Oleksandr Zaichenko

Lviv Polytechnic National University · Department of Organic Chemistry

Background. Mitochondria can influence cancer cells both indirectly via reactive oxygen species mediation and directly through mitochondrial biogenesis. Energy production in mitochondria is crucial as it facilitates the synthesis of essential molecules needed for cellular biosynthesis, growth, and proliferation. The development of new anticancer dr...

Background. Our previous studies have shown a minor embryotoxic effect of polymeric poly(VEP-co-GMA)-graft-mPEG carrier on Missgurnus fossilis L. embryos and prelarvae. At the same time, it was found that a 3-day exposure to 10-15 M polymer carrier slowed developing, which is characterized by a delayed hatching of larvae. However, in the 10-day exp...

Many chemotherapeutics drugs have low water solubility, which potentially can decrease their anticancer potential. The use of drug delivery systems has proven to be highly effective in addressing the challenges associated with delivering hydrophobic chemotherapy drugs to tumor tissues. However, two major issues that arise in the clinical nanopartic...

The routes of tailored synthesis and properties of novel polymeric surfactants and derived supramolecular structures, micelles, intermolecular complexes and nanoparticles, of desired size, morphology and functionality are developed. Combined radical and non-radical methods of the synthesis of primary building blocks containing end or side reactive...

Molybdenum disulphide (MoS2) is a layered material with interesting photocatalytic properties. In this study, a layered MoS2 was produced using a hydrothermal method. The obtained material was characterised by XRD (X-ray diffraction), XPS (X-ray photoelectron spectroscopy), SEM (scanning electron microscopy), UV-Vis spectroscopy, DLS (dynamic light...

Background. Drug delivery systems (DDS) have demonstrated a significant ability to overcome many of the challenges associated with the delivery of hydrophobic chemotherapeutic compounds to tumor tissues. However, hepatotoxicity and suppression of the hematopoietic system are the key problems in the clinical treatment of cancer by nanoparticle-based...

Background. Previous studies have shown a pronounced cytotoxic effect of thiazole derivatives in combination with polymeric carriers on tumor cells. At the same time, the derivatives were not cytotoxic against non-cancerous cells in vitro. It was shown that thiazole derivatives at concentrations of 10 and 50 μM affected the prooxidant and antioxida...

Background. A pronounced cytotoxic action of the thiazole derivatives complexed with polymeric carriers on tumor cells in vitro was reported earlier, while no cytotoxicity of these compounds was detected toward noncancerous cells. It was found that thiazole derivatives at concentrations of 10 and 50 µM affected lymphoma cell ultrastructure in vitro...

Thiazole derivatives are perspective antitumor compounds characterized by a broad range of bioactivity, while polymeric carriers are widely used to enhance the efficiency of biological action of drugs, improve their biocompatibility and water solubility. Previously, we identified that the thiazole-based derivative BF1 (N-(5-benzyl-1,3-thiazol-2-yl)...

The controlled delivery of anticancer drugs is driven by their interaction with carrier molecules. By creating complicated micelle-like complexes, amphiphilic polymers provide an opportunity to load drugs of various kinds. In this work, the interaction of the comb-like PEG-containing polymer poly(VEP-co-GMA)-graft-PEG with the water-soluble antitum...

Two-dimensional nanofiber mats based on a mixture of polybenzimidazole with telechelic oligoperoxide are obtained by the method of electrospinning. It is shown that the reactive peroxide groups on the surface of nanofibers can be modified by the initiation of radical polymerization and grafting of various polymeric chains. The phenomenon of “negati...

Досліджено зміни у перебігу процесів перекисного окиснення ліпідів у зародкових клітинах в’юна упродовж раннього розвитку за наявності наночастинок, синтезованих на основі похідних поліетиленгліколю. Встановлено, що наявність даних наночастинок у середовищі інкубації зародків в’юна веде до неоднозначних змін рівня вільного перекисного окиснення ліп...

Method of determining of magnetic moment and size from measurements of dependence of the nonlinear magnetic susceptibility upon magnetic field is proposed, substantiated and tested for superparamagnetic nanoparticles (SPNP) of the “magnetic core-polymer shell” type which are widely used in biomedical technologies. The model of the induction respons...

Malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) occur more frequently than other types of primary central nervous system tumors, having a combined incidence of 5-8/100,000 population. Even with aggressive treatment using surgery, radiation, and chemotherapy, median reported survival is less than one year. Alkylating agents, s...

Nonlinear refraction and absorption of a suspension of Au nanoparticles was studied by CW Z-scan at near-resonant excitation. Spatial coherency and selfinterference of the laser beam results in the emerging of ring-like interference pattern observed at the plane of the detector. The number of the interference fringes and their diameter depends on v...

