Olga Sysoeva

Olga Sysoeva
Russian Academy of Sciences | RAS · Institute of Higher Nervous Activity and Neurophysiology

PhD

About

66
Publications
5,149
Reads
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388
Citations
Citations since 2016
48 Research Items
248 Citations
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
Additional affiliations
February 2012 - present
Moscow State University of Psychology and Education
Position
  • Leading Researcher
May 2004 - December 2010
Russian Academy of Sciences
Position
  • Senior Researcher
July 2000 - July 2003
University of Helsinki
Position
  • Visiting reseacher

Publications

Publications (66)
Article
Full-text available
Rett syndrome (RTT), a severe neurodevelopmental disorder caused by MECP2 gene abnormalities, is characterized by atypical EEG activity, and its detailed examination is lacking. We combined the comparison of one-time eyes open EEG resting state activity from 32 girls with RTT and their 41 typically developing peers (age 2–16 years old) with longitu...
Preprint
Full-text available
Rett Syndrome (RS) is a rare neurodevelopmeтtal disorder characterized by mutations in the MECP2 gene. Patients with RS have severe motor abnormalities and are often unable to walk, use hands and speak. The preservation of perceptual and cognitive functions is hard to assess, while clinicians and care-givers point out that these patients need more...
Article
We study the specific features of the organization of the functional brain networks of children with autism spectrum disorder (ASD) by analyzing at the source level the data obtained in the EEG experiment in the resting-state paradigm. We pay special attention to age-related changes in the characteristics of functional networks during the particula...
Preprint
Full-text available
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Article
Full-text available
Our study reviewed abnormalities in spontaneous, as well as event-related, brain activity in syndromes with a known genetic underpinning that are associated with autistic symptomatology. Based on behavioral and neurophysiological evidence, we tentatively subdivided the syndromes on primarily hyper-sensitive (Fragile X, Angelman) and hypo-sensitive...
Article
Full-text available
Independent Component Analysis (ICA) is a conventional approach to exclude non-brain signals such as eye movements and muscle artifacts from electroencephalography (EEG). A rejection of independent components (ICs) is usually performed in semiautomatic mode and requires experts’ involvement. As also revealed by our study, experts’ opinions about th...
Article
High-frequency electrical stimulation induces increases in synchronous transmission between pairs of neurons which persists for prolonged periods (long-term potentiation, LTP). Recent studies showed that sensory (so-called LTP-like, with a frequency of over 9 Hz) stimulation can induce effects analogous to those seen after electrical stimulation an...
Article
Full-text available
A fuller understanding of the effects of auditory tetanization in humans would inform better language and sensory learning paradigms, however, there are still unanswered questions. Here, we probe sustained changes in the event‐related potentials (ERPs) to 1020Hz and 980Hz tones following a rapid presentation of 1020Hz tone (every 75 ms, 13.3Hz, tet...
Article
Full-text available
Rett syndrome (RTT) is a rare neurodevelopmental disorder that is usually caused by mutations of the MECP2 gene. Patients with RTT suffer from severe deficits in motor, perceptual and cognitive domains. Electroencephalogram (EEG) has provided useful information to clinicians and scientists, from the very first descriptions of RTT, and yet no reliab...
Preprint
Full-text available
Independent Component Analysis (ICA) is a conventional approach to exclude non-brain signals such as eye-movements and muscle artifacts from electroencephalography (EEG). Due to other possible EEG contaminations, a rejection of independent components (ICs) is usually performed in semiautomatic mode and requires experts’ involvement. Noteworthy, as...
Article
Full-text available
SHANK3 encodes a scaffold protein involved in postsynaptic receptor density in glutamatergic synapses, including those in the parvalbumin (PV)+ inhibitory neurons—the key players in the generation of sensory gamma oscillations, such as 40-Hz auditory steady-state response (ASSR). However, 40-Hz ASSR was not studied in relation to SHANK3 functioning...
Article
Full-text available
Background Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses—the auditory steady state response (ASSR) and the sustained fie...
Preprint
Full-text available
SHANK3 encodes scaffold protein involved in postsynaptic receptor density in glutamatergic synapses, including those in the parvalbumin (PV)+inhibitory neurons – the key players in generation of sensory gamma oscillations, such as 40-Hz auditory steady-state response(ASSR). Here we describe a clinical and neurophysiological phenotype of a 15-years...
