Olga Loginova

• PhD
• Researcher at PERM FEDERAL RESEARCH CENTER

The peptide hormone kisspeptin, produced by neurons of the hypothalamus anterior zone, is a key regulator of the gonadostat formation and reproductive function, and has immunoregulatory activity. During pregnancy, kisspeptin is produced by the placenta, presents in the peripheral blood and affects on immune cells that express specific receptors for...

The functions of peripheral blood NK cells change significantly during pregnancy, which is mainly due to the inhibition of their cytotoxicity. The functional activity of NK cells is directly related to their metabolic status, but these changes in physiological pregnancy have not been studied. The aim of this work is to study the expression of Glut-...

Physiologically, pregnancy is accompanied by profound changes in the functions of cells of both adaptive and innate immunity, which is necessary to prevent rejection of a semi-allogenic fetus and preserve the protective properties of the mother’s body. Objective: to investigate the metabolic activity of CD16hi and CD16int subpopulations of peripher...

During physiological pregnancy, the number of low-density neutrophils in the peripheral blood increases, but their phenotypic and functional features have not been practically studied. Therefore, the aim of this work is to study the expression of molecules characterizing cytotoxicity (CD16, CD107a), glucose transport (GLUT-1) and the state of mitoc...

Аннотация.Галектинами называют семейство β-галактозид-связывающих низкомолекулярных белков (лектинов), гомологичных по аминокислотной последовательности углевод-связывающего сайта. Галектины взаимодействуют с гликанами на поверхности клеток и участвуют в регуляции функциональной активностибольшинства клеток организма человека. Галектин-9 играет важ...

РЕЗЮМЕ Цель-оценить метаболическую активность разных субпопуляций натуральных киллеров (NK-клеток) периферической крови в I и в III триместрах физиологически протекающей беремен-ности (ФПБ). Материал и методы. В исследование включены здоровые женщины в I или III триместрах ФПБ. Группу сравнения составили условно-здоровые небеременные женщины в фол...

Infection with hepatitis C virus (HCV) is common among HIV-positive patients, with up to 50% of them being coinfected in Russia. While highly active antiretroviral therapy (HAART) suppresses HIV replication and restores the immune system of HIV-infected subjects, HCV coinfection interferes with CD4 + T cell regeneration and increases the risk of pa...

Galectin-9 is a b-galactoside binding lectin with expressed immunoregulatory activity. During pregnancy galectin-9 is produced by trophoblast cells and regulates the function of natural killer (NK) cells at the maternal-fetal interface via binding to Tim-3 (T-cell Ig and mucin domain-containing protein 3) molecules. Natural killer (NK) lymphocytes...

Monocytes play an important role in the systemic immune defense against pathogens and maintaining physiological pregnancy. During pregnancy peripheral monocytes migrate into the decidua and form the pool of decidual macrophages which participate in the formation and development of placental tissues. The population of peripheral blood monocytes is p...

The aim was to study leptin-primed conventional dendritic cells (cDCs) influence on CD4 and CD8 expression in human thymic gamma delta T cells (γδT) in vitro. cDCs and thymocytes were isolated from the human postnatal thymus (0–1 years). cDCs were cultured with leptin (35 ng/ml) for 24 h. Leptin-primed cDCs were incubated with autologous thymocytes...

Natural killer (NK) lymphocytes belong to the innate lymphoid cells, which have a cytotoxic effect on target cells and are capable of producing a large number of regulatory factors (cytokines, chemokines). During pregnancy, the peripheral blood CD56brightCD16-NK cells migrate to the uterus and transform into decidual (d)NK cells. dNK have a toleran...

Natural killer cells (NK) and T-lymphocytes with NK functions (NKT) are the leading effectors of the mother’s immune tolerance to a semi-allogeneic fetus and have a fetal trophic effect during physiological pregnancy. Tim-3 (T-cell Ig and mucin domain-containing protein 3) and CD9 molecules play a critical role in the immunoregulatory and fetal tro...

Leptin, the adipocyte-derived hormone, involved in regulating food intake and body weight, plays an important role in immunity and reproduction. Leptin signals via the specific membrane receptors expressed in most types of immune cells including dendritic cells (DCs) and thymocytes. Leptin enhances thymopoiesis and modulates T-cell-mediated immunit...