This paper presents the results of the experimental investigations of the surface plasmon resonances and nonlinear refraction of water suspensions of gold nanoparticles coated with a polymer shell. The linear dependence of nonlinear refraction investigated for suspensions in a wide range of beam power density has been reported.

The aim of this study was to measure the activity of enzymes which reflect cardiotoxic action in rats of novel synthetic 4-thiazolidone derivatives--3882, 3288 and 3833 that demonstrated antineoplastic effect in vitro towards 60 lines of human tumor cells tested in the framework of the program of screening new anticancer drugs at the National Cance...

The aim of this study was to compare the effect of new synthetic 4-tiazolidinone derivatives (compounds 3882, 3288 and 3833) and doxorubicin (positive control) in free form and in their complexes with synthetic polyethyleneglycol-containing nanoscale polymeric carrier on the biochemical indicators of hepatotoxicity in blood serum of rats. The activ...

There is much progress in application of genetic engineering for improving the biological properties of different organisms. Viral and nonviral carriers are used for delivery of genetic material into target cells. Polymeric materials of natural and synthetic origin are the most promising gene delivery agents. These polymers demonstrated high effici...

The aim of the study was to evaluate the possibility to reduce the doxorubicin toxic effects by its immobilization with N-stearoylethanolamine (NSE) on nanocarier polyethylene glycol. The studied parameters of the doxorubicin toxicity were: the level of creatinine in the mice blood plasma and activity of alanine aminotransferase and aspartate amino...

Rapid development of new nanomaterials and nanotechnologies is accompanied by significant achievements in various fields of medicine, industry and precise technology, as well as by undesirable effects on human health and environment. Our studies were focused on determination of toxicity in vitro and evaluation of the mutagenic activity of novel pol...

Adjuvant properties of the polymer containing acrylic acid, glycidyl methacrylate, triethylene glycol methacrylate and butyl acrylate have been established. Antibodies to ovalbumin and bovine serum albumin in the blood of mice were revealed using dot blot analysis and immunoenzyme analysis when applying the investigated polymer as a carrier of thes...

Development of novel nanoscale functionalized carriers is nowadays one of the most urgent problems in cancer treatment. The aim of our study was to compare the antineoplastic effect of free doxorubicin and its complex with a nanoscale polymeric carrier towards HTC116 colorectal carcinoma cells. It was established that application of the complex of...

The effect of metal-nanocomposites (Me-NC) of cobalt and zinc (Co- and Zn-NC, correspondingly) synthecized on the basis of vinylpyrrolidone (PS) on the metal-accumulative proteins with antioxidant potential metallothioneins (MT) in crucian carp (Carassius auratus gibelio) was studied. Fish was subjected to the effect of Co-NC, Zn-NC, Co2+, Zn2+ or...

The antioxidant effects of N-stearoylethanolamine (NSE) in the nanocomplex composition and in suspension are shown on the model of intoxication by doxorubicin in conditions of development of the Lewis carcinoma in the heart, kidneys and liver tissue and in the blood plasma of female mice. The NSE suspension reduces the level of urea in the blood pl...

Application of special systems for drug delivery into target cells might be useful for overcoming several problems in treatment of dangerous diseases. These are: consequences of nonspecific negative effects of drugs towards healthy cells, low sensitivity of cancer cells to anticancer drugs used in doses that are non-toxic for the organism, resistan...

In current work the interaction of doxorubicine-containing lipophilic nanocarriers and human breast cancer MCF-7 cells was revealed. The mechanism, dynamics and efficiency of nanoparticle's penetration was studied.

Intensive implementation of nanomaterials requires development of novel methods for evaluation of their potential ecotoxicity. The aim of our study was to identify specific characteristics of the effect of cobalt-nanocomposite (Co-NC) on the molecular stress-responsive system in the digestive gland of bivalve mollusk Anodonta cygnea. Nanocomposite...

У статті розглянуто деякі аспекти використання нової полімерної сполуки для транспортування антисенс-олігодезоксинуклеотидів (асОДН) у клітини ссавців. Досліджено ДНК-зв’язувальну здатність олігоелектроліта на основі диметиламіно­етилметакрилату (поліДМАЕМ). Встановлено, що поліДМАЕМ у концентрації менше 5 мкг/мл не чинить вірогідного цитотоксичног...

New anion surfmers of the family of maleic acid asymmetrical esters have been synthesized. Some of its features in the process of emulsion copolymerization with styrene have been studied. The characteristics of covering, obtained on the basis of such latexes of new generation have been investigated as well.