Preprint
Full-text available
Background: Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these abnormalities is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses – the auditory steady state response (ASSR) and the susta...
Preprint
Full-text available
Background: Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these abnormalities is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses – the auditory steady state response (ASSR) and the susta...
Preprint
Full-text available
Background: Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses – the auditory steady state response (ASSR) and the sustained...
Article
Perceptual learning is defined by increased effectiveness of completing perceptual tasks as a result of experience or training. This review presents the analysis of changes in the components of event-related potentials (ERPs) after visual and auditory perceptual learning in humans. The use of the EEG method, which has a high temporal resolution, ma...
Article
Full-text available
Due to severe motor impairments and the lack of expressive language abilities seen in most patients with Rett Syndrome (RTT), it has proven extremely difficult to obtain accurate measures of auditory processing capabilities in this population. Here, we examined early auditory cortical processing of pure tones and more complex phonemes in females wi...
Article
Objective: Systematically review the abnormalities in event related potential (ERP) recorded in Rett Syndrome (RTT) patients and animals in search of translational biomarkers of deficits related to the particular neurophysiological processes of known genetic origin (MECP2 mutations). Methods: Pubmed, ISI Web of Knowledge and BIORXIV were searche...
Preprint
Due to severe motor impairments and the lack of expressive language abilities seen in most patients with Rett Syndrome (RTT), it has proven extremely difficult to obtain accurate measures of auditory processing capabilities in this population. Here, we examined early auditory cortical processing of pure tones and more complex phonemes females with...
Article
Full-text available
Rett syndrome (RTT), a rare neurodevelopmental disorder caused by mutations in the MECP2 gene, is typified by profound cognitive impairment and severe language impairment, rendering it very difficult to accurately measure auditory processing capabilities behaviorally in this population. Here we leverage the mismatch negativity (MMN) component of th...
Preprint
Rett syndrome (RTT), a rare neurodevelopmental disorder caused by mutations in the MECP2 gene, is typified by profound cognitive impairment and severe language impairment, rendering it very difficult to accurately measure auditory processing capabilities behaviorally in this population. Here we leverage the mismatch negativity (MMN) component of th...
Article
Gamma oscillations facilitate information processing by shaping the excitatory input/output of neuronal populations. Recent studies in humans and nonhuman primates have shown that strong excitatory drive to the visual cortex leads to suppression of induced gamma oscillations, which may reflect inhibitory‐based gain control of network excitation. Th...
Article
Full-text available
Background: Inherited abnormalities of perception, recognition, and attention to faces have been implicated in the etiology of autism spectrum disorders (ASD) including abnormal components of event-related brain potentials (ERP) elicited by faces. Methods: We examined familial aggregation of face processing ERP abnormalities previously implicate...
Article
Full-text available
Gamma-band oscillations arise from the interplay between neural excitation (E) and inhibition (I) and may provide a non-invasive window into the state of cortical circuitry. A bell-shaped modulation of gamma response power by increasing the intensity of sensory input was observed in animals and is thought to reflect neural gain control. Here we sou...
Preprint
Gamma-band oscillations arise from the interplay between neural excitation (E) and inhibition (I) and may provide a non-invasive window into the state of cortical circuitry. A bell-shaped modulation of gamma response power by increasing the intensity of sensory input was observed in animals and is thought to reflect neural gain control. Here we sou...
Article
Full-text available
Excitation/Inhibition (E/I) imbalance in neural networks is now considered among the core neural underpinnings of autism psychopathology. In motion perception at least two phenomena critically depend on E/I balance in visual cortex: spatial suppression (SS), and spatial facilitation (SF) corresponding to impoverished or improved motion perception w...
Article
Full-text available
People are very precise in the discrimination of a line orientation relative to the cardinal (verti-cal and horizontal) axes, while their orientation discrimination sensitivity along the oblique ax-es is less refined. This difference in discrimination sensitivity along cardinal and oblique axes is called the “oblique effect”. Given that the oblique...
