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Olivier Chassany

Olivier Chassany
Université Paris Cité

MD, PhD

About

327
Publications
32,120
Reads
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4,723
Citations
Citations since 2016
67 Research Items
2065 Citations
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Introduction
Experienced Professor with a demonstrated history of working in the hospital -Gastroenterology, Internal Medicine) & health care industry. Strong professional skilled in Patient-Reported Outcomes, Methodology and Ethics of Clinical Research, management of clinical research, evaluation of clinical trials and dossiers for drug approval and HTA, and in Epidemiology. _____ Long experience with Pharma industry of 1/ expertise and counseling for drug dossiers in many conditions from redaction of protocol, to critical review of a dossier for drug approval or HTA, with a specfic in-depth experience in Patient-Reported Outcomes and 2/ in organization of training seminars from half-day to 2 weeks, on most subjects of clinical research. Contact: chassany.o@gmail.com
Additional affiliations
December 2012 - present
Paris Diderot University
Position
  • Managing Director
September 2006 - June 2012
Ethics Committee, Ile de France IV (IRB) - Comité de Protection des Personnes Ile de France IV
Position
  • Chair
January 2001 - October 2014
Assistance Publique – Hôpitaux de Paris
Position
  • Medical leader
Education
November 2008 - November 2008
Paris Diderot University
Field of study
  • Patient-Reported Outcomes
September 1998 - September 2001
Paris Diderot University
Field of study
  • Patient-Reported Outcomes
September 1990 - September 1992
Sorbonne Université
Field of study
  • Master of Pharmacology - Protein binding study of a series of anthracycline cytostatics

