempts have been made to ameliorate this technique. One of the most remarkable advancements in this field was made by robotic platforms. Absent tremor, improved precision, increased optical magnification, and optimizable instrumentation are the primary advantages of these platforms...

Objectives Prior studies have suggested that few systematic reviews (SRs) published in the urological literature provide reliable evidence. We performed this study to provide a longitudinal analysis of the methodological quality of SRs published in 5 major urology journals over a 6-year period (2016–2021).Methods As an extension of a prior study wi...

Background: Peyronie's disease is a condition that results in the development of penile plaques that can lead to penile curvature, pain, and erectile dysfunction, making sexual activity difficult. A number of non-surgical interventions exist to improve this condition, which include topical and injection agents as well as mechanical methods; howeve...

Objectives: To determine whether we can surpass the traditional R.E.N.A.L. nephrometry score (H-score) prediction ability of pathologic outcomes by creating artificial intelligence(AI)-generated R.E.N.A.L.+ score(AI+score) with continuous rather than ordinal components. We also assessed the AI+ score components' relative importance with respect to...

Robot-assisted microsurgery is a trending approach for the treatment of male infertility and chronic scrotal pain. The advantages seem to include increased optical magnification, improved surgical efficiency, absent tremor, and similar outcomes with standard methods. This chapter covers robotic microsurgical application and techniques for: robot-as...

Background Over the last 20 years, the prevalence of severe obesity (body mass index ≥ 35 kg/m²) has almost doubled. This condition increases the challenge of laparoscopic adrenalectomy (LA) by creating problems with instrument reach, adequate exposure, and visualization. The aim was to compare perioperative outcomes of laparoscopic versus robotic...

Background: Small bowel carcinoid (SBC) primary tumors can be multifocal in 40%-55% of patients and challenging to detect. Near infrared autofluorescence (NIRAF) is used for detection of parathyroid glands. It is unknown if this technology can be used to identify SBCs and how it would compare with current imaging modalities. Methods: This was a...

Ablative therapies have recently emerged as an alternate to the gold-standard liver resection in treatment of malignant liver tumors. These modalities include radiofrequency ablation and microwave ablation which utilize thermo-coagulative energy and microwave energy, respectively, to create a complete necrosis zone encircling the lesion. In this re...

Background and objectives: Pheochromocytoma is a challenging tumor type requiring resection with a clear margin and an intact capsule to prevent recurrences. Our aim was to compare perioperative outcomes of laparoscopic adrenalectomy (LA) versus robotic adrenalectomy (RA) for pheochromocytoma. Methods: In an institutional review board-approved r...

Background: Previous work demonstrated that abnormal versus normal parathyroid glands (PGs) exhibit different patterns of autofluorescence, with former appearing darker and more heterogenous. Our objective was to develop a visual artificial intelligence model using intraoperative autofluorescence signals to predict whether a PG is abnormal (hypers...

Background and objectives: Fluorescence from adrenal tumors can be detected with near-infrared imaging after injection with indocyanine green. However, it is unknown if adrenal tumors exhibit autofluorescence. The aim of this study was to determine whether adrenal tumors emit near-infrared autofluorescence (NIRAF). Methods: This was a prospectiv...

Introduction Chronic scrotal content pain (CSP) or chronic orchialgia can be debilitating for patients and difficult to treat. There is a paucity of structured treatment algorithms to approach this difficult condition. Methods A review of the literature was performed. Conservative treatment options are presented and then targeted surgical interven...