Olivier Chassany

Université Paris Cité

Background Migrants are disproportionately affected by HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). Clinicians, at times, fail to offer rapid diagnostic testing (RDT) for these viruses when a language barrier exists in the patient-clinician relationship, therefore creating missed testing opportunities. Although their effectiveness has...

Background: Among people living with HIV/AIDS (PLWHA), comorbid conditions, including COVID-19, could favor impairment of health-related quality of life (HRQL). This study aimed to assess HRQL and its correlates among PLWHA co-infected with SARS-CoV-2 in France. Methods: This cross-sectional study was conducted using data from PLWHA co-infected wit...

Background Long-term therapeutic adherence remains an essential challenge for better management of chronic diseases. It is estimated at 50% in developed countries. Objective The study aimed to evaluate, under real conditions, the influence of satisfaction with Flexig use on adherence to subcutaneous immunoglobulin home-treatment therapy in a sampl...

Purpose: To analyse and compare patients' and healthcare professionals' (HPs) perspectives concerning patient care pathways for painful osteoarthritis (OA). Patients and methods: We performed a qualitative study of two focus groups corresponding to eight patients with painful OA and eight HPs involved in OA management. Results: Six key themes...

BACKGROUND Migrants are disproportionately affected by HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). Clinicians, at times, fail to offer rapid diagnostic testing (RDT) for these viruses when a language barrier exists in the patient-clinician relationship, therefore creating missed testing opportunities. Although their effectiveness has...

Background Many risk factors impact the health of hospital night workers, which can lead to physical and mental health disorders. During the recent period, night hospital workers have been particularly stressed. This study therefore aims to: (i) To document the prevalence of depression, anxiety, sleep disorders, and symptoms suggestive of post-trau...

Introduction The sexual quality of life is a neglected concern in women living with HIV (WHIV) or with HCV (WHCV), which can further be affected by their experience with stigma, social instability, fear of transmission and reduced access to treatment. The objective of this study was to identify sociodemographic, psychosocial, and behavioural factor...

Background: Migrants from high HIV, HBV or HCV endemicity regions, have a great burden of these infections and related diseases in the host countries. This study aimed to assess the predictive capacity of the TROD Screen questionnaire for HIV, HBV and HCV infections among migrants arriving in France. Methods: An observational and multicenter study...

Purpose: Dry eye disease (DED) impacts quality of life. Ocular Surface Disease Index (OSDI) and Dry Eye questionnaire (DEQ-5) are 2 frequently used tools. OSDI is psychometrically sound but its 12 items do not cover all the patient experience. Validity of DEQ-5 is questioned and the 1-month recall period may introduce a memorization bias¹. Aim of t...

Purpose: Dry eye disease (DED) is characterized by ocular discomfort and visual disturbance that can impact quality of life. This study evaluated, after 84 days of daily use, the improvement of ocular surface disease (OSD) and various Patient-Reported Outcomes Measurements (PROM) in patients with DED receiving a preservative-free combination contai...

Résumé Les essais plateformes connaissent depuis quelques années un essor important, amplifié récemment par la pandémie de coronavirus disease 2019 (COVID-19). La mise en œuvre d’un essai plateforme s’avère particulièrement utile dans certaines pathologies, notamment lorsqu’il y a un nombre important de candidats médicaments à évaluer, une évolutio...

For the past few years, platform trials have experienced a significant increase, recently amplified by the COVID-19 pandemic. The implementation of a platform trial is particularly useful in certain pathologies, particularly when there is a significant number of drug candidates to be assessed, a rapid evolution of the standard of care or in situati...

Introduction: Regulatory agencies encourage the incorporation of the patient voices throughout clinical drug development. Patient-Reported Outcomes (PROs) offer one way of doing this and their use has markedly increased in many therapeutic areas, particularly oncology, in recent years. However, few oncology drug labels include PRO data and those wh...

This article discusses a recent methodological change to assess the additional benefit of drug intervention by the German Federal Joint Committee (Gemeinsamer Bundesausschuss), a key stakeholder in EUnetHTA21 (European Network for Health Technology Assessment joint consortium for future EU HTA regulation), methodological workstream. The German Fede...

BACKGROUND Migrants underutilize screening opportunities for HIV, Hepatitis B, and Hepatitis C despite elevated risk factors for contracting these infections. Language barriers are an often given as reasons for limiting access to services. Translation and communication apps increase communication and overall patient-satisfaction in the patient-prov...

Background: Migrants underuse screening opportunities for HIV, hepatitis B, and hepatitis C despite elevated risk factors for contracting these infections. Language barriers are an often given as reasons for limiting access to services. Translation and communication apps increase communication and overall patient satisfaction in the patient-provid...

Background Many risk factors impact the health of hospital night workers, which can lead to physical and mental health disorders. During the recent period, night hospital workers have been particularly stressed. This study therefore aims to: (i) To document the prevalence of depression, anxiety, sleep disorders, and symptoms suggestive of post-tra...

