Olufunke E Ola-Davies

• DVM, MSc Vet Parasitology, MSc Biochemistry, PhD Biochemistry, FCVSN
• Professor at University of Ibadan

Environmental pollutants, such as heavy metal contamination in water sources, especially groundwater and surface water, have been documented to have various health impacts on humans and animals. In the study, samples were collected from forty African catfish (Clarias gariepinus) harvested (n=10) from three selected polluted rivers (Eleyele, Oluyole...

Diazinon is a commonly used organophosphate (OP) insecticide especially in developing countries for the control of insect pests, however, exposure to its toxic impact especially in humans and other non-target species remains an important public health concern. The study aimed to investigate the effect of epigallocatechin − 3- gallate (EGCG), abunda...

Objectives The objective of this study was the assessment of the ameliorative roles of alpha-tocopherol and quercetin on the toxic mechanisms associated with ethanol (EtoH) exposure in the cardiac and renal systems of rats. Material and Methods Forty male rats were randomly selected and divided into five groups as follows: 0.2 mL distilled water;...

Chemotherapy with Vincristine (Vcr) is often compromised by undesirable gastrointestinal, myeloid and hepatic effects. In this study, we evaluated and compared the efficacy of taurine (Tau) and/or protocatechuic acid (Pca) in alleviating Vcr-induced hepatotoxicity, enterotoxicity and myelotoxicity in rats. In two cycles of five daily injections eac...

BACKGROUND Informal electronic waste (e-waste) reprocessing in Nigeria is reportedly substantial in Africa, putting the growing exposed population at high risk of metal toxicity. This study aimed to investigate the existence of chromosomal aberration in the growing e-waste exposed populations in Nigeria, using induction of micronuclei (MN) expressi...

Objective Curcuma longa Rhizome (CLR), due to its potent antioxidant phytochemical constituents, was investigated for its effects on bisphenol A (BPA)-induced cardiovascular and renal damage. Materials and Methods Sixty rats were randomly selected, and grouped as control, BPA (100 mg/ kg), BPA and CLR 100 mg/kg, BPA and CLR 200 mg/kg, CLR 100 mg/k...

Introduction: Alterations of antioxidant defense, neuroinflammation, and neurodegeneration are common pathological occurrences associated with neurodegenerative diseases. This study evaluated the neuroprotective effect of Launaea taraxacifolia (LT), popularly known as African Wild lettuce, against neuroinflammation, memory loss, and neurobehavioral...

Artemether-Lumefantrine (AL) is one of the alternative drugs used in treating malaria – an endemic scourge in Africa. AL has been reported to generate free radicals with long term use implicated in testicular pathologies. The antioxidative properties of Aloe vera (AV) has been well documented. This study investigated the ameliorative effect of etha...

The menace of cancer and the nightmare of complications of cancer chemotherapy have driven researchers to explore simple but efficient combination therapy that includes antioxidants, in cancer therapy. The ability of gallic acid to correct the toxic complication of Vincristine was investigated. Twenty adult male rats of the Wistar strain were group...

Fluoride is an important toxicological and environmental toxicant that is implicated in diverse cardiorenal system dysfunctions via the induction of oxidative stress. The present study aims at evaluating the cardioprotective and renoprotective effects of melatonin and vitamin E on fluoride toxicity on biomarkers of oxidative stress, clinical pathol...

Background Sesame oil, an edible essential oil, is known to be rich in unsaturated fatty acids, vitamins and lignans with several reported health-promoting benefits. Acute arsenic poisoning produces toxic hepatitis, bone marrow depression and adverse gastrointestinal responses. In this study, we investigated the protective effect of sesame seed oil...

This toxicological study was carried out to determine possible adverse effects of Telfairia occidentalis and Ipomoea batatas leaves in Clarias gariepinus. Ninety-six Clarias gariepinus growers (431.25±6.13 g) randomly distributed into four feeding groups were fed with herbal leaf diet containing 20 g/kg of T. occidentalis (group A), 100 g/kg of I....

Purpose: Anacardium occidentale commonly known as Cashew is a plant that is widely used in Africa traditional medicine. It is endowed with phytochemical constituents that are responsible for its medicinal properties. Methods: Twenty-five male Wistar rats were grouped as follows: Control (Group A), Group B (L-NAME 40 mg/kg), Group C (100 mg/kg An...

