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Olufunso Abosede

Olufunso Abosede
Federal University, Otuoke, Nigeria · Chemical Sciences

PhD

About

27
Publications
6,533
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59
Citations
Introduction
Skills and Expertise
Additional affiliations
February 2014 - December 2016
Federal University, Otuoke, Nigeria
Position
  • Lecturer
January 2010 - February 2014
University of Ilorin
Position
  • Researcher

Publications

Publications (27)
Article
Full-text available
Two novel vanadyl complexes (ML) with steroid ligands (betamethasone and prednisolone) have been successfully synthesized at ambientconditionsusing suitable solvents, where M is VO IV and L is betamethasone or prednisolone. The complexes were synthesized by reacting VOSO 4 and the corresponding ligands in 1:2 molar ratio. The synthesized compounds...
Article
Objective: The aim of this research work is to synthesize silver-mebendazole complexes with imidazole (imi), 2,2-bipyridine (bpy) and 1,10-phenanthroline (phen) as secondary ligands that will be active and effective against microbes. Methods: Environmentally friendly techniques were employed to synthesize the new complexes by reacting silver nitrat...
Article
Environmentally friendly synthesis of copper oxide nanoparticles (NPs) has been achieved using aqueous extracts of Ocimum gratissimum leaf (scent leaf). The reduction of Cu2+ was followed by the change of color from green to dark brown color and formation of precipitate. The reaction was monitored by visual observation and characterization of coppe...
Article
In the recent past, the pharmaceutical modification of drug molecules by complexation with biologically relevant metals to improve their properties such as stability, dissolution rate, absorption and bioavailability has been extensively studied. In order to achieve better and enhanced medicinal activity, vanadyl complexes of the widely used lincomy...
Article
Metals complexed to organic ligands have attracted much attention as potential treatments for cancer. In this paper we present the synthesis and anticancer activity of four metal complexes [Cu(theo)2(H2O)3]·2H2O (1), Cu(theo)2bpy(H2O)·4H2O (2), Cu(theo)2phen(H2O)·5H2O (3), and [Mn(theo)2(H2O)4] (4) (Theo=theophylline; Bpy=1,2-bipyridine; Phen=1,10-...
Article
Co-crystal engineering is an important aspect of pharmaceutical development as it enables the obtainment of structural varieties of drug forms of same active pharmaceutical compounds while maintaining or improving physico-chemical and therapeutic activities of the active pharmaceutical compounds. In this work, we report the green synthesis of two c...
Article
Full-text available
Co-crystals have become an area of research interest for pharmaceutical drug improvements due to their characteristic nature in modifying the physico-chemical properties of active pharmaceutical ingredients (APIs) with the aid of a co-former. Co-crystals improve the solubility, dissolution rate, melting point, and stability of the API without chang...
Article
Full-text available
Background: This study investigated the effect of games teaching approach on students’ academic performance in IUPAC inorganic nomenclature in Senior Secondary Schools in Rivers State, Nigeria. Quasi-experimental design, specifically pre-test post-test control groups was adopted. The sample comprised 93 Senior Secondary 2 and 3 chemistry students M...
Article
In the present study, we have described the synthesis and characterisation of theophylline hydrate (Theo hydrate), cocrystal (Theo-Phen.2H2O) and hydrated sodium co-crystal of theophylline (Na-(Theo)2ClO.2H2O), where Theo = Theophylline and Phen = 1,10-phenathroline. SC-XRD characterisation revealed strong interactions such as N···H···O, C=O···H an...
Article
Three new compounds containing mono- and dinuclear Cu(II) complexes, [Cu(Met)2Cl2]2, Cu(H2O)(Met)2Cl]2 and [Cu(H2O)(phen)2]NO3 (Met= metronidazole; Phen= 1,10-phenathroline) have been synthesized and characterized by Infra-Red, UV-Vis, Single Crystal X-ray analyses, Thermogravimetric techniques and Scanning electron micrography. The biological acti...
Article
The preparation of cocrystals from active pharmaceutical ingredients (APIs) and biologically relevant coformers offers the opportunity of obtaining compounds with more desirable physicochemical and biological properties. This work focuses on theophylline-trimesic acid, caffeine-isophthalic acid, and caffeine-trimesic acid cocrystals. All the cocrys...
Article
Full-text available
Three manganese complexes of the antibiotic doxycyline viz.: manganese doxycyline, [MnDox 2 ]Cl 2 ‧2H 2 O (1), and manganese doxycyline with bipyridine, [MnDox 2 (bpy)]Cl 2 ‧8H 2 O (2), and phenanthroline, [MnDox 2 (phen)]Cl 2 ‧8H 2 O (3), as the ancillary ligand were synthesized and characterized by FT-IR, elemental analysis and electrospray mass...
Article
Full-text available
Three new iron(III) complexes of doxycycline viz: [Fe(dox)2Cl]Cl2 (1), [Febpy(dox)Cl]Cl2 (2) and [Fephen(dox)Cl]Cl2 (3), where dox is doxycycline, bpy is 2,2ʹ-bipyridine and phen is 1,10-phenanthroline, were synthesized and characterized by elemental analysis, electronic absorption, FT-IR, and electrospray ionization mass spectroscopy. Doxycycline...
Article
Novel mixed-ligand coordination frameworks, occurring concomitantly namely [Cu(Im)3(H2Cit)] (1) and [Cu(Im)2(HCit)]·HIm (2) (with Im = imidazole and H4Cit = citric acid) were obtained as a result of the one-pot reaction between imidazole, citric acid and copper chloride. The complexes were structurally characterized by elemental analysis, FTIR spec...
Article
The reduction of cis -[Co III ( κ²N , N′ -1,10-phenanthroline-5,6-dione) 2 Cl 2 ]Cl into the neutral compound cis -[Co II ( κ²N , N′ -1,10-phenanthroline-5,6-dione) 2 Cl 2 ] was observed during developmental studies of new antimalarial drugs. The crystal structure of cis -[Co II ( κ²N , N′ -1,10-phenanthroline-5,6-dione) 2 Cl 2 ] was unveiled by po...
Article
Full-text available
Mixed-ligand Cu(II) complexes of the type [Cu(doxycycline)(L)(H2O)2](NO3)2, where doxycycline = [4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide] and L= 2,2'-bipyridine (bpy, 1), 1,10-phenanthroline (phen, 2), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 3) and dipyrido[3,2-a:2',3'...

