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The present investigation aimed to outline the effects of PNP on Amphiregulin (AREG)-induced oocytes maturation. Bovine COCs were aspirated from small antral follicles (2–6 mm in diameter) and incubated in IVM medium contained 1 µl /ml Amphiregulin of human origin supplemented with PNP at 0 (control), 10 7 M (LD), 10 M (MD), 10 M (HD) and 10 M (VHD...