Most studies on the effect of Bisphenol A (BPA) on the endocrine organs are either not environmentally relevant due to high doses of BPA exposure or involve direct exposure to adult rats. To bridge this knowledge gap, this present study was designed to investigate the protective effects of melatonin (MLT) on adrenal gland dysfunction in pubertal ma...

Purpose: The persistent and alarming rates of increase in cardiovascular and renal diseases caused by chemicals such as cobalt chloride (CoCl2) in mammalian tissues have led to the use of various drugs for the treatment of these diseases. This study aims at evaluating the nephron-protective action of Naringin (NAR), a metal-chelating antioxidant a...

Sodium fluoride (NaF) is one of the neglected environmental toxicants that has continued to silently cause toxicity to both humans and animals. NaF is universally present in water, soil, and atmosphere. The persistent and alarming rate of increase in cardiovascular and renal diseases caused by chemicals such as NaF in mammalian tissues has led to t...

Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the...

Sodium fluoride (NaF) is one of the neglected environmental toxicants that has continued to silently cause toxicity to both humans and animals. NaF is universally present in water, soil and the atmosphere. The persistent and alarming rate of increase in cardiovascular and renal diseases and disorders caused by chemicals such as sodium fluoride (NaF...

This study was designed to investigate the modulatory role of Luteolin (Lut), a flavonoid phytochemical, on haemodynamic parameters and the potential mechanisms involving renal Angiotensin II (AT2R) and Mineralocorticoid (MCR) receptors in renal toxicity induced by co-exposure to Diclofenac (Dcf) and sodium fluoride (NaF) in rats.Male Wistar rats w...

Hypertension is a condition with chronic elevation of blood pressure and a common preventable risk factor for cardiovascular disease with attendant global morbidity and mortality. The present study investigated the novel antihypertensive action of Naringenin on NƱ -Nitro-L-arginine Methyl Ester (L-NAME)-induced hypertension together with possible m...

Sodium fluoride (NaF) is one of the neglected environmental pollutants. It is ubiquitously found in the soil, water, and environment. Interestingly, fluoride has been extensively utilized for prevention of dental caries and tartar formation, and may be added to mouthwash, mouth rinse, and toothpastes. This study is aimed at mitigating fluoride-indu...

H ELMINTHOSIS still a neglected disease, especially in developing countries, in spite of its economic and public health importance. A ten-year retrospective study on confirmed canine helminthosis cases presented to the Veterinary Teaching Hospital, Abeokuta, Nigeria was conducted. Descriptive statistics were used to characterize animal signalment,...

This study was designed to investigate the modulatory role of Luteolin (Lut) on haemodynamic parameters and the potential mechanisms involving renal Angiotensin II (AT 2 R) and Mineralocorticoid (MCR) receptors in renal toxicity induced by co-exposure to Diclofenac (Dcf) and sodium fluoride (NaF) in rats. Male Wistar rats were administered with eit...

Sodium fluoride (NaF) is one of the neglected environmental toxicants that has continued to silently cause toxicity to both humans and animals. NaF is universally present in water, soil and the atmosphere. The persistent and alarming rate of increase in cardiovascular and renal diseases and disorders caused by chemicals such as sodium fluoride (NaF...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). This virus has become a global pandemic with unprecedented mortality and morbidity along with attendant financial and economic crises. Furthermore, COVID-19 can easily be transmitted regardless of religion, race, sex, or sta...

Environmental and occupational exposure to chromium compounds has become potential aetiologic agent for kidney disease with excessive generation of free radicals, apoptosis, and inflammatory. These pathophysiologic mechanisms of potassium dichromate (K2Cr2O7) have been well correlated with nephrotoxicity and cardiotoxicity. The cardioprotective and...

Aim: This report aims to render a proposed concept model for cancer risk in Nigerian electronic waste exposure by making deductions from data on the assessment of Nigerians' exposure to toxic metals in e-waste, using biomarkers of exposure and genotoxicity to evaluate the risk of cancer development. Material and methods: In the cross-sectional stud...