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Projects

Projects (3)
Project
(a) environmentally-friendly synthesis of co-crystals and metal complexes of APIs using biologically important metal ions such as Cu2+, VO2+ and Ag+, and APIs that include theophyline, metronidazole, mebendazole, lincomycin, neomycin and gentamycin; (b) characterization and elucidation of the structure of the new complexes, using molar conductance measurements, Fourier transform infrared spectroscopy, the measurement of magnetic moment, electrospray mass spectroscopy, and X-ray analysis; (c) Antifungal studies of the co-crystals and metal complexes, using agar well diffusion method on Potato Dextrose Agar (PDA) plate inoculated with two fungal isolates namely: Aspergillus flavus and Candida albicans; (d) Testing of antibacterial susceptibility of the co-crystals and complexes in vitro using standard nutrient agar media and working with Klebsiella pneumonia, Escherichia coli (E. coli) and Staphylococcus aureus; (e) Antiplasmodial studies for testing complexes against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum; (f) Studies of interactions of the complexes with DNA, using electronic absorption titration, viscosity measurements, thermal melting experiments, and also performing the DNA cleavage experiments, and cytotoxicity and fluorescence measurements.
Archived project
This project aims at exploiting the several advantages transition metal complexes have over organic compounds, including a range of oxidation states and a variety of geometries of the central metal ion. Dr Abosede will synthesize, elucidate the structures and evaluate the pharcological profile of the new transition metal complexes of polypyridyl ligands with some biologically relevant ligands (macrocycles such as macrolides and aminoglycoside antibiotics). Transition metal ions of biological importance such as copper, silver, gold, manganese, platinum, and oxovanadium will be used in synthesizing these metal complexes. The characterization of the new complexes and ligands will involve ultraviolet-visible, FT-IR, nuclear magnetic resonance and electrosspray mass spectroscopy. Some of the complexes will also be characterized by magnetic measurements, electron paramagnetic resonance and X-ray crystallography. Conductivity and potentiometric studies will also be undertaken to determine the stability and integrity of these new metal complexes in solution. Biological activity studies of these metal complexes will include antibacterial, antimalarial, cytotoxicity and antifungal studies. These complexes will also be tested as superoxide dismutase (SOD) mimic and employed in the catalytic disproportionation of hydrogen peroxide. The interactions of these complexes with DNA will be investigated by techniques such as electronic titration of DNA with the complexes, solution viscosity, cyclic voltammetry and DNA cleavage by gel electrophoresis.  Although drug development per se is not a focus of this research, it will contribute to the identification of new targets for drug discovery, diagnosis, and future therapeutic approaches involving metal complexes. It will also further help to understand the mechanisms of action of the drug compounds and in the design of new diagnostic and therapeutic products if the results are utilized.This research will be conducted at our laboratory at Department of Chemistry, Federal University Otuoke, Bayelsa State, Nigeria and in collaboration with other scientists.