Publications

Publications (327)
Article
Full-text available
Introduction: Regulatory agencies encourage the incorporation of the patient voices throughout clinical drug development. Patient-Reported Outcomes (PROs) offer one way of doing this and their use has markedly increased in many therapeutic areas, particularly oncology, in recent years. However, few oncology drug labels include PRO data and those wh...
Article
This article discusses a recent methodological change to assess the additional benefit of drug intervention by the German Federal Joint Committee (Gemeinsamer Bundesausschuss), a key stakeholder in EUnetHTA21 (European Network for Health Technology Assessment joint consortium for future EU HTA regulation), methodological workstream. The German Fede...
Preprint
BACKGROUND Migrants underutilize screening opportunities for HIV, Hepatitis B, and Hepatitis C despite elevated risk factors for contracting these infections. Language barriers are an often given as reasons for limiting access to services. Translation and communication apps increase communication and overall patient-satisfaction in the patient-prov...
Preprint
Full-text available
Background Many risk factors impact the health of hospital night workers, which can lead to physical and mental health disorders. During the recent period, night hospital workers have been particularly stressed. This study therefore aims to: (i) To document the prevalence of depression, anxiety, sleep disorders, and symptoms suggestive of post-tra...
Article
Full-text available
Introduction: We aimed to estimate the prevalence and incidence of specific symptoms and predictors of post-acute COVID-19 syndrome using data collected from an anonymous online survey. Methods: We included adult participants with symptoms ≥60 days (D60+), fulfilling the World Health Organization COVID-19 cases definition, and/or hospitalized fo...
Article
Full-text available
Background Many risk factors related to altered circadian rhythms impact the health of night-shift hospital workers (NSHW), resulting in mental and somatic disorders. Easy access to psychoactive substances (PS) may facilitate addictive behaviors in NSHW. They are also exposed to a stressful work environment, which may further affect sleep quality....
Article
Full-text available
This study evaluated the association between dietary patterns, Gas-Related Symptoms (GRS) and their impact on quality of life (QoL) in a representative sample (n=936) of the French adult population. During the 2018-2019 “Comportements et Consommations Alimentaires en France” (CCAF) survey (Behaviors and Food Consumption in France), online evaluatio...
Preprint
Full-text available
Background Since the last decade, prevalence of hepatitis C virus (HCV)-infection has increased among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). We aimed to assess the prevalence of HCV coinfection in HIV-positive MSM and identify associated factors in Île-de-France Method This was a multicentric study conducted a...
Article
Full-text available
Background An understanding of the experience of patients with progressive fibrosing interstitial lung disease (PF-ILD) is needed to select appropriate patient-reported outcome measures (PROMs) to evaluate treatment effect in clinical trials. Methods A systematic literature review was conducted to develop a preliminary conceptual model of the symp...
Article
Full-text available
Objective Documenting the perceptions and experiences of frontline healthcare workers during a sanitary crisis is key to reinforce healthcare systems. We identify the determinants of quality of working life (QWL) among night-shift healthcare workers (NSHW) in Paris public hospitals shortly after the first-wave of the COVID-19 pandemic. Methods The...
Article
Full-text available
Objectives This study aimed to estimate the prevalence of psychoactive substance (PAS) use in night-shift healthcare workers (NSHW) during France’s first COVID-19 wave (March–May 2020). Design Observational cross-sectional online survey. Setting 39 public hospitals in the Assitance Publique des Hôpitaux de Paris (AP-HP) network in the Parisian ar...
Article
Full-text available
Purpose: Identified factors associated with multiple emergency department (ED) visits (≥) for asthma, which is associated with death. Patients and methods: We first conducted a qualitative study. We invited French-speaking adults (≥18 years old) with a diagnosis of asthma for more than 6 months. The identified concepts were transcribed into item...
Article
In the context of health technologies assessment, patient-reported outcome measures (PROMs) have become assessment criteria that are expected by evaluation agencies along with the other usual clinical criteria. PROMs instruments measure all aspects of patient experience in connection with their health: symptoms, activities of daily living (physical...
Preprint
Full-text available
BACKGROUND: Many risk factors related to alteration of circadian rhythms impact the health of night-shift hospital workers (NSHW), resulting in mental and somatic disorders. NSHW working conditions – including a stressful work environment – and related sleep disorders can foster addictive behaviors in this population. To study how the environment a...
Article
Résumé Dans le cadre de l’évaluation des technologies de santé, les mesures rapportées par les patients, les PROMs (patient-reported outcome measures), sont désormais des critères d'évaluation attendus par les agences d’évaluation au même titre que des critères cliniques habituels évalués par un observateur. Les instruments PROMs mesurent tous les...
Article
Introduction La santé perçue des travailleurs hospitaliers de nuit (THN), plus vulnérables du fait de leur rythme de travail, demeure peu étudiée. L’enquête AP–HP ALADDIN documente les perceptions et expériences des THN lors de la première vague épidémique de COVID-19. Notre étude s’est déroulée auprès des professionnels travaillant dans les établi...
Article
Full-text available
Background: Some subjective symptoms may be reported at all stages of Lyme borreliosis (LB) and may persist for several months after treatment. Nonspecific symptoms without any objective manifestation of LB are sometimes attributed by patients to a possible tick bite. The aim of our study was to explore the perceptions, representations, and experi...
Article
Full-text available
The burden of STIs is particularly high in HIV-infected MSM patients. A recent increase in STIs prevalence has been noticed in the US and western European countries. We aim to assess trends in asymptomatic STIs following the publication of recommendations for STIs screening, i.e. Chlamydia (CT) and gonorrhea (NG). Seventeen centers located in the P...
Article
Full-text available
Background Gas-related symptoms (GRS) are common in the general population (GPop) and among patients with disorders of gut-brain interactions but there is no patient-reported outcome evaluating these symptoms and their impact on daily life. We have previously developed a 43-item intestinal gas questionnaire (IGQ). The aim of the present study is to...
Article
Introduction et but de l’étude Cette étude évalue pour la première fois les associations entre les habitudes alimentaires et les symptômes liés à la production de gaz intestinaux dans un échantillon représentatif de la population française adulte. Matériel et méthodes Habitudes alimentaires : échantillon représentatif de données de consommation d’...
Article
Résumé Cet article détaille le processus et les aléas de publication de trois articles se rapportant au SARS-CoV-2 et à la maladie qu’il provoque (COVID-19). Ces trois articles ont été publiés à un mois d’intervalle, entre mars et mai 2020. Leur médiatisation a conduit les autorités de santé françaises à intervenir. Notre article ne s’intéresse pas...
Presentation