Petroleum exploration has continued to impact negatively the Niger Delta region of Nigeria. Oil spills from petroleum exploration contaminate both the aquatic and non- aquatic environments and destroy the ecosystem which makes people in these regions to be prone to diseases such as cancer, cardiovascular diseases, neurodegenerative disease, inferti...

Ethanolic extract of Spondias mombin, at 800mg/kg body weight, appeared to potentiate gestational patterns in wistar rats

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the etiological agent for the Coronavirus Disease 2019 (COVID‐19). The COVID‐19 pandemic has created unimaginable and unprecedented global health crisis. Since the outbreak of COVID‐19, millions of dollars have been spent, hospitalization overstretched with increasing morbidity and...

An outbreak of acute coccidiosis is reported in West African Dwarf (WAD) goats kept under a semi intensive management system at the University of Ibadan farm. During the period of the outbreak, clinical signs observed among the animal included anorexia, fever, coughing, ocular and nasal discharges and diarrhoea. Sixty nine out of eighty-five (85%)...

Hypertension is the most common cardiovascular disease that affects approximately 26% of adult population, worldwide. Rutin is one of the important flavonoids that is consumed in the daily diet, and found in many food items, vegetables, and beverages. Uninephrectomy (UNX) of the left kidney was performed, followed by induction of hypertension. The...

Acute renal failure (ARF) has been documented as a life-threatening disease with high morbidity and mortality. We investigated the protective effect of Luteolin against ARF. In this study, forty-male Wistar albino rats were randomly divided into four groups (n = 10). Group A received normal saline. Group B received glycerol (10 ml/kg BW, 50% v/v in...

Cobalt-induced cardiomyopathy and renal toxicity have been reported in workers in processing plants, hard metal industries, diamond polishing and manufacture of ceramics. This study was designed to investigate the influence of Luteolin supplementation on cobalt-induced cardiac and renal toxicity in rats. Exposure of rats to cobalt chloride (CoCl2)...

Exposure to bisphenol A (BPA), an endocrine disrupting chemical (EDC), has been shown to result in a number of reproductive dysfunction. Melatonin (MLT) is a potent antioxidant known to protect against EDC-induced toxicity. We aimed at investigating the protective effects of MLT on prostate gland dysfunction in the F1 adult male Wistar rats exposed...

Hypertension is a condition with chronic elevation of blood pressure and a common preventable risk factor for cardiovascular disease with attendant global morbidity and mortality. The present study investigated the novel antihypertensive and neuroprotective effect of Naringenin on L-NG-Nitro arginine methyl ester (L-NAME) induced hypertension toget...

Launeae taraxacifolia popularly known as African Wild lettuce is rich in flavonoids, cardiac glycosides, saponins, β carotenes and also some valuable minerals. It has been reported as a local remedy for tooth pains, vomiting and diabetes. Hypertension was induced by non‐selective endothelial nitric oxide synthase (eNOS) inhibitor L‐Nitro Arginine M...

The Anacardium occidentale plant; commonly known as Cashew has been widely reported for its efficacy in the treatment of various ailments such as hypertension. The efficacy of the plant has been attributed to its phytochemical constituents. Hypertension was induced in rats via oral administration of L‐Nitro Arginine Methyl Ester (L‐NAME); a non‐sel...

Objectives. Bisphenol A (BPA) has been reported that among other male reproductive dys-functions, it can cause marked estrogenic effects including alteration in serum hormones as well as testicular lesions in exposed animals. This work sought to study the role of gallic acid (GA), a known antioxidant, on the BPA-induced testicular oxidative stress...

Heavy metals are leading causes of environmental contamination and arsenic (As) is currently one of the most important metal contaminants particularly in the developing countries such as Nigeria. The effects of chromatographic fractions of Spondias mombin L. (SM) leaves on sodium arsenite-induced toxicities in male Wistar rats were evaluated. Thi...

Proper semen extension is essential for successful artificial insemination and increased livestock production thereby helping in bridging the imbalance between livestock production and the high demand for animal protein in the developing world. Eight healthy multiparous non gravid West African Dwarf (WAD) ewes and two sexually matured rams intensiv...

