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Publications (14)
Objective:
A sensorimotor network structural phenotype predicted motor task performance in a previous study in Huntington's disease (HD) gene carriers. We investigated in the visual network whether structure - function - behaviour relationship patterns, and the effects of the HD mutation, extended beyond the sensorimotor network.
Methods:
We use...
Reliable markers measuring disease progression in Huntington’s disease (HD), before and after disease manifestation, may guide a therapy aimed at slowing or halting disease progression. Quantitative electroencephalography (qEEG) may provide a quantification method for possible (sub)cortical dysfunction occurring prior to or concomitant with motor o...
In this study we longitudinally investigated the rate of microstructural alterations in the occipital cortex in different stages of Huntington’s disease (HD) by applying an automated atlas-based approach to diffusion MRI data. Twenty-two premanifest (preHD), 10 early manifest HD (early HD) and 24 healthy control subjects completed baseline and two...
Closed-Loop Medical Devices Might Reduce Iatrogenic Loss of Autonomous Action Selection - Volume 26 Issue 4 - OMAR F.F. ODISH, MARTIJN BEUDEL
Background:
Electrophysiological measures can help understand brain function both in healthy individuals and in the context of a disease. Given the amount of information that can be extracted from these measures and their frequent use, it is essential to know more about their inherent reliability.
Objective/hypothesis:
To understand the reliabil...
Objectives: To longitudinally investigate the connectome in different stages of Huntington's disease (HD) by applying graph theoretical analysis to diffusion MRI data.
Experimental design: We constructed weighted structural networks and calculated their topological properties. Twenty-two premanifest (preHD), 10 early manifest HD and 24 healthy co...
Objectives:
To investigate both cross-sectional and time-related changes of striatal and whole-brain microstructural properties in different stages of Huntington's disease (HD) using diffusion tensor imaging.
Experimental design:
From the TRACK-HD study, premanifest gene carriers (preHD), early manifest HD and controls were scanned at baseline a...
Background Diffusion Tensor Imaging provides indirect information about the quality of the microstructural organisation of tissues. In this longitudinal study, cross-sectional as well as time-related changes of diffusion measures were assessed in (premanifest) Huntington’s disease using automated histogram analysis.
Methods Twenty-two premanifest (...
Background:
We previously demonstrated that in the premanifest stage of Huntington's disease (preHD), a reduced functional connectivity exists compared to healthy controls. In the current study, we look at possible changes in functional connectivity occurring longitudinally over a period of 3 years, with the aim of assessing the potential usefulne...
Invasion of tumor cells into blood vessels is essential for metastasis of uveal melanoma. The occurrence of ingrowth of tumor cells in blood vessels in uveal melanoma was analyzed, and this parameter was compared with the survival of the patients.
Between 1972 and 2007, 643 eyes primarily enucleated for uveal melanoma were evaluated histopathologic...
We report a patient with myelodysplastic syndrome (refractory anemia) showing the karyotype 46,XY,+1,der(1;10)(q10;p10), resulting in trisomy 1q and monosomy 10q abnormality. This finding suggests that either trisomy of 1q or centromeric connection between chromosomes 1 and 10, rather than the absence of 10q, might be essential toward neoplastic tr...