Article
Full-text available
Recent studies link autism spectrum disorders (ASD) with an altered balance between excitation and inhibition (E/I balance) in cortical networks. The brain oscillations in high gamma-band (50-120 Hz) are sensitive to the E/I balance and may appear useful biomarkers of certain ASD subtypes. The frequency of gamma oscillations is mediated by level of...
Article
Full-text available
Gamma oscillations are generated in networks of inhibitory fast-spiking (FS) parvalbumin-positive (PV) interneurons and pyramidal cells. In animals, gamma frequency is modulated by the velocity of visual motion; the effect of velocity has not been evaluated in humans. In this work, we have studied velocity-related modulations of gamma frequency in...
Article
Full-text available
THIS STUDY AIMED TO EXAMINE EFFECT OF PHYSICAL EXERCISE ON MOTOR TIMING: personal, maximum and "once per second" tapping. The acute effect was examined by comparing the baseline tapping with that after acute exercise in 9 amateur athletes, 8 elite synchronous swimmers and 9 elite biathletes. Then the baseline tapping was compared among athletes of...
Article
Full-text available
Establishing links between experimental data, their models, and the neural substrates presents a permanent challenge for research in timing and time perception. This applies particularly to the problem of internal repre-sentation of temporal duration and its neural implementation. In this short communica-tion we will report on progress achieved wit...
Article
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Background: The present study investigates neurobiological underpinnings of individual differences in time perception.
Article
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Association of brain processes presumably underlying aggression with serotonin transporter gene polymorphism in men was studied. Carriers of more active gene variant are characterized by higher aggression index, increased component of brain potential mismatch negativity responsible for automatic difference detection, and decreased P300 component ch...
Article
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Aggression is a heterogeneous heritable psychological trait, also influenced by environmental factors. Previous studies, mostly conducted on male population, have found some associations of the aggression with the polymorphisms of genes, regulating the activity of serotonin (5-HT) in the brain. However, psychological as well as biochemical manifest...
Article
Full-text available
Previous studies have repeatedly found that late (300–800 ms) components of event-related potentials (ERP) reflected semantic analysis, i.e. the differentiation between abstract and concrete words. However, the human brain may detect the meaning of the words much earlier. This study investigated the brain mechanisms of the processing of abstract an...
Article
Full-text available
Studies using a brain index for pre-attentive change detection, the mismatch negativity (MMN), suggested distinct neuronal populations for signaling changes in sound duration and frequency. However, these studies used only durations within the temporal window of loudness summation (ca. 200 ms) in which any duration change is accom-panied by a loudn...
Article
Two brain subsystems of short duration coding in vision were described based on the results of the work and the literature. The equivalent current dipoles (ECDs), approximating the correlated with duration activity (latency 300 ms in ERP on the termination of stimuli), were found in auditory cortex and caudate nucleus when subjects estimate the dur...
Article
Full-text available
Time perception in everyday life deals with various intervals. Here we investigated whether an automatic duration-discrimination mechanism in audition operates even for intervals of an order of seconds, by using the mismatch negativity (MMN), an index of automatic change detection in audition. In Experiment 1, occasional decrements of the duration...
Article
There were investigated the mechanisms of perception of short duration stimuli in complex psychophysic and electroencephalographic study. Visual and auditory stimuli of different duration (200-1000 ms) were presented; EEG and subjective evaluation of stimulus duration were recorded in the experiment. Evoked potentials (EP) at F4, C4, T4, P4, F8 and...
Article
Full-text available
Stimulus onset asynchrony (SOA) and inter-stimulus interval (ISI) are important factors in the perceptual organization of sound sequences. The present study tested whether these two temporal parameters are independently processed in the auditory system. Independence was studied by testing the additivity of mismatch negativity (MMN). Four conditions...

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Project (1)
Project
The goal is to define the componentry of the event-related potential that could relate to visual forms of distraction.