Oliviero Bruni

Oliviero Bruni
Sapienza University of Rome | la sapienza · Department of Developmental and Social Psychology

Associate Professor

About

320
Publications
68,183
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Introduction
Oliviero Bruni received his M.D. in 1982 and residency in Child Neuropsychiatry in 1986 from the Sapienza University (Rome, Italy). He has been involved in sleep research for over 20 years and has published more than 100 peer-reviewed papers - President of the International Pediatric Sleep Association - Member of the Directors of the Italian Association of Sleep Medicine - Field Editor of journal Sleep Medicine - Chair of the Development Section of American Academy of Sleep Medicine (2009-2011)
Additional affiliations
January 2013 - present
Sapienza University of Rome
Position
  • Professor (Associate)

Publications

Publications (320)
Article
Study objectives: To evaluate the effects of bupropion on periodic limb movements during sleep (PLMS) and chin electromyography (EMG) tone in children taking it for their mood disorder, compared to the effects of selective serotonin reuptake inhibitors (SSRIs) and of bupropion combined with SSRIs. Methods: Six adolescents (age 16.0±0.63 years) t...
Article
Background: Children with Attention-Deficit/Hyperactivity (ADHD) and/or Developmental Coordination Disorder (DCD) show high rates of motor difficulties in daily activities. This study aimed to examine the validity and reliability of the Developmental Coordination Disorder Questionnaire (DCDQ) in identifying motor characteristics in daily activitie...
Article
Study objectives: To test the hypothesis that children taking trazodone have less leg movements during sleep (LMS) and higher REM sleep atonia than children taking selective serotonin reuptake inhibitors (SSRIs), but more than normal controls. Methods: Fifteen children (9 girls and 6 boys, mean age 11.7 years, SD 3.42) on trazodone (median dosag...
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Between 50–80% of children with autism spectrum disorder (ASD) have insomnia, which adversely affects their mental and physical health. However, there is no consensus to-date on suitable tools for insomnia screening and monitoring in daily clinical practice. An expert panel of child neuropsychiatry and sleep specialists, with expertise in children...
Article
Purpose This study sought to describe patient characteristics and treatment patterns among patients with insomnia prescribed trazodone in the United States. Methods This real-world, retrospective, descriptive cohort study used US commercial insurance claims from July 1, 2009, through June 30, 2019. The index date was the first prescription for tra...
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Purpose of Review Restless sleep disorder (RSD) is a recently identified pediatric sleep disorder characterized by frequent movements during sleep associated with daytime symptoms. In this review we summarize the expanding evidence of the clinical presentation of RSD, potential pathophysiology, associated comorbidities, and current treatment option...
Article
Background Pediatric headaches have been linked to adverse life events or psychological factors in children and their families, with a complex and bidirectional association. Moreover, it is well-known that psychological stress can trigger headaches. Methods We searched three databases for studies focusing on headaches and adverse events or psychol...
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The European Somnologist certification programme was developed by the European Sleep Research Society to improve patient care in sleep medicine by providing an independent evaluation of theoretical and practical knowledge. The examination of eligible experts plays a key role in this procedure. A process was started more than 15 years ago to create...
Article
Background and objective Tuberous Sclerosis Complex (TSC) is a rare systemic disease with a high prevalence of sleep disorders (SD), although they are still largely under-recognized. The objective of this study was to assess the prevalence of SD in adult patients with TSC, and to evaluate the relationship between sleep, epilepsy and TSC associated...
Article
Objective Non-Rapid Eye Movement (NREM) sleep promotes the spread and propagation of Interictal Epileptiform Discharges (IEDs), while IEDs are suppressed during REM. Recently, it has been shown that the inhibitory effect on epileptic activity is mostly exerted by the phasic REM (PREM) microstate. This study aims at assessing if this holds true even...
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This review investigates the association between vitamin D and sleep disorders. Vitamin D is an essential nutrient known to play an important role in the growth and bone health of the human body, but it also appears to play a role in sleep. The goal of our review is to examine the association between vitamin D and sleep disorders in children and ad...
