Olga Dobrushina

• Ph D
• Visiting Researcher & Consultant in Tech at University of Strathclyde

Although the neural systems supporting interoception have been outlined in general, the exact processes underlying the integration of visceral signals still await research. Based on the predictive coding concept, we aimed to reveal the neural networks responsible for the bottom-up (stimulus-dependent) and top-down (model-dependent) processing of in...

Aging is known to be associated with a decline in interoceptive abilities and changes in emotional processing, including alexithymia. As the brain areas supporting interoceptive awareness participate in the perception of emotion, we suggested that interoceptive decline and alexithymia in older adults may share common neural ground. To test this hyp...

The perception of signals from within the body, known as interoception, is increasingly recognized as a prerequisite for physical and mental health. This study is dedicated to the development of effective technological approaches for enhancing interoceptive abilities. We provide evidence of the effectiveness and practical feasibility of a novel rea...

Cerebral small vessel disease (CSVD) associated with age and vascular risk factors has a high prevalence and social significance. Psychoemotional changes are an early manifestation of CSVD that require methods for their correction. Objective: to evaluate and compare the efficacy of biofeedback (BF) at infra-low frequencies and alpha waves frequenci...

The article presents a review and analysis of literature aimed at grounding psychotherapy within the context of contemporary neuroscientific concepts. It is suggested that on the neural level psychotherapy is associated with changes in the mentalizing and empathy networks’ connectivity. Several mechanisms underlying these changes are proposed: enha...

The perception of signals from within the body, known as interoception, is increasingly recognized as a prerequisite for physical and mental health. The study is dedicated to the development of effective technological approaches for enhancing interoceptive awareness. We provide evidence of the effectiveness and practical feasibility of a novel real...

Objective: To develop individualized approaches to the use of neuromodulation as a non-pharmacological treatment of cognitive impairment (CI) based on the assessment of compensatory brain reserves in functional MRI (fMRI). Material and methods: Twenty-one adults over 45 years of age, representing a continuum from healthy norm to mild cognitive i...

Objective: To compare the effectiveness of neurofeedback (NFB) at infra-low and alpha frequencies in the treatment of cognitive impairment in patients with early cerebral small vessel disease (cSVD). Material and methods: The study included 71 patients (average age 52.8±6.3 years, men 15%, women 85%) with early cSVD and 21 healthy volunteers (av...

• CSVD is linked to emotional dysregulation with alexithymia and depressive symptoms • Emotional dysregulation can serve as a predisposition factor or consequence of CSVD • Emotional dysregulation in CSVD is underlain by network dysconnectivity • Affected nodes of salience and language networks are involved in allostasis

The article presents a review and analysis of literature aimed at grounding psychotherapy within the context of contemporary neuroscientific concepts. It is suggested that on the neural level psychotherapy is associated with changes in the mentalizing and empathy networks' connectivity. Several mechanisms underlying these changes are proposed: enha...

Interoception is critically important for allostatic adaptation and emotional regulation, and aberrant interoceptive processing is increasingly recognized to be involved in the pathogenesis of neurological, psychiatric and cardiovascular diseases. Despite the fact that interoceptive abilities decline with age, the corresponding neural correlates an...

Primary headaches are highly prevalent and represent a major cause of disability in young adults. Neurofeedback is increasingly used in the treatment of chronic pain; however, there are few studies investigating its efficacy in patients with headaches. We report the results of a cross-over sham-controlled study on the efficacy of neurofeedback in t...

Aging is associated with decreased functional connectivity in the main brain networks, which can underlie changes in cognitive and emotional processing. Neurofeedback is a promising non-pharmacological approach for the enhancement of brain connectivity. Previously, we showed that a single session of infra-low frequency neurofeedback results in incr...

The concept of body schema is still under development, and there is no consensus regarding the taxonomy of body representations. The study aimed to investigate body schema components with the use of two well-validated experiments, the rubber hand illusion (RHI) and the hand laterality judgment task (HLJT). Overall, we observed that participants wit...

Although the neural systems supporting interoception have been outlined in general, the exact processes underlying the integration of visceral signals still await research. Based on the predictive coding concept, we aimed to reveal the neural networks responsible for the bottom-up (stimulus-dependent) and top-down (model-dependent) processing of in...

Introduction Due to limited efficacy and side effects of pharmacological therapy in tension-type headache (TTH), alternative approaches are feasible. Neurofeedback is a noninvasive neuromodulation technique increasingly used in practice, but, however, there is limited research on its efficacy. Objectives To evaluate the efficacy of neurofeedback i...

Impairments to nociception are currently regarded as the pathogenetic mechanism of psychosomatic disorders and as a potential therapeutic target. An aim of the present work was to investigate the functional cerebral grounds linking the perception of internal sensations and emotional intelligence. The interoceptive paradigm for detection of the hear...

Despite the increasing popularity of neurofeedback, its mechanisms of action are still poorly understood. This study aims to describe the processes underlying implicit electroencephalographic neurofeedback. Fifty-two healthy volunteers were randomly assigned to a single session of infra-low frequency neurofeedback or sham neurofeedback, with electr...

Objective: Goldberg, the author of the “novelty-routinization” framework, suggested a new pair of cognitive styles for agent-centered decision-making (DM), context-dependency/independency (CD/CI), quantified by the Cognitive Bias Task (CBT) and supposedly reflecting functional brain hemispheric specialization. To date, there are only three lesion...

