Omolara Amina Fatiregun

Lagos State University College of Medicine, Lagos

Purpose: To examine cancer patients' perspectives on the impact of COVID-19 on teleoncology in Nigeria. Methods: Data from a multicenter survey conducted at 15 outpatient clinics to 1,097 patients with cancer from April and July 2020 were analyzed. The study outcome was telemedicine, defined as patients who reported their routine follow-up visit...

Men of African ancestry (MAA) have the highest global incidence and mortality of prostate cancer (PCa); however, the biology underlying this harsh disease presentation remains poorly understand, largely due to Africans and people within the African diaspora being under-represented in genomics research. MAA are younger at diagnosis, have higher tumo...

In this study, we used whole-exome sequencing of a cohort of 45 advanced-stage, treatment-naive Nigerian (NG) primary prostate cancer (PCa) tumors and 11 unmatched non-tumor tissues to compare genomic alterations with African American (AA) and European American (EA) TCGA PCa. NG samples were collected from 6 sites in central and southwest Nigeria....

Purpose: Because of the global COVID-19 pandemic, health care organizations introduced guidelines for modifications to health and cancer medical care delivery to mitigate transmission and ensure quality health outcomes. To examine the extent and impact of these modifications on oncology service disruptions in Nigeria, we surveyed oncology patients...

Objective: This study aimed to evaluate the dosimetric properties of treatment plans obtained from three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy techniques (IMRT) plans for left chest wall breast cancer patients. Materials and methods: A total of 20 patients with left-sided chest wall radiotherapy were ra...

The rapidly rising cancer burden and mortality rate in Africa are in contrast to the increase in cancer survivorship in Europe and North America. Genomic medicine has contributed to the rise in survival and has facilitated precision cancer control. However, there is a shortage of African representation in genomic databases, even for cancers that di...

PURPOSE Breast cancer is the most common malignancy in women worldwide. In Nigeria, it accounts for 22.7% of all new cancer cases among women. Evidence-based medicine (EBM) entails using the results from healthcare research to enhance the clinical decision-making process and develop evidence-based treatment guidelines. Level 1 and 2 studies, such a...

Background: Men of African ancestry experience higher burden from prostate cancer compared to men of other ancestral backgrounds. Limitations in the availability of high-quality biospecimens have hindered the inclusion of this population in genetic studies of prostate cancer. The use of formalin-fixed paraffin-embedded (FFPE) tissues represents a p...

Background Globally, cancer is a major leading health problem with an estimated 10 million incidences and 6 million cancer deaths annually. In Nigeria, an estimated 72,000 cancer deaths occur annually, and 102,000 new cases are diagnosed from its population of 200 million people. These are, however, estimates, it is necessary to document the yearly...

Editorial that explores an overview of prostate cancer

INTRODUCTION Prostate Cancer (CaP) disproportionately overburden men of African ancestry, especially Black men (BM). Unfortunately, few CaP studies have focused on the heterogeneity of BM within the US as well as the source population of US BM in Africa. The Prostate Cancer Transatlantic Consortium (CaPTC) team has documented differences in CaP-rel...

Background Healthcare disparities among racial and ethnic groups have been well documented across all aspects of clinical healthcare, and disparities in attainment of preventive services are particularly prevalent. African immigrants may be particularly susceptible to factors that contribute to healthcare disparities but little is known about this...

Introduction One of the confirmed risk factors for prostate cancer (CaP) is race, with Black men (BM) more likely to get and die from CaP globally. Although CaP affects BM globally, little is known about CaP and its risk factors in foreign-born BM and the source population of US BM in Africa. The Prostate Cancer Transatlantic Consortium (CaPTC) stu...

Background African immigrants represent one of the fastest growing groups of immigrants in the US, resulting in increased diversity of Blacks in the US. Therefore, there is a growing need to assess the healthcare needs and practices of this population. The main public health concern has been on infectious disease but priority should also focus on c...

Background: Incidence and mortality from cervical cancer have remained high due to many obstacles facing the implementation of organized screening programs in resource-constrained countries such as Nigeria. The application of mobile technologies (mHealth) to health services delivery has the potential to reduce inequalities, empower patients to cont...

Cancer is rapidly becoming a public health crisis as a result of the continued growth and ageing of the global population and will greatly affect resource-limited low- to middle-income countries. It is widely acknowledged that research should be conducted within countries that will bear the greatest burden of disease, and Africa has the unparallele...