Fluoride is an environmental contaminant that is ubiquitously present in air, water, and soil. It is commonly added in minute quantity to drinking water, toothpaste, and mouth rinses to prevent tooth decay. Epidemiological findings have demonstrated that exposure to fluoride induced neurodevelopmental toxicity, developmental neurotoxicity, and moto...

This study investigated the protective effects of melatonin (MLT), a potent antioxidant, in male Wistar rats exposed to environmentally relevant doses of bisphenol A (BPA) in utero. Pregnant Wistar rats were randomly assigned into five groups. Group 1 (control) received 0.2 mL 1% dimethyl sulfoxide (DMSO)/99% canola oil as vehicle; group 2 received...

Heavy metals are leading causes of environmental contamination and arsenic (As) is currently one of the most important metal contaminants particularly in the developing countries such as Nigeria. The effects of chromatographic fractions of Spondias mombin L. (SM) leaves on sodium arsenite-induced toxicities in male Wistar rats were evaluated. Thirt...

Proper semen extension is essential for successful artificial insemination and increased livestock production thereby helping in bridging the imbalance between livestock production and the high demand for animal protein in the developing world. Eight healthy multiparous non gravid West African Dwarf (WAD) ewes and two sexually matured rams intensiv...

Background Recently, the incidences of hypertension and environmental pollution have increased significantly. This study investigates the antihypertensive effect of Annona muricata extract against K 2 Cr 2 O 7 -induced hypertension. Methods Fifty rats were used for this study, which were divided into five groups of 10 rats each. Rats in Group A re...

Cobalt is a ferromagnetic metal with extensive industrial and biological applications. To assess the toxic effects of, and mechanisms involved in cobalt chloride (CoCl2)-induced cardio-renal dysfunctions. Male Wistar rats were exposed orally, daily through drinking water to 0 ppm (control), 150 ppm, 300 ppm, and 600 ppm of CoCl2, respectively. Foll...

Bisphenol A (BPA), an endocrine disrupting chemical (EDC) used in the production of plastics and epoxy resins has been incriminated in a number of biological dysfunctions while melatonin (MLT) is a known antioxidant capable of ameliorating EDC‐induced perturbations. Although limited number of studies exist on the effect of BPA on the cardio‐renal s...

This study investigated the role of melatonin (MLT) on adrenal gland toxicity induced by bisphenol A (BPA). Adult male rats were divided into four groups of seven animals each: Group I (control) received oral 0.2 ml canola oil; group II received intra-peritoneal 10 mg/kg BW/day MLT; and group III received oral BPA (10 mg/kg BW/day). Group IV rats w...

The testicular, sperm and endocrine protective properties of Chromolaena odorata (CA) in arsenic treated rats were investigated using forty male wistar rats (190-200g) grouped into 4 (A to D) of ten rats each. Oral administrations for 2 weeks of 0.2ml corn oil (A), 2.5mg/kg of sodium arsenite (B), 200mg/kg ethanol leaf extract (ELE) of CA (C), 200m...

The use of sodium fluoride (NaF) as a major ingredient for tooth paste, mouth wash, and mouth rinse has become inevitable in our day‐to‐day life. However, flavonoids such as Luteolin might be of great value in the prevention of toxicity associated with accidental or inevitable ingestion of NaF. In the study, 40 male Wistar albino rats were randomly...

In this study we investigated the protective effect of Azadirachta indica on sodium fluoride‐induced hypertension, oxidative stress, cardio‐renal toxicity and genotoxicity. Sixty rats were used in this study. They were divided into six groups each containing 10 rats. Group A served as the controls and they received distilled water only for a period...

Sodium fluoride is one of the neglected environmental contaminants. Inorganic fluorides in the environment are found in the air, water, and land. In the study, forty‐male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Group A was the control group which was given normal saline, Group B was exposed to 300 ppm of N...

Hypertension is one of the silent killers in the world with high mortality and morbidity. The exposure of humans and animals to fluoride and/or fluoride containing compounds is almost inevitable. This study investigated the modulatory effects of quercetin on sodium fluoride (NaF)‐induced hypertension and cardiovascular complications. Forty male rat...

Gallic acid (GA) derivatives occur naturally in plants and it has been reported to possess antioxidant properties against various disease conditions. Here, the ameliorative effects of GA on sodium fluoride (NaF) induced-hypertension and hepatotoxicity was studied. Four groups of seven rats each were used in this study. Group A received distilled wa...

