Oliver Stojkovic

Oliver Stojkovic
University of Belgrade · Institute of Forensic Medicine

PhD

About

64
Publications
13,159
Reads
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1,439
Citations
Additional affiliations
April 2002 - present
University of Belgrade
Position
  • Principal Investigator

Publications

Publications (64)
Article
Full-text available
We explored the cryptic speciation of the Nannospalax leucodon species complex, characterised by intense karyotype evolution and reduced phenotypic variability that has produced different lineages, out of which 25 are described as chromosomal forms (CFs), so many cryptic species remain unnoticed. Although some of them should be classified as threat...
Article
Full-text available
In Europe, the first case of coronavirus disease (COVID-19) and the first COVID-19-related death were reported in France on January 24th and February 15th, 2020, respectively. Officially, the first case of COVID-19 infection in the Republic of Serbia was registered on March 6th. Herein, we presented the first case of retrospective detection of the...
Article
During normal pregnancy depressed fibrinolytic system is caused by changes in many factors, which could be influenced by different gene polymorphisms. The aim of this study was to investigate the combination of fibrinolysis-related gene polymorphisms in women with idiopathic infertility. We genotype polymorphisms 4G/5G in plasminogen activator inhi...
Article
The role of intraspecific karyotype variability in reproductive isolation and speciation has been widely studied. Among the 26 genera of Palaearctic mammals, the blind mole rats genus Nannospalax has the highest karyotype variability with 74 chromosomal forms (CFs). Although these CFs have been described in detail, taxonomic effects of chromosomal...
Article
Full-text available
Plethora of drugs and toxic substances is metabolized by cytochrome P450 enzymes (CYP450). These enzymes are coded by highly variable genes abundant with single nucleotide variants (SNVs) and small insertions/deletions (indels) that affect the functionality of the enzymes, increasing or decreasing their activity. CYP genes genotyping, followed by h...
Poster
Full-text available
Abstract: Among the 26 genera of Palaearctic mammals, the genus Nannospalax has the highest karyotype variability with 74 chromosomal forms (CFs). Chromosomal number and morphology have been described in detail, but taxonomic effects of chromosomal rearrangements are still lacking, especially among CFs of European N. leucodon superspecies. As gene...
Article
: A numerous factor can cause infertility, but around one of four reproductive failure cases remain unexplained and diagnosed as idiopathic infertility. In the past few decades, analysis of gene polymorphisms takes a significant place in pathogenesis of infertility. The aim of this study was to evaluate the possible role of hemostasis-related gene...
Article
Unexplained infertility refers to the absence of a definable cause of reproductive failure. Vitamin D receptor (VDR) acts as a transcription factor and regulates a number of vitamin D-responsive genes, including those involved in the immune system. Recent finding that VDR is expressed in reproductive tissues suggests a possible importance of vitami...
Article
Full-text available
Physiological adaptations to various types of prolonged and intensive physical activity, as seen in elite athletes from different sports, include changes in blood pressure (BP) response to acute exercise. Also, functional polymorphisms of the angiotensin I converting enzyme (ACE) and alfa-actinin-3 (ACTN3) genes are shown to be associated with BP p...
Article
Full-text available
Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in the folate metabolism. The polymorphism 677C>T of the MTHFR gene, producing thermolabile enzyme with decreased function, is widely studied and associated with many conditions. Additionally, it has been shown that another polymorphism, 1298A>C, also reduces the activity of this enz...
Article
Reproductive failure (recurrent foetal loss, unexplained infertility and IVF implantation failure) may be, in a number of cases, explained by thrombophilia, either acquired or inherited. Several genes contribute to thrombophilia, some with major effect (Factor V, Factor II), and some with minor effect (MTHFR, PAI-1, ATIII, etc.). The aim of this st...
Article
Human-specific quantitative PCR (qPCR) has been developed for forensic use in the last 10 years and is the preferred DNA quantification technique since it is very accurate, sensitive, objective, time-effective and automatable. The amount of information that can be gleaned from a single quantification reaction using commercially available quantifica...
Article
