Oliver Gembruch

Oliver Gembruch
University Hospital Essen | UK Essen · Department of Neurosurgery and Spinesurgery

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70
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395
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Publications

Publications (70)
Article
Objective The demographic change in the population leads to a rising number of patients presenting with fractures of the cervical spine, especially C-2, due to falls. With an increase of co-morbidities in these elder patients, the risk for intra- and postoperative complications is increased likewise. Thus, an alternative strategy instead of operat...
Article
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Objective The demographic change leads to a higher incidence of C-2 fractures, especially in elderly patients. For these patients, treatment is still controversial discussed for Type II fractures according to Anderson and D`Alonzo due to rising morbidity and mortality rates for any treatment. The aim of this study was to compare the conservative an...
Article
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Background: Degenerative cervical myelopathy (DCM) is the most common reason for spinal cord disease in elderly patients. This study analyzes the preoperative status and postoperative outcome of higher-aged patients in comparison to young and elderly patients in order to determine the benefit to those patients from DCM surgery. Methods: A retros...
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Study design: Retrospective study (data analysis). Objective: The purpose of this study was to assess the role of different factors on postoperative outcome of patients with degenerative cervical myelopathy (DCM). Summary of background data: Ongoing degenerative changes of DCM lead to progressive neurological deficits. The optimal timing of su...
Article
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Background and Objectives: Spinal schwannomas are benign tumours that can present with various symptoms such as pain, radiculopathy and neurological deficit. Gross total resection (GTR) is of key importance for local recurrence. The aim of this study is to describe the clinical characteristics, resection rate, clinical outcome, as well as tumour re...
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Objective The objective of this study is to investigate the relationship between the thrombus signal intensity and aneurysm wall thickness in partially thrombosed intracranial aneurysms in vivo with magnetization-prepared rapid acquisition gradient echo (MPRAGE) taken using 7T magnetic resonance imaging (MRI) and correlate the findings to wall inst...
Article
Objective: The prevalence of multiple intracranial aneurysms (MIAs) has increased over the last decades. Because MIAs have been identified as an independent risk factor for formation, growth, and rupture of intracranial aneurysms (IAs), a more profound understanding of the underlying pathophysiology of MIAs is needed. Therefore, the authors' exten...
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Purpose Degenerative cervical myelopathy (DCM) is the most common non-traumatic cause of spinal cord dysfunction. Prediction of the neurological outcome after surgery is important. The aim of this study was to analyze the relationship between first symptoms of DCM and the neurological outcome after surgery. Methods A retrospective analysis over a...
Article
Full-text access: https://rodemerk.com/publications/original-research/ptgwt/ Background: Preoperative traction with the Gardner-Wells tongs (PTGWT) is a valuable option for cervical spine injuries with malalignment. The aim of this study was to analyze the factors related to the treatment success of PTGWT. Methods: All consecutive cases with P...
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Spinal epidural lipomatosis (SEL) is a rare condition caused by hypertrophic growth of epidural fat. The prevalence of SEL in the Western world is approximately 1 in 40 patients and is likely to increase due to current medical and socio-economic developments. Rarely, SEL can lead to rapid severe neurological deterioration. The pathophysiology, opti...
Article
OBJECTIVE Cavernous spinal cord malformations (SCMs) are believed to have a high rate of bleeding. The risk of intramedullary hemorrhage (IMH) or recurrent IMH and the neurological impact of bleeding events are important for clinical decision-making and could impact current treatment strategies. METHODS The authors screened their institutional dat...
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Objective Spinal cord ependymomas account for 3–6% of all central nervous system tumors and around 60% of all intramedullary tumors. The aim of this study was to analyze the neurological outcome after surgery and to determine prognostic factors for functional outcome. Patients and Methods Patients treated surgically due to a spinal cord ependymoma...
Article
Traumatic acute subdural hematoma (aSDH) is associated with a high mortality rate due to postoperative cerebral infarction. Recently, brain natriuretic peptide (BNP) was considered a reliable biomarker in the acute phase of traumatic brain injuries. We therefore aimed in this study to analyze BNP levels on admission, identify the predictors of thei...
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Introduction: Brain natriuretic peptide (BNP) is a reliable biomarker in the acute phase of traumatic brain injury. However, the relationship between BNP and traumatic acute subdural hematoma (aSDH) has not yet been addressed. This study aimed to analyze BNP levels on admission in surgically treated patients and assess their relationship with earl...
Article
Objective Microsurgical resection of spinal ependymomas is associated with a considerable risk of postoperative neurological deterioration. We aimed to develop a risk score for outcome prediction after surgery for spinal ependymoma. Materials and Methods All patients who underwent microsurgical resection of spinal ependymoma between 1980 and 2015...