The investigation into the potential health risks associated with the use of engineered nanoparticles is a major scientific interest in recent years. The present study elucidated the involvement of pro-inflammatory cytokines, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in carboxylated multi-walled carbon nanotubes (MWCNTs)-i...

Drug Res (Stuttg). 2019 Jan;69(1):12-22. doi: 10.1055/a-0635-0638. Epub 2018 Jun 19. Antihypertensive Effect of Polyphenol-Rich Fraction of Azadirachta indica on Nω-Nitro-L-Arginine Methyl Ester-Induced Hypertension and Cardiorenal Dysfunction. Omóbòwálé TO1, Oyagbemi AA2, Ogunpolu BS1, Ola-Davies OE2, Olukunle JO3, Asenuga ER4, Ajibade TO2, Adejum...

Background: Bisphenol A (BPA) has received attention in environmental and toxicological research due to its widespread effects in biological systems. While several anti-oxidants have been used in ameliorating BPA-induced toxicities in experimental animals, there is the scarcity of research information on the use of Gallic acid (GA) in protecting ag...

Azadirachta indica (AI) is a medicinal plant with reported antioxidant and cardio-protective properties. The use of plant-based polyphenols has become greatly increased in the last one decade. The present study investigated the protective effect of the polyphenol-rich fraction (PRF) of the methanol-extract of Azadirachta indica against Nω-Nitro-L-A...

Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that has been demonstrated to induce alterations in reproductive organs while melatonin (ML), an antioxidant, present in plants and animals, is capable of protecting against EDC-induced alterations. Adult male Wistar rats (average weight, 240 + 10 g) were divided into four groups of ten an...

Indiscriminate use of organophosphate acaricides especially among livestock and dog owners in the control of ticks and other ectoparasites has taken a worrisome dimension. In the present study, we investigated, the effects of acute dermal exposure in the form of acaricides baths of coumaphos at different concentrations on the haematology, blood pre...

With the rising rates of cardiovascular diseases, increase cost of modern therapeutic drugs, as well as the adverse effects of the modern medicine on the users; there is a surge in the need to search for herbs with excellent antioxidant properties for use in preventive medicine. Morinda Lucida, commonly found in the Tropics, precisely in the rain f...

Potassium dichromate is an environmental and industrial pollutant. It has already been reported that the accumulation of K 2 Cr 2 O 7 can alter the activities of some enzymes involved in the free‐radical metabolism and also decrease the activities of some enzymes involved in the antioxidant defense system. This study investigated the antihypertensi...

Carbendazim [methyl-2-benzimidazole carbamate, MBC (CBZ)], a metabolite of benomyl, is one of the most widespread environmental contaminants of major concern to human and animal health. The protective effect of resveratrol (RSV), vitamin E (E) and a combination of both on carbendazim-induced toxicity was investigated using haematology, serum bioche...

Parquetina nigrescens is commonly used to treat diseases in humans and animals in developing countries, including Nigeria. This study evaluates the effects of its polyphenol-rich fraction (prf) on dichlorvos-induced cardio- and renal toxicity. There were several factors assessed during this study, including cardiac and renal markers, serum myeloper...

Sodium arsenite (NaAsO2) is one of the major environmental toxicants with severe toxicological consequences in some developing and developed countries. Rats in Group A received normal saline. Genotoxicity and apoptosis were induced by single intraperitoneal injection of 10 mg/kg sodium arsenite to rats in Groups B–F. Rats in Groups C and D had earl...

Hepatotoxicity has been found to be one of the main side effects associated with doxorubicin (Dox) administration in cancer therapy. The aim of the present study was to examine the ameliorative effect of gallic acid (GA) in Dox-induced hepatotoxicity. Sixty male Wistar rats of 10 rats per group were used in this study and were randomly divided into...

Twelve sexually matured West African Dwarf bucks from were used for the experiment. Plant extraction was by cold extraction method using hexane and ethanol as solvents. All the goats had bilaterally well descended free testicles. They were kept in standard goat pen, were served water ad libitum, centrosema plant and ration. They were stabilised for...