Objectives This study aimed to evaluate the association of ACE insertion/deletion (I/D) and ACTN3 R577X polymorphisms with resting, maximal and recovery blood pressure (BP) and left ventricular hypertrophy measured by left ventricular mass index (LVMI) in elite athletes. Methods A group of 107 white, healthy, elite male athletes, aged between 20 a...
Article
Here we report the results of fine resolution Y chromosomal analyses (Y-SNP and Y-STR) of 267 Bantu-speaking males from three populations located in the southeast region of Africa. In an effort to determine the relative Y chromosomal affinities of these three genotyped populations, the findings are interpreted in the context of 74 geographically an...
Conference Paper
Full-text available
Introduction: Working memory is essential for the development of many language-related traits. It has been suggested that the rare trait of backwardspeaking is linked to working memory. This trait is described as an ability to spontaneously and accurately reverse words. Here we describe individuals (the father and daughter) from a Serbian family wh...
Article
Introduction: Working memory is essential for the development of many language-related traits. It has been suggested that the rare trait of backwardspeaking is linked to working memory. This trait is described as an ability to spontaneously and accurately reverse words. Here we describe individuals (the father and daughter) from a Serbian family wh...
Article
Full-text available
Case studies of unusual traits can provide unique snapshots of the effects of modified systems. In this study, we report on an individual from a Serbian family with the ability to rapidly, accurately and voluntarily speak backwards. We consider psychological, neural and genetic correlates of this trait to identify specific relevant neural mechanism...
Article
Full-text available
Since the renin-angiotensin-aldosterone system (RAAS) was originally described, it has become one of the best described hormonal systems, especially regarding the fact that it plays an important role in regulating blood volume and systemic vascular resistance, and thus indirectly influencing blood pressure (BP). On the other hand, arterial hyperten...
Article
Full-text available
The aim of this investigation is to determine the capacity of the newly available Y-STR multiplex system, PowerPlex ® Y23, to discriminate between populations of similar ancestry, specifically of African descent. Using network analysis, the parti - tioning of the 23-loci haplotypes was assessed in relation to Y-specific haplogroups. In the network...
Article
Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder caused by an interaction between genes and environmental triggers. Intrathyroid lymphocytic infiltration may lead to progressive destruction of thyroid tissue and consequently to hypothyroidism. Many studies in different populations have shown association between vitamin...
Article
We describe the implementation of short tandem repeats-polymerase chain reaction (STR-PCR) chimerism analyses coupled with reverse transcription PCR detection of recurrent translocations characteristic for childhood leukemia in monitoring of patients after allogeneic hematopoietic stem cell transplantation in Serbia and the first clinical results t...
Article
In the present study, we analyzed 17 Y-STR loci in 350 Tibetan males from three culturally defined regions of historical Tibet: Amdo (88), Kham (109) and U-Tsang (153). A total of 299 haplotypes were observed, 272 (90.9%) of which were unique. Only one Y-STR profile is shared across the three Tibetan groups and, incidentally, is also the most frequ...
Article
Full-text available
The European Network of Forensic Science Institutes (ENFSI) recommended the establishment of forensic DNA databases and specific implementation and management legislations for all EU/ENFSI members. Therefore, forensic institutions from Bosnia and Herzegovina, Serbia, Montenegro, and Macedonia launched a wide set of activities to support these recom...
Article
Full-text available
Linguistic and ethnic diversity throughout the Himalayas suggests that this mountain range played an important role in shaping the genetic landscapes of the region. Previous Y-chromosome work revealed that the Himalayas acted as a biased bidirectional barrier to gene flow across the cordillera. In the present study, 17 Y-chromosomal short tandem re...
Article
Afghanistan's unique geostrategic position in Eurasia has historically attracted commerce, conflict and conquest to the region. It was also an important stop along the Silk Road, connecting the far eastern civilizations with the western world. Nevertheless, limited genetic studies have been performed in Afghan populations. In this study, 17 Y-chrom...
Article
Full-text available
Dentin provides a protective enclosure for genomic and mitochondrial DNA. In the present study, DNA was obtained from pulverized or ground teeth. The quality of the DNA extracted from the teeth of 70 unrelated individuals was tested in the context of assessing the allelic and genotypic frequencies of autosomal loci D19S216, D20S502 and D20S842, and...