Purpose: Diagnosis and treatment of cancer are associated with significant psychological distress, and patients face a broad range of challenges that create a vacuum of unmet needs felt by patients, such as a loss of personal control and frustration. The aim of the current study was to determine the magnitude, distribution, and correlates of unmet...

Prostate cancer (CaP) has been identified as the most common cancer among men globally with higher prevalence, incidence and mortality rates in Black men. This study aims to assess the risk factors for CaP among West African men residing in Nigeria, Cameroon and the United States. A validated Prostate Cancer Transatlantic Consortium (CaPTC) familia...

Poor understanding of the clinicopathological features of prostate cancer (CaP) in Black men (BM) is one of the major challenges implicated in the management and prevention of the disease. The development of CaP involves an accumulation of multiple oncogenic events with associated increase in prostate specific antigen (PSA) and stress related hormo...

Background: Prostate cancer is a significant public health problem affecting men globally. In 2012, it was the second most commonly diagnosed cancer among men worldwide and disproportionately impact men of African ancestry. Established risk factors for this disease include older age; family history; and African ancestry. While these factors are non...

Prostate cancer (CaP) is the most common male gender cancer and present with a 5-year prevalence, incidence and mortality rate in Nigerian Black men. There is disproportionate prevalence and poor understanding of CaP in Black men globally. The Prostate Cancer Transatlantic Consortium (CaPTC) has documented significant CaP burden among Nigerian blac...

Background: Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. The incidence of cancer is on the increase, due to growth and ageing of the global population. More than half of all cancers (56.8%) and cancer deaths (64.9%) in 2012 occurred in less developed regions of the world, and these proportions wil...

Human glutathione-S-transferases play a key role in the metabolism of drugs and environmental chemicals. There have been conflicting reports on the association of breast cancer susceptibility with null genotypes of glutathione-S-transferase (GST) classes of mu and theta (GSTM1 and GSTT1). However, this is the first report of the association of null...

Purpose: Comorbidities have been indicated to influence cancer care and outcome, with strong associations between the presence of comorbidities and patient survival. The objective of this study is to determine the magnitude and pattern of comorbidities in Nigerian cancer populations, and demonstrate the use of comorbidity indices in predicting mort...

ackground: Globally, 32.5 million people diagnosed with cancer within the 5 years previously were alive at the end of 2012. 8.2 million deaths and 14.1 million new cases are recorded annually, but 70% will be in developing countries. Lung, breast, and colorectal cancers are commonly diagnosed. Aim and Objectives: The aim and objectives of this stud...

The 2014 World Health Organization (WHO) Cancer Report describes an alarming growth in the cancer burden worldwide and underscores that, of the 14 million new cases of cancer and 8.2 million cancer-related deaths per year, 60% and 70%, respectively, occur in low-income and middle-income countries (LMICs). These countries are the least capable of de...

e18198 Background: Clinical trials has continued to sharpen the treatment guidelines in managing breast cancer in the United States. The trends in breast cancer management in developed countries and the shifts in treatment paradigms have impacted on breast cancer diagnosis from an incurable entity in the early 1900s’ to the situation today where mo...

Purpose: Health Related Quality of life (HRQoL) is increasingly recognised as an important indicator of outcome and well-being in oncology care. We set out in this study to evaluate whether significant association exists between anxiety disorders (ADs) and HRQoL in breast cancer, such that any intervention addressing ADs would potentially improve...

Breast cancer is a major disease in Nigeria; in 2012, 27,304 new occurrences were diagnosed, and the number of mortalities was 13,960. Greater than 70% of patients present with advanced disease, which has a poor survival outcome. The mortality rates are high mainly because of a lack of awareness about breast health, screening guidelines, and treatm...

Background: Prostate cancer has become a global health challenge because of its rising morbidity and mortality in males. It is the second cause of cancer death following lung cancer in men. It is rare under the age of 40 and its incidence has been shown to increase exponentially with age. Previously, Prostate cancer was thought to be a disease rar...

Ovarian cancer was considered to be rare in Nigeria. This study was therefore conducted to look into the current incidence and management of ovarian cancer patients cases seen in the Lagos state University Teaching Hospital, Ikeja, Lagos State. All the case notes of histo-logically diagnosed cases of Ovarian Cancers seen in LASUTH from 1st January...