Olufunso Abosede

Federal University, Otuoke, Nigeria · Chemical Sciences

Great results are emerging subsequently from the isolation and characterization of graphene and have resulted in increasing interest in two-dimensional (2D) materials that are different from their three-dimensional (3D) analogues. Over the past decade, science-inclined researchers have invested in the synthesis of novel MXenes with combined transit...

Two novel vanadyl complexes (ML) with steroid ligands (betamethasone and prednisolone) have been successfully synthesized at ambientconditionsusing suitable solvents, where M is VO IV and L is betamethasone or prednisolone. The complexes were synthesized by reacting VOSO 4 and the corresponding ligands in 1:2 molar ratio. The synthesized compounds...

Objective: The aim of this research work is to synthesize silver-mebendazole complexes with imidazole (imi), 2,2-bipyridine (bpy) and 1,10-phenanthroline (phen) as secondary ligands that will be active and effective against microbes. Methods: Environmentally friendly techniques were employed to synthesize the new complexes by reacting silver nitrat...

Environmentally friendly synthesis of copper oxide nanoparticles (NPs) has been achieved using aqueous extracts of Ocimum gratissimum leaf (scent leaf). The reduction of Cu2+ was followed by the change of color from green to dark brown color and formation of precipitate. The reaction was monitored by visual observation and characterization of coppe...

In the recent past, the pharmaceutical modification of drug molecules by complexation with biologically relevant metals to improve their properties such as stability, dissolution rate, absorption and bioavailability has been extensively studied. In order to achieve better and enhanced medicinal activity, vanadyl complexes of the widely used lincomy...

Metals complexed to organic ligands have attracted much attention as potential treatments for cancer. In this paper we present the synthesis and anticancer activity of four metal complexes [Cu(theo)2(H2O)3]·2H2O (1), Cu(theo)2bpy(H2O)·4H2O (2), Cu(theo)2phen(H2O)·5H2O (3), and [Mn(theo)2(H2O)4] (4) (Theo=theophylline; Bpy=1,2-bipyridine; Phen=1,10-...

Co-crystal engineering is an important aspect of pharmaceutical development as it enables the obtainment of structural varieties of drug forms of same active pharmaceutical compounds while maintaining or improving physico-chemical and therapeutic activities of the active pharmaceutical compounds. In this work, we report the green synthesis of two c...

Co-crystals have become an area of research interest for pharmaceutical drug improvements due to their characteristic nature in modifying the physico-chemical properties of active pharmaceutical ingredients (APIs) with the aid of a co-former. Co-crystals improve the solubility, dissolution rate, melting point, and stability of the API without chang...

A new convenient and efficient route for the synthesis of two very important hydroxo-bridged stepped-cubane copper complexes viz: [Cu4(bpy)4Cl2(OH)4]Cl2.6H2O (1) and [Cu4(phen)4Cl2(OH)4]Cl2.6H2O (2) have been obtained. This synthetic route from the mononuclear CubpyCl2 complex is easier, more reproducible and afforded the complex in a much higher y...

Background: This study investigated the effect of games teaching approach on students’ academic performance in IUPAC inorganic nomenclature in Senior Secondary Schools in Rivers State, Nigeria. Quasi-experimental design, specifically pre-test post-test control groups was adopted. The sample comprised 93 Senior Secondary 2 and 3 chemistry students M...

In the present study, we have described the synthesis and characterisation of theophylline hydrate (Theo hydrate), cocrystal (Theo-Phen.2H2O) and hydrated sodium co-crystal of theophylline (Na-(Theo)2ClO.2H2O), where Theo = Theophylline and Phen = 1,10-phenathroline. SC-XRD characterisation revealed strong interactions such as N···H···O, C=O···H an...

Three new compounds containing mono- and dinuclear Cu(II) complexes, [Cu(Met)2Cl2]2, Cu(H2O)(Met)2Cl]2 and [Cu(H2O)(phen)2]NO3 (Met= metronidazole; Phen= 1,10-phenathroline) have been synthesized and characterized by Infra-Red, UV-Vis, Single Crystal X-ray analyses, Thermogravimetric techniques and Scanning electron micrography. The biological acti...

The preparation of cocrystals from active pharmaceutical ingredients (APIs) and biologically relevant coformers offers the opportunity of obtaining compounds with more desirable physicochemical and biological properties. This work focuses on theophylline-trimesic acid, caffeine-isophthalic acid, and caffeine-trimesic acid cocrystals. All the cocrys...

Three manganese complexes of the antibiotic doxycyline viz.: manganese doxycyline, [MnDox 2 ]Cl 2 ‧2H 2 O (1), and manganese doxycyline with bipyridine, [MnDox 2 (bpy)]Cl 2 ‧8H 2 O (2), and phenanthroline, [MnDox 2 (phen)]Cl 2 ‧8H 2 O (3), as the ancillary ligand were synthesized and characterized by FT-IR, elemental analysis and electrospray mass...

Three new iron(III) complexes of doxycycline viz: [Fe(dox)2Cl]Cl2 (1), [Febpy(dox)Cl]Cl2 (2) and [Fephen(dox)Cl]Cl2 (3), where dox is doxycycline, bpy is 2,2ʹ-bipyridine and phen is 1,10-phenanthroline, were synthesized and characterized by elemental analysis, electronic absorption, FT-IR, and electrospray ionization mass spectroscopy. Doxycycline...

Novel mixed-ligand coordination frameworks, occurring concomitantly namely [Cu(Im)3(H2Cit)] (1) and [Cu(Im)2(HCit)]·HIm (2) (with Im = imidazole and H4Cit = citric acid) were obtained as a result of the one-pot reaction between imidazole, citric acid and copper chloride. The complexes were structurally characterized by elemental analysis, FTIR spec...

The reduction of cis -[Co III ( κ²N , N′ -1,10-phenanthroline-5,6-dione) 2 Cl 2 ]Cl into the neutral compound cis -[Co II ( κ²N , N′ -1,10-phenanthroline-5,6-dione) 2 Cl 2 ] was observed during developmental studies of new antimalarial drugs. The crystal structure of cis -[Co II ( κ²N , N′ -1,10-phenanthroline-5,6-dione) 2 Cl 2 ] was unveiled by po...

Mixed-ligand Cu(II) complexes of the type [Cu(doxycycline)(L)(H2O)2](NO3)2, where doxycycline = [4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide] and L= 2,2'-bipyridine (bpy, 1), 1,10-phenanthroline (phen, 2), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 3) and dipyrido[3,2-a:2',3'...