Omonkhelin. J. Owolabi

• PhD
• Professor (Associate) at University of Benin

Cancer is imposing a global health burden because of the steady increase in new cases. Moreover, current anticancer therapeutics are associated with many drawbacks, mainly the emergence of resistance and the severe adverse effects. Therefore, there is a continuous need for developing new anticancer agents with novel mechanisms of action and lower s...

This study investigated the effects of Citrus paradisi fruit juice on biochemical, haematological and histopathological indices in streptozotocin-induced diabetic rats. Wistar rats of either sex (180-300 g) were fasted overnight and diabetes mellitus induced using streptozotocin 40 mg/kg IP. Diabetes mellitus (fasting blood glucose ≥ 200 mg/dl) was...

Ethnopharmacological relevance: Parkia biglobosa seeds are used to treat diabetes and complications hence this study. Aim: This study investigated the effects of Parkia biglobosa aqueous seed extract on some biochemical, haematological and histopathological indices in streptozotocin-induced diabetic rats. Materials and methods: Wistar rats of...

Mucuna pruriens (velvet beans) is an unconventional legume commonly found in the tropical regions of Africa with several ethnomedicinal uses. The present study was designed to investigate the effect of aqueous extract of Mucuna pruriens leaves in rats intoxicated with lead acetate. Thirty rats were divided into six groups (five rats per group). Gro...

The study intended to demonstrate the effects of arachis and eucalyptus oils as release modifiers in insulin transdermal patches. Patches were prepared by solvent casting technique using hydroxypropyl methylcellulose solution as the aqueous phase and polysorbate 80 as emulsifying agent. Various batches (TD1-TD5) were prepared using varying proporti...

Aims: To develop a powder dosage form of insulin for intranasal administration and investigate its glucose-lowering effect in albino rabbits. Methods: Nine different powder formulations, each containing 500 mg powder equivalent to 50 IU of insulin were prepared by adsorbing soluble insulin solution mixed with varying amounts of polysorbate 80, guar...

Purpose: To evaluate the antihyperglycaemic and hypolipidemic effects of Napoleona vogelii Hook. & Planch (Lecythidaceae) methanol leaves extract in alloxan-induced diabetes in rats. Methods: The leaves were extracted via cold maceration using 70 % methanol. Diabetes was then induced using alloxan (150 mg/kg I.P). Alloxan-induced diabetic rats were...

Elaeis guineensis- Jacq (Arecaceae) is reported for the treatment of a variety of ailments notable amongst these are diabetes and hyperlipidemia. The present study is aimed at evaluating its anti-hyperlipedemic effect, via olive oil induced hyperlipidemia.The aqueous extract was obtained from a decoction of the roots, and later administered to oliv...

Purpose: To assess the effects of potassium adaptation on some biochemical parameters in diabetic rats treated with metformin. Methods: Diabetes was induced via intraperitoneal administration of streptozotocin in potassium-adapted and non-adapted rats and, then metformin (350 mg/kg) was administered orally. The following parameters were then evalua...

Background: Levcromakalim is a vasorelaxant used in the management of hypertension in diabetes mellitus. Thus, the effects of levcromakalim were investigated in streptozotocin (STZ)-diabetic rats. Methods: Diabetes was induced in Wistar albino rats with a single injection of STZ (60 mg/kg, i.p.) following chronic (4 weeks) treatment with levcrom...

Newbouldia laevis (life plant) is a medicinal plant used to facilitate birth among traditional healers in Nigeria. In this study, extraction was maintained in N-Hexane solvent using soxhlet extractor and solvent remove via rotary evaporator at less than 50 o C. Phytochemical screening were performed on the extract by standard methods. Oxytocic (con...

Purpose: To assess the effects of potassium adaptation on some biochemical parameters in diabetic rats treated with metformin. Methods: Diabetes was induced via intraperitoneal administration of streptozotocin in potassiumadapted and non-adapted rats and, then metformin (350 mg/kg) was administered orally. The following parameters were then evaluat...

Musanga cecropioides R. Apud Tedlie (Cecropiaceae), also known as umbrella tree is one of the medicinal plants used in Nigeria for pain and inflammation. The stem bark was extracted with absolute ethanol and screened for analgesic activities. The screening for analgesic properties was done using: acetic acid induced writhing; formalin induced pain,...

Cocus nucifera Linne., (Arecaceae or Palm family) is used in traditional medicine for the treatment of several disorders including diabetes mellitus. The root of the plant was extracted using distilled water and the aqueous root extract was then investigated for hypoglycaemic and hypolipidemic effects in diabetic rats. Diabetes was induced using st...

Newbouldia Laevis (N.L) has been used by traditional medical practitioner in Benin city for the treatment of diarrhoea which has high mortality especially in children. The aim of this study is to use different models to evaluate anti diarrhoeal potential of the methanolic leaf extract of this plant.Results showed that the extract caused a significa...

Using steam distillation method, the volatile oils of Eucalyptus citriodora and Callistemon citrinus were obtained and their chromatographic profiles examined in hexane: ethylacetate (4:1; 7:3) and hexane-chloroform (7:3). The effects of the volatile oils on acetylcholine (Ach) induced contraction of the rat isolated ileum were investigated based o...

Struchium sparganophora (L.) Ktze (Asteraceae) is one of the vegetables equally consumed for medicinal purposes in the South Western part of Nigeria where it is used to treat a range of infections. The ethnomedical claimed use of the plant as an abortifacient crude drug was investigated on diethylstilboestrol treated rats. The methanol extract and...

