Oleg Werbitzky

Oleg Werbitzky
LOGSCALE venture partners

Dr. rer. nat.

About

28
Publications
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428
Citations

Publications

Publications (28)
Article
Although diverse, the potential business opportunities for biotechnology outside the biopharmaceutical market are very large. White biotechnology can offer sustainable operations and products, while investments tend to be lower than those in red biotechnology. But a number of bottlenecks and roadblocks in Switzerland must be removed to realise the...
Article
Chemical synthesis of small molecules is well established and enzyme-mediated chemical synthesis is a growing area, with great potential to be expanded in the future. The recombinant production of proteins has become routine. But molecules of intermediate size remain generally much more difficult to be produced in a sustainable way. Oligopeptides,...
Chapter
IntroductionHow Green (Sustainable) can the Industry become?Fine Chemicals and Small-Molecule PharmaceuticalsOligopeptidesOligonucleotidesOligosaccharidesSummary and OutlookAcknowledgmentsReferences
Article
Linaclotide, a small 14-mer peptide highly rich in cysteines, is currently in phase III clinical trials for the treatment of gastrointestinal disorders. The challenge in the assembly of linaclotide consists of achieving the correct and clean folding of its three disulfide bridges. For this purpose, a number of regioselective, semiregioselective, an...
Article
This chapter describes the manufacturing process to a certain level for a possible oligonucleotide cargo and a peptide API in a multi-kilogram scale from a manufacture's point of view. In the concluding remarks, possible conjugation methods will be discussed from an industrial-scale perspective.
Article
Today, there are more than 40 peptides on the pharmaceutical world market and more than 100 in several clinical phases. Although in the past the pharmaceutical industries had reduced their interest in peptides research, in recent decades, they have rekindled their interest in peptides as a result of contemporary novel technological accomplishments,...
Article
The new title compounds (±)-(VI), (±)-(X) and (±)-(XIII) are prepared in order to test their use as aminocyclitol antibiotics.
Article
This contribution presents stereoselective routes to various cis-inos-1,3-diamines starting from readily available cis-4-aminocyclohexenols (7) and (8). The second nitrogen function is introduced into the ring by use of intramolecular cyclisations of neighbouring trichloroacetimidate groups. Hydrolytic cleavage of the resulting oxazolines (15), (16...
Article
The reaction of the cis-cyclohexadiene (I) with the chiral nitroso dienophile (II) occurs with induction of four asymmetric centers in very high optical yield to give the dihydro oxazine (III).
Article
The Diels-Alder reaction of cis-5,6-diacetoxy-1,3-cyclohexadiene (1), which has a meso configuration, with the chiral nitroso dienophile 2 occurs with induction of four asymmetric centers in very high optical yield (ee = 94%) and leads to the dihydro oxazine 3 (89%). The influence of the reaction temperature on the asymmetric induction was investig...
Article
Two genes, aphE and orf, coding for putative Mr 29,000 and Mr 31,000, proteins respectively, were identified in the nucleotide sequence of a 2.8 kbp DNA segment cloned from Streptomyces griseus N2-3-11. The aphE gene expressed streptomycin (SM) resistance and a SM phosphorylating enzyme in S. lividans strains. The two genes were found to be in oppo...
Article
Two genes, aphE and orf, coding for putative Mr 29,000 and Mr 31,000, proteins respectively, were identified in the nucleotide sequence of a 2.8 kbp DNA segment cloned from Streptomyces griseus N2-3-11. The aphE gene expressed streptomycin (SM) resistance and a SM phosphorylating enzyme in S. lividans strains. The two genes were found to be in oppo...
Article
In the presence of artificial mediators many bacteria reductively split the NO bond of dihydrooxazines in a chemoselective way if hydrogen is used as an electron source. The yields as determined by HPLC are almost quantitative i.e. considerably better than by chemical reductions.
Article
Polyhydroxyamino Compounds via Diene Synthesis with Nitroso Compounds.
Article
Die Darstellung und Diels-Alder-Reaktionen der Titelverbindung 3 mit α-Chlornitrosoverbindungen (4, 7) werden beschrieben. Bei Verwendung des Androstanderivats 7 erhält man hochstereoselektiv das Addukt (+)-5a, dessen optische Reinheit nach verschiedenen Verfahren vergleichend bestimmt wird. Polyhydroxyamino Compounds via Diene Synthesis with Nitro...
Article
Full-text available
A total of 16 idiotrophic mutants unable to produce the aminoglycoside antibiotic streptomycin (smi) were isolated from Streptomyces griseus N2-3-11. Cosynthesis of streptomycin, its formation from various precursors and analysis of accumulated intermediates allowed grouping of the mutants in 3 classes, blocked: (I) in the first transamination step...

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