Article
The dynamic interplay between central and autonomic nervous system activities plays a pivotal role in orchestrating sleep. Macrostructural changes such as sleep-stage transitions or phasic, brief cortical events elicit fluctuations in neural outflow to the cardiovascular system, but the causal relationships between cortical and cardiovascular activ...
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Objective and Background Sleep disorders (SD) are very common in childhood, especially in certain genetic syndromes. Tuberous Sclerosis Complex (TSC) is a genetic syndromesassociated with a high rate of SD, although these are still under-recognized. The aim of this study was to assess the prevalence of SD in TSC, and to evaluate the relationship be...
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Orofacial myofunctional therapy has been shown to be effective in the multidisciplinary management of obstructive sleep apnoea syndrome in children, adolescents, and adults, and is prescribed at several stages of such management. However, given the lack of consistency in treatment protocols and outcome measures, the lack of research on the type, fr...
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La rééducation myofonctionnelle orofaciale a été montrée efficace dans la prise en charge multidisciplinaire du syndrome d’apnées obstructives du sommeil chez l’enfant, l’adolescent et l’adulte, et elle est prescrite à plusieurs étapes de ces prises en charge. Cependant, compte tenu du manque d’homogénéité des protocoles de traitement et de mesures...
Article
Background: Coronavirus disease 2019 (COVID-19) related confinement severely impacted people wellbeing. Many studies focused on general population, although it is reasonable to expect that patients with neurodevelopmental disorders might have been at higher risk. Children/adolescents with Attention Deficit/Hyperactivity Disorder (ADHD) might be po...
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Study objectives To evaluate leg movements during sleep (LMS) in children taking serotonergic antidepressants, compared to those of children with restless legs syndrome (RLS) and controls, and to assess the time structure of intermovement intervals (IMI). Methods Twenty-three children (12 girls, mean age 14.1 years) on antidepressants and with a t...
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Background: The COVID-19 lockdown determined important changes in the sleep of a large percentage of the world population. We assessed the modifications of reported sleep patterns and disturbances in Italian children and adolescents with autism spectrum disorders (ASD) or attention deficit hyperactivity disorders (ADHD), compared to control childr...
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There is a high comorbidity between migraine and sleep disorders (SD), with a mutual dependence between sleep and headache. This study aimed to analyze the relationship between headache features (migraine frequency and severity, migraine equivalents, use and efficacy of treatments) and sleep in pediatric migraine. Parents of children and adolescent...
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Introduction: Insomnia is common among children and adolescents with Autism spectrum disorder (ASD). A pediatric-appropriate prolonged-release melatonin (PedPRM) formulation is the first drug licensed for insomnia in this population. Areas covered: The authors describe PedPRM, assess its efficacy and safety profile in clinical trials, and evaluate...
Article
Study objectives: The impact of the COVID-19 outbreak on sleep of participants with autism spectrum disorder (ASD) was assessed. Methods: Parents of 111 children and adolescents with ASD filled out an anonymous online survey shared via social media, investigating the sleep patterns and disturbances before and during the lockdown. Results: The...
Article
Study Objectives To assess if selective serotonin reuptake inhibitor (SSRI) antidepressants are able to modify the chin EMG tone during sleep also in children. Methods Twenty-three children and adolescents (12 girls, mean age 14.1 years, SD 2.94) under therapy with antidepressant for their mood disorder were consecutively recruited and had a PSG r...
Article
The analysis of sleep microstructure in attention deficit hyperactivity disorder (ADHD) revealed an under‐representation of the EEG slow component during NREM sleep. Previous studies either excluded or did not characterize objectively sleep disorders, which notoriously affect sleep architecture. The present study aimed to investigate the cyclic alt...
Article
The objective of this study was to describe in detail the heart rate changes accompanying short-interval leg movements during sleep, periodic leg movements during sleep, and isolated leg movements during sleep in children and adolescents with restless legs syndrome, and to compare them with the same findings in adults with restless legs syndrome. W...
Article
Background: A parent survey was conducted to assess the sleep habits of children residing in various countries before and during the SARS-CoV-2 pandemic. It was hypothesized that lockdown would be associated with increased sleep duration. Methods: Outcomes were changes in bedtime, wake time, and sleep duration in the pandemic compared to before....
