Oleksandr Holichenko

Ukrainian State University of Chemical Technology · Department of Inorganic Chemistry

Versatile procedures for the synthesis of possible structural types of dirhenium(III) halocarboxylates with adamantanecarboxylic acids were developed. A comprehensive study of the synthesis and interconversions of isomeric dirhenium(III) trans-and cis-tetrahalodi-μ-carboxylates led us to a discovery of a versatile route of prepation of trans deriva...

A new dirhenium(III) complex cis-[Re2(GABA)2Cl5(H2O)]Cl.2H2O with zwitterionic gamma-aminobutyrate ligands was prepared and characterized by spectral methods and crystallography. The structure of the compound is comprised of dinuclear complex cations (Re-Re 2.2437(3) A) involving cis-oriented double carboxylate bridges, four equatorial chloride ion...

In this study we report the synthesis, the X-ray crystal structure and the in vivo tumor growth suppression and nephroprotective activity of bis-dimethylsulfoxide-cis-tetrachlorodi-μ-pivalatodirhenium(III), cis-Re2[(CH3)3CCOO]2Cl4·2(CH3)2SO (I). The interactions of I with DNA were also investigated by electrophoretic mobility shift assays, electron...

The synthesis of four dirhenium(III) cis-dicarboxylates with the α-amino acids residues Asp (I), Glu (II), Phe (III) and Tyr (IV) is presented. The G–quadruplex stabilization potential was evaluated by fluorescence resonance energy transfer – melting analysis. All derivatives show specific binding to c-kit1 quadruplex, while II and IV have also str...

Метою роботи було дослідження зв’язуючої активності сполук диренію(III) з бензімідазольними лігандами, до складу яких входить четверний зв’язок метал-метал, з ДНК G4-квадруплексами. Комплекси диренію(III) з унікальним четверним зв’язком є особливо багатообіцяючими кандидатами для клінічного застосування через їх дуже низьку токсичність, протипухлин...

We report about the interactions of dirhenium(III) compound cis-[Re2(Trp)2Cl4(CH3CN)2]Cl2 (I) with bovine serum protein (BSA) and guanine (G4) quadruplexes DNA by UV-Vis titration. Addition of I to BSA led to the interaction between these compounds with binding constant 5.6103 M–1 and hyperchromism (20.9%) of the main protein absorption band (280...

The aim of the study. The aim of the work was to investigate in vivo anticancer activity of cis- and trans-diadamanthylcarboxylates of dirhenium(III) alone and together with cisplatin in form of nanobins. Materials and methods. Model of tumor growth, Guerin’s carcinoma; intraperitoneal administration of cisplatin, dirhenium(III) compounds in lipos...

The previously developed methods for the synthesis of cis-tetrachlorodi--carboxylates of dirhenium(III) were modified, due to which the derivatives of Re26+ with proteinogenic amino acids (AA) isoleucine, serine and proline were synthesized for the first time. The composition and structure of these substances with the general formula cis-[Re2(АA)2...

Hydrolysis of a dirhenium(III) complex compound with β-alanine ligands was investigated by UV-vis, IR- and NMR-spectroscopy methods. Electronic absorption spectra (EAS) of cis[Re2(β-Ala)2(H2O)2Cl4]Cl2 in physiological solution over time showed a gradual decrease in the absorbance of a characteristic absorption maximum at 15630 cm-1 during 3 days. C...

Study of hydrolysis of cis-tetrachlorodi-m-carboxylates of dirhenium (III) was carried out due to the electronic adsorption and IR spectroscopy and pHmeter. As a result, itwas shown that the hydrolysis is a multistage process which can be attributed to the reactions of the pseudo-first order. It is also shown that the electronic absorption spectros...

Study of hydrolysis of cis-tetrachlorodi-m-carboxylates of dirhenium (III) was carried out due to the electronic adsorption and IR spectroscopy and pHmeter. As a result, itwas shown that the hydrolysis is a multistage process which can be attributed to the reactions of the pseudo-first order. It is also shown that the electronic absorption spectros...

Two methods for the synthesis of dirhenium derivatives were developed. Depending on the initial products, complex compounds of two structural types, octachlorodirhenate(III) and cis-tetrachlorodicarboxylate of dirhenium(III) with threonine, were synthesized for the first time. The preparation of (ThrÍ) 2 Re 2 Cl 8 ( ²⁾ was performed in a mixture of...

Complex compounds of dirhenium(III) with bridge carboxylates and halide ligands show various types of bioactivity, and the entry into the internal coordination sphere of the central “atom”- complexing the ligands that have their own physiological activity may extend the range of useful properties of dirhenium(III) complex compounds. From this persp...

Two charge-transfer salts of ET (bis(ethylenedithio)tetrathiafulvalene or BEDT-TTF) molecule and the anions containing multiple Re–Re bond have been investigated using Raman scattering and electron spin resonance (ESR) spectroscopies. Q-band ESR study allowed to record well-split ESR spectra and determine spectroscopic splitting coefficients of ET+...

Voltammetric study of the system consisted of cis-tetrachlorodi-μ-carboxylate dirhenium(III) and stable radical was conducted for detailization of the mechanism of interaction between the Re(III) coordination compounds with the metal-metal quadruple bond and the artificial radical. As a result of voltammetric studies, the electrochemical behavior o...