In order to evaluate the antidotal potential of Mangifera indica L leaves extract on sodium arsenate exposed male Wistar rats using some biochemical markers, forty-two apparently healthy male Wistar rats (weight range 120-160 g) were used in the study. The animals were randomly separated into six groups. Other than groups “A” (non-exposed control)...

Cobalt chloride (CoCl2 ) is one of the many environmental contaminants, used in numerous industrial sectors. It is a pollutant with deadly toxicological consequences both in developing and developed countries. We investigated toxicological impact of CoCl2 on hepatic antioxidant status, apoptosis, and genotoxicity. Forty Wistar rats were divided int...

Background The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because of the myriad of toxic sequelae associated with it. The aim of this study was to assess the protective effects of gallic acid (GA) on DOX-induced cardiac toxicity in rats. Methods Sixty male rats (Wistar strain) were used in this study. They were di...

Background Toxicities due to fluoride exposure from natural and industrial sources occur commonly in man and animals with severe consequences ranging from mild cardiac derangements to sudden death. In this study, we investigated the protective effects of the methanol extract of Methods Sixty rats were divided into six groups of ten rats each as fo...

Sodium arsenite has been proven to be abundant in nature and released into the environment through human activities, including agricultural and industrial processes. The objective of our study was to investigate the sperm protective potential of : The sperm protective potential of : Group B had a significantly lower (p<0.05) percentage sperm motili...

The effect of ethanol extract of Tridax procumbens L. on sodium arsenite-induced haemotoxicity, hepatotoxicity and clastogenecity in male Wistar rats was evaluated. Thirty two healthy male albino Wistar rats (80-100g) were grouped into four groups (A to D) of eight rats each. Rats in group A were treated with 1 ml/kg body weight diluted olive oil (...

Organophosphate poisoning (OP) is one of the most common poisonings in developing countries. In this study, twenty-four dogs in four groups of six each were used. Control group bathed with water only, group B with 16% Coumaphos (recommended), groups C and D with times 10 and 20 of 16% Coumaphos, respectively. Blood was collected from cephalic vein...

Lead poisoning continues to pose a serious health challenge and more significantly so in developing countries with ineffective waste disposal systems. Recent efforts at solving lead poisoning issues have seen entire towns being resettled from lead-contaminated areas. This study was designed to investigate whether withdrawal of lead exposure results...

The sperm protective potential of Pistia stratiotes Linn (Aracea) was carried out in arsenic‐exposed rats using twenty‐four male albino rats (225 to 228g) aged between 14 and 16 weeks old. They were grouped into 4 (A–D), each group containing 6 rats. Group A animals were orally treated with 100mg/kg ethanol leaf extract of Pistia stratiotes Linn. d...

The effect of ethanol extract of Tridax procumbens L. on sodium arsenite‐induced haemotoxicity, hepatotoxicity and clastogenecity in male Wistar rats was evaluated. Thirty two healthy male albino Wistar rats (80–100g) were grouped into four groups (A to D) of eight rats each. Rats in group A were treated with 1 ml/kg body weight diluted olive oil (...

The persistent existence of lead in the environment is associated with severe health issues due to its cumulative effect and its ability to affect virtually every organ in the body. Recent discoveries have attributed the tissue damaging and inflammatory effects of lead toxicity to oxidative stress. Natural antioxidants are now being employed in the...

Background: Ageratum conyzoides L. (Asteraceae) is an annual herbaceous plant used in folklore medicine for the treatment of a wide range of diseases. Objective: To investigate the protective effect of the ethanol leaf extract of A. conyzoides (EEAC) against hematological, serum biochemical and histological alterations induced by Sodium arsenite...

Arsenite is a major environmental toxicant that is well known to cause reproductive injury. The sperm protective potential of Ageratum conyzoides Linn in arsenic-treated rats was carried out in this study taking advantage of the antioxidant constituents and its androgenic activities. Twenty-four male albino rats aged 16 weeks, weighing 225 to 228g...

Adriamycin, though, a drug of choice in cancer therapy, its use is associated with acute and chronic complications, which are capable of exacerbating the conditions of the patients. Thus, efforts are being directed at evaluating several compounds, antioxidants and natural products that are capable of ameliorating these complications whilst still re...