Chapter
Parasomnias are defined as “undesirable physical events or experiences that occur during entry into sleep, within sleep, or during arousal from sleep.” They occur during the night, without altering the normal structure of sleep, the evolution is usually benign, with spontaneous resolution at puberty. The prevalence is variable depending on the type...
Article
Study objectives: The current study examined the impact of home confinement (lockdown) due to the COVID-19 pandemic on sleep patterns of children and adolescents with ADHD. Methods: Nine hundred ninety-two parents of children and adolescents with ADHD filled out an anonymous online survey through the ADHD family association website. The survey i...
Chapter
Hypersomnolence is a common complaint evaluated in pediatric sleep centers. The majority of children present with symptoms of daytime sleepiness secondary to insufficient sleep. Sleep requirements vary by age and are often unknown by families. Excessive daytime sleepiness due to insufficient sleep resolves when appropriate sleep time is obtained. N...
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Study objectives: Narcolepsy type 1 (NT1) is a chronic neurological disorder typically arising during adolescence and young adulthood. Recent studies demonstrated that NT1 presents with age-specific features, especially in children. With this study we aimed to describe and to compare the clinical pictures of NT1 in different age groups. Methods:...
Article
Sleep terrors (STs) are sleep disorders characterized by abrupt arousal from sleep with autonomic hyperactivity and inappropriate behavior. Though a common condition in childhood that usually affects children between 4 and 12 years of age, STs, however, may be present even in adulthood. The exact etiology of STs is not known yet, however, several h...
Article
Objective To analyze and identify differences in sleep spindles in children with restless sleep disorder (RSD), restless legs syndrome (RLS) and normal controls. Methods PSG (polysomnography) from children with RSD, RLS and normal controls were analyzed. Sleep spindle activity was detected on one frontal and one central electrode, for each epoch o...
Article
Objectives The aim of the present study is to assess the psychometric properties of the Sleep Disturbance Scale for Children (SDSC) in an Italian population of infants and toddlers. Methods The SDSC was distributed to the primary caregivers of infants aged 6-36 months recruited via nurseries in the urban area of Rome. Reliability analysis for eval...
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Objective To examine the impact of home confinement during the COVID-19 pandemic on the sleep patterns and sleep disturbances in Italian children and adolescents. Methods Participants completed an anonymous online survey, shared via social media and targeting children and adolescents aged 1 to 18 years, subdivided into age groups: 1-3, 4-5, 6-12,...
Chapter
Sleep is essential for human life. It has different characteristics in the early stages of life compared to later periods: during development, qualitative and quantitative changes in sleep features occur such as the onset of REM/NREM sleep at 3 months, the progressive increase of night sleep duration, and the reduction of total sleep time. Sleep se...
Article
Parasomnias usually present in childhood and resolve spontaneously. The diagnosis of non-rapid eye movement-related parasomnias is mainly based on clinical descriptors and can be challenging. Rapid eye movement-related parasomnias may index an underlying psychiatric disorder. Even if benign, parasomnias can affect quality of life. Pediatricians and...
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Children with psychiatric comorbidities frequently are referred for evaluation of sleep complaints. Common sleep symptoms can include difficulty falling asleep, frequent nocturnal awakening, restless sleep, and symptoms of restless legs syndrome (RLS). The understanding of the sleep condition in relation to the psychiatric comorbidity often is a ch...
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This systematic review assessed the prevalence of restless sleep in children, documented the association of restless sleep with other conditions, and summarized the existing evidence regarding whether restless sleep should be considered a distinct sleep disorder. A comprehensive search of electronic databases was performed using the broad search te...
Article
The current study examined the impact of the lockdown due to the Covid-19 disease on mood state and behaviours of children and adolescents with ADHD. Nine hundred ninety-two parents of children and adolescents with ADHD filled out an anonymous online survey through the ADHD family association website. The survey investigated the degree of severity...
