Olha Hancheva

Zaporizhzhia State Medical University · Department of Pathologic Physiology

The aim of the work was to define the pattern of changes and pathogenetic mechanisms of glycemic curve shape during a glucose tolerance test in rats at 6, 15, and 21 weeks of environmental space restriction. Materials and methods. A total of 55 male Wistar rats aged 6–10 months were used and divided into 4 groups (1 – intact control, 10 rats; 2, 3...

The aim of the work is to ascertain the character of changes in the hormonal profile (concentrations of corticosterone, insulin, and adrenocorticotropic hormone) in conjunction with metabolic alterations and elevated blood pressure, which are induced in rats by restraint stress at 6th, 15th and 21st weeks of environmental space restriction. Materia...

Intermittent hypoxia has been studied for many years as a promising non-pharmacological method of cardiovascular disease prevention. Hypoxic effects are accompanied by structural and functional changes in the myocardium. There is a direct link between the duration of hypoxic exposures and the severity of left ventricular myocardial remodeling. A ra...

За останні роки досягнутий особливий прогрес у розумінні значення гіпоталамічнихядер у регуляції вегетативних функцій, метаболічних процесів, а також артеріального тиску. Завдяки застосуванню імуноцитохімічних та молекулярногенетичних методів стало можливим вивчення не тільки морфології нейросекреторних клітин, але і їх зв'язків з іншими відділами...

The aim of our study was to establish the morphodensitometric features of locus coeruleus (LC) neurons nuclei in the brain stem of rats with arterial hypertension of various origin (essential – SHR and endocrine-salt hypertension (ESH)). Matherials and methods: the study was carried out on 30 mature male rats: 10 control Wistar rats, 10 Wistar rat...

The article contains information about the structure of promoter region, ways of activation and function of protooncogen c-Fos, its product - early response protein c-Fos and transcriptional complex АР- 1. The subjects of discussion аге: c-Fos effects оп immune system, mechanisms of its influence оп cellular proliferation, maturation and apoptosis...

The influence of chronic hyperglycemia оn fetus in prenatal time in last trimester of pregnancy was investigated. Chronic hyperglycemia disrupts the normal morphogenesis of the insular apparatus of pancreatic islets and its morphofuntional of state in the adults with the development of hyperglycemia, hyperinsulinemia, hypertriglyceridemia and hyper...

Neuroimmune – endocrine mechanisms of endocrine pancreatic islets regulation Kolesnik Yu.M.1, Abramov A.V.1, Gancheva O.V.1, Kamyshny A.M.1, Grekova T.A.1 1 Zaporozhye State Medical University. The review contains brief an alysis of the results of long-term investigations that were carried out in Pathophysiology department of Z aporozhye State M...

The aim of this work is to determine the features of the neurotensin content in the hypothalamic ARC in Wistar rat and SHR strains in arterial hypertension of different etiology: endocrine-salt and essential. Materials and methods. The study was performed on 24 adult male rats at the age of 13–14 months, weight of 250–270 g, which were divided int...

Modern biomedical research conducted in scientific laboratories is a basis not only for studying the pathogenetic mechanisms of diseases formation and progression, today they are widely used for highly informative diagnostic methods development, new medicines creation, and the study of newly developed pharmaceutical compounds influence on the organ...

In is known, that one of the main regulators of the blood pressure (BP) is hypothalamus. The efficiency of the BP regulation in a changeable environment is dependable on its coherence and coordination. This intrahypothalamic coordinator is an arcuate nucleus. One of the main conditions of the proper neuronal function is combination of their functio...

The aim of our study was to find out the features of the nitric oxide synthase (NOS) isoforms expression in longitudinal and transversal layers of the myocardium of the left ventricle in male rats of 3 months, which are descendants of female rats with experimental gestational diabetes (EGD). Materials and methods. Study was carried out on 10 male...

The regulation of the paraventricular (PVN) and supraoptic (SON) nuclei’s activity is carried out with a great amount of different neurotransmitters, in particular, with nitric oxide. In order to get clear understanding of the local NO effects in hypothalamus in normal condition and different models of hypertension it is necessary to study all isof...

The aim was to study patterns of the nNOS, iNOS and eNOS expression in pancreatic islets in prepubescent male offsprings of female rats with experimental gestational diabetes mellitus. Materials and methods. The study was carried out in 10 prepubescent male offsprings of female rats with normal pregnancy and in 10 prepubescent male offsprings of f...

Aim. The purpose was to evaluate the features of the neuronal and endothelial nitric oxide synthase expression pattern in supraoptic and magnocellular part of paraventricular nuclei of the hypothalamus in different models of hypertension. Materials and methods. The study was carried out on 20 Wistar male rats and 10 SHR male rats. There were two e...

The state of hypothalamic oxytocin-synthesizing system in Wistar rats were investigating. The morphometric measurements and immunocytochemical detection of oxytocin-containing cells was used for determining of the functional state of supraoptic nucleus, anterior and posterior-medialis magnocellular subdivisions of paraventricular nucleus. It was es...