Introduction: We aimed to estimate the prevalence and incidence of specific symptoms and predictors of post-acute COVID-19 syndrome using data collected from an anonymous online survey. Methods: We included adult participants with symptoms ≥60 days (D60+), fulfilling the World Health Organization COVID-19 cases definition, and/or hospitalized fo...

Background Many risk factors related to altered circadian rhythms impact the health of night-shift hospital workers (NSHW), resulting in mental and somatic disorders. Easy access to psychoactive substances (PS) may facilitate addictive behaviors in NSHW. They are also exposed to a stressful work environment, which may further affect sleep quality....

This study evaluated the association between dietary patterns, Gas-Related Symptoms (GRS) and their impact on quality of life (QoL) in a representative sample (n=936) of the French adult population. During the 2018-2019 “Comportements et Consommations Alimentaires en France” (CCAF) survey (Behaviors and Food Consumption in France), online evaluatio...

Background Since the last decade, prevalence of hepatitis C virus (HCV)-infection has increased among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). We aimed to assess the prevalence of HCV coinfection in HIV-positive MSM and identify associated factors in Île-de-France Method This was a multicentric study conducted a...

Background An understanding of the experience of patients with progressive fibrosing interstitial lung disease (PF-ILD) is needed to select appropriate patient-reported outcome measures (PROMs) to evaluate treatment effect in clinical trials. Methods A systematic literature review was conducted to develop a preliminary conceptual model of the symp...

Objective Documenting the perceptions and experiences of frontline healthcare workers during a sanitary crisis is key to reinforce healthcare systems. We identify the determinants of quality of working life (QWL) among night-shift healthcare workers (NSHW) in Paris public hospitals shortly after the first-wave of the COVID-19 pandemic. Methods The...

Objectives This study aimed to estimate the prevalence of psychoactive substance (PAS) use in night-shift healthcare workers (NSHW) during France’s first COVID-19 wave (March–May 2020). Design Observational cross-sectional online survey. Setting 39 public hospitals in the Assitance Publique des Hôpitaux de Paris (AP-HP) network in the Parisian ar...

Purpose: Identified factors associated with multiple emergency department (ED) visits (≥) for asthma, which is associated with death. Patients and methods: We first conducted a qualitative study. We invited French-speaking adults (≥18 years old) with a diagnosis of asthma for more than 6 months. The identified concepts were transcribed into item...

In the context of health technologies assessment, patient-reported outcome measures (PROMs) have become assessment criteria that are expected by evaluation agencies along with the other usual clinical criteria. PROMs instruments measure all aspects of patient experience in connection with their health: symptoms, activities of daily living (physical...

BACKGROUND: Many risk factors related to alteration of circadian rhythms impact the health of night-shift hospital workers (NSHW), resulting in mental and somatic disorders. NSHW working conditions – including a stressful work environment – and related sleep disorders can foster addictive behaviors in this population. To study how the environment a...

Résumé Dans le cadre de l’évaluation des technologies de santé, les mesures rapportées par les patients, les PROMs (patient-reported outcome measures), sont désormais des critères d'évaluation attendus par les agences d’évaluation au même titre que des critères cliniques habituels évalués par un observateur. Les instruments PROMs mesurent tous les...

Introduction La santé perçue des travailleurs hospitaliers de nuit (THN), plus vulnérables du fait de leur rythme de travail, demeure peu étudiée. L’enquête AP–HP ALADDIN documente les perceptions et expériences des THN lors de la première vague épidémique de COVID-19. Notre étude s’est déroulée auprès des professionnels travaillant dans les établi...

Background: Some subjective symptoms may be reported at all stages of Lyme borreliosis (LB) and may persist for several months after treatment. Nonspecific symptoms without any objective manifestation of LB are sometimes attributed by patients to a possible tick bite. The aim of our study was to explore the perceptions, representations, and experi...

The burden of STIs is particularly high in HIV-infected MSM patients. A recent increase in STIs prevalence has been noticed in the US and western European countries. We aim to assess trends in asymptomatic STIs following the publication of recommendations for STIs screening, i.e. Chlamydia (CT) and gonorrhea (NG). Seventeen centers located in the P...

Background Gas-related symptoms (GRS) are common in the general population (GPop) and among patients with disorders of gut-brain interactions but there is no patient-reported outcome evaluating these symptoms and their impact on daily life. We have previously developed a 43-item intestinal gas questionnaire (IGQ). The aim of the present study is to...

Our review of the latest IQWIG guidance on a meaningful threshold for PRO data.

Introduction et but de l’étude Cette étude évalue pour la première fois les associations entre les habitudes alimentaires et les symptômes liés à la production de gaz intestinaux dans un échantillon représentatif de la population française adulte. Matériel et méthodes Habitudes alimentaires : échantillon représentatif de données de consommation d’...

Résumé Cet article détaille le processus et les aléas de publication de trois articles se rapportant au SARS-CoV-2 et à la maladie qu’il provoque (COVID-19). Ces trois articles ont été publiés à un mois d’intervalle, entre mars et mai 2020. Leur médiatisation a conduit les autorités de santé françaises à intervenir. Notre article ne s’intéresse pas...