Article
A bidirectional connection between sleep and cancer exists; however, the specific associations between individual sleep disorders and particular tumors are not very clear. An accurate assessment of sleep disorders in cancer patients is necessary to improve patient health, survival, response to therapy, quality of life, reduction of comorbidities/co...
Article
Study Objectives To determine in children with obstructive sleep apnea (OSA) the effect of adenotonsillectomy on the cyclic alternating pattern (CAP) and the relationship between CAP and behavioral, cognitive, and quality-of-life measures. Methods CAP parameters were analyzed in 365 overnight polysomnographic recordings of children with mild-to-mo...
Article
Study objectives Restless sleep disorder (RSD) is a newly recognized condition characterized by motor movements involving large muscle groups with frequent repositioning or bed sheets disruption. We analyzed cyclic alternating pattern (CAP) in these children, a marker of sleep instability that might be associated with the motor episodes of RSD and...
Article
Background Restless sleep is a frequent complaint in clinical practice and has been reported in the medical literature since the 1970s. Most often, it has been described in association with specific sleep or medical conditions. However, more recently, publications have emerged that describe a disorder characterized by restless sleep as the core fea...
Article
Study objectives: Restless sleep disorder (RSD) has been recently characterized clinically and polysomnographically in children and differentiated from restless legs syndrome (RLS). Heart rate variability (HRV) is a reliable method to quantify autonomic changes during sleep. The aim of this study was to characterize HRV in children with RSD, RLS a...
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Full-text available
Autism Spectrum Disorders (ASD) are lifelong neurodevelopmental conditions characterized by abnormal social interaction, communication, and behavior. Sleep disturbances represent a common comorbidity in children and adolescents with ASD, with prevalence ranging from 50 to 80%. It has been proved that sleep disruption worsens the symptoms of autism...
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Full-text available
Cognitive impairment is frequent in pediatric cancer, and behavioral and psychological disturbances often also affect children who have survived cancer problems. Furthermore, pediatric tumors are also often associated with sleep disorders. The interrelationship between sleep disorders, neurodevelopmental disorders and pediatric cancer, however, is...
Article
Introduction Restless sleep disorder (RSD) is a newly recognized condition characterized by motor movements involving large muscle groups with frequent repositioning or bed sheets disruption. We analyzed cyclic alternating pattern (CAP) in these children, a marker of sleep instability that might be associated with the motor episodes of RSD and may...
Article
Introduction Restless sleep disorder (RSD) has been recently characterized clinically and polysomnographically in children and differentiated from restless legs syndrome (RLS). Heart rate variability (HRV) is a reliable method to quantify autonomic changes during sleep. The aim of this study was to characterize HRV in children with RSD, RLS and nor...
Article
Sleep problems are a common complaint in children/adolescents with autism spectrum disorder (ASD). Correctly diagnosing and treating sleep problems in individuals with ASD is key, as they can add to the psychosocial burden of the disorder and exacerbate associated symptoms, such as inattention or irritability. Here, we provide an overview of the ep...
Article
Background: The association of snoring and sleep-disordered breathing (SDB) with daytime sleepiness is well documented. The exact mechanisms, and especially the role of sleep microstructure that may account for this association remain, however, not completely understood. Study objectives: In a cohort of children with SDB, we aimed to compare sle...
Article
Study Objectives To assess the microstructural architecture of non-rapid eye movement (NREM) sleep known as cyclic alternating pattern (CAP) in relation to the age, gender, subjective sleep quality and the degree of sleep disruption in large community-based cohort studies of older people. Methods We applied a high performance automated CAP detecti...
Article
Study objectives: Executive functions (EFs) in children with insomnia have not been sufficiently assessed in the literature. This study aimed to describe sleep patterns and habits and EF abilities in preschool children with insomnia, compared to healthy control patients, and to evaluate the relationships between sleep patterns and EFs. Methods:...
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This retrospective study aims at helping physicians select babies considered at risk for fatal events during sleep. It does so by describing the clinical features and outcome of worrying infants’ behaviour during sleep, with the activation of an emergency medical service and/or emergency department, subsequently referred to the Centre for Paediatri...