Методом електронної абсорбційної спектроскопії досліджено антирадикальну активність цис-тетрахлороди-m-карбоксилатів диренію(III) по реакції з вільним ради-калом 2,2-дифеніл-1-пікрилгідразілом. Показано, що комплексні сполуки ренію(III) мають антирадикальну активність. Встановлено, що використання кластерів диренію(III) з екваторіальними лігандами,...

Complex compounds of dirhenium(III), containing an unique quadruple metal-metal bond with low toxicity have a number of useful biological properties, such as antitumoral, antihemolytic, antiradical, hepato- and nephroprotective that stimulates the expansion of the range of such compounds due to the diversity of the ligand sphere. The method of synt...

The asymmetric unit of the title salt, (C$sb 10$H$sb 8$S$sb 8$)[Re$sb 2$Br$sb 6$(CH$sb 3$COO)]$cdot$0.5C$sb 2$H$sb 3$Cl$sb 3$, contains one bis-(ethyl-enedi-thio)-tetra-thia-fulvalene (ET) radical cation, one $mu$$sb 2$-acetato-bis-[tri-bromido-rhenate(III)] anion and a 1,1,2-tri-chloro-ethane mol-ecule with half-occupancy disordered about a twofol...

The title compound, [Re 2 (C 3 H 7 COO) 2 Cl 4 {(CH 3 ) 2 SO} 2 ], comprises binuclear complex molecules [Re—Re = 2.24502 (13) Å] involving cis -oriented double carboxylate bridges, four equatorial chloride ions and two weakly bonded O atoms from dimethyl sulfoxide ligands in the axial positions at the Re III atoms. In the crystal, molecules are li...

The structure of the title compound, [Re2Cl6(C3H7NO2)2]·1.5H2O, comprises a dinuclear complex cation [Re-Re = 2.2494 (3) Å] involving cis-oriented double carboxyl-ate bridges, four equatorial chloride ions and two weakly bonded chloride ligands in the axial positions at the two rhenium(III) atoms. In the crystal, two complex mol-ecules and two wate...

The antioxidant and anticancer properties of dirhenium dicarboxylates of cis- and transconfiguration with different organic ligands in a model of tumor growth (Guerin carcinoma) were studied. It was shown that compounds of different configuration had similar antitumor effect, and dirhenium (III) cis-dicarboxylates were characterized by higher antio...

Aim. To investigate differences in the interactions of binuclear cluster rhenium(III) compounds of cis(I)and trans(II)-configuration with bovine serum albumin (BSA) and human serum albumin (HSA). Methods. Electronic spectroscopy, tryptophan fluorescence and circular dichroism spectroscopy. Results. It was shown that in the process of interaction of...

Aim. To investigate differences in the interactions of binuclear cluster rhenium(ІІІ) compounds of cis(I)- and trans(II)-configuration with bovine serum albumin (BSA) and human serum albumin(НSA). Меthods. Electronic spectroscopy, tryptophan fluorescence and circular dichroism spectroscopy. Results. It was shown that in the process of interaction o...

Influence of the antitumour rhenium-platinum system on biochemical liver characteristics in the model of tumor growth (Guerin carcinoma) was studied and possible hepatoprotective activity of rhenium cluster compounds when introducing them in different forms was shown, that was confirmed by decreasing of diagnostic enzymes activity in blood (aminotr...

Synthesis of five structural types of cluster dirhenium(III) compounds with halogenide and carboxylates ligands is elaborated. It was shown that binuclear cluster fragment Re26+ actively reacted with artificial radicals; the rate of such interactions depended on the ligand environment of the cluster center Re26+, especially from the inductive effec...

The catalysis of breaking the oxidation chains of organic compounds by binuclear clusters cis–[Re2(O2CCH3)2Cl4x2H2O] is detected. The effective breaking constant of acidification chains of benzylperoxy radicals on (I) k = (2,1± 0,4)x10^4 l/(mol s).

The interaction cis-Re2(RCOO)2Cl4, trans-Re2(RCOO)2Cl4, Re2(RCOO)3Cl3, Re2(RCOO)4Cl2 (where R - alkyl group) with 1,3,5-triphenylverdazyle radical in 1,2-dichlorethane was investigated. It is discovered, that gradual substitution of halogenide ligands by carboxylates in dirhenium(III) clusters led to slowing down of reaction with a radical due to d...

The coordination compounds of general formula Re2(L)4X2 (X = Cl, Br; R = 1-adamantylcarboxylate and 1-adamantylacetate) have been prepared and characterized by means of UV-VIS spectroscopy (20000 cm-1, δ→δ*). Crystal and molecular structure of Re2(AdCOO)4Cl2*4CHCl3 solvate was determined by X-ray analysis. The coordination units Re2(AdCOO)4Cl2 adop...

The authors showed stabilizing effect of rhenium binuclear cluster compounds with organic ligands on erythrocytic membranes. Estimation of functional condition of cells was studied by a chemical fragility method. Biphase type of rhenium complexes concentration curves stabilization has been found out; the influence of organic radicals and axial subs...