Article
Full-text available
Previous studies have revealed that the European Roma share close genetic, linguistic and cultural similarities with Indian populations despite their disparate geographical locations and divergent demographic histories. In this study, we report for the first time Y-chromosome distributions in three Roma collections residing in Belgrade, Vojvodina a...
Article
Full-text available
Southeastern Europe and, particularly, the Balkan Peninsula are especially useful when studying the mechanisms responsible for generating the current distribution of Paleolithic and Neolithic genetic signals observed throughout Europe. In this study, 404 individuals from Montenegro and 179 individuals from Serbia were typed for 17 Y-STR loci and co...
Article
Full-text available
To develop in house protocol for DNA analyses of contact traces, we conducted a series of experiments using low copy number (LCN-PCR) [P. Gill, Application of low copy number DNA profiling, Croatian Med. J. 42(3)(2001) 229–232] amplification of DNA isolated from touched objects. In each experiment, touched objects were swabbed using double swab tec...
Article
Seventeen Y-chromosomal STR (short tandem repeat) loci were analyzed in a group of 185 healthy unrelated male individuals (n=185) from the population of Serbian province of Vojvodina. After minimal haplotype STR loci analysis we observed 129 different haplotypes. The most frequent haplotype was found in 13 copies, and total haplotype diversity was...
Article
Full-text available
Hyper-immunoglobulin E syndrome (HIES) is a compound primary immunodeficiency characterized by a highly elevated serum IgE, recurrent staphylococcal skin abscesses and cyst-forming pneumonia, with disproportionately milder inflammatory responses, referred to as cold abscesses, and skeletal abnormalities. Although some cases of familial HIES with au...
Article
Full-text available
Hematopoietic stem cell transplantation (HSCT) is a very successful method of treatment for children with different aquired or inborn diseases. The main goal of post-transplantation chimerism monitoring in HSCT is to predict negative events (such as disease relapse and graft rejection), in order to intervene with appropriate therapy and improve the...
Article
Microsatellites could be of great potential use in the analysis of ancient remains, but so far such analyses have failed to be reproducible mainly because of the high degree of ancient DNA (aDNA) degradation. During PCR, annealing of the primers to the complementary sequences of microsatellites occurs together with cross-annealing of partially degr...
Article
Mutations at two fragile sites, FRAXA and FRAXE, loci are caused by an expansion of a CGG/GCC trinucleotide repeat and are characterized by mental retardation. Here we report molecular screening survey of 97 unrelated individuals diagnosed with non-specific mental retardation (MR), which produced positive test for FRAXA in two boys and none positiv...
Article
Myotonic dystrophy type 1 (DM1) is associated with an expansion of CTG repeats in the 3'UTR of the DMPK gene. It is accepted, as in other trinucleotide diseases, that the number of the repeats is correlated with age at onset and severity of the disease. However, assessment of genotype-phenotype correlation in DM1 is complicated with the expansion-b...
Article
Myotonic dystrophy type 1 (DM1) is caused by large expansions of cytosine-thymine-guanine (CTG)-repeats in myotonic dystrophy protein kinase (DMPK)-gene. This gene is highly polymorphic in healthy individuals. It has been proposed that expanded alleles originated from the group of large sized normal alleles. If this is correct, one should expect a...
Article
A number of human hereditary neuromuscular and neurodegenerative disorders are caused by the expansion of trinucleotide repeats within certain genes. The molecular mechanisms that underlie these expansions are not yet known. We have analyzed six trinucleotide repeat-containing loci [spinocerebellar ataxias (SCA1, SCA3, SCA8), dentatorubral-pallidol...
Article
Allele frequencies of nine short tandem repeats (TH01, TPOX, CSF1P0, vWA, FES/FPS, F13A01, D13S317, D7S820 and D16S539) were obtained in a sample of 111-125 unrelated Yugoslavs.
Article
A number of human hereditary neuromuscular and neurodegenerative disorders are caused by the expansion of trinucleotide repeats within certain genes. Here we report the results of the analysis of five trinucleotide repeats containing genes (SCA1, MJD/SCA3, DRPLA, FRDA and MD) in HD patients and in a group of healthy controls. Allelic frequency dist...
Article
We report two large, unrelated families with spinocerebellar ataxia type 1 (SCA1) from the same village in the southeastern, mountain region of Serbia: Family 1 with 16, and Family 2 with nine affected members, identified in four consecutive generations. They significantly differ in the age at onset (31.8 ± 10.7 and 45.0 ± 8.4 years in Family 1 and...