Cerebral small vessel disease (SVD) is a major cause of cognitive impairment in elderly people. While most research focuses on the role of the classical vascular risk factors in SVD, a description of the psychophysiological mechanisms leading to the age-related brain damage may open new possibilities for prophylaxis. In the current study, we evalua...

Introduction: Development of individualized neuromodulation techniques for mild cognitive impairment (MCI) is a feasible practical goal. Preliminary research exploring the brain-level compensatory reserves on the base of neuroimaging is necessary. Methods: Twenty-one older adults, representing a continuum from healthy norm to MCI, underwent functio...

Background: Stroke patients develop the ability to perform higher levels of functional activity on basis of concentrated rehabilitative training which affects sensory, motor and cognitive functions. Objective: The main aim of our work was to show the usefullness of neurofeedback therapy in rehabilitation of stroke patients. Design: 27 stroke patien...

Background. Contemporary rehabilitation of memory impairments relies on the use of external compensatory strategies. In Russian neuropsychological tradition, rehabilitation is understood as a transformation of a higher mental function, based on intact elements of that function and on use of external and internal means. Such a restructuration approa...

Introduction In Russia there was a misconception about employment of people with physical or cognitive disability that served as a psychological barrier for both employers and applicants. The situation has recently changed and special vacancies for invalids are open in some companies. A patient in residual period of traumatic brain injury (2010) at...

Introduction Present article introduces the case of a patient who had traumatic brain injury (TBI) in 2010. During examination V. demonstrated mild sensory aphasia, frontal lobes deficit, memory disorder, limiting beliefs, lack of adequate coping strategies, emotional reactions and disability to describe his feelings and body awareness. Objectives...

Introduction Sham-controlled studies of neurofeedback are aimed to provide evidence-based data regarding its efficacy. However, a sophisticated sham procedure may turn out to be an intervention rather that a neutral control. Methods Data from a single-case cross-over sham-controlled study of NF in migraine were analyzed to access the effects of sh...

Introduction Existing polysemy in definitions of human consciousness creates the major difficulty in its understanding. With the development of intensive care modern methods, the number of patients survived after coma and dwelling in disorders consciousness conditions rises. Aims Among, the most important practical questions of neuropsychology is...

Introduction Neurofeedback in migraine aims to improve neurophysiological state, which is linked to psychosomatic, emotional and cognitive regulation. Objective and complex evaluation of neurofeedback effects is feasible. Methods A single case design cross-over placebo-controlled study with blinded evaluator included 3 females with frequent migrai...

Introduction Dependents of human behavior on the hemispheric interaction quality is extremely interesting question. The СС impairments are observed at schizophrenia, autism, Tourette syndrome, ADHD, etc. Difficulties in the sphere of emotional intelligence are typical at not only frontal zones disorders and right hemisphere of brain. Aims Analyze...

Introduction Rehabilitaton of concurrent psychiatric disorder and brain injury is a major challenge. E. underwent neurosurgery for right fronto-parietal astrocytoma. Before illness he was managing automatization of big companies, but was fired after the operation. E. felt into severe depression and anxiety with catastrofization of his illness, suic...

The present review is focused on the randomized controlled trials and meta-analyses in the field of technological means for neurorehabilitation. The available literature data and the results of original observations provide a basis for distinguishing between the following levels of evidence: instrumental verticalization--2a, robot-assisted mechanot...

The objective of the present study was to evaluate the effectiveness of various systems for the analysis of gait biomechanics during the early period of rehabilitation in the patients presenting with central hemiparesis. 30 patients with central hemiparesis were examined with the use of the "Raptor-12", motion capture system, "TRUST-M" gyroscopic s...

Unlabelled: The objective of the present study was to compare the safety and effectiveness of navigated and non-navigated rhythmic transcranial magnetic stimulation rTMS in the patients presenting with post-stroke hemiparesis. Methods: Group 1 consisted of 31 patients with post-stroke hemiparesis treated by navigated rTMS. Thirty comparable pati...

Due to population aging in developed countries, there are increasingly more patients with cardiovascular comorbidities in anesthesiological care. The frequency of cardiac complications of extracardiac surgery is 1.4% in patients over age 50 years following elective noncardiac surgery and amounts to 26.6% in those aged over 85 years after emergency...

In elderly and senile patients, extracardiac surgery frequently leads to cardiovascular complications. For their prevention, it is necessary to early detect patients with a potentially poor postoperative period. Routine preoperative examination is of limited prognostic value and instrumental techniques are inaccessible. Objective: to reveal the pre...

The report describes two patients with lateral amyotrophic sclerosis complicated by respiratory insufficiency. Instead of long-term hospitalization to ICU the patients were kept at home, where prolonged mechanical ventilation was applied to them: in the first case - through tracheostomy tube, in the second - through mask. The use of prolonged home...

Objective: to analyze the causes of fatal outcomes in victims with severe concomitant injury (SCI) in an intensive care unit (ICU) of a multidisciplinary hospital. Subjects and methods. The data on 78 victims with SCI (65 men, 13 women) with SCI without the leading severe brain or spinal injury were retrospectivly analyzed. Results. Intrahospital m...