Article
Introduction: Sleep disturbances are highly prevalent in children with neurodevelopmental disabilities. Without appropriate treatment, sleep disorders can become chronic and last for many years. However, there are no sleep medications approved by the United States Food and Drug Administration and only one has been approved by the European Medicines...
Article
Background: Habitually snoring children are at risk of manifesting disease-related problems even if their sleep studies are overall within normal limits. Study objectives: To compare sleep spindle activity in children with primary snoring and healthy controls. Methods: Sleep spindle activity including analysis of fast and slow spindles (ie, >1...
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Study objectives: To investigate the prevalence and neurophysiological correlates of obstructive sleep disordered breathing (OSA) in type 1 narcolepsy (NT1) children and adolescents. Methods: Thirty-eight, drug-naïve, NT1 children and adolescents and 21 age- and sex-balanced clinical controls underwent nocturnal polysomnography (PSG) and multipl...
Article
The objective of this observational cohort study was to analyse the age‐related changes of periodic leg movements during sleep using the newest international scoring rules, to expand past analyses, including patients in the paediatric age range, and also to analyse the changes of short‐interval and isolated leg movements during sleep throughout the...
Article
Full-text available
Introduction We aimed to study the age-related changes of periodic leg movements during sleep (PLMS) using the newest international scoring rules, to expand past analyses, including patients in the pediatric age range, and also to analyze the changes of short-interval (SILMS) and isolated (ILMS) leg movements during sleep across the lifespan. Meth...
Article
Introduction Children with restless sleep disorder (RSD) a recently identified condition to describe subjects who do not fit the criteria for any other sleep disorder but with restless sleep and daytime symptoms are studied to quantify clinically, polysomnographically and with video recordings their sleep-related movement disorder, in order to bett...
Poster
Introduction Childhood generalized anxiety disorder (GAD) is common, impairing, and linked with development of depression; however potential neurophysiological markers of the disorder have not been identified. Despite frequently reported sleep difficulties in children with GAD, studies using polysomnography (PSG) have largely failed to find abnorma...
Article
Objective: Changes of sleep architecture have been reported in children with Spinal Muscular Atrophy type 2 (SMA2), mainly represented by a decrease of arousability. No studies have evaluated the effect of long-term ventilation on sleep parameters in these children. The aim of this study was to evaluate the effects of long-term non-invasive positi...
Article
Objective Children with “restless sleep disorder” (RSD) were previously identified clinically and polysomnographically. In this study we attempt to characterize their sleep-related movements and describe them in terms of type of movement, duration and timing. Methods Video-polysomnography (vPSG) from 15 school-aged children with RSD, 15 sex- and a...
Article
The aim of the study is to explore the impact of Generalized Anxiety Disorder (GAD) comorbidity in children with Attention Deficit Hyperactivity Disorder (ADHD). Six hundred children with ADHD (mean age = 9.12 years), recruited from 2013 to 2017, participated in the study. A total of 96 (16%) children with ADHD displayed a comorbidity with GAD. ADH...
Article
Study Objectives A group of children with “restless sleep” who do not fit the criteria for any other sleep disorder but with daytime impairment are studied to identify restless sleep disorder (RSD) clinically and polysomnographically and to differentiate it from other sleep disorders of childhood. Methods A pilot study of 15 school aged children w...
Article
Introduction: For several years, pineal cysts have been considered an incidental finding on brain MRI's even though research and case reports have shown a possible association of pineal cysts with headaches and sleep disturbances. This pilot study aims to evaluate sleep disorders in school-age children with an incidental pineal cyst in an otherwis...
Article
Objective: The aim of this study was to examine sleep and psycho-behavioral variables in Georgian Internally Displaced (ID) Children and their population-based controls. Methods: One hundred and sixty one children (10.85 ± 0.9) from ID families escaped from Shida Kartli, Georgia, and 161 non-ID children (10.94 ± 0.9) were studied after seven yea...
Article
Introduction The pineal gland is key in circadian regulation by secretion of melatonin. Little is known about the effects of anatomic abnormalities on the pineal gland such as the presence of cysts. For years pineal cysts have been considered to be an incidental finding on brain MRI even though research and case reports have shown a possible associ...