Conference Paper
Objective: Brain natriuretic peptide serum levels (BNP) on admission are frequently elevated in patients with symptomatic chronic subdural hematoma (cSDH). However, the reasons for these elevated levels remain unclear. In patients with traumatic brain injuries, elevated BNP was associated with increased intracranial pressure (ICP), but cSDH exhibit...
Conference Paper
Objective: Brain natriuretic peptide (BNP) is known as a reliable biomarker in the acute phase of traumatic brain injury, related to its severity, presence of increased intracranial pressure and unfavorable outcome. The purpose of this study was to analyze the plasma BNP level in patients with traumatic acute subdural hematoma (aSDH) and assess its...
Conference Paper
Objective: A recent study showed a frequent elevation of brain natriuretic peptide (BNP) serum levels in patients with symptomatic chronic subdural hematoma (cSDH). In this study, the prediction of the long-term functional outcome was assessed, and a new predictive score developed. Methods: We prospectively included patients with symptomatic cSDH...
Conference Paper
Objective: The increase of plasma brain natriuretic peptide (BNP) concentrations on admission was demonstrated in patients with traumatic brain injury (TBI), but has been not yet addressed in traumatic acute subdural hematoma (aSDH). The aim of this study was to assess the relationship between plasma BNP levels and radiological findings in patients...
Article
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Objective: The frequency of aneurysmal subarachnoid hemorrhage (aSAH) presents complex fluctuations that have been attributed to weather and climate changes in the past. In the present long-term big data and deep learning analysis, we have addressed this long-held myth. Methods: Bleeding dates and basic demographic data for all consecutive patients...
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Background: Brain natriuretic peptide serum levels (BNP) on admission are frequently elevated in patients with symptomatic chronic subdural hematoma (cSDH) and predict unfavorable long-term functional outcomes. However, the reasons for these elevated levels remain unclear. Therefore, we aimed to identify the predictors of BNP elevation. Methods:...
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Introduction Brachial plexus lipomas are extremely rare benign tumors that may cause slow progression of neurological deficits leading to thoracic outlet syndrome. Up to now, surgery remains challenging. The aim of this study is to present our surgical treatment regime and long-term neurological outcome in three cases of giant brachial plexus lipom...
Article
Objective To investigate the role of brain natriuretic peptide (BNP) in predicting long-term functional outcome and develop a new predictive score of poor functional outcome after surgery for chronic subdural hematoma (cSDH). Methods Patients with cSDH that were surgically treated in our department between November 2016 and December 2019 were inclu...
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Objectives Isocitrate dehydrogenase ( IDH1/2 ) mutations and O6-alkylguanine DNA methyltransferase ( MGMT ) promoter methylations are acknowledged survival predictors in patients with glioblastoma (GB). Moreover, tumor growth patterns like multifocality and subventricular zone (SVZ) involvement seem to be associated with poorer outcomes. Here, we w...
Article
Objective To evaluate the incidence of CAM in a pediatric population receiving brain tumor surgery, and to identify the major risk factors involved. Methods We retrospectively analyzed the medical and radiological records of 205 pediatric patients who received 251 EVDs between January 2008 and December 2017. All patients less than 18 years old who...
Article
Background Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an increasingly recognized neuroinflammatory syndrome that predominantly affects pontine and cerebellar brain structures. Characteristically, patients develop glucocorticoid-responsive brainstem disorders, demonstrate pontocerebell...
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The purpose of this study was to analyze BNP serum levels of patients with chronic subdural hematoma (cSDH) and their clinical implication. Patients with cSDH, who underwent surgery in our department between November 2016 and October 2019, were eligible for enrollment in the study. Patients with recurrent bleedings, traumatic brain injury, cSDH ass...
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Background Anterior transarticular screw fixation (ATSF) of C1/C2 can be used for the treatment of unstable dens fractures. Here, we evaluated the feasibility of an anterior C1/C2 fixation in elderly patients with unstable dens fractures. Furthermore, we tried to analyze safe entry zones for ATSF surgery. Methods A consecutive cohort of 13 patie...
Article
Objective: Several parameters are known to predict the survival of glioblastoma (GB), including extent of resection and MGMT promotor methylation. Staining for glial fibrillary acidic protein (GFAP) is a common component of routine histological work-up, but its clinical utility in GB is unclear. The aim of the present study was to analyze the predi...
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Background Perineuriomas are rare benign peripheral nerve sheath tumours of perineurial cell origin and can be classified into intraneural and extraneural perineuriomas. They most commonly present a mononeuropathy of gradual onset and slow progression, resulting in progressive neurological deficits like hypoesthesia or motor weakness. Therapy is s...