We described the issue for variability in successful PRO submission is the lack of statistical homogeneity and approaches. Will International guidance (IQWIG, FDA, SisaQol /IMI) resolve or conflict these discrepancies?

BACKGROUND Migrants may face significant delays and barriers in accessing health care, especially those who do not speak fluently the language of the host country. Some applications (apps) or electronic tools have been specifically developed to be used in medical consultations to facilitate the dialogue between health care professionals and migrant...

Background People who have migrated or with a language barrier may face significant hurdles in accessing health care. Some apps have been specifically developed to facilitate the dialogue between health care professionals and people who have migrated who have low-level language proficiency or to promote health among people who have migrated. Object...

BACKGROUND Late diagnoses of HIV, Hepatitis B and Hepatitis C are important public health problems that affect the population at large and migrants in particular. Missed opportunities of HIV and hepatitis’ screening are numerous, with language differences being a significant barrier to testing. Several studies have shown that migrants who do not sp...

Background Late diagnoses of HIV, hepatitis B, and hepatitis C are important public health problems that affect the population at large and migrants in particular. Missed opportunities of HIV and hepatitis screening are numerous, with language differences being a significant barrier to testing. Several studies have shown that migrants who do not sp...

Introduction The prevalence of HIV, hepatitis B, and hepatitis C amongst migrants in France is high. Thus, effective screening and follow-up is needed. The mandatory medical check-up for residency application is an opportunity to offer rapid HIV and hepatitis testing. The main objective of the STRADA study is to create a feasible and acceptable scr...

Immunoglobulins are 2nd or 3rd-line treatments in dermatomyositis (DM) or polymyositis (PM) refractory to high-dose corticosteroids and immunosuppressants. Immunoglobulins (2 g/kg/mo) are usually administered intravenously (IVIg) once a month and the patients stay at hospital for a few days. Recently, subcutaneous injections (SCIg) were proposed 2...

Background: Continuing medical education is important but time-consuming for general practitioners (GPs). Current learning approaches are limited and lack the ability to engage some practitioners. Serious games are new learning approaches that use video games as engaging teaching material. They have significant advantages in terms of efficiency an...

Background In France, the prevalence of HIV, HBV and HCV is high amongst migrants and widespread testing is recommended. All legal migrants in France undergo a mandatory medical check-up at the immigration center (OFII). This check-up is an opportunity to offer rapid HIV and hepatitis testing. A screening questionnaire for risk factors (TROD screen...

Introduction La prévalence élevée du VIH et des hépatites B et C, ainsi que leur retard au diagnostic chez les migrants issus de certains pays justifient les recommandations actuelles de dépistage ciblé des autorités sanitaires. Dans ce contexte, l’étude STRADA a mis en place le dépistage par TROD, sur la base du volontariat, lors de la visite médi...

Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients livi...

BACKGROUND Continuing medical education is important but time-consuming for general practitioners (GPs). Current learning approaches are limited and lack the ability to engage some practitioners. Serious games are new learning approaches that use video games as engaging teaching material. They have significant advantages in terms of efficiency and...

We reviewed the efficacy of SCIg administration in terms of muscle strength maintenance and patient satisfaction comparing with IVIg in the treatment of auto-immune neuromuscular diseases. A systematic review was conducted, and identified studies from databases (PUBMED, EMBASE, EBSCO, Web of Science and Google Scholar) which were analyzed. The meth...

Introduction La précarité ou l’instabilité sociale sont fréquentes chez les personnes vivant avec le VIH (PVVIH) et altèrent leur vie quotidienne. L’étude EQUIPIER a estimé l’impact de l’instabilité sociale sur les différentes dimensions de la qualité de vie liée à l’état de santé, l’anxiété, la dépression et le comportement d’évitement de danger c...

Introduction L’usage de substances et les comportements à risque associés sont courants chez les PVVIH et nécessitent des interventions de réduction des risques. L’objectif de cette étude est de mieux comprendre leur lien avec la qualité de vie liée à l’état de santé, le niveau d’anxiété et de dépression et avec les traits de personnalité. Matérie...

Introduction Les patients HSH infectés par le VIH sont fréquemment affectés par des IST. Ceux bénéficiant d’un traitement antirétroviral stabilisé ont une visite de suivi semestrielle. Celle-ci peut être l’occasion de dépister des IST asymptomatiques. Nous rapportons ici les résultats épidémiologiques poolés des deux périodes d’inclusion. Matériel...

Introduction Direct oral anticoagulants (DOACs) have shown noninferiority to vitamin K antagonists (VKA) in stroke prevention in patients with atrial fibrillation. DOAC treatment may be less demanding than VKA, improving quality of life. To date, there have been no studies of the real-life experience of outpatients receiving anticoagulation therapy...

Introduction Direct oral anticoagulants (DOACs) have shown non-inferiority and ease of use compared to vitamin K antagonists (VKA) in the treatment of venous thromboembolism (VTE). No study so far has been directed toward real-life experience of outpatients receiving anticoagulants for VTE in France. Methods This is an observational descriptive re...