При физиологически протекающей беременности в матке нарастает количество натуральных киллеров (NK) и Т-лимфоцитов с функциями NK (NKT), экспрессирующих молекулы Tim-3, CD49a, CD9, которые играют критическую роль в реализации иммунорегуляторной и фетотрофической функции. Учитывая возможность образования децидуальной популяции из клеток периферическо...

Physiological pregnancy is characterized by significant changes in the phenotype and functions of peripheral blood lymphocytes. Thus, the number of lymphocytes migrating from peripheral blood in the uterus and expressing Tim-3, CD49a, CD9 molecules which limit their cytotoxicity and participate in their migration, is significantly increased in the...

Objective: Congenital heart diseases (CHD) are often associated with thymus development disorders and immune dysfunctions. However, the features of thymocyte differentiation in cyanotic and acyanotic CHD remain unknown. Materials and Methods: We have analyzed the main thymocyte subsets depending on CD4 and CD8 co-expression, and the number of natu...

Изучено влияние гормонов (хорионического гонадотропина, эстриола, лептина, грелина, кисспептина) в концентрациях, сопоставимых с их содержанием в периферической крови при беременности, в регуляции процессов клеточной дифференцировки в тимусе. Установлено, что исследуемые гормоны разнонаправленно регулируют функциональную активность миелоидных и пла...

Molecular mechanisms of the immunomodulatory effects of leptin and ghrelin in concentrations typical for preg–nancy on the maturation and functional activity of dendritic cells (DCs) generated from the peripheral blood monocytes of women are investigated. The presence of leptin during DC maturation did not affect the levels of CD83⁺CD1c⁺, CD86⁺CD1c...

Грелин – пептидный гормон, обладающий широким спектром эффектов в организме человека. Грелин принимает участие в регуляции энергетического и жирового обмена, ростовых процессов, полового созревания, половых циклов, беременности, контроле поведенческих реакций, а также обладает выраженными иммуномодулирующими и противовоспалительными свойствами. В о...

Molecular mechanisms of the immunomodulatory effects of leptin and ghrelin in concentrations typical for pregnancy on the maturation and functional activity of dendritic cells (DCs) generated from the peripheral blood monocytes of women are investigated. The presence of leptin during DC maturation did not affect the levels of CD83+CD1c+, CD86+CD1c+...

We studied the effect of hormones estriol, ghrelin, kisspeptin, and chorionic gonadotropin in concentrations corresponding to their content in the peripheral blood in each trimester of pregnancy on the expression of membrane molecules on myeloid and plasmacytoid dendritic cells of the thymus. It was found that thymic myeloid dendritic cells are sen...

Тимус является центральным органом иммунитета, где происходит формирование основных эффекторных и регуляторных субпопуляций Т-лимфоцитов. Беременность сопровождается стероид-индуцированной инволюцией тимуса. Подобная гормон-зависимая инволюция тимуса наблюдается также при стрессе, старении, ряде аутоиммунных заболеваний. При беременности плацента п...

Studied the influence of leptin, ghrelin, and thereof combinations in concentrations typical of pregnancy, to the maturation of dendritic cells and the induction of formation of regulatory T-lymphocytes. Installed that hormones do not affect the expression of molecules HLA-DR, CD83, CD86 on dendritic cells, reflecting their degree of maturity. The...

Изучено влияние лептина и грелина, и их комбинаций в концентрациях, отражающих уровень гормонов в периферической крови при беременности, на экспрессию поверхно- стных молекул и продукцию цитокинов дендритными клетками, генерированными из мо- ноцитов периферической крови. Установлено, что лептин, грелин, а также их комбинация, в концентрациях, харак...

Investigated oligopeptides (LQGV, AQGV, VLPALP) are products of catabolism molecule chorionic gonadotropin (hCG), and possess structural relatedness to the -subunit of the hormone. In the works of Khan N.A. & Benner R. (2011) demonstrated that these oligopeptides have expressed anti-inflammatory and anti-shock effects and block the development of...

Изучены эффекты лептина и грелина, и их комбинаций в концентрациях, характерных для беременности, на экспрессию мембранных молекул (CTLA-4, GITR, GARP) и продукцию цитокинов (IL-10, TGF-b1) в культуре натуральных Т-регуляторных клеток in vitro. LEPTIN AND GHRELIN REGULATION OF MEMBRANE MOLECULES EXPRESSION AND CYTOKINES PRODUCTIONS BY NATURAL TREG...