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Background: A huge spherical intracranial mass can sometimes be misdiagnosed, due to the lack of typical radiographic features. Thrombosed giant intracranial aneurysms (GIAs) are an uncommon but still a possible differential diagnosis that must be kept in mind to guarantee the best surgical approach and resection of the lesion. We describe an extr...
Article
Introduction Glioblastoma multiforme (GBM) has a peak incidence in patients older than 65 years. The aim of the present study is to evaluate the impact of surgical strategy on short- and long-term outcomes of older GBM patients. Methods A total of 273 older patients (65–84 years) from 2006 to 2014 were operated in our neurosurgical center. The stu...
Conference Paper
Introduction: Tuberous sclerosis complex (TSC) is a rare autosomal-dominant inherited disease. Arterial wall developmental disorders, such as aneurysms, in association with TSC have been well described for extracranial vasculature. Whereas, intracranial aneurysms (IAs) have not previously been addressed in the literature. A systematic review was p...
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Background: Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation: Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syn...
Preprint
Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndr...
Article
BACKGROUND AND PURPOSE: The pathophysiology of wall contrast enhancement in thrombosed intracranial aneurysms is incompletely understood. This in vivo study aimed to investigate wall microstructures with gadolinium-enhanced 7T MR imaging. MATERIALS AND METHODS: Thirteen patients with 14 thrombosed intracranial aneurysms were evaluated using a 7T wh...
Conference Paper
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https://www.dgnc-kongress.de/fileadmin/media/jahrestagung/pdf/DGNC2019_Hauptprogramm.pdf
Poster
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Objective: Tuberous sclerosis complex (TSC) is a rare multisystem genetic disease. Arterial wall developmental disorders in TSC such as aneurysms have been well described for extracranial vasculature. The characteristics of intracranial aneurysms (IA) in TSC have not been addressed in the literature yet. This study aimed to perform a systematic rev...
Poster
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Objective: External ventricular drainage (EVD) is frequently used in pediatric brain surgery. During the externalization of cerebrospinal fluid (CSF), catheter-associated meningitis (CAM) remains a major issue. This study aimed to evaluate the incidence of CAM in a pediatric population and to elucidate major risk factors. Methods: We analyzed retr...
Preprint
Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndr...
Article
OBJECTIVE Tuberous sclerosis complex (TSC) is a rare multisystem genetic disease. Arterial wall developmental disorders, such as aneurysms, in association with TSC have been well described for extracranial vasculature. The characteristics of intracranial aneurysms (IAs) in TSC have not previously been addressed in the literature. This systematic re...
Article
Objective Extent of resection (EOR) and Karnofsky Performance Status (KPS) are at odds in glioblastoma (GBM) surgery, that is, the anticipated postoperative disability limits the EOR. This study analyzes the correlation of different surgical modalities with the resulting physical status and survival of patients with GBM. Methods A total of 565 pati...
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Knowledge of the exact tumor location and structures at risk in its vicinity are crucial for neurosurgical interventions. Neuronavigation systems support navigation within the patient's brain, based on preoperative MRI (preMRI). However, increasing tissue deformation during the course of tumor resection reduces navigation accuracy based on preMRI....
Article
BACKGROUND: Delayed cerebral ischemia (DCI) has a strong impact on outcome of patients with aneurysmal subarachnoid hemorrhage (SAH). Positive effect of antiplatelet therapy on DCI rates has been supposed upon smaller SAH series. OBJECTIVE: To analyze the benefit/risk profile of antiplatelet use in SAH patients. METHODS: This retrospective case-con...
Conference Paper
https://programm.conventus.de/index.php?id=dwg2018&tx_coprogramm_programm%5Bsession%5D=70&tx_coprogramm_programm%5Bday%5D=3&tx_coprogramm_programm%5Baction%5D=session&tx_coprogramm_programm%5Bcontroller%5D=Source&cHash=7b32086f92e89ae1e951f8d41cc745c6
Conference Paper
Differences in clinical outcome in younger patients with Cervical Spondylotic Myelopathy caused by a spinal stenosis or disc prolaps: A single center study.
Conference Paper
Differences in clinical outcome in younger patients with Cervical Spondylotic Myelopathy caused by a spinal stenosis or disc prolaps: A single center study.
Article
Objective: Several parameters like extent of resection and MGMT promotor methylation in glioblastoma (GBM) are known to influence survival. Other elements like multifocality and proliferation indices are not commonly used. The aim of the present study was to analyze routinely and not routinely assessed prognostic markers for survival of patients su...
Article
Objective: Liponeurocytoma is a rare benign tumor of the central nervous system, which develops mainly in adult patients within the posterior fossa. The WHO has categorized this entity in their last classification of 2016 as a benign grade II tumor. Histopathological characteristics contain neuronal and variable astrocytic differentiation with foci...