Purpose: To investigate anti-diabetic effect of the ethanol leaf extract of Newbouldia laevis (P. Beauv) in alloxan-induced diabetic rats.Methods: Alloxan (150 mg/kg) was administered to wistar albino rats via the intraperitoneal route. The diabetic rats were then placed in 5 groups, following stabilization of hyperglycemia. The first group was unt...

Nauclea latifolia (Rubiaceae) is a medicinal plant used in Nigeria folk medicine for the treatment of gastrointestinal disorders. The root bark of the plant was extracted with 70% ethanol and the extract screened for antidiarrheal activity by investigating castor oil-induced diarrhea and small intestinal motility in mice. The effects of the extract...

Alchornea cordifolia has been used traditionally for the induction of labour as an abortifacient. This study is aimed at verifying the folkloric use of the plant by investigating the effect of ethanolic extract of the root bark on the isolated stilboestrol pretreated uteri of non-pregnant female rats. The extract (1, 10, 50 g/l), oxytocin (4Χ10−5 t...

The ethnomedicinal uses of Musanga cecropioides R. Apud Tedlie (Cecropiaceae) as a hypotensive agent have been scientifically investigated and reported. This work examines its effect on various models of diarrhea based on the ethnomedicinal use of the plant for this indication. The stem bark of the plant, used locally by soaking in gin (alcoholic),...

Costus lucanusianus J. Braun (Costaceae) is a climbing herb, found mainly in the Niger Delta region of Nigeria. This plant is locally used in situations of pains, inflammation, dysmenorrhoea and in pyrexia. The purpose of this study was to investigate this claim with view to validating scientifically the ethno-medicinal usage. The aqueous extract w...

The plant Nauclea latifolia has been reported to be used by traditional healers to arrest pre-term labour. The ethanolic extract of the root of N. latifolia was screened for activity via agonist-induced contractions of uterine smooth muscles in non-pregnant female albino rats. The extract, at 0.1 and 0.2 mg/ml (final bath concentration), was tested...

Medicinal plants have always played a great role in preventing, controlling and alleviating various disease conditions. Ficus capensis Thunb. (Moraceae) leaves have been reported in literatures to possess anti-diarrhea properties and have been used as such by herbal practitioners in some parts of Benue State, Nigeria. This work examined the prelimi...

The synthesis of 3-benzamido-1-(4-(2-methoxyphenyl) piperazin-1-yl)-propyl-2-isopropylcarboxamide (BPC) was accomplished by treating N-3-(4-(2-methoxyphenyl)piperazin-1-yl)-propyl-2-isopropylphthalimide with isopropylamine in dimethylformamide at room temperature. The compound was characterized spectroscopically. At concentrations of 0.05 and 0.1 m...

Ficus capensis, a wild fig tree is used in herbal medicines to treat pregnancy related ailment and most especially as a remedy for threatened abortion. The purpose of this study was to investigate this claim with view to validating scientifically the ethno-medicinal usage. The ethanolic extract obtained by maceration technique was subjected to phar...

The anti-diarrhoeal activity of the ethanolic extract of Kigelia africana was evaluated using Swiss albino mice based on its ethnomedicinal use in the treatment of diarrhoea. Mice were divided into five groups of five animals each. Diarrhoea was induced by administering 0.3ml of castor oil orally to mice. Group one served as control (normal saline...

Costus lucanusianus J. Braun (Costaceae) is a climbing herb, found mainly in the Niger Delta region of Nigeria. This plant is locally used in situations of pain, inflammation and pyrexia. Hence the plant was screened to investigate the claimed analgesic and anti-inflammatory properties of the plant and hence validate these uses. The aqueous extract...

The bark of Kigelia africana Lam. (Benth.) as powder or infusion is used in ethnomedicine for the treatment of ulcers, or applied in treatment of pneumonia and malaria. Hence the aqueous and ethanolic extracts of Kigelia africana were investigated for antipyretic activity in albino rabbits. Pyrexia was induced by Escherichia coli, at a dose of 106c...

Boa constrictor is one of the snakes found in the riverine areas of Nigeria, especially in the Niger Delta regions. The fat obtained from the snake is used ethno-medicinally for the treatment of burns and inflammatory conditions. The purpose of this study was to validate the traditional use of this crude fat and oil. The fat obtained from the Boa s...

CNS stimulant effect of the ethanolic stem bark extract of Kigelia africana was studied in mice using the barbiturate induced sleeping time and the Rota rod bar to check the extract's effect on muscle coordination. The results showed that the extract at all doses tested reduced the duration of sleeping time when compared to the control group that r...

The ethanolic extract of Kigelia Africana, Family: (Bignoniaceae) was evaluated for analgesic property using acetic acid induced mouse writhing and hot plate reaction time and anti-inflammatory property using the carrageenan induced paw edema and its probable mechanism evaluated in mice and guinea pigs. K. africana extract showed a dose dependent s...

Studies on the antibacterial and antifungal activities of the stem bark of Kigelia africana, (LAM). Benth (Family: Bignoniaceae), a medicinal plant used in South, Central and West Africa for the treatment of various ailments and infection was carried out using agar diffusion technique. The results revealed that the crude ethanolic extract exhibited...

INTRODUCTION: Nigeria belongs to the group of countries highly endemic for viral hepatitis, unfortunately little is known about the burden of co-infection in HIV positive patients and the interaction between these two viruses as it affects the natural history of viral hepatitis, management and prevalence. METHODS: This work was based on the review...