Article
In 1991 the genes responsible for fragile X syndrome and spinal bulbar muscular atrophy were found to contain unstable expanded trinucleotide repeats. In the following years myotonic dystrophy was also found to be the results of an expanded trinucleotide repeat. These findings were soon followed by discoveries of a remarkable number of neurological...
Article
Dynamic mutations were recently discovered causing hereditary non polyposis colon cancer. Soon almost 15 hereditary neurological diseases were described caused by the expansion of trinucleotide repeats in target genes. These mutations are unstable: the number of trinucleotide repeats is increasing from generation to generation. These mutations do n...
Article
Huntington's disease (HD) is an autosomal dominant, progressive disorder characterized by choreic movements, cognitive decline, and psychiatric manifestations. Eleven patients with HD were retrospectively selected from a larger group of 42 patients based on the similar, early onset of the disease (between 21 and 30 years) and the same duration of H...
Article
Full-text available
In this study we examined the direct and correlated responses for fast and slow preadult development time in three laboratory populations of the bean weevil (Acanthoscelides obtectus). The first population ('base,' B) has experienced laboratory conditions for more than 10 years; the second ('young,' Y) and the third ('old,' O) populations were sele...
Article
In this study we examined the direct and correlated responses for fast and slow preadult development time in three laboratory populations of the bean weevil (Acanthoscelides obtectus). The first population ("base," B) has experienced laboratory conditions for more than 10 years; the second ("young," Y) and the third ("old," O) populations were sele...
Article
In 1993 the gene responsible for Huntington's disease (IT15) was isolated [5]. It was mapped to the tip of the short arm of chromosome 4 and within its coding sequence, near the 5' end, it contained a certain number of trinicleotide (CAG)n (cytosine-adenine-guanine) repeats (Figure 1). This gene codes for a protein (348 kd) called "huntington" that...
Article
We explored the extent to which two populations of Acanthoscelides obtectus (Coleoptera: Bruchidae), maintained in the laboratory for about 60 generations on common bean (Phaseolus vulgaris) and chickpea (Cicer arietinum) seeds, differ genetically in life history traits. Using a half-sib breeding design, we screened for genetic variation in oviposi...
Article
Full-text available
Four types of laboratory populations of the bean weevil (Acanthoscelides obtectus) have been developed to study the effects of density-dependent and age-specific selection. These populations have been selected at high (K) and low larval densities (r) as well as for reproduction early (Y) and late (O) in life. The results presented here suggest that...
Article
Full-text available
Four types of laboratory populations of the bean weevil (Acanthoscelides obtectus) have been developed to study the effects of density-dependent and age-specific selection. These populations have been selected at high (K) and low larval densities (r) as well as for reproduction early (Y) and late (O) in life. The results presented here suggest that...
Article
Full-text available
In this study we examined the effects of long-term selection on early and late reproduction in the bean weevil. The pure lines and the hybrids between the lines within a selection regime were compared for longevity, early and late female fecundity, male mating ability, pre-adult developmental time and wet adult weight. Comparison of hybrid with pur...

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Projects (2)
Project
This research was supported by the Science Fund of the Republic of Serbia, , #7683961, Experimental evolution approach in developing insect pest control methods - ELEVATE. Analysis of genetic differences of genes involved in insecticide metabolism, their expression patterns and changes during evolution of insecticide resistance will be used to determine insecticide efficiency and its proper dosage use. Furthermore, identifying changes in plasticity of life-history traits and population dynamics during host-shift will allow assessment of potential damage to diverse stored products. Finally, we will develop a new pest control method based on mitochondrial mutations that limit reproductive output of males while having no negative effects on females. Pest insects require integrated approaches and development of a wide range of tools for prevention, monitoring, control and implementation of risk management strategies. The ELEVATE project will actively contribute to this endeavor.