Article
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Objective: To present an unusual case of a meningothelial meningioma mimicking a growing symptomatic arachnoid cyst on conventional MRI. Case Presentation: A 47‐year‐old female patient complained about dizziness over three years. Cranial MRI revealed a right‐sided occipital cystic lesion adjacent to the superior sagittal sinus with a slow progressi...
Article
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Background Outcome of aneurysmal subarachnoid hemorrhage (SAH) depends strongly on occurrence of symptomatic vasospasm (SV) leading to delayed cerebral ischemia (DCI). Various demographic, radiographic, and clinical predictors of SV have been reported so far, partially with conflicting results. The aim of this study was to analyze the role of pati...
Article
Objectives: Intracerebral hematoma (ICH) complicates the course of aneurysmal subarachnoid hemorrhage (SAH). To date, there are no unique guidelines for management of aneurysmal ICH. The aim of this study was to identify risk factors for and impact of aneurysmal ICH with special attention on treatment decisions derived from ICH volume. Patients a...
Article
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Background: Cerebellar liponeurocytoma is a rare tumor of the central nervous system occurring mainly in the posterior fossa, which shows neuronal and variable astrocytic differentiation with foci of lipomatous differentiation. Liponeurocytoma develops in adult patients and is defined in the World Health Organization classification of 2016 as a ra...
Article
Object: Aneurysm rupture might be accompanied by intraventricular hemorrhage (IVH) that is associated with poor outcome of subarachnoid hemorrhage (SAH). The aim of this study was to analyze risk factors and clinical impact of IVH severity. Material and methods: 995 consecutive SAH patients treated at our institution between January 2003 and Jun...
Technical Report
Background and Objective We present a treatment approach for a rare condition of patients with a ventral C1 fracture and a congenital cleft in the posterior arch (half-ring Jefferson fracture) with an intact transverse atlantal ligament. Our technique aims to achieve stability of the atlanto-occipital and atlantoaxial joints while preserving mobili...
Article
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Introduction: Heterotopic Ossification (HO) is an ectopic bone formation in the soft tissue outside the skeletal system. This rare disorder is mostly related to musculoskeletal trauma, burns, or central nervous system injury. HO may cause pain and immobility of the joints. In some cases, HO is difficult to diagnose in early stages due to non-specif...
Article
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Introduction: A spinal, intra- and extraforaminal epidural cavernoma is a very rare entity and can be easily misdiagnosed radiologically. Spinal extradural cavernomas can cause mild to devastating permanent neurological symptoms and should be removed before irreversible deficits occur. Case Presentation: We present an uncommon case of a 50-year-old...
Article
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A novel vacuum stable proton sponge, 4-maleicanhydridoproton sponge (MAPS), was prepared and applied as the matrix in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) of an aggressive brain tumor tissue (glioblastoma multiforme). Ionic maps of lactate, 2-hydroxyglutarate and chloride anions (m/z 89, 147, 35, respect...
Article
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Introduction: Spinal vascular malformations can be classified in arteriovenous malformations, cavernomas, and capillary telangiectasias. Arteriovenous malformations are the most common spinal vascular anomaly and may be located intra- and/or perimedullary. According to their nidus type and hemodynamic flow patterns, they can be differentiated into...
Article
Full-text available
Spinal dural arteriovenous fistulas (SDAVFs) are rare pathologies with a yearly incidence of 5-10 new cases/million, constituting 60-80 % of spinal arteriovenous malformations. Clinical symptoms include progressive paraparesis, paresthesias, bladder, and bowel disturbances. The pathophysiology of SDAVFs is not well elucidated. Microneurosurgery and...
Article
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Introduction Spinal vascular malformations can be classified in arteriovenous malformations, cavernomas, and capillary telangiectasias. Arteriovenous malformations are the most common spinal vascular anomaly and may be located intra- and/or perimedullary. According to their nidus type and hemodynamic flow patterns, they can be differentiated into f...
Article
Full-text available
Background: Uterine lipoleiomyomas are rare benign tumors, which preferentially occur in postmenopausal women between the ages of 45 and 70 years. Histologically, these tumors consist of fully differentiated smooth muscle cells and adipocytes. Case: The unusual clinical presentation of a uterine lipoleiomyoma, which was first suspected to be a tumo...
Article
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To assess changes in the Doppler flow profiles of the middle cerebral artery in fetuses with cardiac defects theoretically associated with impaired cerebral oxygen delivery in utero. Z-scores were calculated for pulsatility and resistance indices (PI and RI, respectively) of the middle cerebral artery (MCA) and the cerebroplacental ratio (CPR) betw...