We described the issue for variability in successful PRO submission is the lack of statistical homogeneity and approaches. Will International guidance (IQWIG, FDA, SisaQol /IMI) resolve or conflict these discrepancies?
Preprint
BACKGROUND Migrants may face significant delays and barriers in accessing health care, especially those who do not speak fluently the language of the host country. Some applications (apps) or electronic tools have been specifically developed to be used in medical consultations to facilitate the dialogue between health care professionals and migrant...
Article
Full-text available
Background People who have migrated or with a language barrier may face significant hurdles in accessing health care. Some apps have been specifically developed to facilitate the dialogue between health care professionals and people who have migrated who have low-level language proficiency or to promote health among people who have migrated. Object...
Preprint
BACKGROUND Late diagnoses of HIV, Hepatitis B and Hepatitis C are important public health problems that affect the population at large and migrants in particular. Missed opportunities of HIV and hepatitis’ screening are numerous, with language differences being a significant barrier to testing. Several studies have shown that migrants who do not sp...
Article
Full-text available
Background Late diagnoses of HIV, hepatitis B, and hepatitis C are important public health problems that affect the population at large and migrants in particular. Missed opportunities of HIV and hepatitis screening are numerous, with language differences being a significant barrier to testing. Several studies have shown that migrants who do not sp...
Article
Full-text available
Introduction The prevalence of HIV, hepatitis B, and hepatitis C amongst migrants in France is high. Thus, effective screening and follow-up is needed. The mandatory medical check-up for residency application is an opportunity to offer rapid HIV and hepatitis testing. The main objective of the STRADA study is to create a feasible and acceptable scr...
Article
Full-text available
Immunoglobulins are 2nd or 3rd-line treatments in dermatomyositis (DM) or polymyositis (PM) refractory to high-dose corticosteroids and immunosuppressants. Immunoglobulins (2 g/kg/mo) are usually administered intravenously (IVIg) once a month and the patients stay at hospital for a few days. Recently, subcutaneous injections (SCIg) were proposed 2...
Article
Full-text available
Background: Continuing medical education is important but time-consuming for general practitioners (GPs). Current learning approaches are limited and lack the ability to engage some practitioners. Serious games are new learning approaches that use video games as engaging teaching material. They have significant advantages in terms of efficiency an...
Article
Full-text available
Background In France, the prevalence of HIV, HBV and HCV is high amongst migrants and widespread testing is recommended. All legal migrants in France undergo a mandatory medical check-up at the immigration center (OFII). This check-up is an opportunity to offer rapid HIV and hepatitis testing. A screening questionnaire for risk factors (TROD screen...
Article
Introduction La prévalence élevée du VIH et des hépatites B et C, ainsi que leur retard au diagnostic chez les migrants issus de certains pays justifient les recommandations actuelles de dépistage ciblé des autorités sanitaires. Dans ce contexte, l’étude STRADA a mis en place le dépistage par TROD, sur la base du volontariat, lors de la visite médi...
Article
Full-text available
Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients livi...
Preprint
BACKGROUND Continuing medical education is important but time-consuming for general practitioners (GPs). Current learning approaches are limited and lack the ability to engage some practitioners. Serious games are new learning approaches that use video games as engaging teaching material. They have significant advantages in terms of efficiency and...
Article
We reviewed the efficacy of SCIg administration in terms of muscle strength maintenance and patient satisfaction comparing with IVIg in the treatment of auto-immune neuromuscular diseases. A systematic review was conducted, and identified studies from databases (PUBMED, EMBASE, EBSCO, Web of Science and Google Scholar) which were analyzed. The meth...
Article
Introduction La précarité ou l’instabilité sociale sont fréquentes chez les personnes vivant avec le VIH (PVVIH) et altèrent leur vie quotidienne. L’étude EQUIPIER a estimé l’impact de l’instabilité sociale sur les différentes dimensions de la qualité de vie liée à l’état de santé, l’anxiété, la dépression et le comportement d’évitement de danger c...
Article
Introduction L’usage de substances et les comportements à risque associés sont courants chez les PVVIH et nécessitent des interventions de réduction des risques. L’objectif de cette étude est de mieux comprendre leur lien avec la qualité de vie liée à l’état de santé, le niveau d’anxiété et de dépression et avec les traits de personnalité. Matérie...
Article
Introduction Les patients HSH infectés par le VIH sont fréquemment affectés par des IST. Ceux bénéficiant d’un traitement antirétroviral stabilisé ont une visite de suivi semestrielle. Celle-ci peut être l’occasion de dépister des IST asymptomatiques. Nous rapportons ici les résultats épidémiologiques poolés des deux périodes d’inclusion. Matériel...
Article
Full-text available
Introduction Direct oral anticoagulants (DOACs) have shown noninferiority to vitamin K antagonists (VKA) in stroke prevention in patients with atrial fibrillation. DOAC treatment may be less demanding than VKA, improving quality of life. To date, there have been no studies of the real-life experience of outpatients receiving anticoagulation therapy...
Article
Full-text available
Introduction Direct oral anticoagulants (DOACs) have shown non-inferiority and ease of use compared to vitamin K antagonists (VKA) in the treatment of venous thromboembolism (VTE). No study so far has been directed toward real-life experience of outpatients receiving anticoagulants for VTE in France. Methods This is an observational descriptive re...
Article
Full-text available
Background: As publishing is essential but competitive for researchers, difficulties in writing and submitting medical articles to biomedical journals are disabling. The DIAzePAM (Difficultés des Auteurs à la Publication d'Articles Médicaux) survey aimed to assess the difficulties experienced by researchers in the AP-HP (Assistance Publique - Hôpi...
Article
From humanistic, clinical, and economic perspectives, it is important to understand patients’ health care attitudes and behavior. Of particular interest in defining the value of a pharmacologic therapy is medication adherence. A DIA workstream was convened to define medication adherence in a drug-development context, explore the relevance of medica...
Article
La loi Jardé sur les recherches impliquant la personne humaine a été promulguée en mars 2012 mais n’est entrée en application qu’en novembre 2016. Ce décalage dans le temps est en grande partie expliqué par la mise en œuvre d’un règlement européen sur les essais cliniques de médicaments qui lui ne sera sans doute appliqué qu’à compter d’octobre 201...
Article
Jardé’s law, concerning research studies in humans, was enacted in March 2012 but did not come into force until November 2016. This delay is largely explained by the adoption of a European regulation on clinical trials on medicinal products that will probably not be applicable until October 2018. In addition to covering the respective areas of the...
Article
Introduction Les patients HSH infectés par le VIH sont fréquemment affectés par des IST. Stabilisés sous traitement antirétroviral, ils bénéficient d’une visite de suivi semestrielle qui peut être l’occasion de dépister des IST asymptomatiques. L’étude DRIVER vise à déterminer si ce dépistag